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61. 发明授权

US09280817B2 Image diagnostic device and an image diagnostic method for automatic assessment of the start and end of the inflow of a contrast medium 有权
标题翻译：图像诊断装置和用于自动评估造影剂流入开始和结束的图像诊断方法
公开(公告)号：US09280817B2
公开(公告)日：2016-03-08
申请号：US14342087
申请日：2012-06-26
申请人： Hideki Yoshikawa
发明人： Hideki Yoshikawa
IPC分类号： A61B8/06 , G06T7/00 , A61B5/055 , A61B6/00 , A61B8/08 , G01R33/56 , A61B5/00 , G01R33/563
CPC分类号： G06T7/0012 , A61B5/055 , A61B5/489 , A61B6/481 , A61B6/504 , A61B8/06 , A61B8/481 , G01R33/5601 , G01R33/5635 , G06K2009/00932 , G06K2209/05 , G06T7/0016 , G06T2207/10016 , G06T2207/10081 , G06T2207/10088 , G06T2207/10132 , G06T2207/30104
摘要： Provided is an image diagnostic device with which the start and end of the in-flow of a contrast medium are automatically assessed. An image diagnostic device assesses the start and end times of the in-flow of a contrast medium into organs in a lifeform which is a subject.
摘要翻译：提供了一种图像诊断装置，其中自动评估造影剂的流入的开始和结束。图像诊断装置评估作为受试者的生命方式中造影剂进入器官的流入的开始和结束时间。

62. 发明授权

US09131923B2 Ultrasonic diagnostic device and ultrasonic image display method 有权
标题翻译：超声波诊断装置和超声波图像显示方法
公开(公告)号：US09131923B2
公开(公告)日：2015-09-15
申请号：US13810524
申请日：2011-07-28
申请人： Hideki Yoshikawa
发明人： Hideki Yoshikawa
IPC分类号： A61B8/00 , A61B8/08 , A61B8/06 , A61B8/14
CPC分类号： A61B8/5207 , A61B8/06 , A61B8/0891 , A61B8/14 , A61B8/461 , A61B8/463 , A61B8/465 , A61B8/481 , A61B8/5223
摘要： An ultrasonic diagnostic device and image display method display an inflow time map representing relative differences in blood flow dynamics such as inflow of a contrast agent, including extracting a vessel and constructing a noise-less inflow time map, and, in the comparison of differences in color between the constructed inflow time map and the past inflow time map, unifying the color of regions as a base. A TIC analysis unit calculates a parameter (tα) indicating an inflow starting time of a contrast agent and a difference of brightness ΔI due to the contrast agent using image data in a range designated by an image detection unit. A first pixel selection unit extracts a pixel and removes a non-contrast-enhanced region. An image construction unit constructs an inflow time map colored according to tα, and a second pixel selection unit extracts a vessel using a histogram based on ΔI.
摘要翻译：超声波诊断装置和图像显示方法显示表示血流动力学的相对差异的流入时间图，例如造影剂的流入，包括提取血管并构建无噪声流入时间图，并且在比较差异构建的流入时间图与过去流入时间图之间的颜色，将区域的颜色统一为基础。 TIC分析单元计算指示造影剂的流入开始时间的参数（tα）和由图像检测单元指定的范围内的使用图像数据的造影剂引起的亮度差Dgr; I的差异。第一像素选择单元提取像素并去除非对比度增强区域。图像构造单元构造根据tα着色的流入时间图，第二像素选择单元使用基于＆Dgr; I的直方图提取容器。

