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61. 发明授权

US07001759B1 Compositions and methods for delivery of genetic material 有权
标题翻译：用于遗传物质传递的组合物和方法
公开(公告)号：US07001759B1
公开(公告)日：2006-02-21
申请号：US09359975
申请日：1999-07-23
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K31/167 , C12N15/63 , C12N15/87 , C07H21/04
CPC分类号： A61K39/21 , A61K39/00 , A61K39/0011 , A61K39/0225 , A61K39/12 , A61K39/29 , A61K39/292 , A61K2039/53 , A61K2039/55516 , C12N15/63 , C12N2730/10134 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234 , C12N2760/20134 , C12N2770/24234 , Y02A50/464 , Y02A90/26 , Y10S514/818
摘要： Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a polynucleotide function enhancer and administering to the cells, a nucleic acid molecule that is free of retroviral particles. The nucleic acid molecule comprises a nucleotide sequence that encodes a protein that comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen or an antigen associated with a hyperproliferative or autoimmune disease, a protein otherwise missing from the individual due to a missing, non-functional, or partially functioning gene, or a protein that produces a therapeutic effect on an individual. Methods of prophylactically and therapeutically immunizing an individual against pathogens are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译：公开了将遗传物质引入个体细胞的方法和用于实施其的组合物和试剂盒。所述方法包括使个体的细胞与多核苷酸功能增强子接触并向细胞施用不含逆转录病毒颗粒的核酸分子的步骤。核酸分子包含编码蛋白质的核苷酸序列，该蛋白质包含与病原体抗原或与过度增殖或自身免疫疾病相关的抗原的表位相同或基本相似的至少一个表位，涉及一种缺失的，非功能的或部分功能的基因或对个体产生治疗作用的蛋白质。公开了预防和治疗个体免受病原体的方法。公开了用于本发明的实践方法的药物组合物和试剂盒。

62. 发明授权

US06818627B1 Functional fragments of HIV-1 Vpr protein and methods of using the same 失效
标题翻译： HIV-1 Vpr蛋白的功能片段及其使用方法
公开(公告)号：US06818627B1
公开(公告)日：2004-11-16
申请号：US09485421
申请日：2000-10-05
申请人： Sundarasamy Mahalingam , Velpandi Ayyavoo , Mamata Patel , Thomas Kieber-Emmons , David B. Weiner
发明人： Sundarasamy Mahalingam , Velpandi Ayyavoo , Mamata Patel , Thomas Kieber-Emmons , David B. Weiner
IPC分类号： A61K4800
CPC分类号： C07K14/005 , A61K47/64 , A61K47/6901 , A61K48/00 , A61K2039/53 , C12N2740/16322 , G01N33/56988 , G01N2500/00
摘要： Conjugated compositions comprising a fragment of HIV-1 Vpr or a non-HIV-1 Vpr protein conjugated to a therapeutic compound and methods of using the same to deliver therapeutic compounds to a cell's nucleus or for the preparation of drug delivery particles are disclosed. Functional fragments of HIV-1 Vpr and functional non-HIV-1 Vpr proteins, and pharmaceutical compositions comprising the same are disclosed. Methods of inhibiting cell proliferation and methods of treating an individual who has a hyperproliferative disease are disclosed. Methods of identifying compounds that inhibit Vpr protein binding to the p6 domain of p55 or to p6 protein and kits for performing such methods are disclosed.
摘要翻译：公开了包含与治疗性化合物缀合的HIV-1Vpr片段或非HIV-1Vpr蛋白的片段的共轭组合物及其使用方法将治疗性化合物递送至细胞核或用于制备药物递送颗粒。公开了HIV-1Vpr和功能性非HIV-1 Vpr蛋白的功能片段和包含其的药物组合物。公开了抑制细胞增殖的方法和治疗具有过度增殖性疾病的个体的方法。公开了鉴定抑制Vpr蛋白与p55或p6蛋白的p6结构域结合的化合物的方法和用于进行这些方法的试剂盒。

63. 发明授权

US06468982B1 Genetic immunization 失效
标题翻译：遗传免疫
公开(公告)号：US06468982B1
公开(公告)日：2002-10-22
申请号：US08880576
申请日：1997-06-23
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K4800
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , A61K2039/53 , C12N15/87 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y02A50/464 , Y02A90/26 , Y10S435/975 , Y10S514/818
摘要： Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being, expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译：公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞蛋白质或与自身免疫疾病相关的蛋白质。在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。核酸分子不含病毒颗粒，能够在所述细胞中表达。细胞可以与细胞刺激剂接触细胞。公开了预防和治疗个体免受HIV感染的方法。公开了用于本发明的实践方法的药物组合物和试剂盒。

