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51. 发明申请

US20020183301A1 Method for improving treatment selectivity and efficacy using intravascular photodynamic therapy 失效
标题翻译：使用血管内光动力治疗改善治疗选择性和功效的方法
公开(公告)号：US20020183301A1
公开(公告)日：2002-12-05
申请号：US09871441
申请日：2001-05-31
发明人： Steven J. Rychnovsky
IPC分类号： A61K031/555 , A61K031/407 , A61K031/353 , A61N001/30
CPC分类号： A61K41/0071 , A61K41/0076 , A61N5/0601 , A61N5/062
摘要： A method in which photodynamic therapy is employed to inhibit, stabilize or reduce occlusions within the cardiovascular system by utilizing light within the spectral region of approximately 390 to approximately 610 nm.
摘要翻译：采用光动力疗法来抑制，稳定或减少心血管系统内的闭塞，其方法是利用在约390nm至约610nm的光谱区内的光。

52. 发明申请

US20020183300A1 Zinc ionophores as anti-stress agents 审中-公开
标题翻译：锌离子载体作为抗应激剂
公开(公告)号：US20020183300A1
公开(公告)日：2002-12-05
申请号：US10116535
申请日：2002-04-04
发明人： Henry Fliss
IPC分类号： A61K031/555 , A61K031/325 , A61K031/315
CPC分类号： A61K33/30 , A61K31/00 , A61K31/315 , A61K31/325 , A61K31/555
摘要： The present invention provides methods comprising one or more zinc ionophores for treating or reversing the effects of stress, including surgical stress in patients in need thereof.
摘要翻译：本发明提供包含一种或多种锌离子载体的方法，用于治疗或逆转应激的作用，包括有需要的患者的外科应激。

53. 发明申请

US20020177583A1 Methods and compositions for the treatment of human and animal cancers 失效
标题翻译：用于治疗人类和动物癌症的方法和组合物
公开(公告)号：US20020177583A1
公开(公告)日：2002-11-28
申请号：US09864685
申请日：2001-05-24
发明人： Zoltan Kiss
IPC分类号： A61K031/555 , A61K031/325 , A61K031/30
CPC分类号： A61K31/30 , A61K31/325 , A61K31/555 , A61K2300/00
摘要： Methods and compositions for altering the viability of cells, particularly cancers in animals and humans are disclosed. The compositions of the present invention are formed from a set of components comprising one or more of the following: a dithiocarbonyl, preferably dithiocarbamate, compound; a divalent metal ion; a modulator of cellular glutathione levels; and an inhibitor of the phosphorylation of choline. The compositions described herein induce a relatively selective and rapid effect on the viability of cancer cells by inducing a mixture of apoptotic and necrotic cell death, with the dominant pathway being apoptosis. Particularly preferred active compositions comprise all four components, although combinations of fewer components can be fully effective in certain tumors.
摘要翻译：公开了用于改变细胞，特别是动物和人类癌症的活力的方法和组合物。本发明的组合物由一组包含以下一种或多种的组分形成：二硫代羰基，优选二硫代氨基甲酸酯化合物; 二价金属离子; 细胞谷胱甘肽水平的调节剂; 和胆碱磷酸化的抑制剂。本文描述的组合物通过诱导凋亡和坏死细胞死亡的混合物诱导对癌细胞的存活力的相对选择性和快速的影响，其中显性途径是细胞凋亡。特别优选的活性组合物包含所有四种组分，尽管较少组分的组合可以在某些肿瘤中完全有效。

