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61. 发明授权

US5902549A Analyzer system having sample rack transfer line 失效
标题翻译：分析仪系统具有样品架传输线
公开(公告)号：US5902549A
公开(公告)日：1999-05-11
申请号：US813872
申请日：1997-03-07
申请人： Tomonori Mimura , Hiroshi Mitsumaki , Tadashi Ohishi , Taku Sakazume
发明人： Tomonori Mimura , Hiroshi Mitsumaki , Tadashi Ohishi , Taku Sakazume
IPC分类号： G01N35/04 , G01N35/00 , G01N35/02 , G01N21/13
CPC分类号： G01N35/00663 , G01N35/0092 , G01N35/02 , G01N35/026 , G01N2035/00326 , G01N2035/00673 , G01N2035/0453 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831
摘要： A plurality of analyzer units for serum, a plurality of analyzer units for blood plasma, and a plurality of analyzer units for urine are arranged along a main transfer line for transferring a sample rack from a rack providing portion to a rack storage portion. A reagent bottle for inspecting liver function is contained in each reagent delivery mechanism of two analyzer units among the plurality of analyzer units for serum. When the reagent for inspecting liver function in one of the two analyzer units is to be short, analysis for the liver function analysis item in the samples can be continued by transferring a sample rack from the rack providing portion to the other analyzer unit.
摘要翻译：用于血清的多个分析器单元，用于血浆的多个分析器单元和用于尿液的多个分析器单元沿着用于将样品架从架子提供部分转移到架子存储部分的主传送线布置。用于检查肝功能的试剂瓶包含在用于血清的多个分析器单元中的两个分析器单元的每个试剂递送机构中。当在两个分析器单元之一检查肝脏功能的试剂较短时，可以通过将样品架从架子提供部分转移到另一个分析器单元来分析样品中的肝功能分析项目。

62. 发明授权

US5876670A Multi-item analyzer having plurality of analyzing modules 失效
标题翻译：具有多个分析模块的多项目分析器
公开(公告)号：US5876670A
公开(公告)日：1999-03-02
申请号：US858691
申请日：1997-05-19
申请人： Hiroshi Mitsumaki , Ryuichi Kodama , Tomonori Mimura
发明人： Hiroshi Mitsumaki , Ryuichi Kodama , Tomonori Mimura
IPC分类号： G01N35/02 , G01N1/18 , G01N27/00
CPC分类号： G01N35/026 , Y10T436/114165
摘要： A multi-item analyzer includes a first analyzing module for performing analysis items having a larger request in number arranged in the upstream side of a transporting line, and a second analyzing module for performing analysis items having a smaller request in number arranged in the downstream side. A sample sampling position for the analyzing module in the upstream side is provided on the transporting line, and a sample sampling position for the analyzing module in the downstream side is provided on a rack receiving area.
摘要翻译：多项目分析器包括：第一分析模块，用于执行在输送线的上游侧具有较大数量的请求的分析项目;以及第二分析模块，用于执行排列在下游侧的数量较小的分析项目。上游侧的分析模块的采样采样位置设置在输送线上，并且下行侧的分析模块的采样取样位置设置在机架接收区域。

63. 发明授权

US09217712B2 Method for assisting judgment of abnormality of reaction process data and automatic analyzer 有权
标题翻译：协助判断反应过程数据异常和自动分析仪的方法
公开(公告)号：US09217712B2
公开(公告)日：2015-12-22
申请号：US12995219
申请日：2009-05-28
申请人： Satoshi Mitsuyama , Yuki Fukuyama , Hidekatsu Takada , Hideyuki Ban , Tomonori Mimura
发明人： Satoshi Mitsuyama , Yuki Fukuyama , Hidekatsu Takada , Hideyuki Ban , Tomonori Mimura
IPC分类号： G06F19/00 , G01N35/00 , G01N21/00 , G01N21/77
CPC分类号： G01N21/77 , G01N21/272 , G01N21/78 , G01N35/00603 , G01N2035/0097
摘要： In the event of a suspected abnormality in the device, sample or reagent, a laboratory technician had to examine the abnormal reaction process data item by item, and infer the cause of the abnormality, which took effort and time in some cases. Abnormality judgment is assisted using: indicator computation means that computes an indicator indicating a feature parameter of a given waveform by applying a pre-defined evaluation formula to time series data of photometric values; relative indicator computation means that computes a value indicating a relationship of the indicator of target data to the indicator computed in the past; and indicator display means that simultaneously displays a value computed by the indicator computation means and the value computed by the relative indicator computation means. According to the present method, which is a method for assisting judgment of abnormality wherein a feature parameter of a given absorbance change is computed, it can be made easier to find certain abnormalities, and it becomes possible to attain more efficient device maintenance and improved device reliability without the addition of any new parts.
摘要翻译：如果装置，样品或试剂中有疑似异常，实验室技术人员必须逐项检查异常反应过程数据，并推断异常的原因，在某些情况下花费时间和精力。协助使用以下方式辅助异常判断：指标计算装置，通过对光度值的时间序列数据应用预定义的评估公式来计算指示给定波形的特征参数的指标; 相对指标计算是指计算出目标数据指标与过去计算出的指标的关系的值; 指示符显示装置，同时显示由指标计算装置计算的值和由相关指标计算装置计算的值。根据本方法，其是计算给定吸光度变化的特征参数的异常判断方法，可以更容易地发现某些异常，并且可以实现更有效的装置维护和改进装置可靠性无需添加任何新零件。