64. 发明授权

US5837460A Methods of identifying biologically active receptor-binding peptides 失效
标题翻译：识别生物活性受体结合肽的方法
公开(公告)号：US5837460A
公开(公告)日：1998-11-17
申请号：US712212
申请日：1996-09-03
申请人： Joan M. Von Feldt , Thomas Kieber-Emmons , David B. Weiner , William V. Williams
发明人： Joan M. Von Feldt , Thomas Kieber-Emmons , David B. Weiner , William V. Williams
IPC分类号： C07K14/53 , C07K14/535 , C07K14/54 , C07K14/55 , C07K14/61 , C07K16/06 , C07K16/24 , G01N33/68 , G01N33/74 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/74 , C07K14/53 , C07K14/535 , C07K14/5403 , C07K14/5409 , C07K14/55 , C07K14/61 , C07K16/065 , C07K16/243 , G01N33/68 , G01N33/6863 , G01N33/6869 , C07K2317/34 , C07K2317/73 , G01N2333/535 , G01N2500/00 , Y10S435/965
摘要： A method of identifying peptides which mimic biologically active proteins is disclosed. The method comprises the steps of making a recombinant antibody library from genetic material obtained from an animal which has been immunized against antibodies that bind to the biological active protein to the mimicked. Recombinant antibodies are screened to identify antibodies which compete with the biological active protein. Peptides which comprise the recombinant antibody's CDR sequences are synthesized. Synthetic peptides which mimic GM-CSF are also disclosed.
摘要翻译：公开了鉴定模拟生物活性蛋白质的肽的方法。该方法包括以下步骤：从已经针对结合生物活性蛋白的抗体免疫的动物获得的遗传物质制备重组抗体文库。筛选重组抗体以鉴定与生物活性蛋白竞争的抗体。合成包含重组抗体的CDR序列的肽。还公开了模拟GM-CSF的合成肽。

65. 发明授权

US5830876A Genetic immunization 失效
标题翻译：遗传免疫
公开(公告)号：US5830876A
公开(公告)日：1998-11-03
申请号：US453349
申请日：1995-05-30
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K48/00 , A61K39/00 , A61K39/12 , A61K39/21 , C07K14/16 , C12N15/87 , A61K45/05 , A61K31/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N15/87 , A61K2039/53 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y10S435/975 , Y10S514/818
摘要： A method of immunizing an individual against pathogen is disclosed. Also disclosed is a method of treating an individual who has a hyperproliferative disease, or of treating an individual who is infected by a pathogen. Specifically, the individual is injected with bupivacaine along with DNA in an expressible form, the DNA encoding an antigen. The encoded antigen can be from a protein from the pathogen or from a protein associated with the hyperproliferative disease.
摘要翻译：公开了免疫个体对病原体的方法。还公开了治疗具有过度增殖性疾病的个体或治疗被病原体感染的个体的方法。具体地说，个体以可表达形式的DNA注射布比卡因，编码抗原的DNA。编码的抗原可以来自病原体的蛋白质或来自与过度增殖性疾病相关的蛋白质。

66. 发明授权

US5593972A Genetic immunization 失效
标题翻译：遗传免疫
公开(公告)号：US5593972A
公开(公告)日：1997-01-14
申请号：US125012
申请日：1993-09-21
申请人： David B. Weiner , William V. Williams , Bin Wang
发明人： David B. Weiner , William V. Williams , Bin Wang
IPC分类号： A61K48/00 , A61K39/00 , A61K39/12 , A61K39/21 , C07K14/16 , C12N15/87 , A61K45/05 , A61K31/00
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/21 , C12N15/87 , A61K2039/53 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , C12N2740/16222 , C12N2740/16234 , C12N2740/16322 , C12N2740/16334 , Y10S435/975 , Y10S514/818
摘要： Methods of prophylactic and therapeutic immunization of an individual against pathogen infection, diseases associated with hyperproliferative cells and autoimmune diseases are disclosed. The methods comprise the steps of administering to cells of an individual, a nucleic acid molecule that comprises a nucleotide sequence that encodes a protein which comprises at least one epitope that is identical or substantially similar to an epitope of a pathogen antigen, a hyperproliferative cell associated protein or a protein associated with autoimmune disease respectively. In each case, nucleotide sequence is operably linked to regulatory sequences to enable expression in the cells. The nucleic acid molecule is free of viral particles and capable of being expressed in said cells. The cells may be contacted cells with a cell stimulating agent. Methods of prophylactically and therapeutically immunizing an individual against HIV are disclosed. Pharmaceutical compositions and kits for practicing methods of the present invention are disclosed.
摘要翻译：公开了个体对病原体感染的预防和治疗免疫的方法，与过度增殖细胞和自身免疫疾病相关的疾病。所述方法包括对个体的细胞施用包含编码蛋白质的核苷酸序列的核酸分子的步骤，所述核苷酸序列包含与病原体抗原的表位相同或基本上相似的至少一个表位，相关的过度增殖细胞蛋白质或与自身免疫疾病相关的蛋白质。在每种情况下，核苷酸序列可操作地连接到调节序列以使得能够在细胞中表达。核酸分子不含病毒颗粒，能够在所述细胞中表达。细胞可以与细胞刺激剂接触细胞。公开了预防和治疗个体免受HIV感染的方法。公开了用于本发明的实践方法的药物组合物和试剂盒。

