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61. 发明授权

US08060219B2 Epicardial patch including isolated extracellular matrix with pacing electrodes 失效
标题翻译：心外膜包括分离的细胞外基质与起搏电极
公开(公告)号：US08060219B2
公开(公告)日：2011-11-15
申请号：US11017627
申请日：2004-12-20
申请人： Jeffrey Ross , John Kim , Rodney W. Salo , Ronald W. Heil, Jr. , Randy Westlund
发明人： Jeffrey Ross , John Kim , Rodney W. Salo , Ronald W. Heil, Jr. , Randy Westlund
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N1/0568 , A61N1/059
摘要： An epicardial patch includes an extracellular matrix (ECM) and a plurality of electrodes. The isolated ECM is configured for epicardial attachment over a myocardial region including an injured area to control post-injury remodeling of the myocardial region. The plurality of electrodes is configured for delivering electrical stimulation to enhance the effect of the isolated ECM in remodeling control by altering workload and stress on the myocardial region.
摘要翻译：心外膜贴片包括细胞外基质（ECM）和多个电极。分离的ECM被配置用于在包括受伤区域的心肌区域上的心外膜附着以控制心肌区域的损伤后重建。多个电极被配置为通过改变心肌区域上的工作负荷和压力来传递电刺激以增强孤立的ECM在重塑控制中的作用。

62. 发明申请

US20100324628A1 METHOD AND APPARATUS FOR OPTIMIZING VAGAL NERVE STIMULATION USING LARYNGEAL ACTIVITY 有权
标题翻译：使用Larynge活动优化VAGAL神经刺激的方法和装置
公开(公告)号：US20100324628A1
公开(公告)日：2010-12-23
申请号：US12872408
申请日：2010-08-31
申请人： Randy Westlund , Anthony V. Caparso , Mark Bly
发明人： Randy Westlund , Anthony V. Caparso , Mark Bly
IPC分类号： A61N1/36
CPC分类号： A61N1/36053 , A61B5/04001 , A61B5/0402 , A61B5/1104 , A61B5/6822 , A61B5/7203 , A61N1/0551 , A61N1/36114 , A61N1/36542 , A61N1/37247 , A61N1/37288
摘要： A neural stimulation system delivers neural stimulation to the vagus nerve and senses a signal indicative of laryngeal activity resulting from the neural stimulation. The signal indicative of laryngeal activity is used, for example, to guide electrode placement, determine stimulation threshold, detect lead/electrode problems, detect neural injury, and monitor healing processing following the electrode placement inside the body of a patient.
摘要翻译：神经刺激系统将神经刺激传递给迷走神经，并感测到指示由神经刺激引起的喉部活动的信号。例如，使用指示喉部活动的信号来引导电极放置，确定刺激阈值，检测铅/电极问题，检测神经损伤，以及在患者体内的电极放置之后监测愈合过程。

63. 发明申请

US20080009719A1 METHOD AND APPARATUS FOR INTRODUCING ENDOLYMPHATIC INSTRUMENTATION 有权
标题翻译：引言内分泌仪器的方法和装置
公开(公告)号：US20080009719A1
公开(公告)日：2008-01-10
申请号：US11422423
申请日：2006-06-06
申请人： Allan C. Shuros , Randy Westlund , M. Jason Brooke
发明人： Allan C. Shuros , Randy Westlund , M. Jason Brooke
IPC分类号： A61B5/05
CPC分类号： A61N1/362 , A61B5/0031 , A61B5/0452 , A61B5/415 , A61B5/418 , A61M2202/0405 , A61N1/0504
摘要： Described herein are a method and apparatus for introducing instrumentation into the lymphatic system that can be used for physiological monitoring and/or delivery of therapy. Such instrumentation, for example, may include one or more sensors for measuring physiological variables and/or one or more instruments for delivering therapy that is adapted to be disposed within a lymphatic vessel.
摘要翻译：本文描述了用于将仪器引入淋巴系统中的方法和装置，其可用于治疗的生理监测和/或递送。例如，这种仪器可以包括用于测量生理变量的一个或多个传感器和/或用于递送适于布置在淋巴管内的治疗的一个或多个仪器。

64. 发明授权

US07234977B2 Multi-polar connector 有权
标题翻译：多极连接器
公开(公告)号：US07234977B2
公开(公告)日：2007-06-26
申请号：US11125978
申请日：2005-05-10
申请人： Randy Westlund , Gwen Crevensten , Christopher M. Zerby , Paul E. Zarembo , Brian D. Soltis , Gregory R. Ley
发明人： Randy Westlund , Gwen Crevensten , Christopher M. Zerby , Paul E. Zarembo , Brian D. Soltis , Gregory R. Ley
IPC分类号： H01R13/405
CPC分类号： A61N1/056 , Y10S439/909
摘要： A connector for connecting to an energy source such as a pulse generator for a cardiac stimulator system. The connector assembly includes a pin, at least one ring and a sleeve composed of an insulative hard polymer molded between the pin and ring such that the sleeve provides electrical insulation between the pin and ring and mechanically couples the pin and ring.
摘要翻译：用于连接到能量源的连接器，例如用于心脏刺激器系统的脉冲发生器。连接器组件包括销，至少一个环和由在销和环之间模制的绝缘硬聚合物组成的套筒，使得套筒在销和环之间提供电绝缘并且机械地联接销和环。

