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61. 发明申请

US20080077230A1 Stent with support element 失效
标题翻译：支架与支撑元件
公开(公告)号：US20080077230A1
公开(公告)日：2008-03-27
申请号：US11526278
申请日：2006-09-21
申请人： Barry Heaney , Dave McMorrow , Anthony Malone , Aiden Flanagan , Tim O'Connor
发明人： Barry Heaney , Dave McMorrow , Anthony Malone , Aiden Flanagan , Tim O'Connor
IPC分类号： A61F2/06
CPC分类号： A61F2/91 , A61F2/852 , A61F2/86 , A61F2220/0033 , A61F2220/005 , A61F2220/0058 , A61F2250/0063 , A61F2250/0068
摘要： An implantable stent comprising a first strut having an abluminal surface, and subluminal surface, and at least one side surface; a first depression formed in the abluminal surface; and a first support element at least partially disposed in the first depression; wherein at least a portion of the first support element extends beyond the abluminal surface of the first strut.
摘要翻译：一种可植入支架，其包括具有近端表面的第一支柱和亚锥形表面以及至少一个侧表面; 形成在外侧表面的第一凹陷; 以及至少部分地设置在所述第一凹部中的第一支撑元件; 其中所述第一支撑元件的至少一部分延伸超过所述第一支柱的所述外侧表面。

62. 发明申请

US20080077173A1 Designs for balloon welds 有权
标题翻译：气球焊接设计
公开(公告)号：US20080077173A1
公开(公告)日：2008-03-27
申请号：US11526322
申请日：2006-09-25
申请人： Aiden Flanagan
发明人： Aiden Flanagan
IPC分类号： A61M29/00
CPC分类号： B29C66/534 , A61M25/1034 , B29C61/006 , B29C65/04 , B29C65/1616 , B29C65/1619 , B29C65/1629 , B29C65/1635 , B29C65/1654 , B29C65/1674 , B29C65/168 , B29C65/1683 , B29C65/1696 , B29C65/18 , B29C65/32 , B29C65/3644 , B29C65/3676 , B29C65/3684 , B29C65/68 , B29C66/1122 , B29C66/232 , B29C66/3462 , B29C66/63 , B29C66/65 , B29C66/652 , B29C66/71 , B29C66/73715 , B29C66/73755 , B29C66/73921 , B29C66/7394 , B29C66/91216 , B29C66/91221 , B29C66/91411 , B29C66/9161 , B29C66/91655 , B29C66/919 , B29C66/91921 , B29C66/91935 , B29C66/949 , B29C66/961 , B29K2021/003 , B29K2023/00 , B29K2023/06 , B29K2023/0616 , B29K2023/0625 , B29K2023/0633 , B29K2023/065 , B29K2023/083 , B29K2027/06 , B29K2031/04 , B29K2033/20 , B29K2067/00 , B29K2067/006 , B29K2075/00 , B29K2077/00 , B29K2105/0085 , B29L2031/7543 , B29K2081/04 , B29K2071/00 , B29K2067/003 , B29K2033/08 , B29K2023/0691 , B29K2009/06
摘要： A catheter assembly comprising a first polymer, a second polymer and a first weld region. The first polymer forms a balloon having a first waist. The second polymer forms a catheter shaft. The first waist is positioned about a portion of the catheter shaft thereby forming the first weld region. The first weld region comprises a first weld and a second weld which engage the first waist to the catheter shaft. The first weld has a first longitudinal position and the second weld has a second longitudinal position, where the first longitudinal position is different from the second longitudinal position.
摘要翻译：一种导管组件，包括第一聚合物，第二聚合物和第一焊接区域。第一聚合物形成具有第一腰的气球。第二聚合物形成导管轴。第一腰围围绕导管轴的一部分定位，从而形成第一焊接区域。第一焊接区域包括与导管轴接合第一腰部的第一焊缝和第二焊缝。第一焊缝具有第一纵向位置，第二焊缝具有第二纵向位置，其中第一纵向位置与第二纵向位置不同。