54. 发明申请

US20020156062A1 Drug delivery system for hydrophobic drugs 有权
标题翻译：疏水药物的药物输送系统
公开(公告)号：US20020156062A1
公开(公告)日：2002-10-24
申请号：US09833406
申请日：2001-04-11
发明人： Ronald Erwin Boch , Dev Mitra Ranji Singh , Iman Karmadi
IPC分类号： A61K031/409 , A61K031/555 , A61K009/127
CPC分类号： A61K9/19 , A61K9/1075 , A61K9/127 , A61K41/0038 , A61K41/0057 , A61K41/0071 , Y10S514/937
摘要： Compositions comprising microaggregates containing hydrophobic drugs, as well as methods for their production, are described. Such microaggregates may include micelle structures or combinations thereof with liposomes, and constitute an effective delivery vehicle for a hydrophobic agent. Methods for microaggregate production include the use of preferred lipid compounds and processing conditions favoring the production of small aggregates for improved filter sterilization.
摘要翻译：描述了包含含有疏水性药物的微团聚体的组合物及其生产方法。这种微团聚体可以包括胶束结构或其与脂质体的组合，并且构成疏水剂的有效递送载体。用于微团聚体生产的方法包括使用优选的脂质化合物和有利于生产小聚集体以改进过滤器灭菌的加工条件。

55. 发明申请

US20020142019A1 Cosmetic composition, method of use and method of making 失效
标题翻译：化妆品组合物，使用方法和制备方法
公开(公告)号：US20020142019A1
公开(公告)日：2002-10-03
申请号：US10102721
申请日：2002-03-22
发明人： Steven C. Kuhnau
IPC分类号： A61K031/375 , A61K031/555
CPC分类号： A61K8/4906 , A61K8/46 , A61K8/676 , A61Q19/00
摘要： A cosmetic composition for use as scrubbing agent or a mask uses vitamin C particles or crystals in an oil base, whereby the particles are insoluble in the oil so that they remain as suspended scrubbing particles.
摘要翻译：用作洗涤剂或面具的化妆品组合物使用油基中的维生素C颗粒或晶体，由此颗粒不溶于油，使得它们保留为悬浮的洗涤颗粒。

56. 发明申请

US20020128248A1 SODm therapy for prevention and/or treatment of inflammatory disease 审中-公开
标题翻译： SODm治疗炎症性疾病的预防和/或治疗
公开(公告)号：US20020128248A1
公开(公告)日：2002-09-12
申请号：US09997974
申请日：2001-11-30
申请人： MetaPhore Pharmaceuticals, Inc
发明人： Daniela Salvemini
IPC分类号： A61K031/555
CPC分类号： C07F13/005 , A61K31/555
摘要： The present invention relates to pharmaceutical compositions and methods using such compositions for the treatment of inflammatory disease, specifically rheumatoid arthritis. Such compositions contain a catalyst for the dismutation of superoxide which is a low molecular weight organic ligand derived metal complexes that function as mimics of the superoxide dismutase enzyme (SOD mimetics or SODms).
摘要翻译：本发明涉及使用这种组合物治疗炎性疾病，特别是类风湿性关节炎的药物组合物和方法。这种组合物含有用于歧化超氧化物的催化剂，其是作为模拟超氧化物歧化酶（SOD模拟物或SODms）的低分子量有机配体衍生的金属络合物。

57. 发明申请

US20020099043A1 Freeze-dried product and method for preparing the same 审中-公开
标题翻译：冷冻干燥产品及其制备方法
公开(公告)号：US20020099043A1
公开(公告)日：2002-07-25
申请号：US10041000
申请日：2001-12-28
申请人： Toray Industries, Inc.
发明人： Masahiro Akimoto , Fuminori Tamura , Yumi Ozawa
IPC分类号： A61K031/555 , F26B005/06 , C07F015/00
CPC分类号： C07F15/0093 , A61K9/0019 , A61K9/19 , A61K31/555 , A61K47/26
摘要： A freeze-dried product containing a platinum (II) complex represented by the following general formula as a primary component. 1 The freeze-dried product according to the present invention has superior storage stability, and handling thereof for administration in medical treatments is facilitated due to rapid dissolution thereof in water for injection. In addition, they are characterized in requiring no special storage conditions such as refrigeration and freezing.
摘要翻译：含有由以下通式表示的铂（II）络合物作为主要组分的冷冻干燥产物。根据本发明的冻干产品具有优异的储存稳定性，并且由于其在注射用水中的快速溶解而促进了在医疗中的给药的处理。此外，它们的特征在于不需要特殊的储存条件，例如制冷和冷冻。