63. 发明申请

US20150081033A1 SCAFFOLD-FREE SELF-ORGANIZING 3D SYNTHETIC TISSUE AND ARTIFICIAL BONE COMPLEX FOR BONE/CARTILAGE REGENERATION 审中-公开
标题翻译：自由自由组织3D合成组织和人造骨复合物用于骨/再生
公开(公告)号：US20150081033A1
公开(公告)日：2015-03-19
申请号：US14369122
申请日：2012-12-27
申请人： Hideki Yoshikawa , Norimasa Nakamura , Kazunori Shimomura , Yu Moriguchi
发明人： Hideki Yoshikawa , Norimasa Nakamura , Kazunori Shimomura , Yu Moriguchi
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/30756 , A61F2002/2835 , A61F2230/0063 , A61L27/12 , A61L27/3834 , A61L27/3847 , A61L27/3895 , A61L2430/24
摘要： An improved method of treating an osteochondral defect is provided, which is a composite tissue for treating or preventing a disease, disorder, or condition associated with an osteochondral defect, comprising a three-dimensional synthetic tissue and an artificial bone, wherein the three-dimensional synthetic tissue is substantially made of a cell and an extracellular matrix derived from the cell, the extracellular matrix contains fibronectin, collagen I, collagen III, and vitronectin, and the extracellular matrix is diffusedly distributed in the tissue.
摘要翻译：提供了一种治疗骨软骨缺损的改进方法，其是用于治疗或预防与骨软骨缺损有关的疾病，病症或病症的复合组织，其包括三维合成组织和人造骨，其中三维合成组织基本上由细胞和源自细胞的细胞外基质制成，细胞外基质含有纤连蛋白，胶原I，胶原III和玻连蛋白，细胞外基质扩散分布在组织中。

64. 发明申请

US20140193099A1 IMAGE DIAGNOSTIC DEVICE AND IMAGE CORRECTION METHOD 有权
标题翻译：图像诊断装置和图像校正方法
公开(公告)号：US20140193099A1
公开(公告)日：2014-07-10
申请号：US14236347
申请日：2012-07-24
申请人： Hideki Yoshikawa , Takashi Azuma
发明人： Hideki Yoshikawa , Takashi Azuma
IPC分类号： G06T7/00
CPC分类号： G06T7/003 , A61B5/055 , A61B6/032 , A61B6/461 , A61B6/469 , A61B6/481 , A61B6/486 , A61B6/5211 , A61B6/5235 , A61B6/5241 , A61B6/5264 , A61B6/58 , A61B8/485 , A61B8/5207 , A61B8/5215 , A61B8/5246 , A61B2576/00 , G06T7/337 , G06T2200/24 , G06T2207/20104 , G06T2207/30004
摘要： Provided is an image diagnostic device with which it is possible to correct location misalignment of an image capture subject, and to improve the reliability of the result of the correction, in time series image data. An image diagnostic device is configured of: an input part (13) which receives image data input; a correction unit (14) which computes a correction vector which denotes location misalignment of an image capture subject, and selects image data used with an image correction unit; an image correction part (20) which carries out a correction process on the image data based on the correction vector and creates corrected image data; a control part (21) which controls the correction unit and the image correction part;a memory (22) which stores the corrected image data and measurement data as stored data; an output unit (23) which outputs the stored data externally; a display unit (24) which displays the stored data; and an external input device (30) where an operator makes an input operation
摘要翻译：提供了一种图像诊断装置，可以在时间序列图像数据中校正图像拍摄对象的位置未对准，并且提高校正结果的可靠性。图像诊断装置由以下部分构成：接收图像数据输入的输入部（13）校正单元（14），其计算表示图像拍摄对象的位置未对准的校正矢量，并选择与图像校正单元一起使用的图像数据; 图像校正部（20），其基于所述校正矢量对所述图像数据进行校正处理，并生成校正后的图像数据; 控制部件（21），其控制校正单元和图像校正部件; 存储校正图像数据和测量数据作为存储数据的存储器（22）; 输出单元（23），其从外部输出所存储的数据; 显示单元（24），显示所存储的数据; 以及操作者进行输入操作的外部输入装置（30）

