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61. 发明授权

US07009696B2 Method and apparatus for scanning, stitching, and damping measurements of a double-sided metrology inspection tool 有权
公开(公告)号：US07009696B2
公开(公告)日：2006-03-07
申请号：US10759764
申请日：2004-01-16
申请人： Paul J. Sullivan , George Kren , Rodney C. Smedt , Hans J. Hansen , David W. Shortt , Daniel Ivanov Kavaldjiev , Christopher F. Bevis
发明人： Paul J. Sullivan , George Kren , Rodney C. Smedt , Hans J. Hansen , David W. Shortt , Daniel Ivanov Kavaldjiev , Christopher F. Bevis
IPC分类号： G01N21/84
CPC分类号： G01N21/9501 , G01R31/2656 , G01R31/2831
摘要： A system for inspecting specimens such as semiconductor wafers is provided. The system provides scanning of dual-sided specimens using a damping arrangement which filters unwanted acoustic and seismic vibration, including an optics arrangement which scans a first portion of the specimen and a translation or rotation arrangement for translating or rotating the specimen to a position where the optics arrangement can scan the remaining portion(s) of the specimen. The system further includes means for stitching the scans together, thereby providing both damping of the specimen and the need for smaller and less expensive optical elements.

62. 发明授权

US06458933B1 Therapeutic using a bispecific antibody 有权
标题翻译：使用双特异性抗体治疗
公开(公告)号：US06458933B1
公开(公告)日：2002-10-01
申请号：US09314135
申请日：1999-05-19
申请人： Hans J. Hansen
发明人： Hans J. Hansen
IPC分类号： C12P2108
CPC分类号： A61K51/1048 , A61K38/00 , A61K47/62 , A61K47/6893 , A61K51/0495 , A61K2039/507 , B82Y5/00 , C07K16/1045 , C07K16/14 , C07K16/18 , C07K16/242 , C07K16/2833 , C07K16/3007 , C07K16/4241 , C07K16/4258 , C07K16/4266 , C07K2317/24 , C07K2317/31 , C07K2317/626
摘要： Multivalent, multispecific molecules having at least one specificity for a pathogen and at least one specificity for the HLA class II invariant chain (Ii) are administered to induce clearance of the pathogen. In addition to pathogens, clearance of therapeutic or diagnostic agents, autoantibodies, anti-graft antibodies, and other undesirable compounds may be induced using the multivalent, multispecific molecules.
摘要翻译：给予对病原体具有至少一种特异性和对HLA II类不变链（Ii）至少一种特异性的多价多特异性分子，以诱导病原体的清除。除了病原体之外，还可以使用多价多特异性分子来诱导治疗或诊断剂，自身抗体，抗移植物抗体和其它不期望的化合物的清除。

63. 发明授权

US5443953A Preparation and use of immunoconjugates 失效
标题翻译：免疫缀合物的制备和使用
公开(公告)号：US5443953A
公开(公告)日：1995-08-22
申请号：US162912
申请日：1993-12-08
申请人： Hans J. Hansen , Shui-on Leung , Jerry Shevitz
发明人： Hans J. Hansen , Shui-on Leung , Jerry Shevitz
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K49/00 , A61K51/10 , C07H21/04 , C07K16/00 , C07K16/30 , C07K17/00 , C12N15/09 , C12P21/08 , C12R1/91 , G01N33/532 , G01N33/563 , G01N33/68
CPC分类号： G01N33/6857 , A61K51/1048 , A61K51/1069 , A61K51/1093 , C07K16/00 , C07K16/30 , C07K16/3007 , C07K16/3061 , G01N33/532 , A61K2121/00 , A61K2123/00 , A61K38/00
摘要： The present invention relates to immunoconjugates comprising an antibody fragment which is covalently bound to a diagnostic or therapeutic principle through a carbohydrate moiety in the light chain variable region of the antibody fragment. The invention also relates to immunoconjugates comprising an antibody moiety that is an intact antibody containing a glycosylation site in the light chain variable domain which has been introduced into the antibody by mutating the nucleotide sequence encoding the light chain. The resultant immunoconjugates retain the immunoreactivity of the antibody fragment or intact antibody, and target the diagnostic or therapeutic principle to a target tissue where the diagnostic or therapeutic effect is realized. Thus, the invention contemplates the use of such immunoconjugates for diagnosis and immunotherapy. The invention further relates to methods for preparing such immunoconjugates.
摘要翻译：本发明涉及包含通过抗体片段的轻链可变区中的碳水化合物部分与诊断或治疗原理共价结合的抗体片段的免疫缀合物。本发明还涉及包含抗体部分的免疫缀合物，所述抗体部分是通过突变编码轻链的核苷酸序列而被引入抗体的包含轻链可变结构域中的糖基化位点的完整抗体。所得的免疫偶联物保留抗体片段或完整抗体的免疫反应性，并将诊断或治疗原理靶向实现诊断或治疗效果的靶组织。因此，本发明考虑使用这种免疫缀合物进行诊断和免疫治疗。本发明还涉及制备这种免疫缀合物的方法。