58. 发明申请

US20020068761A1 Gallium complexes of 3-hydroxy-4-pyrones to treat mycobacterial infections 审中-公开
标题翻译： 3-羟基-4-吡喃酮的镓络合物治疗分枝杆菌感染
公开(公告)号：US20020068761A1
公开(公告)日：2002-06-06
申请号：US10032126
申请日：2001-12-20
发明人： Lawrence R. Bernstein
IPC分类号： A61K031/35 , A61K031/555
CPC分类号： C07D309/40 , A61K31/351 , A61K31/555 , A61K31/7036 , A61K33/24 , A61K45/06 , A61N5/10 , A61K2300/00
摘要： Methods are provided for the use of gallium complexes of 3-hydroxy-4-pyrones in the treatment or prevention of infections caused by a prokaryote of the genus Mycobacterium, including but not limited to those infections due to M. tuberculosis and M leprae. Methods are also provided for the treatment of immunocompromised patients infected by these and other mycobacteria species, including species (such as M. avium, M. aurum, and M. smegmatis) that are not pathogenic to immunocompetent individuals but may cause disease in immunocompromised patients.
摘要翻译：提供了使用3-羟基-4-吡喃酮的镓配合物来治疗或预防由分枝杆菌属的原核生物引起的感染的方法，包括但不限于由结核分枝杆菌和麻疯病引起的那些感染。还提供了用于治疗由这些和其他分枝杆菌物种感染的免疫受损患者的方法，所述分枝杆菌物种包括对免疫活性个体不致病，但可能在免疫受损患者中引起疾病的物种（例如鸟分枝杆菌，a木和耻垢分枝杆菌）。

59. 发明申请

US20020045612A1 Endocrine modulation with positive modulators of AMPA type glutamate receptors 失效
标题翻译：内分泌调节与AMPA型谷氨酸受体的正调节剂
公开(公告)号：US20020045612A1
公开(公告)日：2002-04-18
申请号：US09964288
申请日：2001-09-26
发明人： Peter Van Der Klish , Gary Lynch
IPC分类号： A61K031/555 , A61K031/33 , A61K031/35
CPC分类号： A61K31/55 , A61K31/00 , A61K31/4025 , A61K31/44 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/4453 , A61K31/453 , A61K31/5365
摘要： Methods for modulating the endocrine system of a mammal are provided. In the subject methods, a positive allosteric modulator of AMPA receptors of the hypothalamus are administered to the host. The subject methods find use in applications where it is desired to increase the circulatory level of a hormone in a mammalian host, such as diseased states characterized by abnormally depressed circulatory levels of the hormone.
摘要翻译：提供了调节哺乳动物内分泌系统的方法。在本方法中，向宿主施用下丘脑AMPA受体的正变构调节剂。本发明的方法可用于希望增加哺乳动物宿主中激素循环水平的应用，例如以激素异常下降的循环水平为特征的病态。

60. 发明申请

US20020034543A1 Nutritional composition 审中-公开
公开(公告)号：US20020034543A1
公开(公告)日：2002-03-21
申请号：US09949710
申请日：2001-09-12
申请人： DRUGTECH CORPORATION
发明人： Mitchell I. Kirschner , R. Saul Levison , George N. Paradissis
IPC分类号： A61K009/20 , A61K031/555 , A61K031/525 , A61K031/375
CPC分类号： A61K33/30 , A23L33/15 , A23L33/16 , A23V2002/00 , A61K9/0056 , A23V2250/708 , A23V2250/7052 , A23V2250/7106 , A23V2250/712 , A23V2250/1592 , A23V2250/1588 , A23V2250/161 , A23V2250/71 , A23V2250/1642 , A61K2300/00 , A23V2250/211 , A23V2250/704 , A23V2250/702 , A23V2250/705 , A23V2250/156 , A23V2250/70 , A23V2250/1578 , A23V2250/1608 , A23V2250/1586 , A23V2250/16
摘要： The present inventive subject matter is directed to novel chewable prenatal nutritional supplements which contain vitamin C, as well as novel methods for providing optimal vitamin C supplementation to pregnant women. The present invention is also directed to novel compositions and methods for providing nutritional supplementation to individuals planning to conceive a child.

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