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61. 发明授权

US08977360B2 Neurostimulation system with on-effector programmer control 有权
标题翻译：具有效应器程序员控制的神经刺激系统
公开(公告)号：US08977360B2
公开(公告)日：2015-03-10
申请号：US13469990
申请日：2012-05-11
申请人： Chester Kim , Mun Pook Lui , Kerry Bradley
发明人： Chester Kim , Mun Pook Lui , Kerry Bradley
IPC分类号： A61N1/00 , A61N1/36 , A61N1/372
CPC分类号： A61N1/36071 , A61N1/36157 , A61N1/36185 , A61N1/37247
摘要： An external control device for use with a programmable implantable medical device coupled to an operative element. The external control device comprises a user interface comprising a control element and a display screen configured for displaying a graphical representation of the operative element. The external control device further comprises control circuitry configured for prompting the display screen to superimpose a graphical programmer control over the graphical representation of the operative element when the control element is actuated, and modifying an operational parameter for the operative element in response to actuation of the graphical programmer control. The external control device further comprises output circuitry configured for transmitting the modified operational parameter to the programmable implantable medical device.
摘要翻译：一种用于与可操作元件耦合的可编程可植入医疗装置的外部控制装置。外部控制装置包括用户界面，其包括控制元件和被配置为显示操作元件的图形表示的显示屏幕。所述外部控制装置还包括控制电路，所述控制电路经配置以在所述控制元件被致动时提示所述显示屏幕将图形编程器控制叠加在所述操作元件的图形表示上，以及响应于所述操作元件的致动而修改所述操作元件的操作参数图形编程器控制。外部控制装置还包括被配置为将修改的操作参数传送到可编程可植入医疗装置的输出电路。

62. 发明授权

US08504160B2 System and method for modulating action potential propagation during spinal cord stimulation 有权
标题翻译：用于调节脊髓刺激期间动作电位传播的系统和方法
公开(公告)号：US08504160B2
公开(公告)日：2013-08-06
申请号：US12618563
申请日：2009-11-13
申请人： Dongchul Lee , Kerry Bradley
发明人： Dongchul Lee , Kerry Bradley
IPC分类号： A61N1/00
CPC分类号： A61N1/36071 , A61N1/36 , A61N1/3605
摘要： A method and neurostimulator for providing therapy to a patient is provided. In one technique, an electrical pulsed waveform is conveyed between a caudal electrode and spinal cord tissue, thereby evoking action potentials that are orthodromically propagated along dorsal column fibers and evoking action potentials that are antidromically propagated along the DC fibers. Electrical energy is conveyed between a rostral electrode and the spinal cord tissue, thereby modulating times that the action potentials orthodromically propagated along the DC fibers arrive at the brain. In another technique, an electrical pulsed waveform is conveyed through a first electrode, thereby evoking action potentials that are propagated along a neural axon, and electrical energy is conveyed through the second electrode. The electrical energy has a frequency that is greater than a pulse rate of the electrical pulsed waveform, such that the action potentials propagated along the neural axon are blocked by the electrical energy.
摘要翻译：提供了一种用于向患者提供治疗的方法和神经刺激器。在一种技术中，电脉冲波形在尾部电极和脊髓组织之间传送，从而引起沿背侧纤维正交传播的动作电位并引起沿着DC纤维反向传播的动作电位。电能在脊髓电极和脊髓组织之间传送，从而调节沿着DC纤维正交传播的动作电位到达脑部的时间。在另一种技术中，电脉冲波形被传送通过第一电极，从而引起沿着神经轴突传播的动作电位，并且电能被传送通过第二电极。电能的频率大于电脉冲波形的脉冲频率，使得沿着神经轴突传播的动作电位被电能阻挡。