64. 发明授权

US08871080B2 Management system for an electrolyte analyzer 有权
标题翻译：电解质分析仪管理系统
公开(公告)号：US08871080B2
公开(公告)日：2014-10-28
申请号：US13514187
申请日：2010-11-10
申请人： Qing Li , Tomonori Mimura , Shinichi Fukuzono
发明人： Qing Li , Tomonori Mimura , Shinichi Fukuzono
IPC分类号： G01N27/333
CPC分类号： G01N27/333
摘要： Electrolyte analyzers are used in a variety of ways, and problems vary from reagent deterioration due to reagent replenishment, mixing of foreign substances during reagent replenishment, electrode deterioration due to the passage of the validity date, to the operator's inputting errors. It is thus necessary to judge abnormalities of measured values resulting from such inappropriate usage, based on the fluctuation patterns of the results of daily electrolyte calibration. The fluctuation patterns of each measured item are extracted from the results of daily electrolyte calibration. The electromotive force balance ratio between the internal standard solution and high/low-concentration standard solutions is calculated as well as its fluctuation pattern. The obtained fluctuation patterns are compared against atypical fluctuation patterns stored in the electrolyte analyzer. When any of the extracted patterns matches any of the atypical patterns, the analyzer activates an alarm.
摘要翻译：以各种方式使用电解质分析仪，由于试剂补充，试剂补充期间的异物混合，有效期限以后的电极劣化，操作者的输入错误，试剂劣化的问题变化。因此，基于每日电解质校准的结果的波动模式，需要判断由这种不当使用引起的测量值的异常。从日常电解质校准的结果中提取每个测量项目的波动模式。计算内标溶液与高/低浓度标准溶液之间的电动势平衡比及其波动模式。将获得的波动模式与存储在电解质分析仪中的非典型波动模式进行比较。当任何提取的图案与任何非典型图案匹配时，分析仪启动报警。

65. 发明申请

US20140190253A1 AUTOMATIC ANALYZER AND METHOD FOR DETERMINING MALFUNCTION THEREOF 有权
标题翻译：自动分析仪和确定其功能失常的方法
公开(公告)号：US20140190253A1
公开(公告)日：2014-07-10
申请号：US14239958
申请日：2012-05-17
申请人： Masaharu Nishida , Hideto Tamezane , Isao Yamazaki , Kumiko Kamihara , Tomonori Mimura
发明人： Masaharu Nishida , Hideto Tamezane , Isao Yamazaki , Kumiko Kamihara , Tomonori Mimura
IPC分类号： G01F23/00 , G01L7/00 , G01F23/26
CPC分类号： G01F23/00 , G01F23/263 , G01L7/00 , G01N35/1011 , G01N2035/009 , G01N2035/1018 , G01N2035/1025
摘要： An automatic analyzer which performs a suction operation a plurality of times on a same sample has a sample dispensing unit 9, a liquid level sensor which detects the liquid level of the sample in a sample vessel 8, an arithmetic unit 5 which computes a liquid level height h1 at the end of a first suction operation of the two consecutive suction operations from a liquid level height h0 and a sample suction volume V1 detected at the start of the first suction operation, a storage unit 7 which stores the liquid level height h1 computed by the arithmetic unit 5, and a determination unit 18 which compares a liquid level height h2 detected at the start of a second suction operation following the first suction operation with the liquid level height h1 at the end of the first suction operation.
摘要翻译：在同一样品上进行多次抽吸操作的自动分析仪具有样品分注单元9，检测样品容器8中的样品的液位的液位传感器，计算液位的运算单元5 在从第一抽吸操作开始时检测到的液面高度h0和样品吸入容积V1进行两次连续抽吸操作的第一抽吸操作结束时的高度h1，存储单元7，其存储计算出的液位高度h1 以及确定单元18，其将在第一抽吸操作之后的第二抽吸操作开始时检测到的液位高度h2与在第一抽吸操作结束时的液位高度h1进行比较。

