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61. 发明申请

US20110130305A1 Novel dyes and compositions, and processes for using same in analysis of protein aggregation and other applications 有权
标题翻译：新型染料和组合物，以及在蛋白质聚集和其他应用分析中使用相同的方法
公开(公告)号：US20110130305A1
公开(公告)日：2011-06-02
申请号：US12592639
申请日：2009-11-30
申请人： Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlum , Anatoliy Balanda
发明人： Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlum , Anatoliy Balanda
IPC分类号： C40B40/04 , C07D213/02 , C07D213/04 , C07D277/20 , C07D277/62 , C07D285/06 , C07D471/04 , C07D215/12 , C07D277/60 , C07D251/00 , C07K2/00 , C07K14/00 , C07H21/00 , C12N9/00 , C07K16/00 , C12N1/20 , G01N33/53 , G01N33/554 , G01N33/567 , C07K1/00
CPC分类号： C09B23/145 , C07D401/12 , C09B23/0008 , C09B23/0025 , C09B23/0058 , C09B23/0066 , C09B23/04 , C09B23/06 , C09B23/102 , C09B23/141 , G01N33/582 , G01N33/6845 , G01N2458/30 , G01N2800/2821 , G01N2800/2835
摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.
摘要翻译：提供了可用于许多应用的染料和组合物，例如检测和监测蛋白质聚集，蛋白质聚集的动力学研究，神经原纤维斑块分析，蛋白质制剂稳定性的评估，蛋白质热稳定性转移测定和分子伴侣活性的分析。这些染料和组合物也可用作核酸和蛋白质检测中的探针。

62. 发明申请

US20050009077A1 Composition of matter comprising library of first nucleic acid analyte copies 有权
标题翻译：包含第一核酸分析物文库的物质组成
公开(公告)号：US20050009077A1
公开(公告)日：2005-01-13
申请号：US10900455
申请日：2004-07-27
申请人： Flazar Rabbani , Jannis Stavrianopoulos , James Donegan , Jack Coleman
发明人： Flazar Rabbani , Jannis Stavrianopoulos , James Donegan , Jack Coleman
IPC分类号： G01N33/53 , C07B61/00 , C07H21/00 , C07K17/02 , C12M1/00 , C12N15/09 , C12Q1/00 , C40B40/02 , C40B50/06 , G01N33/58 , G01N37/00 , C12Q1/68
CPC分类号： C40B40/06 , B01J19/0046 , B01J2219/00599 , B01J2219/0061 , B01J2219/00612 , B01J2219/00648 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C07H21/00 , C12N15/1006 , C12N15/1058 , C12Q1/68 , C12Q1/6809 , C12Q1/6825 , C12Q1/6837 , C40B40/00 , C40B40/10 , G01N33/68 , C12Q2565/501 , C12Q2563/179 , C12Q2545/114 , C12Q2525/155 , C12Q2565/514 , C12Q2565/537
摘要： This invention provides novel compositions and processes for analyte detection, quantification and amplification. Nucleic acid arrays and libraries of analytes are usefully incorporated into such compositions and processes. Universal detection elements, signaling entities and the like are employed to detect and if necessary or desirable, to quantify analytes. Amplification of target analytes are also provided by the compositions and processes of this invention.
摘要翻译：本发明提供了用于分析物检测，定量和扩增的新型组合物和方法。分析物的核酸阵列和文库可有效地并入到这样的组合物和方法中。使用通用检测元件，信号实体等来检测并且如果需要或期望量化分析物。靶分析物的扩增也由本发明的组合物和方法提供。

63. 发明授权

US10060910B2 Multisignal reagents for labeling analytes 有权
公开(公告)号：US10060910B2
公开(公告)日：2018-08-28
申请号：US13556304
申请日：2012-07-24
申请人： Jack Coleman , Maciej Szczepanik , Richard Jin
发明人： Jack Coleman , Maciej Szczepanik , Richard Jin
IPC分类号： C12Q1/68 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54306 , C12Q1/68 , G01N33/58
摘要： Provided is a composition comprising an analyte bound to a polymer where the analyte is less than about 2000 MW and the polymer further comprises more than one signal or first member of a second binding pair. Also provided is an assay for an analyte comprising combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. Additionally provided is a multisignal labeling reagent comprising a first polymer covalently bound to (a) a reactive group or a first member of a first binding pair, and (b) more than one digoxigenin molecule.

