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61. 发明申请

WO2006058237A3 POLYMER-COATED SUBSTRATES FOR BINDING BIOMOLECULES AND METHODS OF MAKING AND USING THEREOF 审中-公开
公开(公告)号：WO2006058237A3
公开(公告)日：2006-06-01
申请号：PCT/US2005/042785
申请日：2005-11-17
申请人： CORNING INCORPORATED , FRUTOS, Anthony, G. , LAHIRI, Joydeep
发明人： FRUTOS, Anthony, G. , LAHIRI, Joydeep
IPC分类号： G01N33/52 , G01N33/543
摘要： Described herein are polymer-coated substrates for binding biomolecules and methods of making and using thereof.

62. 发明申请

WO2006057669A2 DEFECT REDUCTION IN MANUFACTURE GLASS SHEETS BY FUSION PROCESS 审中-公开
标题翻译：通过熔融过程制造玻璃板的缺陷减少
公开(公告)号：WO2006057669A2
公开(公告)日：2006-06-01
申请号：PCT/US2005/019667
申请日：2005-06-02
申请人： CORNING INCORPORATED , RHOADS, Randy, L.
发明人： RHOADS, Randy, L.
IPC分类号： C03B17/06
CPC分类号： C03B17/064 , Y02P40/57
摘要： Methods and apparatus for manufacturing glass sheets are provided. The apparatus includes an inlet for delivering glass to a trough formed in a refractory body. The lowest point in the trough is located on the end opposite inlet end.
摘要翻译：提供了制造玻璃板的方法和装置。该装置包括用于将玻璃输送到形成在耐火体中的槽的入口。槽中的最低点位于入口端相反的端部。

63. 发明申请

WO2005121182A2 GLASS SHEET FORMING APPARATUS 审中-公开
标题翻译：玻璃纸成型设备
公开(公告)号：WO2005121182A2
公开(公告)日：2005-12-22
申请号：PCT/US2005/018909
申请日：2005-05-26
申请人： CORNING INCORPORATED , RHOADS, Randy L , ADAMOWICZ, John A , BORATAV, Olus N
发明人： RHOADS, Randy L , ADAMOWICZ, John A , BORATAV, Olus N
IPC分类号： C08B7/00
CPC分类号： C03B17/064
摘要： A forming apparatus (635) is described herein that is used in a glass manufacturing system (100) to form a glass sheet (605). The forming apparatus (635) includes a body (722) having an inlet (702) that receives molten glass (626) which flows into a trough (706) formed in the body (722) and then overflows two top surfaces (726a and 726b) of the trough (706) and runs down two sides (708a and 708b) of the body (722) before fusing together where the two sides (708a and 708b) come together to form a glass sheet (605). The trough (706) has a bottom surface (716) and an embedded object (718) formed thereon that are both sized to cause a desired mass distribution of the molten glass (626) to overflow the top surfaces (726a and 726b) of the trough (706) to enable the production of the glass sheet (605).
摘要翻译：本文描述了一种在玻璃制造系统（100）中用于形成玻璃板（605）的成形设备（635）。成型设备（635）包括具有入口（702）的主体（722），入口（702）接收流入形成在主体（722）中的槽（706）中的熔融玻璃（626），然后溢出两个顶表面（726a和726b ），并且在两侧（708a和708b）组合在一起以形成玻璃板（605）之前熔合在一起，并且在主体（722）的两侧（708a和708b）之间向下延伸。槽（706）具有底表面（716）和形成在其上的嵌入物体（718），其尺寸被设计成使得熔融玻璃（626）的期望质量分布溢出所述熔融玻璃（626）的顶表面（726a和726b）槽（706）以制造玻璃板（605）。