63. 发明申请

US20070259125A1 Partially roll coated workpiece and methods and systems for making the same 失效
标题翻译：部分辊涂工件及其制造方法和系统
公开(公告)号：US20070259125A1
公开(公告)日：2007-11-08
申请号：US11415110
申请日：2006-05-02
申请人： Anthony O'Brien , Aiden Flanagan
发明人： Anthony O'Brien , Aiden Flanagan
IPC分类号： B05D1/28
CPC分类号： B05C1/0813 , A61F2/90 , B05C1/08 , B05C1/165
摘要： The present invention is directed to methods, processes, and systems for roll coating portions of a workpiece as well as to workpieces that have themselves been roll coated in accord with the invention. Under these methods and processes of the invention, one of a roller and/or the workpiece may be moved longitudinally to apply coating to a target surface of a workpiece. In some embodiments, a plurality of rollers may be used and supported by arms. Still further, in accord with the embodiments of the present invention, a dispensing member may be provided to fluidly connect the roller with a reservoir. In still other embodiments, the workpiece may be an implantable medical device and the coating may include a therapeutic.
摘要翻译：本发明涉及用于辊涂工件的部分的方法，工艺和系统，以及本身已经根据本发明进行了辊涂的工件。在本发明的这些方法和方法下，辊和/或工件中的一个可以纵向移动以将涂层施加到工件的目标表面。在一些实施例中，多个辊可以由臂使用和支撑。此外，根据本发明的实施例，可以设置分配构件以将辊与储存器流体连接。在其它实施例中，工件可以是可植入医疗装置，并且涂层可以包括治疗剂。

64. 发明申请

US20070255393A1 Medical devices coated with porous carbon and methods of manufacturing the same 失效
标题翻译：涂有多孔碳的医疗器械及其制造方法
公开(公告)号：US20070255393A1
公开(公告)日：2007-11-01
申请号：US11412877
申请日：2006-04-28
申请人： Aiden Flanagan
发明人： Aiden Flanagan
IPC分类号： A61F2/06
CPC分类号： A61L31/084 , A61L31/146
摘要： A method of creating a porous carbon coating on a medical device by applying a precursor carbon material on the medical device and then pyrolysing the precursor carbon material by laser irradiation. The laser irradiation may be focused to carbonize only certain portions of the medical device and any uncarbonized areas can be removed by solvent washing. Also provided is a medical device having a carbonized coating created according to the method of the present invention.
摘要翻译：一种通过在医疗装置上施加前体碳材料然后通过激光照射来热解前体碳材料在医疗装置上形成多孔碳涂层的方法。可以聚焦激光照射以仅将医疗装置的某些部分碳化，并且通过溶剂洗涤可以去除任何未碳化的区域。还提供了具有根据本发明的方法制造的碳化涂层的医疗装置。

65. 发明申请

US20070191816A1 Radio frequency induced drug elution 审中-公开
标题翻译：射频诱导药物洗脱
公开(公告)号：US20070191816A1
公开(公告)日：2007-08-16
申请号：US11353800
申请日：2006-02-13
申请人： Niall Behan , Anthony Malone , Aiden Flanagan , Barry O'Brien , John Motherwell , David McMorrow
发明人： Niall Behan , Anthony Malone , Aiden Flanagan , Barry O'Brien , John Motherwell , David McMorrow
IPC分类号： A61K9/22
CPC分类号： A61F2/88 , A61F2210/009 , A61F2250/0001 , A61F2250/0035 , A61F2250/0068 , A61L31/14 , A61L31/16 , A61L2300/608 , A61M31/002 , A61N2/002
摘要： A medical device including at least one reservoir, adapted to contain a material, such as a therapeutic agent, and sealed by a cover. The reservoir is openable, so as to release the material, for example, by (i) disintegration of the cover, (ii) movement of the cover to an open position, and/or (iii) a change of composition or properties of the cover allowing the material to pass therethrough. The power required to open the reservoir is provied by a current induced in a coil associated with the medical device by a change in magnetic flux in the area of the medical device.
摘要翻译：一种包括至少一个储存器的医疗装置，适于容纳诸如治疗剂的材料，并由盖子密封。储存器是可打开的，以便释放材料，例如通过（i）盖子的分解，（ii）盖子移动到打开位置，和/或（iii）改变构件的组成或性质盖子允许材料通过。通过在医疗装置的区域中的磁通量的变化，通过在与医疗装置相关联的线圈中感应的电流来证明打开储存器所需的功率。

