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61. 发明授权

US06790173B2 Shape lockable apparatus and method for advancing an instrument through unsupported anatomy 有权
公开(公告)号：US06790173B2
公开(公告)日：2004-09-14
申请号：US10173227
申请日：2002-06-13
申请人： Vahid Saadat , Richard C. Ewers , Eugene G. Chen
发明人： Vahid Saadat , Richard C. Ewers , Eugene G. Chen
IPC分类号： A61B104
CPC分类号： A61B1/00154 , A61B1/00078 , A61B1/0008 , A61B1/00082 , A61B1/00105 , A61B1/00135 , A61B1/0052 , A61B1/0055 , A61B1/0058 , A61B1/008 , A61B1/31 , A61B1/32
摘要： Apparatus and methods are provided for placing and advancing a diagnostic or therapeutic instrument in a hollow body organ of a tortuous or unsupported anatomy, comprising a handle, an overtube, a distal region having an atraumatic tip. The overtube may be removable from the handle, and have a longitudinal axis disposed at an angle relative to the handle. The overtube may be selectively stiffened to reduce distension of the organ caused by advancement of the diagnostic or therapeutic instrument. The distal region permits passive steering of the overtube caused by deflection of the diagnostic or therapeutic instrument while the atraumatic tip prevents the wall of the organ from becoming caught or pinched during manipulation of the diagnostic or therapeutic instrument.

62. 发明授权

US08057511B2 Apparatus and methods for positioning and securing anchors 有权
标题翻译：用于定位和固定锚固件的装置和方法
公开(公告)号：US08057511B2
公开(公告)日：2011-11-15
申请号：US10841411
申请日：2004-05-07
申请人： Jesus Flores , Richard C. Ewers , Tracy D. Maahs , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat
发明人： Jesus Flores , Richard C. Ewers , Tracy D. Maahs , Alex Khairkhahan , Ruey-Feng Peh , Vahid Saadat
IPC分类号： A61B17/04
CPC分类号： A61B17/0469 , A61B17/00234 , A61B17/0487 , A61B2017/00827 , A61B2017/00867 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0464 , A61B2017/0475 , A61B2017/0477 , A61B2017/0488 , A61B2017/0496 , A61B2017/06028 , A61B2017/06052 , A61B2017/06176 , Y10T24/39 , Y10T24/3969
摘要： Apparatus and methods for positioning and securing anchors are disclosed herein. The anchors are adapted to be delivered and implanted into or upon tissue, particularly tissue within the gastrointestinal system of a patient. The anchor is adapted to slide uni-directionally over suture such that a tissue plication may be cinched between anchors. A locking mechanism either within the anchor itself of positioned proximally of the anchor may allow for the uni-directional translation while enabling the anchor to be locked onto the suture if the anchor is pulled, pushed, or otherwise urged in the opposite direction along the suture. This uni-directional anchor locking mechanism facilitates the cinching of the tissue plication between the anchors and it may be utilized in one or several anchors in cinching a tissue fold.
摘要翻译：本文公开了用于定位和固定锚固件的装置和方法。锚固件适于被递送并植入到组织中，特别是患者胃肠系统内的组织中。锚固件适于在缝合线上单向滑动，使得组织褶皱可以在锚固件之间束紧。如果锚固件被拉动，推动或沿着缝合线沿相反方向被推动，锚固件本身内的定位器本身内的锁定机构可以允许单向平移，同时使锚固件能够锁定在缝合线上。这种单向锚定锁定机构有助于锚定器之间的组织褶皱收紧，并且可以在一个或多个锚定器中使用，以收紧组织褶皱。

63. 发明授权

US07942898B2 Delivery systems and methods for gastric reduction 有权
标题翻译：用于胃部减少的输送系统和方法
公开(公告)号：US07942898B2
公开(公告)日：2011-05-17
申请号：US10612109
申请日：2003-07-01
申请人： Richard C Ewers , Vahid Saadat , Eugene Chen
发明人： Richard C Ewers , Vahid Saadat , Eugene Chen
IPC分类号： A61B17/04 , A61B17/06
CPC分类号： A61B17/3478 , A61B17/00234 , A61B17/0401 , A61B17/0487 , A61B17/0644 , A61B17/3468 , A61B2017/0404 , A61B2017/0417 , A61B2017/0419 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61B2017/061 , A61B2017/3488
摘要： A delivery catheter for a gastric reduction system includes an elongate torqueable tube, a needle translatably disposed within the torqueable tube, an anchor translatably disposed within the needle and a stabilization device for holding a distal tip of the torqueable tube against a tissue wall.
摘要翻译：用于胃减压系统的输送导管包括细长的可扭转管，可转动地设置在可扭转管内的针，可平移地设置在针内的锚固件和用于将可扭转管的远侧末端保持抵靠组织壁的稳定装置。