66. 发明申请

US20130122596A1 AUTOMATIC ANALYZER, ANALYSIS METHOD, AND INFORMATION PROCESSOR 审中-公开
标题翻译：自动分析仪，分析方法和信息处理器
公开(公告)号：US20130122596A1
公开(公告)日：2013-05-16
申请号：US13808743
申请日：2011-07-04
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G01N21/75 , G06F19/00
CPC分类号： G01N21/75 , B01F11/0266 , B01F15/00214 , G01N21/272 , G01N35/00594 , G01N35/00603 , G01N35/00623 , G01N35/00663 , G01N2035/00465 , G01N2035/00702 , G01N2035/0097 , G16C20/10 , Y10T436/11
摘要： An automatic analyzer includes sample vessels containing samples to be measured and reaction vessels in which to mix a sample and a reagent. A sample dispenser 5 dispenses a sample from any of the sample vessels to any of the reaction vessels. A reagent dispenser dispenses a reagent from a reagent vessel to a reaction vessel, and a stirrer stirs the sample-reagent mix contained in the reaction vessel. A photometric measurement unit is provided for obtaining multiple measurement data points during the progress of reaction of a mixed solution. At least one approximation formula is performed and an approximation curve from the measurement data points is generated. A shape descriptor is calculated from the approximation curve and abnormalities based on the shape descriptor are determined. This not only allows abnormalities to be detected accurately from each measurement result, but also allows the causes of the abnormalities to be identified.
摘要翻译：自动分析仪包括含有要测量样品的样品容器和混合样品和试剂的反应容器。样品分配器5将样品从任何样品容器分配到任何反应容器中。试剂分配器将试剂从试剂容器分配到反应容器中，并且搅拌器搅拌反应容器中包含的样品 - 试剂混合物。提供了一种光度测量单元，用于在混合溶液的反应进程期间获得多个测量数据点。执行至少一个近似公式，并且生成来自测量数据点的近似曲线。根据近似曲线计算形状描述符，并确定基于形状描述符的异常。这不仅允许从每个测量结果准确地检测异常，而且允许识别异常的原因。

67. 发明申请

US20120282139A1 BLOOD COAGULATION ANALYZER 有权
标题翻译：血液凝聚分析仪
公开(公告)号：US20120282139A1
公开(公告)日：2012-11-08
申请号：US13509661
申请日：2010-11-19
申请人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
发明人： Akihisa Makino , Tomonori Mimura , Terumi Tamura , Sakuichiro Adachi
IPC分类号： G01N21/75
CPC分类号： G01N21/51 , G01N21/532 , G01N21/82 , G01N33/18 , G01N33/1826 , G01N33/4905 , G01N33/86 , G01N2021/4711 , G01N2021/825
摘要： A blood coagulation analyzer that realizes both securement of a wide dynamic range and enhancement of sensitivity in blood coagulation analysis by selecting an appropriate angle of detection depending on the intensity of scattered light from each specimen without causing complexity of the analyzer. The analyzer has a reaction container. A storage unit is provided which takes in and stores multiple pieces of chronological light intensity variation data acquired from detectors arranged around a reaction container. A judgment unit selects light intensity variation data to be used for calculation of a blood coagulation time from the multiple pieces of light intensity variation data stored in the storage unit based on the amount of light intensity variation. A calculation unit calculates the blood coagulation time from the light intensity variation data selected by the judgment unit.
摘要翻译：一种血液凝固分析仪，其通过根据来自每个样本的散射光的强度选择适当的检测角度，而不会导致分析仪的复杂性，实现了动态范围的确定和凝固分析中的灵敏度的提高。分析仪具有反应容器。提供一种存储单元，其存储并存储从设置在反应容器周围的检测器获取的多个按时间顺序的光强度变化数据。判断单元基于光强度变化量从存储在存储单元中的多个光强度变化数据中选择要用于计算凝血时间的光强度变化数据。计算单元根据由判断单元选择的光强度变化数据计算凝血时间。