64. 发明授权

US5439665A Detection and treatment of infectious and inflammatory lesions 失效
标题翻译：检测和治疗感染性和炎症性病变
公开(公告)号：US5439665A
公开(公告)日：1995-08-08
申请号：US777499
申请日：1991-10-17
申请人： Hans J. Hansen , Milton D. Goldenberg
发明人： Hans J. Hansen , Milton D. Goldenberg
IPC分类号： A61K47/48 , A61K51/10 , A61K51/00 , A61K39/44
CPC分类号： A61K47/48546 , A61K51/1018 , A61K2123/00
摘要： A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific antibodies or antibody fragments, conjugated to at least one imaging agent, wherein at least two of said antibodies or antibody fragments specifically bind to different leukocyte cell types.A method for targeting an imaging agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above anti-leukocyte imaging conjugate.A therapeutic anti-leukocyte antibody-agent conjugate for targeting foci of leukocyte accretion comprises at least one immunoreactive substantially monospecific antibody or antibody fragment which specifically binds to at least one leukocyte cell type, conjugated to at least one therapeutic antimicrobial agent and/or radionuclide.A method of treatment of an infectious lesion comprises injecting a mammal parenterally with an effective amount for therapy of the above anti-leukocyte therapeutic conjugate.
摘要翻译：用于靶向白细胞增生灶的多特异性抗白细胞抗体缀合物包含与至少一种成像剂缀合的至少两种不同的基本单特异性抗体或抗体片段的免疫反应性多特异性复合物，其中至少两种所述抗体或抗体片段特异性结合到不同的白细胞类型。用于将成像剂靶向炎性或感染性病变的方法包括以有效量肠胃外注射哺乳动物以靶向上述抗白细胞成像缀合物。用于靶向白细胞吸积灶的治疗性抗白细胞抗体 - 试剂缀合物包含与至少一种治疗性抗微生物剂和/或放射性核素缀合的至少一种特异性结合至少一种白细胞类型的免疫反应性基本上单特异性抗体或抗体片段。治疗感染性病变的方法包括用有效量的胃肠外注射哺乳动物治疗上述抗白细胞治疗缀合物。

65. 发明授权

US08367037B2 Anti-CD74 immunoconjugates and methods of use 有权
标题翻译：抗CD74免疫缀合物及其使用方法
公开(公告)号：US08367037B2
公开(公告)日：2013-02-05
申请号：US13347934
申请日：2012-01-11
申请人： John C. Byrd , David M. Goldenberg , Hans J. Hansen
发明人： John C. Byrd , David M. Goldenberg , Hans J. Hansen
IPC分类号： A61K51/00 , C07K16/00
CPC分类号： A61K47/48823 , A61K39/395 , A61K47/6907 , A61K47/6913 , A61K51/1234 , A61K2039/505 , C07K16/2803 , C07K16/2833 , C07K16/2896 , C07K2317/24 , C07K2317/565 , C07K2317/73 , G01N33/574 , G01N2333/70596 , G01N2800/245 , A61K2300/00
摘要： Disclosed are compositions that include anti-CD74 immunoconjugates and optionally a therapeutic and/or diagnostic agent. In preferred embodiments, the immunoconjugates comprise one or more anti-CD74 antibodies or antigen-binding fragments thereof, conjugated to a liposome or micelle. Also disclosed are methods for preparing the immunoconjugates and using the immunoconjugates in diagnostic and therapeutic procedures. In certain preferred embodiments, the therapeutic methods comprise administering to a subject with a CD74-expressing disease an anti-CD74 immunoconjugate and thereby inducing apoptosis of CD74-expressing cells. In more preferred embodiments, the CD74 immunoconjugate is capable of inducing cell death in the absence of any other therapeutic agent, although such agents may be optionally administered prior to, together with or subsequent to administration of the anti-CD74 immunoconjugate. The compositions may be part of a kit for administering the anti-CD74 immunoconjugates or compositions.
摘要翻译：公开了包含抗CD74免疫偶联物和任选的治疗和/或诊断剂的组合物。在优选的实施方案中，免疫偶联物包含缀合至脂质体或胶束的一种或多种抗CD74抗体或其抗原结合片段。还公开了在诊断和治疗过程中制备免疫缀合物和使用免疫缀合物的方法。在某些优选实施方案中，治疗方法包括向具有表达CD74的疾病的受试者施用抗CD74免疫偶联物，从而诱导表达CD74的细胞的凋亡。在更优选的实施方案中，CD74免疫缀合物能够在不存在任何其它治疗剂的情况下诱导细胞死亡，尽管可以任选地在施用抗CD74免疫缀合物之前，之后或之后施用这些试剂。组合物可以是用于施用抗CD74免疫缀合物或组合物的试剂盒的一部分。