64. 发明授权

US07736379B2 Compressible tissue anchor assemblies 有权
标题翻译：可压缩组织锚固组件
公开(公告)号：US07736379B2
公开(公告)日：2010-06-15
申请号：US11179082
申请日：2005-07-11
申请人： Richard C. Ewers , Shirley Vong , Vahid Saadat
发明人： Richard C. Ewers , Shirley Vong , Vahid Saadat
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0644 , A61B2017/00867 , A61B2017/0454 , A61B2017/0464 , A61B2017/0496 , A61B2017/06052 , A61B2090/037
摘要： Apparatus & methods for optimizing anchoring force are described herein. In securing tissue folds, over-compression of the tissue directly underlying the anchors is avoided by utilizing tissue anchors having expandable arms configured to minimize contact area between the anchor and tissue. When the anchor is in its expanded configuration, a load is applied to the anchor until it is optimally configured to accommodate a range of deflections while the anchor itself exerts a substantially constant force against the tissue. Various devices, e.g., stops, spring members, fuses, strain gauges, etc., can be used to indicate when the anchor has been deflected to a predetermined level within the optimal range. Moreover, other factors to affect the anchor characteristics include, e.g., varying the number of arms or struts of the anchor, positioning of the arms, configuration of the arms, the length of the collars, etc.
摘要翻译：本文描述了用于优化锚固力的装置和方法。在固定组织褶皱时，通过利用具有可扩张臂的组织锚来避免直接位于锚固件正下方的组织的过度压缩，所述组织锚构造成使锚和组织之间的接触面积最小化。当锚固件处于其膨胀构型时，将负载施加到锚固件，直到其被最佳地构造成适应一定范围的偏转，同时锚固件本身对组织施加基本恒定的力。可以使用各种装置，例如止动件，弹簧构件，保险丝，应变计等来指示锚固件何时被偏转到最佳范围内的预定水平。此外，影响锚固特征的其他因素包括例如改变锚的臂或支柱的数量，臂的定位，臂的构型，套环的长度等。

65. 发明授权

US07621925B2 Needle assembly for tissue manipulation 有权
标题翻译：用于组织操作的针组件
公开(公告)号：US07621925B2
公开(公告)日：2009-11-24
申请号：US10955243
申请日：2004-09-30
申请人： Vahid Saadat , Chris Rothe , Richard C. Ewers
发明人： Vahid Saadat , Chris Rothe , Richard C. Ewers
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B17/06066 , A61B17/064 , A61B17/08 , A61B17/10 , A61B17/29 , A61B2017/00349 , A61B2017/00867 , A61B2017/0404 , A61B2017/0409 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0446 , A61B2017/045 , A61B2017/0451 , A61B2017/0454 , A61B2017/0456 , A61B2017/0458 , A61B2017/0459 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0475 , A61B2017/0488 , A61B2017/0496 , A61B2017/06052 , A61B2017/081 , A61B2017/3488
摘要： Needle assemblies for tissue manipulation are described herein. In creating tissue folds within the body of a patient, a tissue manipulation assembly may generally have an elongate tubular member, an engagement member slidably disposed through the tubular member and a distal end adapted to engage tissue via a helical member, tissue stabilizing members positioned at the tubular member distal end which are adapted to stabilize tissue therebetween, and a delivery tube pivotable about the tissue stabilizer. A needle deployment assembly is deployable through the tissue manipulation assembly via a handle assembly, through the tubular member, and into or through tissue. An elongate pusher is translationally disposed within a sheath of the needle deployment assembly and can be urged distally for deploying an anchor assembly from the sheath distal end. The anchor assembly is positioned distally of the pusher within the sheath.
摘要翻译：用于组织操作的针组件在本文中描述。在组织折叠在患者体内产生时，组织操作组件通常可以具有细长的管状构件，可滑动地设置穿过管状构件的接合构件和适于通过螺旋构件接合组织的远端，组织稳定构件所述管状构件远端适于在其间稳定组织，以及可围绕所述组织稳定器枢转的输送管。针部署组件可经由手柄组件穿过组织操纵组件展开，穿过管状构件，并且进入或穿过组织。细长的推动器平移地设置在针展开组件的护套内，并且可以向远侧推动以从护套远端展开锚固组件。锚固组件位于鞘内的推动器的远侧。

