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61. 发明申请

WO2013123018A1 MEDICAL DEVICES FOR COLLECTING PATHOGENIC CELLS 审中-公开
标题翻译：用于收集病原细胞的医疗装置
公开(公告)号：WO2013123018A1
公开(公告)日：2013-08-22
申请号：PCT/US2013/025895
申请日：2013-02-13
申请人： COOK MEDICAL TECHNOLOGIES LLC
发明人： BARBICK, Julia, E. , HOFFA, Andrew, K. , BUNCH, Tyler, J. , CHAMBERS, Sean , GEMBORYS. Colleen
IPC分类号： A61L27/22 , A61L27/32 , A61L27/54 , A61L29/04 , A61L31/04 , A61L31/08
CPC分类号： A61K47/6849 , A61F2/01 , A61F2002/016 , A61F2250/0067 , A61K9/0024 , A61K39/39558 , A61K47/6957 , A61K2039/505 , A61L29/08 , A61L29/16 , A61L31/047 , A61L31/08 , A61L31/16 , A61L2300/252 , A61L2300/404 , A61L2300/606
摘要： Disclosed is a medical device constructed and arranged for contact with a flow of blood or other bodily fluid of a patient and including an attached binding agent or a roughened surface that binds to pathogenic cells targeted for elimination from the blood or other bodily fluid. Also disclosed are methods for making and using the device.
摘要翻译：公开了一种构造和布置成与患者的血液或其他体液接触的医疗装置，并且包括附着的结合剂或与从血液或其他体液排出的致病细胞结合的粗糙表面。还公开了用于制造和使用该装置的方法。

62. 发明申请

WO2012174234A2 FISTULA CLOSURE DEVICES AND METHODS 审中-公开
标题翻译： FISTULA闭合装置和方法
公开(公告)号：WO2012174234A2
公开(公告)日：2012-12-20
申请号：PCT/US2012/042448
申请日：2012-06-14
申请人： COOK MEDICAL TECHNOLOGIES LLC , COOK BIOTECH INCORPORATED , OBERMILLER, F., Joseph , AGNEW, Charles, W. , CHEN, Steve , HUNT, James, B.
发明人： OBERMILLER, F., Joseph , AGNEW, Charles, W. , CHEN, Steve , HUNT, James, B.
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00588 , A61B2017/00641
摘要： Described are methods and systems for treating fistulae and other passageways and openings in the body. In certain aspects, an anchored suture is provided that extends from at or near a first fistula opening and through a fistula tract toward a second fistula opening. Various modes of anchoring may be used in this regard including, in some modes, having the suture extend from a deployed anchoring member positioned in and/or around the first opening. The anchored suture, which has a more slender cross sectional dimension relative to the fistula tract through which it extends, is capable of receiving an optional fill substance therealong in the tract. A fill substance can be or include a variety of biodegradable and/or non-biodegradable objects and materials including flowable and non-flowable materials.
摘要翻译：描述了用于治疗瘘管和身体其他通道和开口的方法和系统。在某些方面，提供一种锚固缝合线，其从第一瘘开口处或附近延伸并且通过瘘管道朝向第二瘘开口延伸。在这方面可以使用各种锚固模式，包括在一些模式中，缝合线从位于第一开口中和/或周围的展开的锚定构件延伸。相对于其延伸的瘘管具有更细长的横截面尺寸的锚定缝合线能够在管道中接收可选的填充物质。填充物质可以是或包括各种可生物降解和/或不可生物降解的物体和材料，包括可流动和不可流动的材料。