66. 发明申请

US20070178129A1 Bioabsorbable metal medical device and method of manufacture 有权
标题翻译：生物可吸收金属医疗器械及其制造方法
公开(公告)号：US20070178129A1
公开(公告)日：2007-08-02
申请号：US11344761
申请日：2006-02-01
申请人： Aiden Flanagan
发明人： Aiden Flanagan
IPC分类号： A61F2/02 , A61L2/00
CPC分类号： B23K26/123 , A61F2210/0004 , A61F2240/001 , B23K26/142 , B23K26/40 , B23K2103/50
摘要： A method and apparatus is provided for processing a medical device formed from a bioabsorbable metallic material. The method begins by generating a beam of radiation onto the bioabsorbable metallic material. The radiation beam is transmitted through a fluid medium and onto a heat affected zone (HAZ) of the bioabsorbable metallic material to thereby cool the HAZ and reduce a concentration of oxygen surrounding the HAZ.
摘要翻译：提供了一种用于处理由生物可吸收金属材料形成的医疗装置的方法和装置。该方法通过在生物可吸收金属材料上产生辐射束开始。辐射束通过流体介质传播到生物可吸收金属材料的热影响区（HAZ）上，从而冷却HAZ并降低HAZ周围的氧浓度。

67. 发明授权

US07220336B2 Method of applying a laser beam around the circumference of a catheter 有权
标题翻译：在导管周围施加激光束的方法
公开(公告)号：US07220336B2
公开(公告)日：2007-05-22
申请号：US10883923
申请日：2004-07-02
申请人： Aiden Flanagan
发明人： Aiden Flanagan
IPC分类号： B32B31/28
CPC分类号： B29C65/1667 , A61M25/1025 , A61M25/1034 , B29C65/1409 , B29C65/1412 , B29C65/1606 , B29C65/1616 , B29C65/1619 , B29C65/1629 , B29C65/1638 , B29C65/1664 , B29C65/1674 , B29C65/1687 , B29C65/1696 , B29C66/1122 , B29C66/52272 , B29C66/53241 , B29C66/5344 , B29C66/71 , B29C66/7392 , B29C66/73921 , B29C66/7394 , B29C66/80 , B29C2035/0822 , B29C2035/0827 , B29L2031/7542 , B29L2031/7543 , B29K2083/00 , B29K2077/00 , B29K2075/00 , B29K2071/00 , B29K2067/006 , B29K2067/003 , B29K2067/00 , B29K2027/18 , B29K2027/06 , B29K2023/06 , B29K2023/00
摘要： A polymeric material may be bonded to a polymeric catheter tube by generating at least one annular beam of electromagnetic energy at a wavelength that is at least partially absorbed by at least one of the polymeric material and the polymeric catheter tube, controllably directing the annular beam of energy onto the polymeric material to concentrate the energy in a bond site circumscribing the catheter tube to at least partially melt at least one material selected from the group consisting of the polymeric material and the polymeric catheter tube along the bond site and the immediate region thereof and allowing the at least one partially melted polymeric material to cool and solidify to form a fusion bond between the tube and the polymeric material.
摘要翻译：聚合物材料可以通过在至少部分被聚合材料和聚合物导管管中的至少一个吸收的波长处产生至少一个电磁能的环形束而被结合到聚合物导管上，可控制地将环形束聚合物材料上的能量将能量集中在围绕导管管的粘结部位，以沿着粘结部位及其直接区域至少部分地熔化选自由聚合物材料和聚合物导管管组成的组中的至少一种材料，允许至少一种部分熔融的聚合物材料冷却并固化以在管和聚合物材料之间形成熔合键。