66. 发明授权

US07128708B2 Shape lockable apparatus and method for advancing an instrument through unsupported anatomy 有权
公开(公告)号：US07128708B2
公开(公告)日：2006-10-31
申请号：US10173203
申请日：2002-06-13
申请人： Vahid Saadat , Richard C. Ewers , Eugene G. Chen
发明人： Vahid Saadat , Richard C. Ewers , Eugene G. Chen
IPC分类号： A61B1/00
CPC分类号： A61B1/00154 , A61B1/00078 , A61B1/0008 , A61B1/00082 , A61B1/00105 , A61B1/00135 , A61B1/0052 , A61B1/0055 , A61B1/0058 , A61B1/008 , A61B1/31 , A61B1/32
摘要： Apparatus and methods are provided for placing and advancing a diagnostic or therapeutic instrument in a hollow body organ of a tortuous or unsupported anatomy, comprising a handle, an overtube, a distal region having an atraumatic tip. The overtube may be removable from the handle, and have a longitudinal axis disposed at an angle relative to the handle. The overtube may be selectively stiffened to reduce distension of the organ caused by advancement of the diagnostic or therapeutic instrument. The distal region permits passive steering of the overtube caused by deflection of the diagnostic or therapeutic instrument while the atraumatic tip prevents the wall of the organ from becoming caught or pinched during manipulation of the diagnostic or therapeutic instrument.

67. 发明授权

US06837847B2 Shape lockable apparatus and method for advancing an instrument through unsupported anatomy 有权
标题翻译：形状可锁定装置和方法，用于通过不支持的解剖结构推进器械
公开(公告)号：US06837847B2
公开(公告)日：2005-01-04
申请号：US10173238
申请日：2002-06-13
申请人： Richard C. Ewers , Vahid Saadat , Eugene G. Chen
发明人： Richard C. Ewers , Vahid Saadat , Eugene G. Chen
IPC分类号： A61B1/005 , A61B1/008 , A61B1/01 , A61B1/31 , A61B1/32 , A61B1/04
CPC分类号： A61B1/00154 , A61B1/00078 , A61B1/0008 , A61B1/00082 , A61B1/00105 , A61B1/00135 , A61B1/0052 , A61B1/0055 , A61B1/0058 , A61B1/008 , A61B1/31 , A61B1/32
摘要： Apparatus and methods are provided for placing and advancing a diagnostic or therapeutic instrument in a hollow body organ of a tortuous or unsupported anatomy, comprising a handle, an overtube, a distal region having an atraumatic tip. The overtube may be removable from the handle, and have a longitudinal axis disposed at an angle relative to the handle. The overtube may be selectively stiffened to reduce distension of the organ caused by advancement of the diagnostic or therapeutic instrument. The distal region permits passive steering of the overtube caused by deflection of the diagnostic or therapeutic instrument while the atraumatic tip prevents the wall of the organ from becoming caught or pinched during manipulation of the diagnostic or therapeutic instrument.
摘要翻译：提供了设备和方法，用于将诊断或治疗仪器放置并行进在曲折或无支撑的解剖结构的中空身体器官中，包括手柄，外套管，具有无创尖端的远侧区域。外套管可以从手柄移除，并且具有相对于把手以一定角度设置的纵向轴线。外套管可以选择性地加强，以减少由诊断或治疗仪器的前进引起的器官膨胀。远端区域允许由诊断或治疗仪器的偏转引起的外套管的被动转向，而无创伤的尖端在操纵诊断或治疗仪器期间防止器官的壁被卡住或夹住。