67. 发明授权

US5338829A Peptides derived from human immunodeficiency virus-1 GP160 失效
标题翻译：衍生自人类免疫缺陷病毒-1 GP160的肽
公开(公告)号：US5338829A
公开(公告)日：1994-08-16
申请号：US932078
申请日：1992-10-19
申请人： David B. Weiner , Mark I. Greene , William V. Williams
发明人： David B. Weiner , Mark I. Greene , William V. Williams
IPC分类号： A61K38/00 , A61K39/00 , C07K14/16 , C07K14/705 , C07K16/10 , A61K37/02 , C07K3/00 , C07K5/00 , C07K15/00
CPC分类号： C07K14/005 , C07K14/705 , C07K16/1063 , A61K38/00 , A61K39/00 , C12N2740/16122
摘要： This invention discloses novel polypeptides having an antigenic determinant or determinants immunologically cross-reactive with determinants of a glycoprotein having a molecular weight of approximately 41,000 daltons, and determinants of a glycoprotein having a molecular weight of approximately 160,000 daltons which are obtained from cells infected with human immunodeficiency virus-1. The invention further discloses novel polypeptides having an antigenic determinant or determinants specific for a glycoprotein having a molecular weight of approximately 41,000 daltons obtained from cells infected with human immunodeficiency virus-1, the polypeptides further having an antigenic determinant or determinants immunologically cross-reactive with at least one glycoprotein having a molecular weight of 25,000 to 35,000 daltons, 45,000 daltons to 60,000 daltons, 80,000 to 100,000 daltons or 180,000 or 220,000 daltons, which are obtained from HSB, St, HeLa and human cells. The novel polypeptides of the invention are useful in methods of interfering with the effects of HIV-1 upon host cells having cell surface polypeptides capable of binding HIV-1. Methods of assay for HIV-1 infection are also disclosed. The invention also discloses peptides having amino acid sequences of about 10 to about 50 amino acids that correspond to at least a portion of an epitope of HIV and methods for developing such biologically active peptides.
摘要翻译：本发明公开了具有与具有约41,000道尔顿分子量的糖蛋白的决定簇免疫交叉反应的抗原决定簇或决定簇的新型多肽，以及分子量约为160,000道尔顿的糖蛋白的决定簇，这些糖蛋白是从感染人的细胞获得的免疫缺陷病毒-1。本发明进一步公开了具有抗原决定簇或具有特异性的决定簇的新型多肽，该决定簇具有从感染人类免疫缺陷病毒-1的细胞获得的具有约41,000道尔顿的糖蛋白的特异性，所述多肽还具有抗原决定簇或与抗原决定簇免疫交叉反应的决定簇至少一种由HSB，St，HeLa和人细胞获得的分子量为25,000至35,000道尔顿，45,000道尔顿至60,000道尔顿，80,000至100,000道尔顿或180,000或220,000道尔顿的糖蛋白。本发明的新型多肽可用于干扰HIV-1对具有能够结合HIV-1的细胞表面多肽的宿主细胞的作用的方法。还公开了HIV-1感染的测定方法。本发明还公开了具有对应于HIV表位的至少一部分的约10至约50个氨基酸的氨基酸序列的肽和用于开发此类生物活性肽的方法。

