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61. 发明专利

AU2017213795A1 Systems and methods for growth of intestinal cells in microfluidic devices 未知
公开(公告)号：AU2017213795A1
公开(公告)日：2018-08-16
申请号：AU2017213795
申请日：2017-02-01
申请人： CEDARS SINAI MEDICAL CENTER
发明人： BARRETT ROBERT , SVENDSEN CLIVE , TARGAN STEPHAN R , WORKMAN MICHAEL , SAREEN DHRUV , RAJAMANI UTHRA
IPC分类号： C12N5/071 , C12N5/074 , C12N5/0789 , C12N5/0797 , C12N5/22
摘要： Organs-on-chips are microfluidic devices for culturing living cells in micrometer sized chambers in order to model physiological functions of tissues and organs. Engineered patterning and continuous fluid flow in these devices has allowed culturing of intestinal cells bearing physiologically relevant features and sustained exposure to bacteria while maintaining cellular viability, thereby allowing study of inflammatory bowl diseases. However, existing intestinal cells do not possess all physiologically relevant subtypes, do not possess the repertoire of genetic variations, or allow for study of other important cellular actors such as immune cells. Use of iPSC-derived epithelium, including IBD patient-specific cells, allows for superior disease modeling by capturing the multi-faceted nature of the disease.

62. 发明专利

ES2650228T3 Métodos de diagnóstico de colitis ulcerosa y enfermedad de Crohn 未知
公开(公告)号：ES2650228T3
公开(公告)日：2018-01-17
申请号：ES12762965
申请日：2012-03-26
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： TAYLOR KENT D , MCGOVERN DERMOT P , ROTTER JEROME I , TARGAN STEPHAN R , HARITUNIANS TALIN
IPC分类号： G01N33/48 , C12Q1/68 , G01N33/564 , G01N33/68
摘要： Un método para pronosticar la enfermedad inflamatoria intestinal (IBD) en un individuo, que comprende: evaluar una muestra obtenida del individuo para determinar la presencia o ausencia de una o más variantes de riesgo seleccionadas de rs10001225 (SEQ ID No. 2), rs4694164 (SEQ ID No 3) y rs7668327 (SEQ ID No. 4), evaluar la muestra para determinar la presencia o ausencia de marcador serológico ANCA; y pronosticar una forma agresiva de enfermedad inflamatoria intestinal en el individuo en base a la presencia de una o más de las variantes de riesgo y la presencia de marcador serológico ANCA

63. 发明专利

CL2015002866A1 Tratamiento de fibrosis e inflamación mediante la inhibición de tl1a 未知
公开(公告)号：CL2015002866A1
公开(公告)日：2016-08-05
申请号：CL2015002866
申请日：2015-09-25
申请人： CEDARS SINAI MEDICAL CENTER
发明人： SHIH DAVID Q , TARGAN STEPHAN R , LI DALIN , BILSBOROUGH JANINE
IPC分类号： A61K38/12 , A61K38/16 , C12Q1/68

64. 发明专利

CA2830365A1 ROLE OF IFNG METHYLATION IN INFLAMMATORY BOWEL DISEASE 未知
公开(公告)号：CA2830365A1
公开(公告)日：2012-10-04
申请号：CA2830365
申请日：2012-03-26
申请人： CEDARS SINAI MEDICAL CENTER
发明人： GONSKY REBECCA , DEEM RICHARD , TARGAN STEPHAN R
IPC分类号： C12Q1/68 , C40B30/00 , G01N33/48
摘要： The invention relates to method of diagnosing susceptibility to inflammatory bowel disease (IBD) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in IFNG DNA methylation. In one embodiment, the present invention provides a method of diagnosing susceptibility to inflammatory bowel disease (IBD) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in IFNG DNA methylation relative to a normal subject, and diagnosing susceptibility to inflammatory bowel disease based on the presence of one or more risk genetic variants and/or an increase in IFNG DNA methylation relative to a normal subject. In another embodiment, the IBD is ulcerative colitis.

65. 发明专利

AU2011202664A1 Methods for diagnosis and treatment of Crohn's disease 未知
公开(公告)号：AU2011202664A1
公开(公告)日：2011-06-23
申请号：AU2011202664
申请日：2011-06-03
申请人： CEDARS SINAI MEDICAL CENTER
发明人： TARGAN STEPHAN R , LANDERS CAROL J
IPC分类号： C12P19/34
摘要： The inventors have discovered an elevated serum response to CBirl flagellin in Crohn's disease patients. The present invention relates to methods for diagnosis and 5 treatment of Crohn's disease and/or subtypes of Crohn's disease. Diagnosis is accomplished by determining the presence of the anti-CBirl expression or determining the presence of anti-CBirl expression and detection of the presence of pANCA. Treatment methods include antigen-directed therapy targeting CBirl flagelin and manipulating the bacteria in the colon and/or small intestine.

66. 发明专利

DE602004021367D1 未知
公开(公告)号：DE602004021367D1
公开(公告)日：2009-07-16
申请号：DE602004021367
申请日：2004-04-09
申请人： CEDARS SINAI MEDICAL CENTER
发明人： TARGAN STEPHAN R , VASILIAUSKAS ERIC A , MOW WILLIAM S , YANG HUIYING , FLESHNER PHILLIP R , ROTTER JEROME I
IPC分类号： G01N33/68 , C12Q1/68
摘要： The invention provides a method of diagnosing or predicting susceptibility to a clinical subtype of Crohn's disease in a subject having Crohn's disease by determining the presence or absence of IgA anti-I2 antibodies in the subject, where the presence of the IgA anti-I2 antibodies indicates that the subject has a clinical subtype of Crohn's disease. In one embodiment, a method of the invention is practiced by further determining the presence or absence in the subject of a NOD2 variant, anti-Saccharomyces cerevisiae antibodies (ASCA), IgA anti-OmpC antibodies, or perinuclear anti-neutrophil cytoplasmic antibodies (pANCA). The methods of the invention can be used to diagnose or predict susceptibility to a clinical subtype of Crohn's disease, for example, a fibrostenotic subtype, a subtype characterized by the need for small bowel surgery, or a subtype characterized by the absence of features of ulcerative colitis.