64. 发明申请

WO2005121035A1 ISOPIPE MASS DISTRIBUTION FOR FORMING GLASS SUBSTRATES 审中-公开
标题翻译：用于形成玻璃基材的均匀质量分布
公开(公告)号：WO2005121035A1
公开(公告)日：2005-12-22
申请号：PCT/US2005/019158
申请日：2005-05-31
申请人： CORNING INCORPORATED , ADAMOWICZ, John A , BORATAV, Olus N , RHOADS, Randy L , ELKAHLOUT, Ahdi , MARKHAM, Shawn R
发明人： ADAMOWICZ, John A , BORATAV, Olus N , RHOADS, Randy L , ELKAHLOUT, Ahdi , MARKHAM, Shawn R
IPC分类号： C03B17/06
CPC分类号： C03B17/064
摘要： A method (300) is described herein for producing a glass substrate (105) by melting (302) batch materials to form molten glass (126) and delivering (304) the molten glass (126) to a forming apparatus (135) that has a body (210) with an inlet (136) that receives the molten glass (126) which flows into a trough (137) formed in the body (210) and then overflows two top surfaces (212' and 212'') of the trough (137) and runs down two sides (138' and 138'') of the body (210) before fusing together where the two sides (138' and 138'') come together to form a glass sheet (216). The delivering step (304) also includes a step where the mass flow rate of molten glass (126) that flows over a predetermined length at both end sections of the trough (137) is managed to avoid temporal variations in the glass mass, distribution of the glass mass and thermal energy from the glass mass. In particular, the managing step includes ensuring that more than 17.6 lbs/hour and preferably more than 20.0 lbs/hour of molten glass (126) flows over the first and last four inches of both end sections of the trough (137). And, that more than 57.6 lbs/hour and preferably more than 65.0 lbs/hour of molten glass (126) flows over the first and last nine inches of both end sections of the trough (137). Lastly, the glass sheet (216) formed by the forming apparatus (135) is drawn by a pull roll assembly (140) to produce the glass substrate (105).
摘要翻译：本文描述了一种方法（300），用于通过熔化（302）批料以形成熔融玻璃（126）并将（304）熔融玻璃（304）输送（304）到成型设备（135）来生产玻璃基板（105）具有入口（136）的主体（210），所述入口（136）接收流入形成在所述主体（210）中的槽（137）中的熔融玻璃（126），然后使所述熔融玻璃的两个顶表面（212'和212“）溢出槽（137）并且在两侧（138'和138“）汇合在一起以形成玻璃板（216）之前熔合在一起的同时向下延伸到主体（210）的两侧（138'和138”）。输送步骤（304）还包括一个步骤，其中管理在槽（137）的两个端部处流过预定长度的熔融玻璃（126）的质量流量，以避免玻璃质量的时间变化，玻璃的分布来自玻璃块的玻璃质量和热能。特别地，管理步骤包括确保在槽（137）的两端部的第一和最后四英寸处流动超过17.6磅/小时，优选大于20.0磅/小时的熔融玻璃（126）。而且，超过57.6磅/小时，优选大于65.0磅/小时的熔融玻璃（126）流过槽（137）的两端部的第一和最后九英寸。最后，由成形装置（135）形成的玻璃板（216）由拉辊组件（140）拉伸以制造玻璃基板（105）。