63. 发明申请

US20130138167A1 AUTONOMIC MODULATION USING PERIPHERAL NERVE FIELD STIMULATION 有权
标题翻译：使用外周神经网络自动化调制
公开(公告)号：US20130138167A1
公开(公告)日：2013-05-30
申请号：US13686336
申请日：2012-11-27
申请人： Kerry Bradley , Rafael Carbunaru , Jason J. Hamann
发明人： Kerry Bradley , Rafael Carbunaru , Jason J. Hamann
IPC分类号： A61N1/36 , A61N1/39
CPC分类号： A61N1/36114 , A61N1/3605 , A61N1/36053 , A61N1/36057 , A61N1/36117 , A61N1/36139 , A61N1/36146 , A61N1/3621 , A61N1/3627 , A61N1/37235 , A61N1/37282 , A61N1/37288 , A61N1/3962
摘要： Some embodiments provide a system, comprising a peripheral nerve field modulation (PNFM) therapy delivery system, PNFM electrodes configured to be implanted subcutaneously, and a controller. The PNFM electrodes are electrically connected to the PNFM therapy system. The PNFM therapy delivery system and the PNFM electrodes are configured to deliver current and/or control the field potentials at one or more peripheral nerve fields. The controller is configured to control the PNFM therapy delivery system to deliver a PNFM therapy to the one or more peripheral nerve fields. The controller includes a scheduler configured to control timing of the PNFM therapy.
摘要翻译：一些实施例提供一种包括周边神经域调制（PNFM）治疗递送系统，以及被配置为皮下植入的PNFM电极和控制器的系统。 PNFM电极电连接到PNFM治疗系统。 PNFM治疗递送系统和PNFM电极被配置为在一个或多个周围神经区传递电流和/或控制场电位。控制器被配置为控制PNFM治疗递送系统将PNFM治疗递送到一个或多个周围神经区域。控制器包括被配置为控制PNFM治疗的定时的调度器。

64. 发明申请

US20130006324A1 SYSTEM AND METHOD FOR USING IMPEDANCE TO DETERMINE PROXIMITY AND ORIENTATION OF SEGMENTED ELECTRODES 有权
标题翻译：使用阻抗确定分离电极的近似性和方位的系统和方法
公开(公告)号：US20130006324A1
公开(公告)日：2013-01-03
申请号：US13533532
申请日：2012-06-26
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/08 , A61B5/0538 , A61B5/06 , A61B5/068 , A61N1/0551 , A61N1/36125 , A61N1/36182 , A61N1/37217 , A61N1/37241 , A61N1/3787
摘要： A method for implanting a neurostimulation lead within a patient includes measuring impedances of electrodes on the lead in order to correctly position the lead relative to a target tissue region. The electrodes are circumferentially segmented electrodes that are spaced from each other about the longitudinal axis of the lead. When the difference between the impedances of the electrodes exceeds a threshold value, the lead is in the correct position. In accordance with another embodiment, impedance measurements are used to select which one of the electrodes is closest to the target tissue region. By determining which electrode has the highest impedance and which electrode has the lowest impedance, the type of tissue adjacent to each electrode can be determined based on the conductivity properties of the tissue. The target tissue region may be a spinal cord, a posterior longitudinal ligament, white matter, or gray matter.
摘要翻译：用于在患者体内植入神经刺激引线的方法包括测量引线上的电极的阻抗，以便使引线相对于目标组织区域正确定位。电极是周向分段的电极，其围绕导线的纵向轴线彼此间隔开。当电极的阻抗差超过阈值时，引线处于正确的位置。根据另一个实施例，使用阻抗测量来选择哪个电极最靠近目标组织区域。通过确定哪个电极具有最高阻抗并且哪个电极具有最低的阻抗，可以基于组织的电导率特性来确定与每个电极相邻的组织的类型。目标组织区域可以是脊髓，后纵韧带，白质或灰质。

