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61. 发明授权

US06490486B1 Implantable cardiac stimulation device and method that monitors displacement of an implanted lead 有权
标题翻译：可植入的心脏刺激装置和监测植入引线位移的方法
公开(公告)号：US06490486B1
公开(公告)日：2002-12-03
申请号：US09709698
申请日：2000-11-09
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N104
CPC分类号： A61N1/37 , A61N1/37241 , A61N2001/083
摘要： An implantable cardiac stimulation device and method that monitors displacement of a cardiac lead implanted in a heart. The device includes an impedance measurement circuit that generates a template representing the impedance measured using the lead over a cardiac cycle of the patient's heart. The impedance measurement circuit generates subsequent impedance measurement signals, which are then compared to the template to derive a comparison factor. The comparison factors are stored in a memory and are indicative of lead displacement. A telemetry circuit transmits the comparison factors to a non-implanted receiver for analysis of lead displacement.
摘要翻译：一种可植入心脏刺激装置和方法，其监测植入心脏的心脏线的位移。该装置包括阻抗测量电路，其生成表示在患者心脏的心动周期上使用引线测量的阻抗的模板。阻抗测量电路产生随后的阻抗测量信号，然后与模板进行比较以得出比较因子。比较因子存储在存储器中并且指示引线位移。遥测电路将比较因子传送到非植入接收器，以分析铅位移。

62. 发明授权

US10537741B2 System and method for choosing electrodes in an implanted stimulator device 有权
公开(公告)号：US10537741B2
公开(公告)日：2020-01-21
申请号：US11295168
申请日：2005-12-05
申请人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
发明人： Kerry Bradley , Ljubomir Manola , Jan Holsheimer
IPC分类号： A61N1/36
摘要： A method of selecting a subset of electrodes in a stimulator device implanted in a patient for further clinical evaluation is disclosed. The method comprises measuring at least first and second measurement for each of the plurality of electrodes that are indicative of the ability of the electrode if activated to provide useful therapy to the patient in which the stimulator device is implanted A weight is then determined for each of the measurements. The weight is then applied to each electrode measurement, which measurement may be normalized, and the weighted measurements for each electrode are preferably summed to arrive at a value which itself is indicative of a particular electrode's ability to provide useful therapy to the patient. These values can then be used to determine a subset of the electrodes useful for further clinical evaluation in the patient, which improved the accuracy and speeding determining appropriate patient therapy.

63. 发明申请

US20120089200A1 NEUROSTIMULATION SYSTEM AND METHOD FOR PROVIDING THERAPY TO PATIENT WITH MINIMAL SIDE EFFECTS 有权
标题翻译：用于向患者提供最小化副作用的神经细胞治疗系统和方法
公开(公告)号：US20120089200A1
公开(公告)日：2012-04-12
申请号：US13253735
申请日：2011-10-05
申请人： Emarit A.S. Ranu , Bradley L. Hershey , Kerry Bradley
发明人： Emarit A.S. Ranu , Bradley L. Hershey , Kerry Bradley
IPC分类号： A61N1/36
CPC分类号： A61N1/36071 , A61N1/0553 , A61N1/36171 , A61N1/36182
摘要： A method comprises conveying a pulsed waveform between an electrode and a stimulation site of a spinal cord, thereby evoking the antidromic propagation of action potentials along a first sensory neural fiber creating a therapeutic effect in the tissue region, evoking the orthodromic propagation of action potentials along the first sensory neural fiber potentially creating paresthesia corresponding to the tissue region, and evoking the antidromic propagation of action potentials along a second sensory neural fiber potentially creating a side-effect in another tissue region. The method further comprises conveying electrical energy between an electrode and a blocking site rostral to the stimulation site, thereby blocking the action potentials propagated along the first sensory neural fiber and reducing the paresthesia, and conveying electrical energy between an electrode and a blocking site caudal to the stimulation site, thereby blocking the action potentials propagated along the second sensory neural fiber and reducing the side-effect.
摘要翻译：一种方法包括在电极和脊髓的刺激部位之间传送脉冲波形，从而引起沿着第一感觉神经纤维的动作电位的反向扩散，从而在组织区域产生治疗效果，引起动作电位的正常传播第一感觉神经纤维潜在地产生对应于组织区域的感觉异常，并且引起沿着潜在地在另一组织区域中产生副作用的第二感觉神经纤维的动作电位的反向扩散。该方法还包括将电极和阻塞位点之间的电能传递到刺激部位，从而阻止沿着第一感觉神经纤维传播的动作电位并减少感觉异常，并将电极和阻塞部位尾部之间的电能传递到刺激部位，从而阻止沿着第二感觉神经纤维传播的动作电位并降低副作用。