63. 发明申请

WO2011150055A2 METHODS, SUBSTRATES, AND SYSTEMS USEFUL FOR CELL SEEDING OF MEDICAL GRAFTS 审中-公开
标题翻译：方法，基质和系统用于细胞接种医疗用品
公开(公告)号：WO2011150055A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/037897
申请日：2011-05-25
申请人： COOK BIOTECH INCORPORATED , MUFFIN INCORPORATED , COOK MEDICAL TECHNOLOGIES LLC , HILES, Michael, C. , JOHNSON, Chad, E. , FEARNOT, Neal, E. , PAYNE, Thomas , JANKOWSKI, Ronald
发明人： HILES, Michael, C. , JOHNSON, Chad, E. , FEARNOT, Neal, E. , PAYNE, Thomas , JANKOWSKI, Ronald
IPC分类号： A61L27/38
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
摘要翻译：描述了可用于制备用于给予患者的含细胞的移植材料的方法，细胞生长底物和装置。可以在细胞生长底物中定义管状通道以促进细胞分布到底物中。还描述了用于制备细胞接种组合物的方法和装置，在施用细胞之前预处理细胞生长底物的方法和装置，以及具有新基底的细胞接种移植物及其用途。

64. 发明申请

WO2011047046A1 ETHANOL PRODUCTION FROM LIGNOCELLULOSIC BIOMASS WITH RECOVERY OF COMBUSTIBLE FUEL MATERIALS 审中-公开
标题翻译：来自具有可燃性燃料材料回收的细菌生物量的乙醇生产
公开(公告)号：WO2011047046A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052503
申请日：2010-10-13
申请人： PURDUE RESEARCH FOUNDATION , DEFENSE LIFE SCIENCES, LLC , MOSIER, Nathan , LADISCH, Michael, R. , WARNER, Jerry
发明人： MOSIER, Nathan , LADISCH, Michael, R. , WARNER, Jerry
IPC分类号： C12P7/06
CPC分类号： C12P7/10 , C10L5/445 , Y02E50/10 , Y02E50/16 , Y02E50/17 , Y02E50/30 , Y02P20/136
摘要： Described are processes for producing a product, such as ethanol, from lignocellulosic biomass, and producing a burnable fuel material from byproducts. The burnable fuel material can be burned on site to produce energy to feed back into the production process.
摘要翻译：描述了从木质纤维素生物质生产诸如乙醇的产物，以及从副产物生产可燃燃料的方法。可燃燃料材料可以在现场燃烧以产生能量以反馈到生产过程中。

65. 发明申请

WO2009155607A2 COMPOSITE EXTRACELLULAR MATRIX MATERIALS AND MEDICAL PRODUCTS FORMED THEREFROM 审中-公开
标题翻译：复合细胞基质材料和形成的医药产品
公开(公告)号：WO2009155607A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/048168
申请日：2009-06-22
申请人： COOK BIOTECH INCORPORATED , JOHNSON, Chad E. , ERNST, David M.J. , OVERBY, Amy
发明人： JOHNSON, Chad E. , ERNST, David M.J. , OVERBY, Amy
IPC分类号： A61L31/12 , A61L31/16 , A61L31/14
CPC分类号： A61L27/56 , A61L27/3633
摘要： Described in certain aspects are composite extracellular matrix material products including expanded collagenous materials in combination with non- expanded collagenous materials. Methods for their preparation and use are also disclosed. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, and recovering the expanded material. Expanded materials can exhibit beneficial persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.
摘要翻译：在某些方面描述的是复合细胞外基质材料产品，包括与非扩张胶原材料组合的扩张胶原材料。还公开了其制备和使用方法。某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下用碱性物质处理第一胶原材料并回收膨胀的材料来制备。扩展的材料可以在植入时显示出有益的持续性和组织产生特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

