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61. 发明申请

WO2012106442A1 CENTRIFUGE ROTOR FOR SEPARATION AND PROCESSING OF COMPLEX FLUIDS 审中-公开
标题翻译：用于分离和加工复合流体的离心转子
公开(公告)号：WO2012106442A1
公开(公告)日：2012-08-09
申请号：PCT/US2012/023503
申请日：2012-02-01
申请人： ARRYX, INC. , RUNYON, Matthew, K. , MUETH, Daniel, M. , GUEVARA, Sergio, O. , FU, Haojun
发明人： RUNYON, Matthew, K. , MUETH, Daniel, M. , GUEVARA, Sergio, O. , FU, Haojun
IPC分类号： B04B5/02
CPC分类号： G01N33/80 , B04B5/04 , G01N21/07
摘要： A rotor is provided for use in a centrifuge system configured to spin the rotor for separating complex fluids. The rotor includes a housing configured to be secured by the centrifuge system and several chambers formed in the housing. Each chamber includes a first chamber portion having a port formed therein and a second chamber portion in fluid communication with the port of the first chamber portion. The second chamber portion may be disposed generally below the port of the first chamber portion. Other rotor designs and methods for separating complex fluids are further disclosed.
摘要翻译：提供转子用于离心机系统，该离心机系统构造成旋转转子以分离复杂流体。转子包括构造成由离心机系统固定的壳体和形成在壳体中的若干室。每个室包括具有形成在其中的端口的第一室部分和与第一室部分的端口流体连通的第二室部分。第二室部分可以大致设置在第一室部分的端口下方。进一步公开了用于分离复杂流体的其它转子设计和方法。

62. 发明申请

WO2010144814A9 PARTICLE SORTING USING FLUID STREAMS 审中-公开
标题翻译：使用流体颗粒分选颗粒
公开(公告)号：WO2010144814A9
公开(公告)日：2011-06-03
申请号：PCT/US2010038332
申请日：2010-06-11
申请人： ARRYX INC , XIA ZHENG , CHAKRABARTY TANIA , FU HAOJUN , MUETH DAN
发明人： XIA ZHENG , CHAKRABARTY TANIA , FU HAOJUN , MUETH DAN
IPC分类号： G21K1/00 , B01L3/00
CPC分类号： B01L3/502761 , B01L3/502707 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2300/168 , B01L2400/0415 , B01L2400/043 , B01L2400/0454 , B01L2400/0487 , B01L2400/0638
摘要： A fluidic device includes an arrangement of channels for introducing a sample containing particles of interest into a processing chamber. The chamber is in fluid communication with collecting channels via low-flow connection channels. Particles in the sample may be observed and diverted from the processing chamber by application of a motive force such as optical trapping into a collection channel. Once in the collection channel, particles can be collected, including by trapping in a porous matrix.
摘要翻译：流体装置包括用于将含有感兴趣的颗粒的样品引入处理室的通道布置。室通过低流量连接通道与收集通道流体连通。可以通过将诸如光学捕获的动力施加到收集通道中来观察和转移来自处理室的颗粒。一旦在收集通道中，可以收集颗粒，包括通过捕集在多孔基质中。

63. 发明申请

WO2010144814A3 PARTICLE SORTING USING FLUID STREAMS 审中-公开
标题翻译：使用流体流的粒子分类
公开(公告)号：WO2010144814A3
公开(公告)日：2011-04-14
申请号：PCT/US2010038332
申请日：2010-06-11
申请人： ARRYX INC , XIA ZHENG , CHAKRABARTY TANIA , FU HAOJUN , MUETH DAN
发明人： XIA ZHENG , CHAKRABARTY TANIA , FU HAOJUN , MUETH DAN
IPC分类号： G21K1/00 , B01L3/00
CPC分类号： B01L3/502761 , B01L3/502707 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/0877 , B01L2300/0887 , B01L2300/168 , B01L2400/0415 , B01L2400/043 , B01L2400/0454 , B01L2400/0487 , B01L2400/0638
摘要： A fluidic device includes an arrangement of channels for introducing a sample containing particles of interest into a processing chamber. The chamber is in fluid communication with collecting channels via low-flow connection channels. Particles in the sample may be observed and diverted from the processing chamber by application of a motive force such as optical trapping into a collection channel. Once in the collection channel, particles can be collected, including by trapping in a porous matrix.
摘要翻译：流体装置包括用于将含有感兴趣颗粒的样品引入处理室的通道布置。腔室通过低流量连接通道与收集通道流体连通。通过将诸如光学捕集的动力施加到收集通道中，可以观察样品中的颗粒并将其从处理室转移。一旦进入收集通道，就可以收集颗粒，包括捕集在多孔基质中。