64. 发明申请

US20120083857A1 TISSUE STIMULATION SYSTEM AND METHOD WITH ANATOMY AND PHYSIOLOGY DRIVEN PROGRAMMING 审中-公开
标题翻译：组织刺激系统和方法与解剖学和生理学驱动程序
公开(公告)号：US20120083857A1
公开(公告)日：2012-04-05
申请号：US13244435
申请日：2011-09-24
申请人： Kerry Bradley , Bradley Hershey
发明人： Kerry Bradley , Bradley Hershey
IPC分类号： A61N1/372
CPC分类号： A61N1/37247 , A61N1/0551 , A61N1/36175 , A61N1/36185
摘要： An external control device for use with a tissue stimulation device and at least one tissue stimulation lead having a plurality of electrodes implanted within a patient comprises a user interface configured for allowing a user to enter first information defining a therapeutic indication and second information defining the location of the at least one tissue stimulation lead relative to an anatomical reference, at least one processor configured for analyzing the first and second information and generating a set of stimulation parameters based on the analysis, and output circuitry configured for transmitting the at least one stimulation parameter set to the tissue stimulation device.
摘要翻译：一种与组织刺激装置一起使用的外部控制装置和至少一个组织刺激引线，其具有植入患者体内的多个电极，该用户界面被配置为允许用户输入定义治疗指示的第一信息和定义位置的第二信息所述至少一个组织刺激引线相对于解剖参考，配置用于分析所述第一和第二信息并基于所述分析产生一组刺激参数的至少一个处理器以及被配置为发送所述至少一个刺激参数的输出电路设置到组织刺激装置。

65. 发明授权

US08065013B2 Method for optimizing search for spinal cord stimulation parameter setting 有权
标题翻译：优化脊髓刺激参数设置搜索的方法
公开(公告)号：US08065013B2
公开(公告)日：2011-11-22
申请号：US11746405
申请日：2007-05-09
申请人： Kerry Bradley , James R. Thacker , Carla M. Woods , John D. King
发明人： Kerry Bradley , James R. Thacker , Carla M. Woods , John D. King
IPC分类号： A61N1/34
CPC分类号： A61N1/36071 , A61N1/0551 , Y10S128/92
摘要： A method of transitioning stimulation energy (e.g., electrical stimulation pulses) between a plurality of electrodes implanted within a patient is provided. The method comprises selecting a plurality of stimulation output values (e.g., electrical current amplitude values) for each of the electrodes. The method further comprises selecting a plurality of different modification values for at least one of the electrodes, respectively multiplying the stimulation output values and the modification values to determine modified stimulation output values for the electrode(s), which may optionally be stored in a steering table, and incrementally transitioning the stimulation energy to or from the electrode(s) in accordance with the modified stimulation output values. The modified stimulation output values are stored in a steering table. The modification values may be selected in a manner that maintains paresthesia when transitioning the stimulation energy between the electrodes.
摘要翻译：提供了在植入患者体内的多个电极之间转换刺激能量（例如，电刺激脉冲）的方法。该方法包括为每个电极选择多个刺激输出值（例如，电流振幅值）。该方法还包括为至少一个电极选择多个不同的修改值，分别乘以刺激输出值和修改值，以确定电极的修改的刺激输出值，其可以可选地存储在转向表，并且根据修改的刺激输出值逐渐地将刺激能量转移到电极或从电极移动。经修改的刺激输出值存储在转向表中。可以以在电极之间转换刺激能量时保持感觉异常的方式来选择修饰值。

66. 发明授权

US08036747B2 System and method of rapid, comfortable parameter switching in spinal cord stimulation 有权
标题翻译：快速，舒适的脊髓刺激参数切换的系统和方法
公开(公告)号：US08036747B2
公开(公告)日：2011-10-11
申请号：US12506827
申请日：2009-07-21
申请人： James R. Thacker , John D. H. King , Kerry Bradley
发明人： James R. Thacker , John D. H. King , Kerry Bradley
IPC分类号： A61N1/37
CPC分类号： A61N1/36071 , A61N1/0551
摘要： A system and method for rapidly switching stimulation parameters of a Spinal Cord Stimulation (SCS) system increases the number of stimulation parameter sets that may be tested during a fitting procedure, or alternatively, reduces the time required for the fitting procedure. The switching method comprises selecting a new stimulation parameter set, and setting the initial stimulation levels to levels at or just below an estimated perception threshold of the patient. The estimated perception level is based on previous stimulation results. The stimulation level is then increased to determine a minimum stimulation level for effective stimulation, and/or an optimal stimulation level, and/or a maximum stimulation level, based on patient perception.
摘要翻译：用于快速切换脊髓刺激（SCS）系统的刺激参数的系统和方法增加了在拟合过程期间可以测试的刺激参数集的数量，或者替代地减少了拟合过程所需的时间。切换方法包括选择新的刺激参数集合，以及将初始刺激水平设置为等于或低于估计的患者感知阈值的水平。估计的感知水平是基于以前的刺激结果。然后根据患者的感知，增加刺激水平以确定有效刺激的最小刺激水平和/或最佳刺激水平和/或最大刺激水平。