67. 发明专利

CA2251567C METHODS OF DIAGNOSING CLINICAL SUBTYPES OF CROHN'S DISEASE 未知
公开(公告)号：CA2251567C
公开(公告)日：2009-07-07
申请号：CA2251567
申请日：1997-04-11
申请人： CEDARS SINAI MEDICAL CENTER , PROMETHEUS LAB INC
发明人： TARGAN STEPHAN R , BARRY MARY J , VASILIAUSKAS ERIC A , PLEVY SCOTT E
IPC分类号： G01N33/564 , C12Q1/68 , G01N33/569 , G01N33/68
摘要： Provided herein is a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibody (pANCA) is present in a patient with CD, where the presence of pANC A indicates a clinical subtype of CD with features of ulcerative colitis (UC). The present also provides a method of diagnosing clinical subtypes of Crohn's disease in a patient with CD by determing whether pANCA or speckling anti-pan polymorphonuclear antibo dy (SAPPA) is present in the patient with CD, where the presence of pANCA indicates a clinical subtype of CD with features of ulcerative colitis and where the presence of SAPPA indicates a clinical subtype of CD having perforating, fistulizing or small bowel obstructive disease. The invention further provides a method of diagnosing clinical subtypes of Crohn's disease in a patient with CD by determining the presence or absence of ANCA, pANCA and SAPPA in the patient with CD and determining the presence or absence of anti - Saccharomyces cerevisiae antibodies (ASCA) in the patient with CD, where the presnece of pANCA combined with the absence of ASCA indicate a clinical subtype of CD with features of UC, the presence of SAPPA indicates a clinical subtype of CD having perforating or fistulizing disease or small bowel obstructive disease, and the presence of ASCA combined with the absence of ANCA indicates a clincial subtype of CD lacking features of ulcerative colitis and having perforating or fistulizing disease or small bowel obstructive disease. Kits for diagnosing clinical subtypes of Crohn's disease, which contain neutrophil and antigen specific for ASCA, also are provided.

68. 发明专利

CA2589746A1 METHODS FOR DIAGNOSIS AND TREATMENT OF CROHN'S DISEASE 未知
公开(公告)号：CA2589746A1
公开(公告)日：2006-06-15
申请号：CA2589746
申请日：2005-12-08
申请人： CEDARS SINAI MEDICAL CENTER
发明人： LANDERS CAROL J , TARGAN STEPHAN R
IPC分类号： C12Q1/68 , A61K31/00 , A61K45/00 , C12P19/34 , G01N33/53
摘要： A method of diagnosing a subtype of Crohn's disease in a mammal, comprising:obtaining a sample from the mammal; determining the presence of anti-CBir1 expression in the sample obtained from the mammal; and determining the presence of a perinuclear anti-neutrophil cytoplasmic antibody (pANCA) in the sample obtained from the mammal, wherein the presence of anti-CBir1 expression and the pANCA indicates the subtype of Crohn's disease with features of colitic disease and/or colitic and small bowel disease.

69. 发明专利

AT302411T 未知
公开(公告)号：AT302411T
公开(公告)日：2005-09-15
申请号：AT01935666
申请日：2001-05-17
申请人： CEDARS SINAI MEDICAL CENTER , UNIV CALIFORNIA
发明人： TARGAN STEPHAN R , BRAUN JONATHAN , SUTTON CHRISTOPHER L
IPC分类号： G01N33/53 , A61K39/108 , A61P1/04 , C12N15/09 , G01N33/543 , G01N33/569 , G01N33/68 , G01N33/564 , C12Q1/68 , C07H21/02
摘要： The present invention provides a method of diagnosing Crohn's disease in a subject by determining the presence or absence or IgA anti-OmpC antibodies in the subject, where the presence of the IgA anti-OmpC antibodies indicates that the subject has Crohn's disease.

70. 发明专利

CA2223642C DIFFERENTIAL ASSAY FOR ULCERATIVE COLITIS, PRIMARY SCLEROSING CHOLANGITIS AND TYPE 1 AUTOIMMUNE HEPATITIS 未知
公开(公告)号：CA2223642C
公开(公告)日：2005-08-16
申请号：CA2223642
申请日：1996-06-05
申请人： CEDARS SINAI MEDICAL CENTER
发明人： VIDRICH ALDA , TARGAN STEPHAN R
IPC分类号： G01N33/53 , C07K16/18 , G01N33/564 , G01N33/569 , G01N33/576
摘要： The invention is directed to methods and kits for detecting and measuring th e presence or absence of perinuclear anti-neutrophil cytoplasmic antibody of ulcerative colitis, primary sclerosing cholangitis o r type 1 autoimmune hepatitis. The methods and kits of the present invention provide safe and reliable means for diagnosing ulcerative colitis, primary sclerosing cholangitis, and type 1 autoimmune hepatitis. The antigens reactive with perinuclear anti-neutrophil cytoplasmi c autoantibody of ulcerative colitis and primary sclerosing cholangitis are also provided.

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