64. 发明授权

US09250249B2 Autophagy and phospholipidosis pathway assays 有权
标题翻译：自噬和磷脂通路测定
公开(公告)号：US09250249B2
公开(公告)日：2016-02-02
申请号：US12584958
申请日：2009-09-14
申请人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
发明人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
IPC分类号： G01N33/68 , G01N33/50 , G01N33/58 , G01N33/94
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译：提供用于检测和监测自噬和磷脂病的测定，包括溶酶体贮积病的进展。可以监测溶酶体储存疾病的药物和治疗溶酶体贮积病条件的有效性。药物候选人和疑似毒素也可以筛选对细胞，组织和器官的毒性。还提供了区分磷脂肪激活剂和自噬途径扰动剂的方法。

65. 发明授权

US09062292B2 Mutant T7 polymerases 有权
标题翻译：突变T7聚合酶
公开(公告)号：US09062292B2
公开(公告)日：2015-06-23
申请号：US12807751
申请日：2010-09-13
申请人： Jack Coleman
发明人： Jack Coleman
IPC分类号： C12N9/12
CPC分类号： C12N9/1247
摘要： Provided are mutant polymerases that comprise a deletion of at least four amino acids among the amino acids at positions corresponding to 167-174 of SEQ ID NO:1. Also provided are mutant polymerases having greater resistance to 30 mM NaCl, 7.5 mM phosphate, or 20 μg/ml single stranded DNA than a wild-type T7 RNA polymerase having SEQ ID NO:1 or a wild-type T3 RNA polymerase having SEQ ID NO:3. Nucleic acids comprising a nucleotide sequence encoding any of the above mutant polymerases are also provided, as are vectors comprising those nucleic acids and host cells transformed with the vectors Additionally, methods of amplifying mRNA using the mutant polymerases described herein are also provided. Further, compositions comprising any of the mutant polymerases described herein, and a reagent at a concentration that is inhibitory to wild-type T7 RNA polymerase is provided.
摘要翻译：提供的突变体聚合酶包含在对应于SEQ ID NO：1的167-174位置的氨基酸中至少4个氨基酸的缺失。还提供了比具有SEQ ID NO：1的野生型T7RNA聚合酶或具有SEQ ID NO：1的野生型T3 RNA聚合酶对30mM NaCl，7.5mM磷酸酯或20μg/ ml单链DNA具有更大抗性的突变型聚合酶 NO：3。还提供了包含编码任何上述突变型聚合酶的核苷酸序列的核酸，以及包含用载体转化的那些核酸和宿主细胞的载体。另外，还提供了使用本文所述的突变型聚合酶扩增mRNA的方法。此外，提供了包含本文所述的任何突变型聚合酶的组合物和对野生型T7RNA聚合酶具有抑制浓度的试剂。

66. 发明申请

US20130137112A1 DYES FOR ANALYSIS OF PROTEIN AGGREGATION 审中-公开
标题翻译：用于分析蛋白质聚集的染料
公开(公告)号：US20130137112A1
公开(公告)日：2013-05-30
申请号：US13510976
申请日：2010-11-30
申请人： Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlam , Anatoliy Balanda , Dee Shen
发明人： Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlam , Anatoliy Balanda , Dee Shen
IPC分类号： C07D401/12
摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, and analysis of molecular chaperone activity.
摘要翻译：提供可用于许多应用的染料和组合物，例如检测和监测蛋白质聚集，蛋白质聚集的动力学研究，神经原纤维斑块分析，蛋白质制剂稳定性的评估和分子伴侣活性的分析。

67. 发明申请

US20180027764A1 Bag Breaker 审中-公开
公开(公告)号：US20180027764A1
公开(公告)日：2018-02-01
申请号：US15730518
申请日：2017-10-11
申请人： Jack Coleman
发明人： Jack Coleman
IPC分类号： A01K5/02 , B65B69/00
CPC分类号： A01K5/0225 , B65B69/0008 , B65B69/0041
摘要： A system and method for quickly opening bags of granular material into a hopper. The system utilizes a rigid frame supporting a vertical member configured to tear open the bags of granular material when the bags are placed on the frame. A grating surrounds the vertical member and helps to filter unwanted material from the hopper.

