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61. 发明申请

WO2008124125A1 ANTI-TUMOR ACTIVITY OF TEMSIROLIMUS IN PAPILLARY RENAL CELL CANCER 审中-公开
标题翻译：毛细血管细胞癌中纤维瘤的抗肿瘤活性
公开(公告)号：WO2008124125A1
公开(公告)日：2008-10-16
申请号：PCT/US2008/004501
申请日：2008-04-08
申请人： WYETH , DUKART, Gary , GIBBONS, James, Joseph, Jr. , BERKENBLIT, Anna , FEINGOLD, Jay, Marshall
发明人： DUKART, Gary , GIBBONS, James, Joseph, Jr. , BERKENBLIT, Anna , FEINGOLD, Jay, Marshall
IPC分类号： A61K31/436 , A61P35/00
CPC分类号： A61K31/436 , A61K45/06 , A61K2300/00
摘要： This invention provides the method or use of CCI-779 in the treatment of papillary renal cell carcinoma.
摘要翻译：本发明提供了CCI-779治疗乳头状肾细胞癌的方法或用途。

62. 发明申请

WO2008109056A1 SULFONYLATED HETEROCYCLES USEFUL FOR MODULATION OF THE PROGESTERONE RECEPTOR 审中-公开
标题翻译：用于调节前列腺素受体的SUFFYYLATED HETEROCYCLES
公开(公告)号：WO2008109056A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/002830
申请日：2008-03-04
申请人： WYETH , MCCOMAS, Casey, Cameron , FENSOME, Andrew
发明人： MCCOMAS, Casey, Cameron , FENSOME, Andrew
IPC分类号： C07D401/04 , C07D403/04 , A61K31/404 , A61K31/4709 , A61P15/18 , A61P15/02
CPC分类号： C07D403/04 , C07D401/04
摘要： Compounds of the following structure are provided, wherein R 1 -R 4 and R 6 -R 9 are defined below, as are methods of preparing and using these compounds for contraception; treating or preventing fibroids, uterine leiomyomata, endometriosis, dysfunctional bleeding, polycystic ovary syndrome, and hormone-dependent carcinomas; providing hormone replacement therapy; stimulating food intake; synchronizing estrus; and treating cycle-related symptoms.
摘要翻译：提供以下结构的化合物，其中R 1 -R 4和R 6 -R 9定义以下是制备和使用这些化合物用于避孕的方法; 治疗或预防子宫肌瘤，子宫平滑肌瘤，子宫内膜异位症，功能障碍性出血，多囊卵巢综合征和激素依赖性癌症; 提供激素替代疗法; 刺激食物摄入; 同步发情并治疗周期相关症状。

63. 发明申请

WO2008042218A1 FORMULATIONS CONTAINING AN IONIC MINERAL-ION EXCHANGE RESIN COMPLEX AND USES THEREOF 审中-公开
标题翻译：含有离子交换树脂复合物的配方及其用途
公开(公告)号：WO2008042218A1
公开(公告)日：2008-04-10
申请号：PCT/US2007/020844
申请日：2007-09-27
申请人： TRIS PHARMA, INC. , MEHTA, Ketan , TU, Yu-Hsing , SHAH, Mahendra
发明人： MEHTA, Ketan , TU, Yu-Hsing , SHAH, Mahendra
IPC分类号： A61K33/26 , A61K47/48
CPC分类号： A61K33/26 , A61K31/122 , A61K31/355 , A61K31/455 , A61K33/00 , A61K45/06 , A61K47/585
摘要： A process for preparing a formulation comprising a complex comprising an effective amount of ferrous iron bound to a pharmaceutically acceptable cationic resin and at least one pharmaceutically acceptable carrier is described. Such a formulation may optionally include other desirable dietary supplements including, e.g. , vitamins, omega fatty acids, and/or fluoride. The formulation is particularly well adapted for pediatric use, but is also useful for use in adult populations.
摘要翻译：描述了一种制备包含有效量的与药学上可接受的阳离子树脂和至少一种药学上可接受的载体结合的亚铁的络合物的制剂的方法。这样的制剂可以任选地包括其它所需的膳食补充剂，包括例如维生素，ω-脂肪酸和/或氟化物。该制剂特别适用于儿科用途，但也可用于成年人群。