67. 发明申请

US20090157155A1 GRAPHICAL DISPLAY OF ENVIRONMENTAL MEASUREMENTS FOR IMPLANTABLE THERAPIES 审中-公开
标题翻译：用于可植入治疗的环境测量的图形显示
公开(公告)号：US20090157155A1
公开(公告)日：2009-06-18
申请号：US11959355
申请日：2007-12-18
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/05
CPC分类号： A61N1/37247 , A61N1/37
摘要： A method and system of providing therapy to a patient implanted with an array of electrodes is provided. The electrodes are configured for respectively providing electrical stimulation to tissue of the patient. The method comprises measuring physiological parameter information indicative of the coupling efficiencies between the respective electrodes of the array and the tissue, computing numerical values from the measured physiological parameter information, generating a chart representative of the computed numerical values, and displaying the chart to a user.
摘要翻译：提供了向植入电极阵列的患者提供治疗的方法和系统。电极被配置为分别向患者的组织提供电刺激。该方法包括测量指示阵列和组织的各个电极之间的耦合效率的生理参数信息，根据测量的生理参数信息计算数值，生成表示所计算的数值的图表，以及将图表显示给用户。

68. 发明申请

US20080275515A1 APPARATUS AND METHODS FOR STIMULATING TISSUE 审中-公开
标题翻译：用于刺激组织的装置和方法
公开(公告)号：US20080275515A1
公开(公告)日：2008-11-06
申请号：US12173169
申请日：2008-07-15
申请人： Kerry Bradley
发明人： Kerry Bradley
IPC分类号： A61N1/05
CPC分类号： A61N1/36185 , A61N1/0529 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/36125
摘要： Apparatus and methods for stimulating tissue employing local current imbalance to facilitate more effective stimulation regimens.
摘要翻译：使用局部电流不平衡刺激组织以促进更有效的刺激方案的装置和方法。

69. 发明授权

US07349738B1 Detecting atrial evoked response 有权
标题翻译：检测心房诱发反应
公开(公告)号：US07349738B1
公开(公告)日：2008-03-25
申请号：US10370815
申请日：2003-02-19
申请人： Kerry Bradley , Laurence S. Sloman
发明人： Kerry Bradley , Laurence S. Sloman
IPC分类号： A61N1/08
CPC分类号： A61N1/371 , A61N1/3716
摘要： A pulse is delivered to the atrium using an electrode configuration that includes at least a pulse cathode electrode. Cardiac activity in the atrium is sensed using a unipolar electrode configuration to provide a sensed signal wherein the unipolar electrode configuration does not include the pulse cathode electrode. A determination as to whether the pulse caused an atrial evoked response is made based on a maximum derivative value of the sensed signal with respect to time, a comparison of the sensed signal to a parameter or an integral of the sensed signal with respect to time.
摘要翻译：使用至少包括脉冲阴极的电极配置将脉冲传送到心房。使用单极电极配置来感测心房中的心脏活动以提供感测信号，其中单极电极配置不包括脉冲阴极电极。基于感测信号相对于时间的最大导数值，感测信号与感测信号相对于时间的参数或积分的比较，确定脉冲是否引起心房诱发反应。

70. 发明授权

US07289848B1 Implantable cardiac stimulation device, system and method which provides an electrogram signal having the appearance of a surface electrocardiogram 有权
标题翻译：可植入的心脏刺激装置，系统和方法，其提供具有表面心电图的外观的电描记图信号
公开(公告)号：US07289848B1
公开(公告)日：2007-10-30
申请号：US10723027
申请日：2003-11-25
申请人： Gene A. Bornzin , Joseph J. Florio , Kerry Bradley
发明人： Gene A. Bornzin , Joseph J. Florio , Kerry Bradley
IPC分类号： A61N1/362 , A61B5/402
CPC分类号： A61N1/3702 , A61N1/368
摘要： An implantable cardiac stimulation system and method provides an external display of a heart activity signal sensed internally by an implantable cardiac stimulation device which has the appearance of a surface EKG. The heart activity signal is sensed by the implanted device and is processed by the device or the external display to have frequency characteristics resembling that of a surface EKG. The heart activity signal to be displayed takes the form of an intracardiac electrogram signal with a low frequency roll-on of no greater than 0.4 Hz and a high frequency cutoff of no less than 20 Hz. This provides a heart activity signal for display which has the appearance and most attributes of a surface EKG.
摘要翻译：可植入心脏刺激系统和方法提供外部显示心脏活动信号，该心脏活动信号由具有表面EKG外观的可植入心脏刺激装置内部感测。心脏活动信号由植入装置感测，并被装置或外部显示器处理以具有类似于表面EKG的频率特性。要显示的心脏活动信号采取心内电图信号的形式，具有不大于0.4Hz的低频滚动和不小于20Hz的高频截止。这提供了用于显示的心脏活动信号，其具有表面EKG的外观和大多数属性。

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