65. 发明授权

US08562531B2 Ultrasonic motion detecting device, and image producing device and ultrasonic therapeutic using the detecting device 失效
标题翻译：超声波运动检测装置，以及使用该检测装置的图像生成装置和超声治疗装置
公开(公告)号：US08562531B2
公开(公告)日：2013-10-22
申请号：US10583033
申请日：2004-11-16
申请人： Hideki Yoshikawa , Takashi Azuma , Shin-ichiro Umemura , Ken-ichi Kawabata
发明人： Hideki Yoshikawa , Takashi Azuma , Shin-ichiro Umemura , Ken-ichi Kawabata
IPC分类号： A61B8/00
CPC分类号： A61B8/08
摘要： There is provided a ultrasonic motion detecting device that detects a three-dimensional motion of an object. The ultrasonic motion detecting device, comprises first and second ultrasonic transducers 13 having piezoelectric elements arranged in an array, which transmit ultrasonic waves to an object and acquire reflection signals from the object, a motion detection unit 20 that extracts an estimation region which is used for estimating a motion of the object from the reflection signals that are acquired by the first and second ultrasonic transducers, and detects a three-dimensional motion within the estimation region, and an image display unit 19 that displays the three-dimensional motion within the estimation region, wherein ultrasonic wave scanning surfaces due to the first and second ultrasonic transducers cross over each other.
摘要翻译：提供了一种检测物体的三维运动的超声波运动检测装置。超声波运动检测装置包括具有排列成阵列的压电元件的第一和第二超声波换能器13，其将超声波向对象发送并从物体获取反射信号;运动检测单元20，其提取用于根据由第一和第二超声换能器获取的反射信号估计物体的运动，并且检测估计区域内的三维运动;以及图像显示单元19，其在估计区域内显示三维运动其中由于第一和第二超声波换能器引起的超声波扫描表面彼此交叉。

66. 发明申请

US20130144172A1 ULTRASOUND DIAGNOSIS DEVICE 有权
标题翻译：超声诊断装置
公开(公告)号：US20130144172A1
公开(公告)日：2013-06-06
申请号：US13701838
申请日：2011-05-25
申请人： Kunio Hashiba , Hideki Yoshikawa , Tatsuya Hayashi
发明人： Kunio Hashiba , Hideki Yoshikawa , Tatsuya Hayashi
IPC分类号： A61B8/08
CPC分类号： A61B8/481 , A61B8/08 , A61B8/0891 , A61B8/5269 , G01S7/52038 , G01S7/52039 , G01S7/52077 , G01S15/895 , G01S15/8963
摘要： Disclosed is an ultrasound diagnosis device for creating an ultrasound image with a high contrast-to-tissue ratio. Said device sends a transmission pulse to the subject, uses an ultrasound probe to receive echoes reflected from an ultrasound contrast agent injected into the subject, and forms an image. The transmission pulse is sent such that nonlinear interactions between the constituent frequency components of said transmission pulse, as a result of the acoustic nonlinearity of the subject, do not produce sum and difference components in the frequency sensitivity range of the ultrasonic probe as the transmission pulse propagates across the subject.
摘要翻译：公开了一种用于创建具有高对比度至组织比的超声图像的超声诊断装置。所述装置向对象发送传输脉冲，使用超声波探头接收从注射到对象中的超声造影剂反射的回波并形成图像。发送发送脉冲，使得作为对象的声学非线性的结果，所述发送脉冲的构成频率分量之间的非线性相互作用不会在超声波探头的频率灵敏度范围内产生和和差分量作为发送脉冲传播主题。