65. 发明授权

US07218971B2 Implantable lead with dissolvable coating for improved fixation and extraction 失效
标题翻译：可植入铅，可溶解涂层，用于改进固定和提取
公开(公告)号：US07218971B2
公开(公告)日：2007-05-15
申请号：US10608850
申请日：2003-06-24
申请人： Ronald W. Heil, Jr. , John E. Heil , Randy Westlund
发明人： Ronald W. Heil, Jr. , John E. Heil , Randy Westlund
IPC分类号： A61N1/05
CPC分类号： A61N1/0568 , A61N1/056
摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.
摘要翻译：心脏节律管理系统提供心内心律管理引线，至少部分地可以在其远端处或其远端处的引线体的绝缘部分上具有至少部分可溶解的涂层。溶解后，涂层促进组织向内生长，以将铅固定在脆弱的血管结构或其他地方。一种这样的涂层的溶解释放治疗剂，例如修饰组织向内生长的纤维化瘢痕组织含量的类固醇，使得组织和引线之间产生的结合较弱，从而如果需要，铅可以容易地提取。一个这样的引线包括至少承载的绝缘细长体。引线还包括在外周远端引线表面的绝缘部分上的至少部分可溶解的涂层。在暴露于含水物质之后，涂层提供粗糙表面，多孔表面或溶胀表面中的一种或多种。

66. 发明申请

US20050137674A1 Distal or proximal fixation of over-the-tether myocardial leads 有权
标题翻译：远端或近端固定超过系绳心肌引线
公开(公告)号：US20050137674A1
公开(公告)日：2005-06-23
申请号：US10972298
申请日：2004-10-22
申请人： M. Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme
发明人： M. Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N2001/0578
摘要： The present invention is a myocardial lead attachment system for securing a lead within the myocardium. The attachment system includes an anchor configured to engage the heart, a tether coupled to the anchor and a lead body. The lead body has a proximal end, a distal end, a lumen for accepting the tether and a lock housing in the lumen. A lock structure is on the tether and mates with the lock housing and restrains motion of the lead with respect to the tether in either of a proximal or a distal direction.
摘要翻译：本发明是用于将铅固定在心肌内的心肌引导附着系统。附接系统包括构造成接合心脏的锚，连接到锚固体的系绳和引导体。引线体具有近端，远端，用于接纳系绳的内腔和在内腔中的锁定壳体。锁定结构位于系绳上并且与锁定壳体配合并且在近端或远端方向中抑制引线相对于系绳的运动。

67. 发明申请

US20050119718A1 Absorbable myocardial lead fixation system 有权
标题翻译：可吸收心肌引导固定系统
公开(公告)号：US20050119718A1
公开(公告)日：2005-06-02
申请号：US10971577
申请日：2004-10-22
申请人： M. Sean Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme
发明人： M. Sean Coe , Ronald Heil , Peter Kelley , Jason Shiroff , Randy Westlund , Donald Palme
IPC分类号： A61B5/0492 , A61B17/04 , A61B17/06 , A61N1/05
CPC分类号： A61B17/0469 , A61B5/0492 , A61B17/06109 , A61B2017/0417 , A61B2017/06042 , A61B2017/0608 , A61N1/0568 , A61N1/0587 , A61N2001/0578 , A61N2001/058
摘要： A myocardial lead attachment system for securing a distal end of a lead within a myocardium of a patient's heart. The system includes a lead body, an anchor mechanism formed of a bioabsorbable or biodegradable polymer for engaging a surface of the patient's heart and a surface feature formed on a portion of the lead body for promoting formation of scar tissue around said portion of the lead body.
摘要翻译：用于将铅的远端固定在患者心脏的心肌内的心肌引线附着系统。该系统包括引线体，由生物可吸收或可生物降解的聚合物形成的锚固机构，用于接合患者心脏的表面，以及形成在引线体的一部分上的表面特征，用于促进在引线体的所述部分周围形成瘢痕组织。

