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61. 发明申请

US20120035496A1 BLADDER SENSING USING IMPEDANCE AND POSTURE 有权
标题翻译：使用阻力和姿态进行刮板感应
公开(公告)号：US20120035496A1
公开(公告)日：2012-02-09
申请号：US13264023
申请日：2010-04-20
申请人： Timothy J. Denison , Keith A. Miesel
发明人： Timothy J. Denison , Keith A. Miesel
IPC分类号： A61B5/053
CPC分类号： A61N1/36007 , A61B5/053 , A61B5/1116 , A61B5/204 , A61B5/686 , A61B5/6883 , A61B5/7203 , A61B2560/0462 , A61B2562/0219
摘要： This disclosure provides techniques for bladder sensing. In accordance with the techniques described in this disclosure, a device may measure the impedance of a bladder, determine the posture of a patient, and determine a status of the bladder based on the impedance and posture.
摘要翻译：本公开提供了用于膀胱感测的技术。根据本公开中描述的技术，装置可以测量膀胱的阻抗，确定患者的姿势，并且基于阻抗和姿势来确定膀胱的状态。

62. 发明授权

US08083730B2 Implantable therapeutic substance delivery device with reservoir volume sensor 有权
标题翻译：具有储液容量传感器的可植入治疗物质输送装置
公开(公告)号：US08083730B2
公开(公告)日：2011-12-27
申请号：US11413302
申请日：2006-04-28
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61K9/22 , A61M37/00 , A61M1/00 , A61M31/00 , G01F17/00
CPC分类号： A61M5/14276 , A61F2/022 , A61M2205/3317 , A61M2205/3379 , A61M2205/3389 , A61M2209/045
摘要： An implantable medical device for delivering a therapeutic substance including a housing and a volume sensor assembly. The housing includes a stationary wall and maintains a reservoir containing the therapeutic substance and including a base wall movable relative to the stationary wall such that reservoir volume is a function of a spacing between the base wall and the stationary wall. The volume sensor assembly includes a cap, a shaft, a target, and circuitry. The cap defines a passage extending from an open end, and is mounted to the stationary wall such that the open end is open relative to a stationary wall inner face. The shaft has a first end attached to the base wall and a second end maintaining the target otherwise movably arranged within the passage. The circuitry generates information indicative of a longitudinal position of the target relative to the cap, and thus of the reservoir volume.
摘要翻译：一种用于输送包括壳体和体积传感器组件的治疗物质的可植入医疗装置。壳体包括固定壁并且保持容纳治疗物质的储存器并且包括相对于静止壁可移动的底壁，使得储存器容积是基壁和固定壁之间的间隔的函数。体积传感器组件包括盖，轴，靶和电路。盖限定了从开口端延伸的通道，并且安装到固定壁，使得开口端相对于固定壁内表面敞开。轴具有附接到基壁的第一端和保持目标的第二端，否则可移动地布置在通道内。电路产生指示靶相对于盖的纵向位置的信息，因此产生储存器容积的信息。

63. 发明申请

US20110313261A1 WEARABLE AMBULATORY DATA RECORDER 有权
标题翻译：耐用的数据记录仪
公开(公告)号：US20110313261A1
公开(公告)日：2011-12-22
申请号：US13217011
申请日：2011-08-24
申请人： Duane Bourget , Keith A. Miesel , Gregory F. Molnar
发明人： Duane Bourget , Keith A. Miesel , Gregory F. Molnar
IPC分类号： A61B5/103 , A61B5/04 , A61B5/00
CPC分类号： A61N1/08 , A61B5/0002 , A61B5/0031 , A61B5/0402 , A61B5/0476 , A61B5/0488 , A61B5/08 , A61B5/1116 , A61B5/1118 , A61B5/112 , A61B5/145 , A61B5/4082 , A61B5/4809 , A61B5/4815 , A61B5/4839 , A61B5/6831 , A61B5/6833 , A61B2560/0223 , A61B2560/0412 , A61B2560/0431 , A61B2562/0219 , A61N1/36021 , A61N1/36071 , A61N1/3702 , G06F19/00 , G06F19/3456 , G06F19/3481 , G16H10/60 , G16H40/63
摘要： A wearable ambulatory data recorder that senses physiological parameters of a patient, and stores physiological parameter data for later retrieval, as well as techniques for using such a wearable ambulatory data recorder, are described. The data recorder includes one or more sensors located on or within a housing. The data recorder may include an adhesive layer for attachment to a patient. In some embodiments, the housing may be within a patch, e.g., bandage, which includes the adhesive layer. The housing may be waterproof. Features of the data recorder such as size, waterproofness, and inclusion of an adhesive may allow the data recorder to be unobtrusively worn by a patient during a variety of daily activities. The data recorder may be for single use and thereafter disposable.
摘要翻译：描述了感测患者的生理参数并存储用于稍后检索的生理参数数据的可穿戴式动态数据记录器以及用于使用这种可穿戴式可动态数据记录器的技术。数据记录器包括位于壳体上或壳体内的一个或多个传感器。数据记录器可以包括用于附接到患者的粘合剂层。在一些实施例中，壳体可以在包括粘合剂层的贴片（例如绷带）内。外壳可能是防水的。诸如尺寸，防水性和包含粘合剂的数据记录器的特征可允许数据记录器在各种日常活动期间被患者不佩服地佩戴。数据记录器可以是单次使用的，然后是一次性的。