64. 发明申请

WO2008005448A3 NANOSCALE MASKING AND PRINTING USING PATTERNED SUBSTRATES 审中-公开
标题翻译：使用图案化基底的纳米遮盖和印刷
公开(公告)号：WO2008005448A3
公开(公告)日：2008-11-06
申请号：PCT/US2007015379
申请日：2007-07-03
申请人： ARRYX INC , KNUTSON CHRISTOPHER
发明人： KNUTSON CHRISTOPHER
IPC分类号： G01N33/543 , C12M1/00 , C12M1/34 , C12M3/00 , G01N33/53 , G01N33/551 , G01N33/553
CPC分类号： B01J19/0046 , B01J2219/00382 , B01J2219/005 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00617 , B01J2219/00648 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/00725 , B01J2219/00745 , Y10T428/24893 , Y10T428/2982
摘要： Nanoscale masking using particles patterned on a substrate include assembling particles into a pattern on a first substrate; contacting the particles with a second substrate; adding blocking molecules while the particles are in contact, such that blocking molecules bind to portions of the second substrate not in contact with the particles; and separating the substrates, yielding a functionalized substrate having blocking molecules bound thereto. Nanoscale printing methods include assembling particles into a desired pattern on a first substrate; contacting a print material with the particles such that at least a portion of the print material binds to the particles on the first substrate; removing the first substrate having particles thereon from unbound print material; contacting the particles having print material bound thereto with a second substrate such that at least a portion of the print material binds to the second substrate; and separating the substrates, yielding a printed substrate.
摘要翻译：使用在衬底上图案化的颗粒进行纳米级掩模包括：将颗粒在第一衬底上组装成图案; 使颗粒与第二基底接触; 在颗粒接触时添加阻断分子，使得阻断分子结合到不与颗粒接触的第二基材的部分; 并分离底物，产生具有结合到其上的阻断分子的官能化底物。纳米级印刷方法包括将颗粒在第一基材上组装成期望的图案; 使印刷材料与颗粒接触，使得印刷材料的至少一部分结合到第一基板上的颗粒; 从未结合的印刷材料上去除其上具有颗粒的第一基材; 使具有结合有印刷材料的颗粒与第二基材接触，使得印刷材料的至少一部分结合到第二基材; 并分离基材，产生印刷基材。

65. 发明申请

WO2007008921A3 METHOD AND APPARATUS FOR FORMING MULTI-DIMENSIONAL COLLOIDAL STRUCTURES USING HOLOGRAPHIC OPTICAL TWEEZERS 审中-公开
公开(公告)号：WO2007008921A3
公开(公告)日：2007-01-18
申请号：PCT/US2006/026938
申请日：2006-07-12
申请人： ARRYX, INC. , KNUTSON, Christopher , PLEWA, Joseph, S.
发明人： KNUTSON, Christopher , PLEWA, Joseph, S.
IPC分类号： G21K1/00 , H05H3/04
摘要： Holographic optical tweezers are used to position charge stabilized colloidal particles within a flow cell. Once the particles are positioned, fixation is accomplished by pumping an electrolyte solution or pH adjusted solution (or a combination of the two) into the sample cell. In the former, the Debye length is reduced and aggregation caused by the van der Waals attraction takes place. In the latter, the surface charge density of the suspension is reduced and aggregation caused by the van der Waals attraction takes place. This technique can be applied multiple times, and allows for the formation of two and three dimensional structures composed of multi-colloid types to be formed on or away from a substrate. The technique relies upon forces acting on virtually all colloidal dispersions making it applicable to a wide variety of colloid types and compositions, such as formation of photonic crystals, colloidal electronics, and bioengineered materials.