66. 发明申请

WO2009155600A2 COMPRESSIBLE/EXPANDABLE MEDICAL GRAFT PRODUCTS, AND METHODS FOR APPLYING HEMOSTASIS 审中-公开
标题翻译：可压缩/可扩展的医用产品，以及应用HEMOSTASIS的方法
公开(公告)号：WO2009155600A2
公开(公告)日：2009-12-23
申请号：PCT/US2009/048152
申请日：2009-06-22
申请人： COOK BIOTECH INCORPORATED , JOHNSON, Chad, E. , ERNST, David, M. J. , OVERBY, Amy
发明人： JOHNSON, Chad, E. , ERNST, David, M. J. , OVERBY, Amy
IPC分类号： A61L27/36 , A61L27/56
CPC分类号： A61L27/56 , A61L27/3633
摘要： Described are expanded collagenous materials useful in hemostatic applications. Certain expanded collagenous materials can be prepared by treating a first collagenous material with an alkaline substance under conditions effective to expand the first collagenous material, recovering the expanded material, processing the expanded material to provide a foam, and chemically crosslinking the foam. Expanded materials can exhibit beneficial resilience, persistence and tissue generation characteristics when implanted, and can be used in the formation of highly porous medical implant bodies which can be compressed to fractions of their original volume and will thereafter substantially recover their original volume.
摘要翻译：描述了可用于止血应用的扩张胶原材料。某些扩张的胶原材料可以通过在有效扩张第一胶原材料的条件下处理具有碱性物质的第一胶原材料，回收膨胀的材料，加工膨胀的材料以提供泡沫和化学交联泡沫来制备。膨胀的材料可以在植入时显示出有益的弹性，持续性和组织生成特性，并且可以用于形成高度多孔的医用植入物体，其可以被压缩成其原始体积的分数，然后将基本恢复其原始体积。

67. 发明申请

WO2009076190A1 METHODS AND APPARATUSES FOR DELIVERING ANCHORING DEVICES INTO BODY PASSAGE WALLS 审中-公开
标题翻译：将锚固装置输送到身体通道的方法和装置
公开(公告)号：WO2009076190A1
公开(公告)日：2009-06-18
申请号：PCT/US2008/085649
申请日：2008-12-05
申请人： INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION , RAHMANI, Emad, Y.
发明人： RAHMANI, Emad, Y.
IPC分类号： A61B17/03
CPC分类号： A61B17/0401 , A61B2017/00296 , A61B2017/0409 , A61B2017/0417
摘要： Described, in certain embodiments, are methods and apparatuses for delivering anchoring devices such as T-anchors into body passage walls. Some inventive methods involve inserting one or more anchoring devices into a wall of an organ in a direction from a luminal surface to an abluminal surface of the wall. In some instances, inserting a device in this manner, while providing at least part of the device implanted between the luminal surface and the abluminal surface of the wall, is conducted without the device exiting the wall's abluminal surface. In these and other inventive methods, delivering an anchoring device into a body passage wall may involve manipulating the wall in some manner before, during and/or after placing the device in the wall. Various forms of manipulation are described in this regard.
摘要翻译：在某些实施例中描述了用于将诸如T形锚固件的锚定装置输送到体通道壁中的方法和装置。一些创造性的方法包括将一个或多个锚定装置插入器官的壁中，该方法从腔表面到壁的外侧表面。在一些情况下，以这种方式插入装置，同时提供植入在管腔表面和壁的外腔表面之间的装置的至少一部分，而不会使装置离开壁的外腔表面。在这些和其它创造性方法中，将锚固装置输送到身体通道壁中可以包括在将装置放置在壁中之前，期间和/或之后以某种方式操纵壁。在这方面描述了各种形式的操纵。