64. 发明申请

US20110264006A1 Detecting Empty Medical Pump Reservoir 有权
标题翻译：检测空医用泵水库
公开(公告)号：US20110264006A1
公开(公告)日：2011-10-27
申请号：US12768336
申请日：2010-04-27
申请人： Irfan Z. Ali , Keith A. Miesel , Scott L. Kalpin , Scott A. Sarkinen
发明人： Irfan Z. Ali , Keith A. Miesel , Scott L. Kalpin , Scott A. Sarkinen
IPC分类号： A61M5/142 , G01N27/00 , G01N29/00 , A61B5/103
CPC分类号： A61M5/14276 , A61B5/1116 , A61M5/14212 , A61M5/172 , A61M2205/18 , A61M2205/3317 , A61M2205/50
摘要： A medical device system comprises a reservoir configured to store a therapeutic fluid and a medical pump configured to deliver the therapeutic fluid from the reservoir to a patient. The system also comprises a sensor that can detect a characteristic associated with the pump and a processor to determine if the characteristic detected indicates the reservoir is empty or near empty. The characteristic may comprise a property associated with the energization of an actuation mechanism configured to be energized to provide a pump stroke. The characteristic may also comprise a characteristic of a noise made by an actuator within the pump at the end of a pump stroke.
摘要翻译：医疗设备系统包括被配置为存储治疗流体的储存器和被配置为将治疗流体从储存器输送到患者的医用泵。该系统还包括可以检测与泵相关联的特征的传感器和处理器，以确定检测到的特征是否指示储存器为空或接近空。特征可以包括与致动机构的通电相关联的特性，该致动机构配置成被激励以提供泵冲程。特征还可以包括在泵冲程结束时由泵内的致动器产生的噪声的特性。

65. 发明申请

US20110257591A1 VOLUME MONITORING FOR IMPLANTABLE FLUID DELIVERY DEVICES 有权
标题翻译：用于可植入流体输送装置的体积监测
公开(公告)号：US20110257591A1
公开(公告)日：2011-10-20
申请号：US12762064
申请日：2010-04-16
申请人： Cynthia R. Nelson Konen , Irfan Z. Ali , Keith A. Miesel , Scott L. Kalpin
发明人： Cynthia R. Nelson Konen , Irfan Z. Ali , Keith A. Miesel , Scott L. Kalpin
IPC分类号： A61M5/00 , G06F17/18 , G08B21/00 , G01F23/00
CPC分类号： A61M5/1684 , A61M5/14276 , A61M5/16854 , A61M2005/14264 , A61M2205/3331 , A61M2205/3379 , A61M2205/3389
摘要： Unexpected changes in the volume of therapeutic fluid in the reservoir of a fluid delivery device are detected based on changes in the pressure of the reservoir measured over a period of time by a pressure sensor. Additionally, an ambulatory reservoir fluid volume gauge is provided to indicate an actual volume of therapeutic fluid in a fluid delivery device reservoir. The actual volume of therapeutic fluid in the reservoir indicated by the ambulatory reservoir fluid volume gauge is determined based on changes in the pressure in the reservoir measured over a period of time by a pressure sensor.
摘要翻译：基于通过压力传感器在一段时间内测量的储存器的压力变化来检测流体输送装置的储存器中的治疗流体体积的意外变化。此外，提供了动态储存器流体体积计，以指示流体输送装置储存器中的治疗流体的实际体积。基于动态储存器流体体积计指示的储存器中的治疗流体的实际体积是基于压力传感器在一段时间内测量的储存器中的压力变化来确定的。