66. 发明申请

US20120063993A1 THERAPEUTIC AND DIAGNOSTIC CONJUGATES FOR USE WITH MULTISPECIFIC ANTIBODIES 有权
标题翻译：治疗与诊断联合使用多重抗体
公开(公告)号：US20120063993A1
公开(公告)日：2012-03-15
申请号：US12138065
申请日：2008-06-12
申请人： William J. McBride , David M. Goldenberg , Carl Noren , Hans J. Hansen
发明人： William J. McBride , David M. Goldenberg , Carl Noren , Hans J. Hansen
IPC分类号： A61K51/00 , C07K7/02 , C12N9/00 , A61K9/127 , A61K38/20 , A61K38/21 , A61K38/19 , A61K49/00 , A61P9/00 , A61P31/00 , A61P37/02 , A61P35/00 , A61P3/00 , A61P25/00 , A61P31/04 , A61P31/10 , A61P33/00 , A61P33/02 , A61P35/02 , A61K39/395 , B82Y5/00
CPC分类号： A61K51/0497 , A61K47/665 , A61K51/04 , A61K51/0455 , A61K51/048 , A61K51/1048 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/06078 , C07K5/1013 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2319/00
摘要： Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer/carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and/or precursors of the compounds.
摘要翻译：公开了包含两个或多个通过间隔物或载体缀合的半抗原的化合物。半抗原可以包括二亚乙基三胺五乙酸（DTPA），组氨酰胺 - 琥珀酰 - 谷氨酰胺（HSG）或DTPA和HSG的组合。化合物还包括效应分子，其可以与一个或多个半抗原，间隔物/载体或两者结合。效应分子可以通过多个键连接，包括酯键，亚氨基键，氨基键，硫键，硫代缩氨基脲键，缩氨基脲键，肟键，醚键或这些键的组合。还公开了合成化合物的化合物和/或前体的方法。

67. 发明授权

US08062636B2 Antibody therapy 有权
标题翻译：抗体治疗
公开(公告)号：US08062636B2
公开(公告)日：2011-11-22
申请号：US13030204
申请日：2011-02-18
申请人： David M. Goldenberg , Hans J. Hansen
发明人： David M. Goldenberg , Hans J. Hansen
IPC分类号： A61K39/395
CPC分类号： A61K39/39558 , A61K31/437 , A61K31/4545 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/655 , A61K31/675 , A61K31/704 , A61K38/164 , A61K38/168 , A61K38/1816 , A61K38/191 , A61K38/193 , A61K38/196 , A61K38/20 , A61K38/217 , A61K51/1045 , A61K51/1048 , A61K51/1096 , A61K2039/505 , C07K16/3007 , C07K2317/24 , A61K2300/00
摘要： The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers and other diseases, and methods of use in treatment using this composition.
摘要翻译：本发明提供了包含裸体人源化，嵌合和人抗CEA抗体和治疗剂的组合物，其可用于治疗表达CEA的癌症和其它疾病，以及使用该组合物的治疗方法。