65. 发明申请

WO2005066633A2 FLUORESCENT LIGANDS FOR GPCR ARRAYS 审中-公开
标题翻译：用于GPCR阵列的荧光配体
公开(公告)号：WO2005066633A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/041935
申请日：2004-12-13
申请人： CORNING INCORPORATED , FANG, Ye , HONG, Yulong , PENG, Jinlin
发明人： FANG, Ye , HONG, Yulong , PENG, Jinlin
IPC分类号： G01N33/543
CPC分类号： G01N33/582 , C07K7/083 , C07K14/63 , G01N33/6845 , G01N33/74 , G01N2333/63 , G01N2333/726
摘要： A fluorescent ligand includes a material having a binding affinity in the range of about 0.01 to about 25 nM, or about 0.1 to about 10 nM; a specificity to its cognate receptor in the range of about 50 to about 99%, or about 65 to about 99%; a cross-activity to other receptors of 0 to about 20%, or 0 to about 10%; a net charge per ligand of about -3 to about +5, or more preferably, about -2 to about +2 or most preferably for small compound ligands about -1 to about +2. The ligand may also have a hydrophobicity in the range of about 3 to about 55 minutes eluting time (as measured under specified eluting conditions) . In some embodiments, the ligand including fluorescently labeled motilin 1-16 labeled with Bodipy-TMR, rhodamine or Cy5-. Other embodiments include fluorescently labeled Cy5-naltrexone, Cy5-neurotensin 2-13, N-terminal labeled neurotensin 2-13 or lys-labeled labeled neurotensin 2-13.
摘要翻译：荧光配体包括具有约0.01至约25nM，或约0.1至约10nM范围内的结合亲和力的材料; 在约50至约99％，或约65至约99％的范围内对其同源受体的特异性; 与其他受体的交叉活性为0至约20％，或0至约10％; 每个配体的净电荷为约-3至约+5，或更优选约-2至约+2，或最优选约为-1至约+2的小化合物配体。配体还可以具有约3至约55分钟洗脱时间（在规定的洗脱条件下测量）的疏水性。在一些实施方案中，配体包括用Bodipy-TMR，罗丹明或Cy5-标记的荧光标记的胃动素1-16。其他实施方案包括荧光标记的Cy5-纳曲酮，Cy5-神经丝氨酸2-13，N-末端标记的神经丝氨酸蛋白酶2-13或lys-标记的标记的神经丝氨酸素2-13。

66. 发明申请

WO2005066328A1 CELL CULTIVATING FLASK 审中-公开
标题翻译：细胞培养FLASK
公开(公告)号：WO2005066328A1
公开(公告)日：2005-07-21
申请号：PCT/US2004/042133
申请日：2004-12-15
申请人： CORNING INCORPORATED , RYAN, John, A. , VAUGHAN, Laurence, M. , WALL, Joseph, C. , YOUNGBEAR, Kathy, M.
发明人： RYAN, John, A. , VAUGHAN, Laurence, M. , WALL, Joseph, C. , YOUNGBEAR, Kathy, M.
IPC分类号： C12M1/24
CPC分类号： C12M23/24 , C12M23/08 , C12M29/20
摘要： A stackable flask for the culturing of cells is disclosed. The cell culture chamber is defined by a top plate and a rigid bottom tray (16) of substantially rectangular shape connected by side (18) and end walls (20), the body of the flask has imparted therein a gas permeable membrane (23) that will allow the free flow of gases between the cell culture chamber and the external environment. The flask body also includes a sealed septum (38) that will allow access to the cell growth chamber by means of a needle or cannula. The size of the flask and location of an optional neck and cap section allows for flask manipulation by standard automated assay equipment, making the flask ideal for high throughput applications.
摘要翻译：公开了一种用于培养细胞的可堆叠烧瓶。细胞培养室由顶板和由侧面（18）和端壁（20）连接的大致矩形形状的刚性底部托盘（16）限定，烧瓶的主体在其中赋予透气膜（23）这将允许细胞培养室和外部环境之间的气体自由流动。烧瓶主体还包括密封隔膜（38），其将允许通过针或插管进入细胞生长室。烧瓶的尺寸和可选的颈部和帽部分的位置允许通过标准自动化测定设备进行烧瓶操作，使烧瓶适合于高通量应用。