68. 发明授权

US09696298B2 Multisignal reagents for labeling analytes 有权
公开(公告)号：US09696298B2
公开(公告)日：2017-07-04
申请号：US13556425
申请日：2012-07-24
申请人： Jack Coleman , Maciej Szczepanik , Richard Jin
发明人： Jack Coleman , Maciej Szczepanik , Richard Jin
IPC分类号： G01N33/53 , G01N33/557 , G01N33/549 , C07H21/00 , C07H21/04 , C09B11/08 , C09B11/24 , C12Q1/68 , G01N33/58 , G01N33/82 , G01N33/94 , C07H19/04
CPC分类号： G01N33/53 , C07H21/00 , C07H21/04 , C09B11/08 , C09B11/24 , C12Q1/6818 , G01N33/581 , G01N33/82 , G01N33/94
摘要： Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer. In this composition, the analyte is less than about 2000 MW; the polymer further comprises more than one signal or first member of a second binding pair; and the analyte is not a member of the first binding pair or the second binding pair. Also provided is an assay for an analyte. The assay comprises: combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. Additionally provided is a multisignal labeling reagent comprising a first polymer covalently bound to (a) a reactive group or a first member of a first binding pair, and (b) more than one digoxigenin molecule.

69. 发明授权

US09133343B2 Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications 有权
标题翻译：染料和组合物，以及在蛋白质聚集和其他应用的分析中使用它们的方法
公开(公告)号：US09133343B2
公开(公告)日：2015-09-15
申请号：US12592639
申请日：2009-11-30
申请人： Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlam , Anatoliy Balanda
发明人： Wayne Forrest Patton , Sergiy M. Yarmoluk , Praveen Pande , Vladyslava Kovalska , Lijun Dai , Kateryna Volkova , Jack Coleman , Mykhaylo Losytskyy , Anthony Ludlam , Anatoliy Balanda
IPC分类号： C07D251/00 , C07D471/00 , C07D213/00 , B01L3/00 , G03C5/00 , C09B23/14 , C07H19/04
CPC分类号： C09B23/145 , C07D401/12 , C09B23/0008 , C09B23/0025 , C09B23/0058 , C09B23/0066 , C09B23/04 , C09B23/06 , C09B23/102 , C09B23/141 , G01N33/582 , G01N33/6845 , G01N2458/30 , G01N2800/2821 , G01N2800/2835
摘要： Provided are dyes and compositions which are useful in a number of applications, such as the detection and monitoring protein aggregation, kinetic studies of protein aggregation, neurofibrillary plaques analysis, evaluation of protein formulation stability, protein thermal stability shift assay and analysis of molecular chaperone activity. These dyes and compositions are also useful as probes in nucleic acid and protein detection.
摘要翻译：提供了可用于许多应用的染料和组合物，例如检测和监测蛋白质聚集，蛋白质聚集的动力学研究，神经原纤维斑块分析，蛋白质制剂稳定性的评估，蛋白质热稳定性转移测定和分子伴侣活性的分析。这些染料和组合物也可用作核酸和蛋白质检测中的探针。

70. 发明申请

US20100093004A1 Autophagy and phospholipidosis pathway assays 有权
标题翻译：自噬和磷脂通路测定
公开(公告)号：US20100093004A1
公开(公告)日：2010-04-15
申请号：US12584958
申请日：2009-09-14
申请人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
发明人： Wayne Forrest Patton , Jack Coleman , Yuejun Xiang , Praveen Pande , Zaiguo Li
IPC分类号： G01N33/53 , C12Q1/02
CPC分类号： G01N33/6893 , G01N33/5076 , G01N33/582 , G01N33/94 , G01N2500/10 , G01N2800/02 , G01N2800/04 , G01N2800/52
摘要： Provided are assays useful for detecting and monitoring autophagy and phospholipidosis, including the progression of lysosomal storage diseases. Drugs and treatments for lysosomal storage diseases can be monitored for effectiveness in lysosomal storage disease conditions. Drug candidates and suspected toxic agents can also be screened for toxicity to cells, tissues and organs. Also provided are methods for distinguishing between phospholipidosis activators and autophagy pathway perturbation agents.
摘要翻译：提供用于检测和监测自噬和磷脂病的测定，包括溶酶体贮积病的进展。可以监测溶酶体储存疾病的药物和治疗溶酶体贮积病条件的有效性。药物候选人和疑似毒素也可以筛选对细胞，组织和器官的毒性。还提供了区分磷脂肪激活剂和自噬途径扰动剂的方法。

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