68. 发明授权

US06304786B1 Implantable lead with dissolvable coating for improved fixation and extraction 有权
标题翻译：可植入铅，可溶解涂层，用于改进固定和提取
公开(公告)号：US06304786B1
公开(公告)日：2001-10-16
申请号：US09280096
申请日：1999-03-29
申请人： Ronald W. Heil, Jr. , John E. Heil , Randy Westlund
发明人： Ronald W. Heil, Jr. , John E. Heil , Randy Westlund
IPC分类号： A61N105
CPC分类号： A61N1/0568 , A61N1/056
摘要： A cardiac rhythm management system provides an endocardial cardiac rhythm management lead with an at least partially dissolvable coating at least partially on insulating portions of the lead body at or near its distal end. Upon dissolution, the coating promotes tissue ingrowth to secure the lead in place within fragile vascular structures or elsewhere. Dissolution of one such coating releases a therapeutic agent, such as a steroid that modifies the fibrotic scar tissue content of tissue ingrowth, such that the resulting bond between the tissue and the lead is weak, so that the lead can be easily extracted if desired. One such lead includes an insulating elongate body carrying at least. The lead also includes an at least partially dissolvable coating on an insulating portion of the peripheral distal lead surface. The coating provides one or more of a rough surface, a porous surface, or a swollen surface after being exposed to an aqueous substance.
摘要翻译：心脏节律管理系统提供心内心律管理引线，其至少部分地可以在其远端处或其远端处的引线体的绝缘部分上具有至少部分可溶解的涂层。溶解后，涂层促进组织向内生长，以将铅固定在脆弱的血管结构或其他地方。一种这样的涂层的溶解释放治疗剂，例如改变组织向内生长的纤维化瘢痕组织含量的类固醇，使得组织和引线之间的所得粘合力较弱，从而如果需要，铅可以容易地提取。一个这样的引线包括至少承载的绝缘细长体。引线还包括在外周远端引线表面的绝缘部分上的至少部分可溶解的涂层。在暴露于含水物质之后，涂层提供粗糙表面，多孔表面或溶胀表面中的一种或多种。

69. 发明申请

US20110144734A1 MEDICAL LEAD SYSTEM UTILIZING ELECTROMAGNETIC BANDSTOP FILTERS 有权
标题翻译：医用铅系统利用电磁带式过滤器
公开(公告)号：US20110144734A1
公开(公告)日：2011-06-16
申请号：US13026949
申请日：2011-02-14
申请人： Randy Westlund , Robert A. Stevenson , Christine A. Frysz , Warren S. Dabney
发明人： Randy Westlund , Robert A. Stevenson , Christine A. Frysz , Warren S. Dabney
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0534 , A61N1/0539 , A61N1/0556 , A61N1/0587 , A61N1/086 , A61N2001/0585 , H03H1/0007 , H03H7/0115 , H03H7/1766 , H03H2001/0085 , H03H2007/013
摘要： Medical lead systems utilizing electromagnetic bandstop filters are provide which can be utilized in a magnetic resonance imaging (MRI) environment for patients who have implanted medical devices. The medical lead system includes an implanted lead having at least one bandstop filter associated therewith, for attenuating current flow through the lead over a range of frequencies. The bandstop filter has an overall circuit Q wherein the resultant 3 dB bandwidth is at least 10 kHz. The values of capacitance and inductance of the bandstop filter are selected such that the bandstop filter is resonant at a selected center frequency. Preferably, the bandstop filter has an overall circuit Q wherein the resultant 10 dB bandwidth is at least 10 kHz. Such bandstop filters are backwards compatible with known implantable deployment systems and extraction systems.
摘要翻译：提供利用电磁带阻滤波器的医疗引线系统，其可用于已经植入医疗装置的患者的磁共振成像（MRI）环境中。医疗引线系统包括具有与其相关联的至少一个带阻滤波器的植入引线，用于在一定频率范围内衰减通过引线的电流。带阻滤波器具有总电路Q，其中所得的3dB带宽至少为10kHz。选择带阻滤波器的电容和电感值，使得带阻滤波器在选定的中心频率处谐振。优选地，带阻滤波器具有总电路Q，其中所得的10dB带宽至少为10kHz。这种带阻滤波器与已知的可植入部署系统和提取系统向后兼容。

70. 发明授权

US07899551B2 Medical lead system utilizing electromagnetic bandstop filters 有权
标题翻译：医用引线系统利用电磁带阻滤波器
公开(公告)号：US07899551B2
公开(公告)日：2011-03-01
申请号：US11943883
申请日：2007-11-21
申请人： Randy Westlund , Robert A. Stevenson , Christine A. Frysz , Warren S. Dabney
发明人： Randy Westlund , Robert A. Stevenson , Christine A. Frysz , Warren S. Dabney
IPC分类号： A61N1/00
CPC分类号： A61N1/05 , A61N1/0534 , A61N1/0539 , A61N1/0556 , A61N1/0587 , A61N1/086 , A61N2001/0585 , H03H1/0007 , H03H2007/013
摘要： Medical lead systems utilizing electromagnetic bandstop filters are provide which can be utilized in a magnetic resonance imaging (MRI) environment for patients who have implanted medical devices. Such lead systems may be advantageously used in left ventricle cardiac stimulation systems, neuro-stimulation systems, and deep brain electrodes used for the treatment of Parkinson's disease and other movement disorders. The bandstop filters, which include a tuned parallel capacitor and inductor circuit, are backwards compatible with known implantable deployment systems.
摘要翻译：提供利用电磁带阻滤波器的医疗引线系统，其可用于已经植入医疗装置的患者的磁共振成像（MRI）环境中。这种铅系统可有利地用于左心室心脏刺激系统，神经刺激系统和用于治疗帕金森病和其他运动障碍的深部脑电极。包括调谐并联电容器和电感器电路的带阻滤波器与已知的可植入部署系统向后兼容。

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