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61. 发明申请

US20100018872A1 Small Volume In Vitro Sensor and Methods of Making 有权
公开(公告)号：US20100018872A1
公开(公告)日：2010-01-28
申请号：US12569164
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/26 , C12Q1/26
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

62. 发明申请

US20100012523A1 Small Volume In Vitro Sensor and Methods of Making 有权
公开(公告)号：US20100012523A1
公开(公告)日：2010-01-21
申请号：US12569201
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/26 , C12Q1/26
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

63. 发明授权

US07563350B2 Small volume in vitro analyte sensor 有权
标题翻译：体积小体积分析物传感器
公开(公告)号：US07563350B2
公开(公告)日：2009-07-21
申请号：US10663153
申请日：2003-09-15
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

64. 发明授权

US07090756B2 Transition metal complexes with bidentate ligand having an imidazole ring 有权
标题翻译：与具有咪唑环的二齿配体的过渡金属络合物
公开(公告)号：US07090756B2
公开(公告)日：2006-08-15
申请号：US10639181
申请日：2003-08-11
申请人： Fei Mao , Adam Heller
发明人： Fei Mao , Adam Heller
IPC分类号： C12M1/00
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/1477 , C07F9/005 , C07F15/0026 , C07F15/0053 , C07F15/025 , C07F15/065 , C08F8/42 , C08F8/44 , C09B57/10 , C12Q1/004
摘要： Novel transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The transition metal complexes can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand. Transition metal complexes attached to polymeric backbones are also described.
摘要翻译：描述了铁，钴，钌，锇和钒的新型过渡金属络合物。过渡金属络合物可用作酶基电化学传感器中的氧化还原介质。在这种情况下，过渡金属配合物以高速率接受电子或将电子转移到酶，并且还与传感器快速交换电子。过渡金属络合物包括至少一个取代或未取代的双咪唑配体，并且还可以包括第二取代或未取代的双咪唑配体或取代或未取代的联吡啶或吡啶基咪唑配体。还描述了连接到聚合物主链上的过渡金属络合物。

65. 发明申请

US20050241957A1 Biosensor membranes composed of polymers containing heterocyclic nitrogens 有权
标题翻译：由包含杂环氮的聚合物组成的生物传感器膜
公开(公告)号：US20050241957A1
公开(公告)日：2005-11-03
申请号：US11174222
申请日：2005-07-01
申请人： Fei Mao , Hyun Cho
发明人： Fei Mao , Hyun Cho
IPC分类号： G01N33/66 , A61B5/145 , A61B5/1477 , C08F12/28 , C08J5/22 , C12Q1/00 , G01N27/327 , G01N27/40 , G01N27/416
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/6846 , C12Q1/002 , C12Q1/004 , C12Q1/006
摘要： Novel membranes comprising various polymers containing heterocyclic nitrogen groups are described. These membranes are usefully employed in electrochemical sensors, such as amperometric biosensors. More particularly, these membranes effectively regulate a flux of analyte to a measurement electrode in an electrochemical sensor, thereby improving the functioning of the electrochemical sensor over a significant range of analyte concentrations. Electrochemical sensors equipped wish such membranes are also described.
摘要翻译：描述了包含含有杂环氮基团的各种聚合物的新型膜。这些膜可用于电化学传感器，如电流分析生物传感器。更具体地，这些膜有效地将分析物的通量调节到电化学传感器中的测量电极，由此在显着的分析物浓度范围内改善了电化学传感器的功能。还描述了装有电化学传感器的这种膜。

66. 发明授权

US06618934B1 Method of manufacturing small volume in vitro analyte sensor 有权
标题翻译：制造体积小体积分析物传感器的方法
公开(公告)号：US06618934B1
公开(公告)日：2003-09-16
申请号：US09594285
申请日：2000-06-15
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H05K336
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

67. 发明授权

US06461496B1 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 有权
标题翻译：小体积体外分析物传感器，具有可扩散或不可浸出的氧化还原介体
公开(公告)号：US06461496B1
公开(公告)日：2002-10-08
申请号：US09427808
申请日：1999-10-27
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

68. 发明授权

US06338790B1 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 有权
公开(公告)号：US06338790B1
公开(公告)日：2002-01-15
申请号：US09295962
申请日：1999-04-21
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffrey V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffrey V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N2726
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

69. 发明授权

US06291203B1 Cyanine dyes that stain cells and mitochondria 有权
标题翻译：染色细胞和线粒体的花青染料
公开(公告)号：US06291203B1
公开(公告)日：2001-09-18
申请号：US09266697
申请日：1998-12-03
申请人： Martin Poot , Fei Mao
发明人： Martin Poot , Fei Mao
IPC分类号： G01N130
CPC分类号： G01N1/30 , C09B23/02 , G01N2001/302
摘要： The present invention relates to the use of positively-charged unsymmetrical cyanine dyes, including novel unsymmetrical cyanine dyes, to stain cells and selectively stain intracellular organelles, with particular advantages in staining mitochondria. The dyes are generally weakly fluorescent in aqueous solution but highly fluorescent in cells and organelles, typically staining cells or mitochondria with a green fluorescence. The dyes stain mitochondria in both live and dead cells, and are retained in mitochondria even where the cells are treated with solvents that permeabilize cell and mitochondrial membranes. Mitochondria or cells stained according to this method are optionally stained with an additional detection reagent, such as a labeled antibody, labeled oligonucleotide, fluorogenic enzyme substrate, or other indicator for a specific cellular component or substructure, including another unsymmetrical cyanine stain of the same or different class.
摘要翻译：本发明涉及使用带正电荷的不对称花青染料，包括新颖的不对称花青染料，染色细胞和选择性染色细胞内细胞器，具有染色线粒体特别的优点。染料通常在水溶液中弱荧光，但在细胞和细胞器中高度荧光，通常用绿色荧光染色细胞或线粒体。染料在活细胞和死细胞中染色线粒体，并且保留在线粒体中，甚至在用细胞和线粒体膜透化的溶剂处理细胞的情况下。线粒体或根据该方法染色的细胞任选地用另外的检测试剂如标记的抗体，标记的寡核苷酸，荧光酶底物或用于特定细胞组分或亚结构的其它指示剂进行染色，包括其它不对称花青染色不同班

70. 发明授权

US08650751B2 Methods of making small volume in vitro analyte sensors 有权
标题翻译：制作体积小体积分析物传感器的方法
公开(公告)号：US08650751B2
公开(公告)日：2014-02-18
申请号：US12569350
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H01R43/20
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于测定生物流体如血液或血清中生物分子如葡萄糖或乳酸的浓度，使用诸如库仑法，电流分析法; 和电位法。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

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