67. 发明申请

WO2005043139A1 OPTICAL READING SYSTEM FOR RESONANT WAVEGUIDE GRATINGS AND METHOD OF SPECTRAL MULTIPLEXING OF RESONANT WAVEGUIDE GRATINGS 审中-公开
标题翻译：共振波长光栅光学读取系统及共振波导光栅光谱多路复用方法
公开(公告)号：WO2005043139A1
公开(公告)日：2005-05-12
申请号：PCT/US2004/034790
申请日：2004-10-20
申请人： CORNING INCORPORATED , PIECH, Garrett A , KROL, Mark F
发明人： PIECH, Garrett A , KROL, Mark F
IPC分类号： G01N21/77
CPC分类号： G01N21/7743 , G01N21/431
摘要： An optical reading system (100) is described herein which can be used to detect the presence of a biological substance (102) (e.g., cell, drug, chemical compound) on a surface (104) of a grating-based waveguide sensor (100). In one embodiment, the reading system includes a light source (122) (e.g., laser, diode) for directing a light beam (126) into the grating-based waveguide sensor and a detector (124) (e.g., spectrometer, CCD imaging device) for receiving a reflected light beam (128) from the grating-based waveguide sensor and analyzing the reflected light beam so as to detect a resonant wavelength/angle which corresponds to a predetermined refractive index that indicates whether a biological substance is located on the surface of the grating-based waveguide sensor. The grating-based waveguide sensor is tuned to have a resonance at a predetermined wavelength/angle by adjusting a skew angle defined as an angle between a plane of incidence of the light beam directed into the grating-based waveguide sensor and a grating vector which is perpendicular to the lines of a diffraction grating within the grating-based waveguide sensor. In another embodiment, the reading system is arranged to perform a multiplexed interrogation of an array of grating-based waveguide sensors.
摘要翻译：本文描述了光学读取系统（100），其可用于检测在基于光栅的波导传感器（100）的表面（104）上存在生物物质（102）（例如细胞，药物，化合物））。在一个实施例中，读取系统包括用于将光束（126）引导到基于光栅的波导传感器中的光源（122）（例如，激光器，二极管）和检测器（124）（例如，光谱仪，CCD成像装置），用于从基于光栅的波导传感器接收反射光束（128）并分析反射光束，以检测对应于表示生物物质位于表面上的预定折射率的共振波长/角度的基于光栅的波导传感器。基于光栅的波导传感器通过调整被定义为被引导到基于光栅的波导传感器中的光束的入射平面之间的角度和光栅矢量的角度来调节以预定波长/角度的谐振，垂直于基于光栅的波导传感器内的衍射光栅的线。在另一个实施例中，读取系统被布置成执行基于光栅的波导传感器阵列的多路询问。

68. 发明申请

WO2005026066A3 SURFACE PROTECTION COATING FOR GLASS SHEETS 审中-公开
公开(公告)号：WO2005026066A3
公开(公告)日：2005-03-24
申请号：PCT/US2004/027727
申请日：2004-08-25
申请人： CORNING INCORPORATED , FRIEDMAN, Thomas, J. , KIM, Hongkyu , NOLET, Teresa, C.
发明人： FRIEDMAN, Thomas, J. , KIM, Hongkyu , NOLET, Teresa, C.
IPC分类号： B32B17/00
摘要： A method is described herein for packaging a plurality of glass sheets by: (1) coating a top surface of each glass sheet with a removable top protective film; (2) coating a bottom surface of each glass sheet with a removable bottom protective film; and (3) stacking the coated glass sheets next to one another such that the top protective film of one glass sheet is adjacent to the bottom protective film of another glass sheet. The top protective film and/or bottom protective film on each glass sheet has embossed features (e.g., rough features) formed therein which make it easier to separate one glass sheet from one another glass sheet because of the presence of air pockets caused by the embossed features located between the stacked glass sheets. The coated glass sheet and a container that can store a plurality of the coated glass sheets are also described herein.