64. 发明申请

WO2008027322A1 IMPLANTABLE SHUNT OR CATHETER ENABLING GRADUAL DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：可植入分流器或导管使得治疗药物的分级递送
公开(公告)号：WO2008027322A1
公开(公告)日：2008-03-06
申请号：PCT/US2007/018796
申请日：2007-08-27
申请人： WYETH , DRAGOON, Deborah, L. , COHEN, Jonathan, Marc
发明人： DRAGOON, Deborah, L. , COHEN, Jonathan, Marc
IPC分类号： A61M27/00 , A61M31/00
CPC分类号： A61M27/006 , A61M27/00 , A61M27/008 , A61M31/00 , A61M31/002
摘要： An implantable catheter or shunt (24) for draining fluid from a body cavity. The catheter or shunt body has a wall structure (28) that carries one or more therapeutic agents (26) in a manner enabling release of the therapeutic agent from the wall structure in situ after surgical implantation of the catheter or shunt body. The therapeutic agent can be gradually released over time to prevent infection, inhibit tissue ingrowths, and/or provide some other desired medicinal purpose. As an example, the therapeutic agent can be rapamycin or an mTOR inhibitor. According to some contemplated embodiments of the present invention, the therapeutic agent carried by the catheter/shunt is rechargeable or refillable in situ so that the therapeutic agent can be gradually released from the catheter/shunt over the expected useful life of the catheter/shunt.
摘要翻译：用于从体腔排出流体的可植入导管或分路器（24）。导管或分流体具有壁结构（28），该壁结构承载一种或多种治疗剂（26），以使得能够在手术植入导管或分流体之后将治疗剂从壁结构释放。治疗剂可以随着时间逐渐释放以防止感染，抑制组织向内生长和/或提供一些其它期望的药物用途。作为实例，治疗剂可以是雷帕霉素或mTOR抑制剂。根据本发明的一些预期的实施例，由导管/分流器承载的治疗剂可以在现场进行可再充电或可再填充，使得治疗剂可以在导管/分流器的预期使用寿命期间从导管/分流器逐渐释放。

65. 发明申请

WO2008010864A3 MODIFIED ADENOVIRUS HEXON PROTEIN AND USES THEREOF 审中-公开
公开(公告)号：WO2008010864A3
公开(公告)日：2008-01-24
申请号：PCT/US2007/010347
申请日：2007-04-27
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , SOUMITRA, Roy , WILSON, James, M.
发明人： SOUMITRA, Roy , WILSON, James, M.
IPC分类号： A61K39/12 , A61K39/21 , C07K14/075 , C12N15/861 , A61K48/00
摘要： The present invention provides a method of altering the specificity of an adenovirus vector. The method involves providing an adenovirus having a capsid with a modified adenovirus hexon protein. The modified adenovirus has a capsid comprising a hexon protein with a deletion in hypervariable region 1 and/or hypervariable region 4 of the hexon and an insert of an exogenous molecule therein.

66. 发明申请

WO2007103348A2 PROCESS FOR PREPARING WATER-SOLUBLE POLYETHYLENE GLYCOL CONJUGATES OF MACROLIDE IMMUNOSUPPRESSANTS 审中-公开
标题翻译：制备高分子量免疫球蛋白的水溶性聚乙烯甘油的方法
公开(公告)号：WO2007103348A2
公开(公告)日：2007-09-13
申请号：PCT/US2007/005646
申请日：2007-03-05
申请人： Wyeth , GU, Jianxin , RUPPEN, Mark , ZHU, Tianmin , FAWZI, Mahdi
发明人： GU, Jianxin , RUPPEN, Mark , ZHU, Tianmin , FAWZI, Mahdi
IPC分类号： A61K47/48 , A61P37/06
CPC分类号： C07D498/18 , A61K47/60
摘要： Processes are described for preparing 42-pegylated rapamycins including reacting a rapamycin with an acylating agent in the presence of a lipase to form an acylated rapamycin and reacting the acylated rapamycin with a methoxy poly(ethylene glycol) derivative in the presence of a base. Also described are processes for preparing 32-pegylated tacrolimus and/or ascomycin using these steps.
摘要翻译：描述了制备42-聚乙二醇化雷帕霉素的方法，包括在脂肪酶存在下使雷帕霉素与酰化剂反应形成酰化雷帕霉素，并在碱的存在下使酰化雷帕霉素与甲氧基聚（乙二醇）衍生物反应。还描述了使用这些步骤制备32-聚乙二醇化他克莫司和/或小霉素的方法。

67. 发明申请

WO2007067566A2 METHODS FOR PREPARING CRYSTALLINE RAPAMYCIN AND FOR MEASURING CRYSTALLINITY OF RAPAMYCIN COMPOUNDS USING DIFFERENTIAL SCANNING CALORIMETRY 审中-公开
标题翻译：制备结晶雷帕霉素的方法和使用差示扫描量热法测定RAPAMYCIN化合物的结晶度
公开(公告)号：WO2007067566A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/046445
申请日：2006-12-06
申请人： WYETH , DESHMUKH, Subodh, S. , MIRMEHRABI, Mahmoud
发明人： DESHMUKH, Subodh, S. , MIRMEHRABI, Mahmoud
CPC分类号： C07D498/18 , C07D498/14 , C07H17/08 , G01N25/4866
摘要： Methods for purifying rapamycin are described. Methods for measuring particle quality, median particle size, and crystallinity of samples containing rapamycin or a derivative thereof are also provided.
摘要翻译：描述了雷帕霉素的纯化方法。还提供了用于测量含有雷帕霉素或其衍生物的样品的颗粒质量，中值粒径和结晶度的方法。