68. 发明申请

US20150335726A1 Filovirus Consensus Antigens, Nucleic Acid Constructs And Vaccines Made Therefrom, And Methods Of Using Same 有权
标题翻译：纤维病毒共识抗原，核酸构建体和疫苗，以及使用相同的方法
公开(公告)号：US20150335726A1
公开(公告)日：2015-11-26
申请号：US14391952
申请日：2013-04-12
申请人： David B. Weiner , Devon Shedlock
发明人： David B. Weiner , Devon Shedlock
IPC分类号： A61K39/12 , C12N7/00
CPC分类号： A61K39/12 , A61K38/20 , A61K38/208 , A61K38/2086 , A61K2039/53 , A61K2039/545 , A61K2039/57 , A61K2039/572 , A61K2039/70 , A61N1/327 , C07K14/005 , C07K2319/02 , C12N7/00 , C12N2760/14122 , C12N2760/14134 , C12N2760/14171 , C12N2760/14222 , C12N2760/14234 , C12N2760/14271
摘要： Nucleic acid molecules and compositions comprising one or more nucleic acid sequences that encode a consensus filovirus immunogen including a consensus Marburgvirus filovirus glycoprotein MARV GP immunogen, a consensus Ebolavirus Sudan filovirus glycoprotein SEBOV GP immunogen and a consensus Ebolavirus Zaire glycoprotein ZEBOV GP immunogen are disclosed. The coding sequences optionally include operable linked coding sequence that encode a signal peptide. Immunomodulatory methods and methods of inducing an immune response against filovirus, particularly Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Method of preventing filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire and methods of treating individuals infected with filovirus infection, particularly infection by Marburgvirus, Ebolavirus Sudan and Ebolavirus Zaire are disclosed. Consensus filovirus proteins are disclosed.
摘要翻译：公开了包含一个或多个核酸序列的核酸分子和组合物，所述核酸序列编码包括共有的马尔堡病毒filov病毒糖蛋白MARV GP免疫原，共有的埃博病毒苏丹filovirus糖蛋白SEBOV GP免疫原和共有的埃博病毒扎伊尔糖蛋白ZEBOV GP免疫原的共有的病毒免疫原。编码序列任选地包括编码信号肽的可操作的连锁编码序列。公开了免疫调节方法和诱导针对病毒，尤其是马尔堡病毒，埃及病毒苏丹和埃博拉病毒扎伊尔的免疫应答的方法。公开了防止病毒感染的方法，特别是马尔堡病毒，埃及病毒苏丹和埃博拉病毒扎伊尔的感染，以及治疗感染了病毒感染的个体，特别是马尔堡病毒，埃博病毒苏丹和埃博拉病毒扎伊尔感染的方法。公知共识的病毒蛋白。

69. 发明申请

US20150328298A1 WT1 Vaccine 审中-公开
标题翻译： WT1疫苗
公开(公告)号：US20150328298A1
公开(公告)日：2015-11-19
申请号：US14651492
申请日：2013-12-13
申请人： David B. WEINER , Jian YAN , Jewell WALTERS , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , INOVIO PHARMACEUTICALS, INC.
发明人： David B. Weiner , Jian Yan , Jewell Walters
IPC分类号： A61K39/00 , C07K14/47
CPC分类号： A61K39/0011 , A61K2039/53 , C07K14/4748
摘要： Disclosed herein are nucleic acid molecules comprising one or more nucleic acid sequences that encode a mutated WT1 antigen. Vectors, compositions and vaccines comprising one or more nucleic acid sequences that encode a mutated WT1 antigen are disclosed. Methods of treating an individual who has a WT1-expressing tumor and methods of preventing a WT1-expressing tumor are disclosed. Mutated WT1 antigen is disclosed.
摘要翻译：本文公开了包含编码突变的WT1抗原的一个或多个核酸序列的核酸分子。公开了包含编码突变的WT1抗原的一个或多个核酸序列的载体，组合物和疫苗。公开了治疗具有WT1表达肿瘤的个体的方法和预防表达WT1的肿瘤的方法。公开了突变的WT1抗原。

70. 发明申请

US20130045180A9 VACCINES, IMMUNOTHERAPEUTICS AND METHODS FOR USING THE SAME 审中-公开
标题翻译：疫苗，免疫球蛋白及其使用方法
公开(公告)号：US20130045180A9
公开(公告)日：2013-02-21
申请号：US13360389
申请日：2012-01-27
申请人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
发明人： David B. Weiner , Jong J. Kim , Jeong-Im Sin
IPC分类号： A61K38/20 , A61K39/00 , A61K39/245 , A61K39/21 , A61K38/19 , C07K16/24 , C07K16/28 , C07K16/40 , C07K16/18 , A61K39/395 , A61P37/06 , A61P37/04 , A61P31/18 , A61P35/00 , A61P31/22 , A61P31/00 , C12N15/63
CPC分类号： A61K39/39 , A61K39/12 , A61K39/21 , A61K39/245 , A61K2039/53 , A61K2039/545 , A61K2039/555 , A61K2039/55522 , A61K2039/55527 , C07K14/523 , C07K14/5421 , C07K2319/00 , C12N2710/16634 , C12N2740/16034 , C12N2740/16134 , C12N2740/16234
摘要： Improved vaccines which include a nucleotide sequence that encodes immunomodulating protein operably linked to regulatory elements are disclosed. The improved vaccines include DNA vaccines, recombinant vaccines for delivering foreign antigen and live attenuated vaccines. Methods of immunizing individuals are disclosed. Compositions for and methods of treating individuals with autoimmune diseases are disclosed.
摘要翻译：公开了包括编码与调控元件可操作地连接的免疫调节蛋白的核苷酸序列的改进的疫苗。改进的疫苗包括DNA疫苗，用于递送外源抗原和减毒活疫苗的重组疫苗。公开了免疫个体的方法。公开了治疗患有自身免疫性疾病的个体的组合物和方法。

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