69. 发明申请

WO2005017507A2 POLARIZATION MODULATION INTERROGATION OF GRATING-COUPLED WAVEGUIDE SENSORS 审中-公开
标题翻译：光栅耦合波导传感器的极化调制介质
公开(公告)号：WO2005017507A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/020017
申请日：2004-06-23
申请人： CORNING INCORPORATED , MOZDY, Eric, J.
发明人： MOZDY, Eric, J.
IPC分类号： G01N21/77
CPC分类号： G01N21/7743 , G01N21/21 , G01N21/253 , G01N33/54373
摘要： An optical interrogation system and a GCW sensor are described herein that are used to determine whether a biological substance (e.g., cell, molecule, protein, drug) is located in a sensing region of the GCW sensor. The optical interrogation system includes a light source, a polarization modulator and a detection system. The light source outputs a polarized light beam and the polarization modulator modulates the polarized light beam and outputs a polarization-modulated light beam. The GCW sensor receives and converts the polarization-modulated light beam into an amplitude modulated light beam that is directed towards the detection system. The detection system receives the amplitude modulated light beam and demodulates the received amplitude modulated light beam by responding to signals at a modulation frequency of the polarization-modulated light beam and ignoring noise affecting the signals outside the modulation frequency to detect a resonant condition (e.g., resonant angle, resonant wavelength). The detected resonant condition that has a one-to-one relationship with the refractive index of the superstrate containing the biological substance is analyzed to determine whether or not the biological substance is located in the sensing region of the GCW sensor.
摘要翻译：本文描述了用于确定生物物质（例如，细胞，分子，蛋白质，药物）是否位于GCW传感器的感测区域中的光学询问系统和GCW传感器。光学询问系统包括光源，偏振调制器和检测系统。光源输出偏振光束，偏振光调制器调制偏振光束并输出偏振调制光束。 GCW传感器将偏振调制光束接收并转换成朝向检测系统的幅度调制光束。检测系统接收幅度调制光束并通过响应于偏振调制光束的调制频率的信号来解调所接收的幅度调制光束，并且忽略影响调制频率之外的信号的噪声以检测谐振条件（例如，谐振角，谐振波长）。分析与包含生物物质的覆盖物的折射率具有一对一关系的检测到的共振条件，以确定生物物质是否位于GCW传感器的感测区域中。

70. 发明申请

WO2005016841A1 POROUS GLASS SUBSTRATES WITH REDUCED AUTO-FLUORESCENCE 审中-公开
标题翻译：具有降低自动荧光的多孔玻璃基板
公开(公告)号：WO2005016841A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/019751
申请日：2004-06-21
申请人： CORNING INCORPORATED , DANIELSON, Paul, S. , MONTONDO, Jodelle, K.
发明人： DANIELSON, Paul, S. , MONTONDO, Jodelle, K.
IPC分类号： C03C17/00
CPC分类号： C03C17/42 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , B01J2219/00743 , C03C8/14 , C03C17/007 , C03C17/04 , C03C2217/425 , C03C2218/114 , C03C2218/119 , C40B40/06 , C40B40/10
摘要： A porous inorganic substrate that may be used as a support, upon which biological, biochemical, or chemical reactions may be executed, is provided. A porous layer of the substrate is tinted with a colorant agent, and the porous substrate has at least about 15-20% less auto-fluorescence background relative to a conventional "white" porous substrate. The tinted porous layer provides improved signal to noise ratios that are important in detection metrics when performing biological or chemical binding assays. Once the porous layer is functionalized, one may immobilize probe molecules on or within the porous layer to create a microarray having a greater probe concentration and retention capability than conventional non-porous inorganic substrates, without suffering relatively high levels of auto-fluorescence and other detriments common to un-tinted porous substrates.
摘要翻译：提供了可用作支持物的多孔无机基质，其可以进行生物，生物化学或化学反应。衬底的多孔层用着色剂着色，并且多孔衬底相对于常规的“白色”多孔衬底具有至少约15-20％的自发荧光背景。有色多孔层提供改进的信噪比，这在进行生物或化学结合测定时在检测度量中是重要的。一旦多孔层被功能化，就可以将探针分子固定在多孔层之上或内部，以产生具有比常规非多孔无机底物更大的探针浓度和保留能力的微阵列，而不会遭受相对高水平的自发荧光和其他损害对于未着色的多孔基材是共同的。

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