68. 发明申请

US20120109534A1 AUTOMATIC ANALYZER AND ANALYSIS METHOD 有权
标题翻译：自动分析仪和分析方法
公开(公告)号：US20120109534A1
公开(公告)日：2012-05-03
申请号：US13318535
申请日：2010-04-12
申请人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
发明人： Kumiko Kamihara , Satoshi Mitsuyama , Tomonori Mimura , Chihiro Manri
IPC分类号： G06F19/00
CPC分类号： G01N35/00603 , G01N21/272
摘要： In known automatic analyzers for detecting an abnormality by approximating reaction process data using a function, accuracy of detecting a reaction abnormality is degraded because of poor approximation accuracy depending on test items. Data processing means stores the absorbance and time of day at which the absorbance is measured as time-series data. Letting x denote absorbance, t denote time, and * denote a symbol representing multiplication, we have a function x=a0+a1*exp(−k1*t)+a2*exp(−k2*t). Values of parameters a0, a1, a2, ai, k1, and k2 are calculated so that a difference between the absorbance at the measured time calculated using the above expression and the time-series data is minimal, and presence of an abnormality is determined based on the parameter values.
摘要翻译：在用于通过使用功能近似反应过程数据来检测异常的已知的自动分析器中，由于根据测试项目的近似精度不足，检测反应异常的精度降低。数据处理装置将吸光度和吸光度时间的时间存储为时间序列数据。令x表示吸光度，t表示时间，*表示表示乘法的符号，我们有函数x = a0 + a1 * exp（-k1 * t）+ a2 * exp（-k2 * t）。计算参数a0，a1，a2，ai，k1和k2的值，使得使用上述表达式计算的测量时间的吸光度与时间序列数据之间的差异最小，并且基于对参数值。

69. 发明申请

US20120064636A1 AUTOMATIC ANALYSIS DEVICE AND ANALYSIS METHOD 有权
标题翻译：自动分析装置及分析方法
公开(公告)号：US20120064636A1
公开(公告)日：2012-03-15
申请号：US13321072
申请日：2010-05-10
申请人： Satoshi Mitsuyama , Chihiro Manri , Tomonori Mimura , Kumiko Kamihara
发明人： Satoshi Mitsuyama , Chihiro Manri , Tomonori Mimura , Kumiko Kamihara
IPC分类号： G01N21/00 , G01N35/00
CPC分类号： G01N35/00663 , G01N35/00623 , G01N2035/00702 , G01N2035/0097
摘要： Provided are an automated analyzer and an automatic analysis method for highly accurately determining presence or absence of abnormality based on reaction process data obtained when concentration of a chemical component or an activity level of an enzyme is measured. The reaction process data is approximated by a function, and shape feature quantities indicating features of a shape of a curve section at an early stage of reaction are calculated. The obtained shape feature quantities are used to determine the presence or absence of abnormality.
摘要翻译：本发明提供一种自动分析装置和自动分析方法，用于根据测定化学成分浓度或酶活性水平时获得的反应过程数据，高精度地确定异常存在或不存在。反应过程数据由功能近似，并且计算表示在反应初期的曲线部分的形状的特征的形状特征量。获得的形状特征量用于确定是否存在异常。

70. 发明申请

US20120000268A1 ACCURACY MANAGEMENT METHOD 有权
标题翻译：准确管理方法
公开(公告)号：US20120000268A1
公开(公告)日：2012-01-05
申请号：US13141984
申请日：2009-11-19
申请人： Qing Li , Tomonori Mimura , Shinichi Fukuzono , Naomi Ishii
发明人： Qing Li , Tomonori Mimura , Shinichi Fukuzono , Naomi Ishii
IPC分类号： G01D18/00
CPC分类号： G01N35/00693 , G01D18/00 , G01N35/00613 , G01N35/00712 , G01N35/025 , Y10T436/10 , Y10T436/11
摘要： It is convenient and useful in inspection work to assess a fluctuation pattern of accuracy management results based on operation events occurring in a clinical laboratory and detect an abnormal fluctuation pattern before a control range is exceeded. However, an accuracy management system having such a function is not provided. When the cause of fluctuations in accuracy management results or calibration results is to be estimated, one depends on a variety of related information and one's specialized knowledge and experience. Much time and efforts are required to sort out useful pieces of information from useless ones and obtain organized information.There is provided a comprehensive accuracy management method attained by including the steps of: displaying operation event information in time series in an accuracy management result chart or a calibration result chart on the same screen; accumulating a characteristic daily measurement value fluctuation pattern on the basis of a kind of an operation event; displaying the latest fluctuation pattern of measurement results and the daily measurement value fluctuation pattern in superposition with each other to warn of fluctuations which differ from the daily measurement value fluctuation pattern; and estimating and reporting the cause of the fluctuations.
摘要翻译：在检验工作中，根据临床实验室发生的手术事件评估精度管理结果的波动模式，检测出超出控制范围之前的异常波动模式，方便实用。然而，没有提供具有这种功能的精度管理系统。当准确管理结果波动的原因或校准结果被估计时，一个取决于各种相关信息和专业知识和经验。需要大量时间和精力从无用的信息中整理出有用的信息，并获得有组织的信息。提供了一种全面的准确度管理方法，其包括以下步骤：在同一屏幕上的精度管理结果图表或校准结果图表中以时间序列显示操作事件信息; 基于操作事件的种类积累特征的日测量值波动模式; 显示测量结果的最新波动模式和每日测量值波动模式相互叠加以警告与日测量值波动模式不同的波动; 并估计和报告波动的原因。

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