68. 发明授权

US06764709B2 Method for making and measuring a coating on the surface of a medical device using an ultraviolet laser 失效
公开(公告)号：US06764709B2
公开(公告)日：2004-07-20
申请号：US10007457
申请日：2001-11-08
申请人： Aiden Flanagan
发明人： Aiden Flanagan
IPC分类号： B05D714
CPC分类号： B05D3/065
摘要： This invention relates to a method for manufacturing an implantable medical device, having a surface covered with a coating that can include a desired amount of a biologically active material, using an ultraviolet (UV) laser. The invention also pertains to a method for manufacturing an implantable medical device having a surface covered with a coating having more than one layer wherein a desired portion of the top layer is ablated with an ultraviolet (UV) laser. Also, the invention relates to a method for measuring a thickness of a coating applied to an implantable medical device. Furthermore, the invention is directed to a method for manufacturing an implantable medical device having a surface covered with a coating free of webbing or cracking.

69. 发明授权

US10369256B2 Use of nanocrystals for drug delivery from a balloon 有权
公开(公告)号：US10369256B2
公开(公告)日：2019-08-06
申请号：US12815158
申请日：2010-06-14
申请人： Aiden Flanagan , Jan Weber , John Clarke
发明人： Aiden Flanagan , Jan Weber , John Clarke
IPC分类号： A61F2/06 , A61L29/16
摘要： A drug delivery balloon (10) has a drug thereon in the form of crystalline particles (12), the drug having a predetermined size distribution. Optionally marker particles (14, 16) are also provided. A texturized coating (18), a cap layer (20) and/or other methods may be used to increase particle loading capacity of the balloon.

70. 发明授权

US09227041B2 Balloon catheters with fibers for delivery of therapeutic agent and methods of making the same 有权
标题翻译：用于递送治疗剂的纤维的气球导管及其制备方法
公开(公告)号：US09227041B2
公开(公告)日：2016-01-05
申请号：US13082562
申请日：2011-04-08
申请人： Jan Weber , John T. Clarke , Aiden Flanagan
发明人： Jan Weber , John T. Clarke , Aiden Flanagan
IPC分类号： A61M25/10 , A61L29/16
CPC分类号： A61M25/1002 , A61L29/16 , A61L2300/602 , A61L2300/802 , A61L2420/02 , A61M2025/1031 , A61M2025/105
摘要： A medical device comprises a catheter with an expandable member, fibers extending from the outer surface of the expandable member, and therapeutic agent coated on the fibers or carried in the spaces between the fibers. Upon expansion of the expandable member, the therapeutic agent is delivered from the medical device. A surfactant may be coated on the fibers. A method of manufacturing comprises coating the outer surface of an expandable member with a metallic layer, coating the metallic layer with at least one polymeric layer, forming a plurality of holes in at least one polymeric layer, forming fibers in the holes, and removing at least one polymeric layer.
摘要翻译：医疗装置包括具有可扩张构件的导管，从可扩张构件的外表面延伸的纤维，以及涂覆在纤维上或被携带在纤维之间的空间中的治疗剂。在可膨胀构件膨胀时，治疗剂从医疗装置输送。可以在纤维上涂布表面活性剂。一种制造方法包括用金属层涂覆可膨胀构件的外表面，用至少一个聚合物层涂覆金属层，在至少一个聚合物层中形成多个孔，在孔中形成纤维，并在至少一个聚合物层。

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