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61. 发明专利

HUE046120T2 DNS-szekvenciákat kódoló poli (A) szekvenciák stabilizálása 未知
公开(公告)号：HUE046120T2
公开(公告)日：2020-02-28
申请号：HUE15738014
申请日：2015-07-06
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
发明人： EBERLE FLORIAN , SAHIN UGUR , KUHN ANDREAS , VALLAZZA BRITTA , DIKEN MUSTAFA
IPC分类号： C12N15/09 , C12N15/67 , C12N15/68

62. 发明专利

SG11202000961SA ANTIBODIES USEFUL IN CANCER DIAGNOSIS 未知
公开(公告)号：SG11202000961SA
公开(公告)日：2020-02-27
申请号：SG11202000961S
申请日：2018-09-05
申请人： ASTELLAS PHARMA INC , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
发明人： MITNACHT-KRAUS RITA , WÖLL STEFAN , WALTER KORDEN , TÜRECI ÖZLEM , SAHIN UGUR
IPC分类号： C07K16/28
摘要： The invention relates to antibodies directed against an epitope located within the C-terminal portion of CLDN6 which are useful, for example, in diagnosing cancer and/or in determining whether cancer cells express CLDN6.

63. 发明专利

AU2018333530A1 RNA replicon for expressing a T cell receptor or an artificial T cell receptor 未知
公开(公告)号：AU2018333530A1
公开(公告)日：2020-02-27
申请号：AU2018333530
申请日：2018-09-12
申请人： BIONTECH CELL & GENE THERAPIES GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
发明人： SIMON PETRA , PERKOVIC MARIO , SAHIN UGUR , BEISSERT TIM
IPC分类号： C07K14/725 , C12N5/0783 , C12N15/86
摘要： The present invention embraces a RNA replicon that can be replicated by a replicase of alphavirus origin and comprises an open reading frame encoding a chain of a T cell receptor or of an artificial T cell receptor. Such RNA replicons are useful for expressing a T cell receptor or an artificial T cell receptor in a cell, in particular an immune effector cell such as a T cell. Cells engineered to express such T cell receptor or artificial T cell receptor are useful in the treatment of diseases characterized by expression of antigens bound by the T cell receptor or artificial T cell receptor.

64. 发明专利

DK2847225T3 ANTISTOFFER MOD CLAUDIN 18.2, DER KAN ANVENDES TIL CANCERDIAGNOSE 未知
公开(公告)号：DK2847225T3
公开(公告)日：2020-01-20
申请号：DK13721596
申请日：2013-05-06
申请人： ASTELLAS PHARMA INC , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
发明人： SAHIN UGUR , TÜRECI ÖZLEM , MITNACHT-KRAUS RITA , WÖLL STEFAN
IPC分类号： C07K16/30

67. 发明专利

ZA201805520B TRANS-REPLICATING RNA 未知
公开(公告)号：ZA201805520B
公开(公告)日：2019-11-27
申请号：ZA201805520
申请日：2018-08-17
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
发明人： TIM BEISSERT , UGUR SAHIN , MARIO PERKOVIC
摘要： The present invention generally relates to systems and methods suitable for high-level protein production. While one or more elements of the present invention are derived from an alphavirus, the present invention does not require propagation of virus particles. In particular, a system comprising two separate RNA molecules is foreseen, each comprising a nucleotide sequence derived from an alphavirus: one RNA molecule comprises a RNA construct for expressing alphavirus replicase, and one RNA molecule comprises a RNA replicon that can be replicated by the replicase in trans. The RNA construct for expressing alphavirus replicase comprises a 5'-cap. It was surprisingly found that the 5'-cap is suitable for efficiently driving expression of a transgene from the replicon in trans. The system of the present invention enables expression of a protein of interest in a cell or organism, but is not associated with undesired virus-particle formation. Therefore, the present invention is suitable for efficiently and safely producing a protein of interest, e.g. a therapeutic protein or an antigenic protein, such as a vaccine, in a target organism. Respective methods of protein production in vitro and in vivo as well as medical uses are provided herein. The present invention also provides DNA encoding the RNA molecules of the invention, and cells comprising the RNA molecules of the invention.

68. 发明专利

ZA201805519B RNA REPLICON FOR VERSATILE AND EFFICIENT GENE EXPRESSION 未知
公开(公告)号：ZA201805519B
公开(公告)日：2019-11-27
申请号：ZA201805519
申请日：2018-08-17
申请人： BIONTECH RNA PHARMACEUTICALS GMBH , TRON TRANSLATIONALE ONKOLOGIE AN DER UNIV DER JOHANNES GUTENBERG UNIV MAINZ GEMEINNUETZIGE GMBH
发明人： TIM BEISSERT , UGUR SAHIN , MARIO PERKOVIC
摘要： The present invention embraces a RNA replicon that can be replicated by a replicase of alphavirus origin. The RNA replicon comprises sequence elements required for replication by the replicase, but these sequence elements do not encode any protein or fragment thereof, such as an alphavirus non-structural protein or fragment thereof. Thus, in the RNA replicon according to the invention, sequence elements required for replication by the replicase and protein-coding region(s) are uncoupled. According to the present invention the uncoupling is achieved by the removal of at least one initiation codon compared to a native alphavirus genomic RNA. In particular, the RNA replicon comprises a 5' replication recognition sequence, wherein the 5' replication recognition sequence is characterized in that it comprises the removal of at least one initiation codon compared to a native aiphavirus 5' replication recognition sequence. The replicase of alphavirus origin may be encoded by an open reading frame on the RNA replicon or on a separate RNA molecule. The present invention enables efficient and safe expression of a protein of interest in a cell or organism, but is not associated with undesired production of fragments of alphavirus non-structural protein. Methods of protein productionin vitroandin vivo, as well as medical uses, are provided herein.

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