68. 发明申请

WO2009045824A2 ABSORBABLE ADHESIVES AND THEIR FORMULATION FOR USE IN MEDICAL APPLICATIONS 审中-公开
标题翻译：可吸收的粘合剂及其用于医疗应用的配方
公开(公告)号：WO2009045824A2
公开(公告)日：2009-04-09
申请号：PCT/US2008/077602
申请日：2008-09-25
申请人： COOK BIOTECH INCORPORATED , SHAH, Bhavin , HALL, Paul, J.
发明人： SHAH, Bhavin , HALL, Paul, J.
IPC分类号： A61L24/00 , A61L24/08 , A61L26/00
CPC分类号： A61L27/3633 , A61L24/104 , A61L27/34 , A61L27/3629 , C08L89/06
摘要： Described are medical products including an adhesive containing a polypeptide component such as gelatin and a tackiness-providing polyhydroxy compound, such as at least one compound selected from the group consisting of glycerin and fructose. Such medical products can find use as a bolster material for use in conjunction with a surgical fastening device such as a stapler. Other medical applications utilizing a medical product of the invention include tissue repair and pharmaceutical delivery to a desired location. Related methods of manufacture and use are also described.
摘要翻译：描述了包括含有多肽成分如明胶和提供粘性的多羟基化合物的粘合剂的医疗产品，例如选自甘油和果糖中的至少一种化合物。这样的医疗产品可以用作与诸如吻合器的手术紧固装置结合使用的枕垫材料。利用本发明的医疗产品的其它医疗应用包括组织修复和药物递送到期望的位置。还描述了相关的制造和使用方法。

69. 发明申请

WO2009036250A8 ENHANCED REMODELABLE MATERIALS FOR OCCLUDING BODILY VESSELS AND RELATED METHODS AND SYSTEMS 审中-公开
公开(公告)号：WO2009036250A8
公开(公告)日：2009-03-19
申请号：PCT/US2008/076139
申请日：2008-09-12
申请人： COOK INCORPORATED , BATES, Brian, L. , PAUL, Ram, H., Jr. , FLAGLE, Jacob, A.
发明人： BATES, Brian, L. , PAUL, Ram, H., Jr. , FLAGLE, Jacob, A.
IPC分类号： A61L27/36 , A61L31/14 , A61B17/00 , A61B17/12
摘要： Described are methods, devices, and systems for occluding or ablating vascular vessels. Noninvasive procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous valve insufficiency. Further described is the cooperative use of an angiogenic remodelable material with one or more sclerosing agents to cause closure of a targeted bodily vessel.

70. 发明申请

WO2009025970A1 FISTULA PLUGS AND APPARATUSES AND METHODS FOR FISTULA PLUG DELIVERY 审中-公开
标题翻译： FISTULA PLUGS和装置和方法用于FISTULA PLUG交付
公开(公告)号：WO2009025970A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/071491
申请日：2008-07-29
申请人： COOK BIOTECH INCORPORATED , AGNEW, Charles
发明人： AGNEW, Charles
IPC分类号： A61B17/00
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12159 , A61B17/12168 , A61B2017/00004 , A61B2017/00641 , A61B2017/00659 , A61B2017/12054 , A61F2/0004 , A61F2/0009 , A61F2/0013 , A61F2002/045
摘要： Described are methods and apparatuses for delivering fistula plugs into fistulae having at least a primary fistula opening, a secondary fistula opening, and a fistula tract extending therebetween. Illustratively, some inventive methods involve delivering a fistula plug into a fistula tract through a primary fistula opening and toward a secondary fistula opening, while others involve delivering a fistula plug into a fistula tract through a secondary fistula opening and toward a primary fistula opening. In certain aspects, a fistula plug is pushed and/or pulled through a fistula tract along a guide wire or other plug-guiding device, potentially protected by a protective delivery device such as a sheath, capsule or other suitable delivery vehicle.
摘要翻译：描述了用于将瘘塞递送到瘘管中的方法和装置，所述瘘管至少具有主瘘开口，次级瘘开口和在其间延伸的瘘管道。说明性地，一些创造性的方法包括将瘘塞通过主瘘开口并朝向次级瘘开口输送到瘘管道中，而另一些涉及将瘘塞通过次级瘘开口并朝向主瘘开口输送到瘘管道中。在某些方面，瘘塞被沿着引导线或其他插塞引导装置推动和/或拉动通过瘘管道，该导管或潜在的保护性输送装置例如护套，胶囊或其它合适的输送载体。

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