66. 发明申请

US20110238136A1 CLOSED-LOOP THERAPY ADJUSTMENT 审中-公开
标题翻译：闭环治疗调整
公开(公告)号：US20110238136A1
公开(公告)日：2011-09-29
申请号：US13154303
申请日：2011-06-06
申请人： Duane Bourget , Keith A. Miesel
发明人： Duane Bourget , Keith A. Miesel
IPC分类号： A61N1/36
CPC分类号： A61N1/37252 , A61N1/36021 , A61N1/36071 , A61N1/37247
摘要： Techniques for detecting a value of a sensed patient parameter, and automatically delivering therapy to a patient according to therapy information previously associated with the detected value, are described. In exemplary embodiments, a medical device receives a therapy adjustment from the patient. In response to the adjustment, the medical device associates a sensed value of a patient parameter with therapy information determined based on the adjustment. Whenever the parameter value is subsequently detected, the medical device delivers therapy according to the associated therapy information. In this manner, the medical device may “learn” to automatically adjust therapy in the manner desired by the patient as the sensed parameter of the patient changes. Exemplary patient parameters that may be sensed for performance of the described techniques include posture, activity, heart rate, electromyography (EMG), an electroencephalogram (EEG), an electrocardiogram (ECG), temperature, respiration rate, and pH.
摘要翻译：描述了用于检测感测到的患者参数的值并根据先前与检测值相关联的治疗信息自动地向患者递送治疗的技术。在示例性实施例中，医疗设备从患者接收治疗调节。响应于调整，医疗设备将感测到的患者参数值与基于调整确定的治疗信息相关联。每当随后检测到参数值时，医疗装置根据相关联的治疗信息递送治疗。以这种方式，当患者的感测参数改变时，医疗设备可以“学习”以患者期望的方式自动调整治疗。可以感测用于执行所述技术的示例性患者参数包括姿势，活动，心率，肌电图（EMG），脑电图（EEG），心电图（ECG），温度，呼吸速率和pH。

67. 发明授权

US07955319B2 Pressure sensing in implantable medical devices 有权
标题翻译：可植入医疗器械中的压力感测
公开(公告)号：US07955319B2
公开(公告)日：2011-06-07
申请号：US11778400
申请日：2007-07-16
申请人： Keith A. Miesel
发明人： Keith A. Miesel
IPC分类号： A61M5/142
CPC分类号： A61M5/14276 , A61M5/16854 , A61M2205/3355 , A61M2205/3523
摘要： An implantable medical device for delivering a therapeutic substance to a delivery site in a patient. A reservoir holds a supply of the fluid therapeutic substance. A catheter has a proximal end, a delivery region and a lumen extending from the proximal end to the delivery region. The proximal end of the catheter is operatively coupled to the reservoir. The delivery region of the catheter is adapted to be placed proximate the delivery site in the patient. The therapeutic substance is adapted to be delivered through the lumen to the patient. A sensing device is operatively coupled with the lumen of the catheter being capable of detecting a pressure of the therapeutic substance in the lumen. A controller is operatively coupled to the sensing device, the controller being capable of taking an action in response to the pressure in the lumen.
摘要翻译：一种用于将治疗物质输送到患者的输送部位的可植入医疗装置。储存器容纳流体治疗物质的供应。导管具有近端，输送区域和从近端延伸到输送区域的内腔。导管的近端可操作地联接到储存器。导管的输送区域适于放置在患者体内的输送部位附近。治疗物质适于通过内腔输送给患者。感测装置与导管的内腔可操作地耦合，能够检测内腔中的治疗物质的压力。控制器可操作地耦合到感测装置，所述控制器能够响应于内腔中的压力而采取动作。