65. 发明申请

US20120330218A1 METHOD FOR IMPROVING FAR-FIELD ACTIVATION IN PERIPHERAL FIELD NERVE STIMULATION 失效
标题翻译：用于改善外周场神经刺激中的场激活的方法
公开(公告)号：US20120330218A1
公开(公告)日：2012-12-27
申请号：US13529928
申请日：2012-06-21
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/05 , A61M37/00
CPC分类号： A61N1/36071 , A61N1/0551 , A61N1/3605
摘要： A method of providing therapy to a patient having a disorder using an electrode located adjacent a peripheral target neural region. The method comprises conveying electrical stimulation energy from the electrode that stimulates a first set of nerve endings in the peripheral target neural region. The method further comprises increasing an activation threshold of a second set of nerve endings in the peripheral target neural region, thereby rendering the second set of nerve endings less excitable to the electrical stimulation energy. The first set of nerve endings are relatively far from the electrode and the second set of nerve endings are relatively near the electrode.
摘要翻译：使用位于周边靶神经区域附近的电极向病人提供治疗的方法。该方法包括从刺激第一组神经末梢的周围靶神经区域的电极输送电刺激能量。所述方法还包括增加周围目标神经区域中第二组神经末梢的激活阈值，从而使第二组神经末梢对电刺激能量更不可兴奋。第一组神经末梢距离电极相对较远，第二组神经末梢相对靠近电极。

66. 发明授权

US08233991B2 Method for programming implantable device 有权
标题翻译：编程植入式装置的方法
公开(公告)号：US08233991B2
公开(公告)日：2012-07-31
申请号：US11105643
申请日：2005-04-13
申请人： Carla M. Woods , James R. Thacker , David K. Peterson , Holly A. Segel , Susan E. Ford , Margaret E. Theriot , Kerry Bradley
发明人： Carla M. Woods , James R. Thacker , David K. Peterson , Holly A. Segel , Susan E. Ford , Margaret E. Theriot , Kerry Bradley
IPC分类号： A61N1/04
CPC分类号： A61N1/36071 , A61N1/08 , A61N1/36185 , A61N1/37241 , A61N1/37247
摘要： Methods for selecting Spinal Cord Stimulation (SCS), or other medical electrical stimulator, electrode configurations from a set of electrode configurations are provided. Each electrode configuration represents a polarity or a polarity percentage of the electrodes of an electrode array. The selected electrode configurations may be used in a medical electrical stimulator. Such methods of selecting electrode configurations results in a more efficient programming and use of the stimulation system.
摘要翻译：提供了从一组电极配置中选择脊髓刺激（SCS）或其他医疗电刺激器电极配置的方法。每个电极配置表示电极阵列的电极的极性或极性百分比。所选择的电极配置可以用在医疗电刺激器中。这种选择电极配置的方法导致更有效的编程和使用刺激系统。

67. 发明申请

US20120109257A1 SYSTEM AND METHOD FOR PROVIDING FLUID REAL-TIME VISUALIZATION OF REGION OF TISSUE ACTIVATION 有权
标题翻译：用于提供组织活化区域的流体实时可视化的系统和方法
公开(公告)号：US20120109257A1
公开(公告)日：2012-05-03
申请号：US13244415
申请日：2011-09-24
申请人： Peter J. Yoo , Michael A. Moffitt , Kerry Bradley
发明人： Peter J. Yoo , Michael A. Moffitt , Kerry Bradley
IPC分类号： A61N1/372
CPC分类号： A61N1/37247 , A61N1/36135 , A61N1/36185
摘要： A system for a tissue stimulator coupled to an array of electrodes. The system comprises a user-controlled input device configured for generating control signals, and at least one processor configured for generating a plurality of stimulation parameter sets in response to the control signals that, when applied to the electrodes, will shift electrical current between electrodes to modify a region of tissue activation. The processor(s) is further configured for computing an estimate of the region of tissue activation, and for generating display signals capable of prompting a monitor to display an animated graphical representation of the computed estimate of the region of tissue activation.
摘要翻译：一种耦合到电极阵列的组织刺激器的系统。该系统包括被配置为产生控制信号的用户控制的输入装置，以及至少一个处理器，被配置为响应于控制信号产生多个刺激参数集合，当被施加到电极时将使电极之间的电流移位到修改组织激活的区域。处理器还被配置用于计算组织激活区域的估计，并且用于产生能够促使监视器显示所计算的组织激活区域的估计的动画图形表示的显示信号。