66. 发明申请

WO2006110749A2 APPARATUS FOR OPTICALLY-BASED SORTING WITHIN LIQUID CORE WAVEGUIDES 审中-公开
标题翻译：用于在液体核心波形中进行光学分离的装置
公开(公告)号：WO2006110749A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/013477
申请日：2006-04-10
申请人： ARRYX, INC. , MUETH, Daniel , TANNER, Evan , PLEWA, Joseph , AKCAKIR, Osman
发明人： MUETH, Daniel , TANNER, Evan , PLEWA, Joseph , AKCAKIR, Osman
IPC分类号： G02B6/032
CPC分类号： G01N21/05 , G01N21/0303 , G01N2015/149 , G01N2021/0346 , G02B6/032
摘要： The present invention is related to an apparatus for the sorting of particles in a fluid medium flowing within a liquid-core waveguide, by combining customized light intensity patterns formed inside the waveguide, and diluting the suspension of particles (i.e., cells, blood, nanoparticles, etc.) flowing within the fluid medium of the waveguide. With this customized light intensity pattern, which controls the optical forces introduced by the light confined within the waveguide, and the control of the hydrodynamic forces introduced by the liquid flow (or multiple channel liquid flows), the sorting of particles can be achieved.
摘要翻译：本发明涉及一种用于通过组合形成在波导内的定制的光强度图案和稀释颗粒（即细胞，血液，纳米颗粒）的悬浮液来分选在液体芯波导内流动的流体介质中的颗粒的装置等）在波导的流体介质内流动。通过这种定制的光强度图案，其控制由限制在波导内的光引入的光学力，以及由液体流（或多通道液体流）引入的流体动力的控制，可以实现颗粒的分选。

67. 发明申请

WO2006083907A2 METHOD AND APPARATUS FOR SORTING CELLS 审中-公开
标题翻译：分离细胞的方法和装置
公开(公告)号：WO2006083907A2
公开(公告)日：2006-08-10
申请号：PCT/US2006/003462
申请日：2006-02-01
申请人： ARRYX, INC. , MUETH, Daniel , ANDERSON, Amy, L. , KNUTSON, Christopher, R. , PLEWA, Joseph
发明人： MUETH, Daniel , ANDERSON, Amy, L. , KNUTSON, Christopher, R. , PLEWA, Joseph
IPC分类号： G01N21/01
CPC分类号： G01N21/6428 , C12M47/04 , G01N15/1404 , G01N15/1459 , G01N2015/1409 , G01N2015/1411 , G01N2015/149
摘要： An apparatus for sorting and orienting sperm cells includes a pair of walls in confronting arrangement and forming a flow chamber having an inlet, a downstream outlet, and an intermediate detector region. The inlet receives first and second spaced apart streams of input fluid and a third stream of sample fluid containing the cells to be sorted. The first and second streams have respective flow rates relative to the third stream, such that the third stream is constricted, forming a relatively narrow sample stream, so that the cells are oriented parallel to the walls. A detector detects the desired cells and a sorter downstream of the detector, sorts the desired cells from the stream.
摘要翻译：用于分选和定向精子细胞的装置包括一对面对面的布置并形成具有入口，下游出口和中间检测器区域的流动室。入口接收第一和第二间隔开的输入流体流和含有待分选细胞的第三流样品流体。第一和第二流相对于第三流具有相应的流速，使得第三流收缩，形成相对窄的样品流，使得电池平行于壁定向。检测器检测所需的细胞和检测器下游的分选器，从流中分选所需的细胞。

68. 发明申请

WO2005089437A2 SYSTEM AND METHOD FOR MANIPULATING AND PROCESSING MATERIALS USING HOLOGRAPHIC OPTICAL TRAPPING 审中-公开
标题翻译：使用全息光学跟踪处理和处理材料的系统和方法
公开(公告)号：WO2005089437A2
公开(公告)日：2005-09-29
申请号：PCT/US2005/008934
申请日：2005-03-17
申请人： ARRYX, INC. , PLEWA, Joseph , TANNER, Evan , MUETH, Dan , GRUBER, Lewis , BRADLEY, Kenneth
发明人： PLEWA, Joseph , TANNER, Evan , MUETH, Dan , GRUBER, Lewis , BRADLEY, Kenneth
IPC分类号： G21K1/00 , H05H3/04
CPC分类号： B82Y20/00 , B82Y10/00 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2225/32
摘要： A method and apparatus for manipulating particles (micro, nano, and pico) having one or more characteristics with an optical trap formed by modulating a laser beam with a Diffractive Optical Element (DOE). At least one characteristic of the material is selected; and a laser beam having a selected wavelength corresponding to the at least one selected characteristic of the material is generated. Values of the DOE are calculated corresponding to the least one selected characteristic of the material. The beam and the DOE are modulated to produce a holographic optical trap having properties corresponding to the at least one selected characteristic; the trap is focused to a beam focus or selected spot size; and the beam focus is located near a particle location for trapping the particle therein.
摘要翻译：一种用于通过用衍射光学元件（DOE）调制激光束而形成的光阱来操纵具有一个或多个特性的微粒（微，纳米和微微）的方法和装置。选择材料的至少一种特性; 并且产生具有与材料的至少一个所选特征对应的选定波长的激光束。根据材料的至少一个选定特征计算DOE的值。光束和DOE被调制以产生具有对应于至少一个所选特征的性质的全息光阱; 陷阱聚焦到光束焦点或选定的光斑尺寸; 并且束聚焦位于颗粒位置附近以将颗粒捕获在其中。