68. 发明授权

US08087413B2 Attenuation of environmental parameters on a gastric lumen 有权
标题翻译：胃管内环境参数的衰减
公开(公告)号：US08087413B2
公开(公告)日：2012-01-03
申请号：US11035702
申请日：2005-01-14
申请人： Vahid Saadat , Ruey-Feng Peh , Richard C. Ewers , Eugene G. Chen
发明人： Vahid Saadat , Ruey-Feng Peh , Richard C. Ewers , Eugene G. Chen
IPC分类号： A61B19/00 , A61B17/08 , A61B17/04 , A61F2/04 , A61L17/00
CPC分类号： A61B17/0469 , A61B17/00491 , A61B17/0401 , A61B17/0487 , A61B17/1114 , A61B2017/00349 , A61B2017/00495 , A61B2017/0406 , A61B2017/0454 , A61B2017/0464
摘要： The attenuation or isolation of environmental parameters on a gastric lumen is described herein. Once tissue plications are formed into a gastric lumen or sleeve within a stomach, the newly formed lumen is subjected to a multitude of fluctuating stresses or pressure from food or fluids passing therethrough, from naturally-occurring contractions, and/or from changes in pH levels from caustic stomach acids and hormones. The tissue interface between these plications can be isolated from such environmental fluctuations, or the fluctuations can be attenuated, by a number of methods. One example is to place a gastric stent or sleeve within the newly formed lumen. Another example is to utilize multiple rows of anchors, clips, or sutures along the interface. Alternatively, bio-adhesives can be dispensed to buttress the tissue interface. In another variation, the tissue can be approximated in different configurations which effectively reduce or isolate the adhered tissue region.
摘要翻译：本文描述了在胃腔上的环境参数的衰减或分离。一旦组织消融在胃内形成胃腔或套管，则新形成的内腔经受来自通过其的食物或液体的多种波动的应力或压力，从天然存在的收缩和/或pH水平的变化从苛性胃酸和激素。可以通过多种方法将这些斑点之间的组织界面与这种环境波动隔离，或者波动可以减弱。一个例子是将胃支架或套管放置在新形成的内腔内。另一个例子是沿着界面使用多行锚，剪辑或缝线。或者，可以分配生物粘合剂以支撑组织界面。在另一个实施方式中，可以以有效地减少或隔离粘附的组织区域的不同配置来近似组织。

69. 发明授权

US07041052B2 Shape lockable apparatus and method for advancing an instrument through unsupported anatomy 有权
公开(公告)号：US07041052B2
公开(公告)日：2006-05-09
申请号：US10888531
申请日：2004-07-08
申请人： Vahid Saadat , Richard C. Ewers , Eugene G. Chen
发明人： Vahid Saadat , Richard C. Ewers , Eugene G. Chen
IPC分类号： A61B1/00
CPC分类号： A61B1/0052 , A61B1/00078 , A61B1/0008 , A61B1/00082 , A61B1/00105 , A61B1/00135 , A61B1/00154 , A61B1/0055 , A61B1/0057 , A61B1/0058 , A61B1/31 , A61B1/32
摘要： Apparatus and methods are provided for placing and advancing a diagnostic or therapeutic instrument in a hollow body organ of a tortuous or unsupported anatomy, comprising a handle, an overtube, a distal region having an atraumatic tip. The overtube may be removable from the handle, and have a longitudinal axis disposed at an angle relative to the handle. The overtube may be selectively stiffened to reduce distension of the organ caused by advancement of the diagnostic or therapeutic instrument. The distal region permits passive steering of the overtube caused by deflection of the diagnostic or therapeutic instrument while the atraumatic tip prevents the wall of the organ from becoming caught or pinched during manipulation of the diagnostic or therapeutic instrument.

70. 发明授权

US06942613B2 Shape lockable apparatus and method for advancing an instrument through unsupported anatomy 有权
公开(公告)号：US06942613B2
公开(公告)日：2005-09-13
申请号：US10281461
申请日：2002-10-25
申请人： Richard C. Ewers , Vahid Saadat , Boris Reydel
发明人： Richard C. Ewers , Vahid Saadat , Boris Reydel
IPC分类号： A61B1/005 , A61B1/008 , A61B1/01 , A61B1/31 , A61B1/32 , A61B1/00
CPC分类号： A61B1/00154 , A61B1/00078 , A61B1/0008 , A61B1/00082 , A61B1/00105 , A61B1/00135 , A61B1/0052 , A61B1/0055 , A61B1/0058 , A61B1/008 , A61B1/31 , A61B1/32
摘要： Apparatus and methods are provided for placing and advancing a diagnostic or therapeutic instrument in a hollow body organ of a tortuous or unsupported anatomy, comprising a handle, an overtube disposed within a hydrophilic sheath, and a distal region having an atraumatic tip. The overtube may be removable from the handle, and have a longitudinal axis disposed at an angle relative to the handle. The sheath may be disposable to permit reuse of the overtube. Fail-safe tensioning mechanisms may be provided to selectively stiffen the overtube to reduce distension of the organ caused by advancement of the diagnostic or therapeutic instrument. The fail-safe tensioning mechanisms reduce the risk of reconfiguration of the overtube in the event that the tension system fails, and, in one embodiment, rigidizes the overtube without substantial proximal movement of the distal region. The distal region permits passive steering of the overtube caused by deflection of the diagnostic or therapeutic instrument, while the atraumatic tip prevents the wall of the organ from becoming caught or pinched during manipulation of the diagnostic or therapeutic instrument.

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