68. 发明申请

US20120101537A1 SYSTEM AND METHOD FOR INTRODUCING TISSUE STIMULATION LEAD INTO PATIENT USING REAL-TIME COUPLING EFFICIENCY MEASUREMENTS 有权
标题翻译：使用实时耦合效率测量将组织刺激引导引入患者的系统和方法
公开(公告)号：US20120101537A1
公开(公告)日：2012-04-26
申请号：US13244458
申请日：2011-09-24
申请人： David K.L. Peterson , Kerry Bradley
发明人： David K.L. Peterson , Kerry Bradley
IPC分类号： A61N1/372
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/3605 , A61N1/36185 , A61N1/372
摘要： A system and method for locating an implantable tissue stimulation lead within a patient. A measurement indicative of a coupling efficiency between the tissue stimulation lead and tissue at a location is taken. The location of the tissue stimulation lead relative to the tissue is tracked. Coupling efficiency information based on the measurement from the monitoring device is generated, tracking information based on the tissue stimulation lead location is generated, and the coupling efficiency information and tracking information is concurrently conveyed to the user.
摘要翻译：一种用于定位患者内的可植入组织刺激引线的系统和方法。采用指示组织刺激引线和组织在一处的耦合效率的测量。跟踪组织刺激引线相对于组织的位置。生成基于来自监视装置的测量的耦合效率信息，生成基于组织刺激引导位置的跟踪信息，并且耦合效率信息和跟踪信息被同时传送给用户。

69. 发明授权

US08155750B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08155750B2
公开(公告)日：2012-04-10
申请号：US12509340
申请日：2009-07-24
申请人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
发明人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.
摘要翻译：提供了一种用于编程神经刺激装置的方法和编程器。该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

70. 发明申请

US20120004707A1 USE OF STIMULATION PULSE SHAPE TO CONTROL NEURAL RECRUITMENT ORDER AND CLINICAL EFFECT 审中-公开
标题翻译：刺激脉冲形状的使用来控制神经激励和临床效果
公开(公告)号：US20120004707A1
公开(公告)日：2012-01-05
申请号：US13231493
申请日：2011-09-13
申请人： Dongchul Lee , Michael Moffitt , Christopher Ewan Gillespie , Kerry Bradley
发明人： Dongchul Lee , Michael Moffitt , Christopher Ewan Gillespie , Kerry Bradley
IPC分类号： A61N1/372
CPC分类号： A61N1/36146 , A61N1/36003 , A61N1/36007 , A61N1/36017 , A61N1/36036 , A61N1/36046 , A61N1/3605 , A61N1/3606 , A61N1/36135 , A61N1/37247 , A61N1/378 , A61N1/3787 , A61N1/3906
摘要： A method, electrical tissue stimulation system, and programmer for providing therapy to a patient are provided. Electrodes are placed adjacent tissue (e.g., spinal cord tissue) of the patient, electrical stimulation energy is delivered from the electrodes to the tissue in accordance with a defined waveform, and a pulse shape of the defined waveform is modified, thereby changing the characteristics of the electrical stimulation energy delivered from the electrode(s) to the tissue. The pulse shape may be modified by selecting one of a plurality of different pulse shape types or by adjusting a time constant of the pulse shape.
摘要翻译：提供了一种用于向患者提供治疗的方法，电组织刺激系统和程序员。电极被放置在患者的组织（例如，脊髓组织）的附近，电刺激能量根据定义的波形从电极传送到组织，并且限定波形的脉冲形状被修改，从而改变从电极传递到组织的电刺激能量。可以通过选择多种不同的脉冲形状类型之一或通过调整脉冲形状的时间常数来修改脉冲形状。

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