67. 发明授权

US08416921B2 X-ray convergence element and X-ray irradiation device 有权
标题翻译： X射线会聚元件和X射线照射装置
公开(公告)号：US08416921B2
公开(公告)日：2013-04-09
申请号：US12280136
申请日：2007-02-08
申请人： Hiromoto Nakazawa , Hideki Yoshikawa , Aurel-Mihai Vlaicu , Kenichi Obori , Shintaro Komatani , Sumito Ohzawa
发明人： Hiromoto Nakazawa , Hideki Yoshikawa , Aurel-Mihai Vlaicu , Kenichi Obori , Shintaro Komatani , Sumito Ohzawa
IPC分类号： G21K1/06
CPC分类号： G21K1/06 , G21K2201/064
摘要： An X-ray convergence element and an X-ray irradiation device including the X-ray convergence element are provided. The X-ray convergence element can extend a working distance from an exit-side opening end thereof to a specimen, and can perform analysis of the specimen with rough surface, a fluorescent X-ray analysis, and a X-ray diffraction analysis, regardless of a size of the specimen. An X-ray blocking member 23 is provided with three supporting members 233 for supporting the X-ray blocking member 23, which extend from an annular member 232 having approximately the same diameter as a diameter of an entrance-side opening end (outer diameter of a capillary 20) toward the center of the X-ray blocking member 23 to fix the annular member 232 to the capillary 20. The annular member 232, the supporting members 233, and the X-ray blocking member 23 are integrally formed of a metal that shields X-rays, such as tantalum, tungsten, or molybdenum. A dimension of the X-ray blocking member 23 in the axial direction (thickness) is set to be sufficient for blocking X-rays.
摘要翻译：提供了包括X射线会聚元件的X射线会聚元件和X射线照射装置。 X射线会聚元件可以将其出口侧开口端的工作距离延伸到试样，并且可以进行具有粗糙表面，荧光X射线分析和X射线衍射分析的样品的分析的样本大小。 X射线阻挡构件23设置有用于支撑X射线阻挡构件23的三个支撑构件233，其从具有与入口侧开口端的直径大致相同直径的环形构件232延伸（外径毛细管20）朝向X射线阻挡构件23的中心，以将环形构件232固定到毛细管20.环形构件232，支撑构件233和X射线阻挡构件23由金属屏蔽X射线，如钽，钨或钼。 X射线阻挡构件23的轴向（厚度）的尺寸被设定为足以阻挡X射线。

68. 发明申请

US20110075904A1 ULTRASONIC IMAGING APPARATUS 有权
标题翻译：超声波成像设备
公开(公告)号：US20110075904A1
公开(公告)日：2011-03-31
申请号：US12866712
申请日：2009-02-17
申请人： Hideki Yoshikawa , Takashi Azuma
发明人： Hideki Yoshikawa , Takashi Azuma
IPC分类号： A61B8/00
CPC分类号： A61B8/06 , G01S7/52033 , G01S7/52071 , G01S7/52074
摘要： Provided is an ultrasonic imaging apparatus including: a time-gain controller (TGC) that compensates an amplitude fading occurring in the process of propagation inside a living body; a scan converter (SC) that constructs image data; a TIC measurement unit that measures a TIC of each pixel; an evaluation index input unit that inputs an index for evaluating hemodynamics on the basis of a TIC; a mapping parameter estimation unit that estimates a mapping parameter comparable to an evaluation index; a TIC image construction unit that constructs a two-dimensional image on the basis of the mapping parameter; and a pixel detection unit that extracts a region corresponding to a color map from a TIC image, and utilizing a TIC measured with each pixel so as to measure a difference in hemodynamics.
摘要翻译：提供一种超声波成像装置，包括：补偿在生物体内传播过程中发生的振幅衰落的时间增益控制器（TGC）; 构建图像数据的扫描转换器（SC）; TIC测量单元，测量每个像素的TIC; 评估指标输入单元，其输入用于基于TIC评估血液动力学的指标; 映射参数估计单元，其估计与评估指标相当的映射参数; TIC图像构造单元，其基于映射参数构建二维图像; 以及像素检测单元，其从TIC图像提取与颜色映射相对应的区域，并且利用用每个像素测量的TIC来测量血液动力学的差异。