69. 发明申请

WO2004012133A9 SYSTEM AND METHOD OF SORTING MATERIALS USING HOLOGRAPHIC LASER STEERING 审中-公开
标题翻译：使用全息激光转向分选材料的系统和方法
公开(公告)号：WO2004012133A9
公开(公告)日：2004-04-29
申请号：PCT/US0323822
申请日：2003-07-31
申请人： ARRYX INC , GRUBER LEWIS , BRADLEY KENNETH , LOPES WARD , LANCELOT ROBERT W , PLEWA JOSEPH S , GRIER DAVID
发明人： GRUBER LEWIS , BRADLEY KENNETH , LOPES WARD , LANCELOT ROBERT W , PLEWA JOSEPH S , GRIER DAVID
IPC分类号： B01L3/00 , G01N15/14 , G01N30/00 , G01N30/02 , G21K1/00 , G06K
CPC分类号： G01N15/1459 , B01L3/5027 , G01N2015/149 , G02B21/32 , G03H1/08 , G03H1/2294 , G03H2001/0077 , G03H2001/085 , G03H2225/32 , H05H3/04
摘要： The present invention employs a beam steering apparatus to isolate valuable cells from others cells, tissues, and contaminants. In one embodiment, the system balances optical trapping agains flow to parallelize cell sorting under the flexible control of computer program-directed traps which differentially manipulate cells based on their composition or labels to direct separation.
摘要翻译：本发明采用光束转向装置来从其它细胞，组织和污染物中分离有价值的细胞。在一个实施例中，系统平衡光学捕获流程，以在计算机程序导向的陷阱的灵活控制下平行化细胞分选，其基于它们的组成或标签差异地操纵细胞以引导分离。

70. 发明申请

WO03044483A8 SAMPLE CHIP 审中-公开
标题翻译：样品芯片
公开(公告)号：WO03044483A8
公开(公告)日：2003-08-21
申请号：PCT/US0236804
申请日：2002-11-15
申请人： ARRYX INC , GRUBER LEWIS , MUETH DAN
发明人： GRUBER LEWIS , MUETH DAN
IPC分类号： G01N21/64 , B01L3/00 , C12M1/00 , G01N15/10 , G01N15/14 , G01N37/00 , G02B21/34 , G21K1/00 , G01N
CPC分类号： B01L3/502761 , B01L3/502746 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2400/0418 , B01L2400/0454 , B01L2400/0478 , B01L2400/0487 , B01L2400/086
摘要： A sample chip includes a body portion; and a cover portion disposed on the body portion; wherein an upper surface of the body portion includes a plurality of microchannels in which objects are introduced for examination and manipulation by optical traps. In one embodiment, at least one of the microchannels includes a barrier which holds the objects so that they can be held and manipulated by the optical traps. In another embodiment, at least one of the microchannels includes a sample chamber at which the barrier is disposed. The number of microchannels and their configuration can vary, and the microchannels may intersect, the sample chamber being disposed at the intersection. The barrier includes at least one of a plurality of barrier structures which are integrally formed or removably disposed in the sample chamber. The barrier structures can take different shapes and can be in any combination of shapes.
摘要翻译：样品芯片包括主体部分; 以及设置在所述主体部分上的盖部分; 其中所述主体部分的上表面包括多个微通道，其中物体被引入以通过光学阱进行检查和操纵。在一个实施例中，微通道中的至少一个包括保持物体的屏障，使得它们能够被光学陷阱保持和操纵。在另一个实施例中，微通道中的至少一个包括在其上设置屏障的样品室。微通道的数量及其构造可以变化，并且微通道可以相交，样品室设置在交叉点处。阻挡层包括多个屏障结构中的至少一个，其一体地形成或可移除地设置在样品室中。阻挡结构可以采取不同的形状并且可以是任何形状的组合。

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