68. 发明授权

US07792583B2 Collecting posture information to evaluate therapy 有权
标题翻译：收集姿势信息以评估治疗
公开(公告)号：US07792583B2
公开(公告)日：2010-09-07
申请号：US11691391
申请日：2007-03-26
申请人： Keith A. Miesel , Kenneth T. Heruth
发明人： Keith A. Miesel , Kenneth T. Heruth
IPC分类号： A61N1/36
CPC分类号： A61B5/4848 , A61B5/103 , A61B5/1116 , A61B5/4082 , A61B5/6825 , A61B5/686 , A61M5/14276 , A61N1/0531 , A61N1/0534 , A61N1/36071 , A61N1/36082 , A61N1/36514 , A61N1/36521 , A61N1/36535 , A61N1/36542 , A61N1/36557 , A61N1/37235
摘要： A medical device delivers a therapy to a patient. Posture events are identified, e.g., a posture of the patient is periodically determined and/or posture transitions by the patient are identified, and each determined posture event is associated with a current therapy parameter set. A value of at least one posture metric is determined for each of a plurality of therapy parameter sets based on the posture events associated with that therapy parameter set. A list of the therapy parameter sets is presented to a user, such as a clinician, for evaluation of the relative efficacy of the therapy parameter sets. The list may be ordered according to the one or more posture metric values to aid in evaluation of the therapy parameter sets. Where values are determined for a plurality of posture metrics, the list may be ordered according to the one of the posture metrics selected by the user.
摘要翻译：医疗设备向患者传递治疗。识别姿势事件，例如，周期性地确定患者的姿势和/或患者的姿势转换，并且每个确定的姿势事件与当前治疗参数组相关联。基于与该治疗参数组相关联的姿势事件，为多个治疗参数组中的每一个确定至少一个姿势度量的值。将治疗参数组的列表呈现给诸如临床医师的用户，用于评估治疗参数组的相对功效。可以根据一个或多个姿势度量值对列表进行排序，以帮助评估治疗参数组。在针对多个姿势度量确定值的情况下，可以根据用户选择的姿势度量中的一个排序列表。

69. 发明授权

US07717848B2 Collecting sleep quality information via a medical device 有权
标题翻译：通过医疗设备收集睡眠质量信息
公开(公告)号：US07717848B2
公开(公告)日：2010-05-18
申请号：US10826925
申请日：2004-04-15
申请人： Kenneth T. Heruth , Keith A. Miesel
发明人： Kenneth T. Heruth , Keith A. Miesel
IPC分类号： A61B5/00 , A61B5/02 , A61B5/08 , A61N1/00
CPC分类号： A61N1/36139 , A61B3/113 , A61B5/01 , A61B5/0402 , A61B5/0476 , A61B5/1116 , A61B5/1118 , A61B5/4815 , A61B5/6826 , A61B5/686 , A61M5/14276 , A61M5/1723 , A61N1/36071 , A61N1/36078 , A61N1/36135 , A61N1/36514 , A61N1/36521 , A61N1/36542 , A61N1/36557 , A61N1/3702 , A61N1/37247
摘要： At least one of a medical device, such as an implantable medical device, and a programming device determines values for one or more metrics that indicate the quality of a patient's sleep. Sleep efficiency, sleep latency, and time spent in deeper sleep states are example sleep quality metrics for which values may be determined. In some embodiments, determined sleep quality metric values are associated with a current therapy parameter set. In some embodiments, a programming device presents sleep quality information to a user based on determined sleep quality metric values values. A clinician, for example, may use the sleep quality information presented by the programming device to evaluate the effectiveness of therapy delivered to the patient by the medical device, to adjust the therapy delivered by the medical device, or to prescribe a therapy not delivered by the medical device in order to improve the quality of the patient's sleep.
摘要翻译：诸如可植入医疗设备的医疗设备和编程设备中的至少一个确定了指示患者睡眠质量的一个或多个度量的值。睡眠效率，睡眠延迟和在更深的睡眠状态中花费的时间是可以确定值的示例性睡眠质量度量。在一些实施例中，确定的睡眠质量度量值与当前治疗参数组相关联。在一些实施例中，编程设备基于确定的睡眠质量度量值值向用户呈现睡眠质量信息。例如，临床医生可以使用编程设备呈现的睡眠质量信息来评估由医疗设备递送给患者的治疗的有效性，以调整由医疗设备递送的治疗，或者开出不由医疗器械为了提高病人的睡眠质量。

70. 发明申请

US20100121213A1 SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开
公开(公告)号：US20100121213A1
公开(公告)日：2010-05-13
申请号：US12359037
申请日：2009-01-23
申请人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
发明人： Jonathon E. Giftakis , Nina M. Graves , Jonathan C. Werder , Eric J. Panken , Timothy J. Denison , Keith A. Miesel , Michele H. Herzog
IPC分类号： A61B5/0478 , A61B5/03 , A61B5/103 , A61N1/36
CPC分类号： A61N1/0534 , A61B5/031 , A61B5/4094 , A61N1/36082
摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.

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