69. 发明申请

US20100226477A1 X-RAY CONVERGENCE ELEMENT AND X-RAY IRRADIATION DEVICE 有权
标题翻译： X射线融合元件和X射线辐照器件
公开(公告)号：US20100226477A1
公开(公告)日：2010-09-09
申请号：US12280136
申请日：2007-02-08
申请人： Hiromoto Nakazawa , Hideki Yoshikawa , Aurel-Mihai Vlaicu , Kenichi Obori , Shintaro Komatani , Sumito Ohzawa
发明人： Hiromoto Nakazawa , Hideki Yoshikawa , Aurel-Mihai Vlaicu , Kenichi Obori , Shintaro Komatani , Sumito Ohzawa
IPC分类号： G21K5/00 , G21K1/02
CPC分类号： G21K1/06 , G21K2201/064
摘要： An X-ray convergence element and an X-ray irradiation device including the X-ray convergence element are provided. The X-ray convergence element can extend a working distance from an exit-side opening end thereof to a specimen, and can perform analysis of the specimen with rough surface, a fluorescent X-ray analysis, and a X-ray diffraction analysis, regardless of a size of the specimen. An X-ray blocking member 23 is provided with three supporting members 233 for supporting the X-ray blocking member 23, which extend from an annular member 232 having approximately the same diameter as a diameter of an entrance-side opening end (outer diameter of a capillary 20) toward the center of the X-ray blocking member 23 to fix the annular member 232 to the capillary 20. The annular member 232, the supporting members 233, and the X-ray blocking member 23 are integrally formed of a metal that shields X-rays, such as tantalum, tungsten, or molybdenum. A dimension of the X-ray blocking member 23 in the axial direction (thickness) is set to be sufficient for blocking X-rays.
摘要翻译：提供了包括X射线会聚元件的X射线会聚元件和X射线照射装置。 X射线会聚元件可以将其出口侧开口端的工作距离延伸到试样，并且可以进行具有粗糙表面，荧光X射线分析和X射线衍射分析的样品的分析的样本大小。 X射线阻挡构件23设置有用于支撑X射线阻挡构件23的三个支撑构件233，其从具有与入口侧开口端的直径大致相同直径的环形构件232延伸（外径毛细管20）朝向X射线阻挡构件23的中心，以将环形构件232固定到毛细管20.环形构件232，支撑构件233和X射线阻挡构件23由金属屏蔽X射线，如钽，钨或钼。 X射线阻挡构件23的轴向（厚度）的尺寸被设定为足以阻挡X射线。

70. 发明授权

US07595301B2 Staple type oligonucleotide and drug comprising the same 有权
标题翻译：短链型寡核苷酸和包含其的药物
公开(公告)号：US07595301B2
公开(公告)日：2009-09-29
申请号：US10568226
申请日：2004-09-29
申请人： Yasuo Kunugiza , Naruya Tomita , Hideo Hashimoto , Hideki Yoshikawa , Ryuichi Morishita
发明人： Yasuo Kunugiza , Naruya Tomita , Hideo Hashimoto , Hideki Yoshikawa , Ryuichi Morishita
IPC分类号： A61K48/00 , A61K31/70 , C07H21/02 , C07H21/04
CPC分类号： A61K31/713 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/53 , C12N2320/51
摘要： Conventional oligonucleotides are opened at both ends and thereby unstable. Their stability against catabolic enzymes is increased by phosphorothioate modification, but such phosphorothioate causes toxicity. The present invention provides oligonucleotides and medicaments in which these problems are improved. That is, it provides staple oligonucleotides and medicaments containing the same as the active ingredient. Specifically, it provides transcription factor inhibitors, antisense oligonucleotides and siRNAs. More specifically, it provides agents for preventing, treating or improving inflammation, autoimmune diseases, central diseases, reperfusion injury in ischaemic diseases, worsened prognosis after organ transplantation or organ surgery, or restenosis after PTCA. Further specifically, it provides agents for preventing, treating or improving arthritis, dermatitis, nephritis, hepatitis, renal failure, cystitis, prostatitis, urethritis, ulcerative colitis, Crohn disease, chronic rheumatoid arthritis, osteoarthritis, atopic dermatitis, contact dermatitis, psoriasis, cutaneous ulcer or decubitus.
摘要翻译：常规寡核苷酸在两端开放，从而不稳定。它们对分解代谢酶的稳定性通过硫代磷酸酯修饰而增加，但是这种硫代磷酸酯会引起毒性。本发明提供了改善这些问题的寡核苷酸和药物。也就是说，它提供含有与活性成分相同的主要寡核苷酸和药物。具体来说，它提供转录因子抑制剂，反义寡核苷酸和siRNA。更具体地说，它提供用于预防，治疗或改善炎症，自身免疫性疾病，中枢性疾病，缺血性疾病中的再灌注损伤，器官移植或器官手术后的预后恶化或PTCA后的再狭窄的药剂。更具体地说，它提供预防，治疗或改善关节炎，皮炎，肾炎，肝炎，肾衰竭，膀胱炎，前列腺炎，尿道炎，溃疡性结肠炎，克罗恩病，慢性类风湿性关节炎，骨关节炎，特应性皮炎，接触性皮炎，牛皮癣，皮肤溃疡或褥疮。

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