68. 发明申请

WO2006119104A2 PROCESS FOR PREPARING ISATINS WITH CONTROL OF SIDE-PRODUCT FORMATION 审中-公开
标题翻译：控制边产品形成的方法
公开(公告)号：WO2006119104A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016436
申请日：2006-04-27
申请人： WYETH , WILK, Bogdan, Kazimierz , RAVEENDRANATH, Panolil , DING, Zhixian , WEHRENBERG, Peter
发明人： WILK, Bogdan, Kazimierz , RAVEENDRANATH, Panolil , DING, Zhixian , WEHRENBERG, Peter
IPC分类号： C07D209/38
CPC分类号： C07D209/38 , C07D403/04
摘要： Methods and kits for preventing or minimizing the formation of isatin oximes during formation of an isatin from an isonitrosoacetanilide are provided. Also provided are methods and kits for preventing or minimizing the formation of isatin oxime impurities after formation of an isatin from an isonitrosoacetanilide by using a decoy agent in the quenching and/or extraction steps. The isatins can be prepared using a decoy agent and desirably a strong acid. Further provided are methods for preparing isatin oximes.
摘要翻译：提供了用于防止或最小化来自异硝基乙酰替苯胺的靛红形成期间靛红肟形成的方法和试剂盒。还提供了用于在骤冷和/或萃取步骤中通过使用诱饵剂从异亚氨基乙酰替苯胺形成靛红后，防止或最小化靛红肟杂质形成的方法和试剂盒。异丁锭可以使用诱饵剂和期望的强酸来制备。还提供了制备靛红肟的方法。

69. 发明申请

WO2006116498A2 PURIFIED FORM OF TANAPROGET 审中-公开
标题翻译：纯化形式的TANAPROGET
公开(公告)号：WO2006116498A2
公开(公告)日：2006-11-02
申请号：PCT/US2006/015813
申请日：2006-04-26
申请人： WYETH , CHATLAPALLI, Ramarao , NAGI, Arwinder , POTOSKI, John , HELOM, Jean, Louise , WILK, Bogdan, Kazimierz , RUBEZHOV, Arkadiy, Zinoviy , DRAGAN, Vladimir
发明人： CHATLAPALLI, Ramarao , NAGI, Arwinder , POTOSKI, John , HELOM, Jean, Louise , WILK, Bogdan, Kazimierz , RUBEZHOV, Arkadiy, Zinoviy , DRAGAN, Vladimir
IPC分类号： C07D265/14 , C07D413/04 , A61K31/536 , A61P15/00
CPC分类号： C07D265/14 , C07D413/04
摘要： Micronized tanaproget, purified tanaproget Form I, and micronized, purified tanaproget Form I are provided. Also provided are compositions containing one or more of the prepared tanaproget forms, methods of using one or more of the prepared tanaproget forms, and kits containing one or more of the prepared tanaproget forms.
摘要翻译：提供微粉化的钠盐瓶，纯化的tanaproget Form I和微粉化的纯化的Tanaproget Form I。还提供了含有一种或多种所制备的钛酸钠形式的组合物，使用一种或多种所制备的钛酸钠形式的方法，以及包含一种或多种所制备的钛酸钠形式的试剂盒。

70. 发明申请

WO2006110689A2 METHOD OF INCREASING THE FUNCTION OF AN AAV VECTOR 审中-公开
标题翻译：增加AAV矢量函数的方法
公开(公告)号：WO2006110689A2
公开(公告)日：2006-10-19
申请号：PCT/US2006/013375
申请日：2006-04-07
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , VANDENBERGHE, Luk , GAO, Guangping , WILSON, James, M.
发明人： VANDENBERGHE, Luk , GAO, Guangping , WILSON, James, M.
IPC分类号： C12N15/864 , C12N7/00 , A61K35/76 , A61K48/00
CPC分类号： C12N15/86 , A61K48/00 , A61K48/005 , A61K48/0091 , C07K14/005 , C12N7/00 , C12N2750/14122 , C12N2750/14142 , C12N2750/14143 , C12N2750/14152
摘要： A method of correcting singletons in a selected AAV sequence in order to increasing the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid sequences.
摘要翻译：提供了校正所选AAV序列中的单体以提高所选AAV的包装产率，转导效率和/或基因转移效率的方法。该方法涉及改变亲本AAV衣壳中的一个或多个单体以使单体与对准的功能性AAV衣壳序列的相应位置中的氨基酸一致。

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