68. 发明申请

US20110195023A1 Internalizing Anti-CD74 Antibodies and Methods of Use 审中-公开
公开(公告)号：US20110195023A1
公开(公告)日：2011-08-11
申请号：US13047515
申请日：2011-03-14
申请人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
发明人： Hans J. Hansen , Zhengxing Qu , David M. Goldenberg
IPC分类号： A61K39/395 , A61K51/10 , A61K38/19 , A61K38/21 , A61K38/20 , A61P37/02 , A61P37/06 , A61P17/00 , A61P3/10 , A61P25/14
CPC分类号： A61K45/06 , A61K38/00 , A61K47/6849 , A61K51/1027 , A61K2039/505 , C07K16/2833 , C07K16/2896 , C07K2317/24 , C07K2317/77
摘要： The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, which is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies, other malignancies in which the cells are reactive with CD74, and autoimmune diseases, and methods of treatment and diagnosis.

69. 发明申请

US20110189085A1 Antibody Therapy 有权
标题翻译：抗体治疗
公开(公告)号：US20110189085A1
公开(公告)日：2011-08-04
申请号：US13030204
申请日：2011-02-18
申请人： David M. Goldenberg , Hans J. Hansen
发明人： David M. Goldenberg , Hans J. Hansen
IPC分类号： A61K51/00 , A61K39/395 , A61K38/19 , A61K38/21 , A61K38/20 , A61P35/00
CPC分类号： A61K39/39558 , A61K31/437 , A61K31/4545 , A61K31/4745 , A61K31/475 , A61K31/513 , A61K31/519 , A61K31/555 , A61K31/655 , A61K31/675 , A61K31/704 , A61K38/164 , A61K38/168 , A61K38/1816 , A61K38/191 , A61K38/193 , A61K38/196 , A61K38/20 , A61K38/217 , A61K51/1045 , A61K51/1048 , A61K51/1096 , A61K2039/505 , C07K16/3007 , C07K2317/24 , A61K2300/00
摘要： The present invention provides a composition comprising naked humanized, chimeric, and human anti-CEA antibodies and a therapeutic agent, which is useful for treatment of CEA expressing cancers and other diseases, and methods of use in treatment using this composition.
摘要翻译：本发明提供了包含裸体人源化，嵌合和人抗CEA抗体和治疗剂的组合物，其可用于治疗表达CEA的癌症和其它疾病，以及使用该组合物的治疗方法。

70. 发明授权

US07914787B2 Production and use of novel peptide-based agents with bispecific antibodies 有权
标题翻译：用双特异性抗体生产和使用新的基于肽的试剂
公开(公告)号：US07914787B2
公开(公告)日：2011-03-29
申请号：US12474665
申请日：2009-05-29
申请人： David M. Goldenberg , Hans J. Hansen , William J. McBride
发明人： David M. Goldenberg , Hans J. Hansen , William J. McBride
IPC分类号： A61K39/395 , A61K38/04 , C07K16/46 , C07K7/00
CPC分类号： A61K51/1048 , A61K47/665 , A61K47/6879 , A61K51/1063 , A61K2039/505 , B82Y5/00 , C07K5/0215 , C07K5/1016 , C07K5/1019 , C07K7/06 , C07K16/18 , C07K16/3007 , C07K16/3046 , C07K16/44 , C07K16/468 , C07K2317/12 , C07K2317/13 , C07K2317/24 , C07K2317/31 , C07K2317/55 , C07K2317/622 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to a bi-specific antibody or antibody fragment having at least one arm that specifically binds a targeted tissue and at least one other arm that specifically binds a targetable construct. The targetable construct comprises a carrier portion which comprises or bears at least one epitope recognizable by at least one arm of said bi-specific antibody or antibody fragment. The targetable construct further comprises one or more therapeutic or diagnostic agents or enzymes. The invention provides constructs and methods for producing the bi-specific antibodies or antibody fragments, as well as methods for using them.
摘要翻译：本发明涉及具有特异性结合目标组织的至少一个臂的特异性抗体或抗体片段以及特异性结合可靶向构建体的至少一个其他臂。可靶向构建体包含载体部分，其包含或携带至少一个可被所述双特异性抗体或抗体片段的至少一个臂识别的表位。可靶向构建物还包含一种或多种治疗剂或诊断剂或酶。本发明提供用于产生双特异性抗体或抗体片段的构建体和方法，以及使用它们的方法。

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