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51. 发明申请

US20030139479A1 Non-halogenated biphenyl triol compounds, antimicrobial compositions containing the same, and methods of using the same 审中-公开
标题翻译：非卤化联苯三醇化合物，含有它们的抗微生物组合物及其使用方法
公开(公告)号：US20030139479A1
公开(公告)日：2003-07-24
申请号：US10319723
申请日：2002-12-13
发明人： D. Scott Harper , Robert A. Coburn , Andre Soshinsky , Marianne D. Huntley
IPC分类号： C07C039/12 , A61K031/05
CPC分类号： C07C39/17 , A01N31/16 , A61K8/347 , A61Q11/00 , A61Q15/00
摘要： A antimicrobial compound, compositions containing the same, and method of using the same for reducing the presence of microorganism on a substrate or in a fluid environment comprising an antimicrobial effective carrier and at least one antimicrobial compounds including non-halogenated biphenyl triol compounds.
摘要翻译：抗微生物化合物，含有它们的组合物，以及使用该抗微生物化合物的方法，以及使用该抗微生物化合物来减少微生物在底物或流体环境中的存在的方法，其包含抗微生物有效载体和至少一种包括非卤代联苯三醇化合物的抗微生

52. 发明申请

US20030138489A1 Anaesthetic formulations 失效
标题翻译：麻醉制剂
公开(公告)号：US20030138489A1
公开(公告)日：2003-07-24
申请号：US10203737
申请日：2002-10-31
发明人： John Meadows , James David Du Mayne
IPC分类号： A61K009/14 , A61K031/05
CPC分类号： A61K31/05 , A61K9/0019 , A61K47/26 , Y10S514/937
摘要： Propofol solubilised in aqueous micellar preparations of poloxamers is stable at low concentrations and that such preparations are effective administration forms for Propofol.
摘要翻译：溶解在泊洛沙姆的水性胶束制剂中的丙泊酚在低浓度下是稳定的，并且这种制剂是丙泊酚的有效给药形式。

53. 发明申请

US20030133945A1 Natural food supplement 审中-公开
标题翻译：天然食品补充
公开(公告)号：US20030133945A1
公开(公告)日：2003-07-17
申请号：US10045824
申请日：2002-01-11
发明人： Michael Donald Farley
IPC分类号： A61K035/78 , A61K031/7048 , A61K031/198 , A61K031/685 , A61K031/404 , A61K031/015 , A61K031/05
CPC分类号： A61K31/404 , A23L31/00 , A23L33/105 , A23V2002/00 , A61K31/015 , A61K31/05 , A61K31/198 , A61K31/685 , A61K31/7048 , A61K36/82 , A61K36/9066 , A61K2300/00 , A23V2250/208 , A23V2250/21 , A23V2250/214 , A23V2250/1626
摘要： The present invention is a food supplement for a human body's natural immune function, formed from natural occurring substances in the form of a broth. The food supplement consists of the following: (a) 1 to 35 mg. per mnilliliternullApigenin (b) 200 to 600 mg.nullChrysin (c) 200 to 600 mg.nullColorius Versicolor (d) 50 to 150 mg.null3,3null Diindolymethane (DIM) (e) 50 to 150 mg.nullResveratrol 25% (f) 50 to 150 mg.nullTurmeric Extract 95% (g) 40 to 140 mg.nullGreen Tea Extract 95% (h) 20 to 80 mg.nullQuercitin Dihydrate 99% (i) 15 to 75 mg.nullPhosphtidyl Choline 50% (j) Trace mineral selenium-Lnull10 to 60 mgs. L-Selenium Methionine (5000 mcg/gr) It may be advantageous to also include 25 mg to about 150 mg. of Myricetin.
摘要翻译：本发明是由肉汤形式的天然发生物质形成的人体天然免疫功能的食品补充剂。食物补充剂包括以下物质：（a）1至35mg。（b）200至600mg.- Chrysin（c）200至600mg- Colorius Versicolor（d）50至150mg.-3,3'二聚甲烷（DIM）（e）50至150mg。 - 白藜芦醇25％（f）50至150mg-姜黄提取物95％（g）40至140mg-绿茶提取物95％（h）20至80mg-槲皮素二水合物99％（i）15至75 mg.-磷脂酰胆碱50％（j）痕量矿物硒-L-10至60mg。 L-硒甲硫氨酸（5000mcg / gr）也可以包括25mg至约150mg。的杨梅素。

54. 发明申请

US20030118676A1 Novel herbal chemical composition for the treatment of cancer 有权
标题翻译：用于治疗癌症的新型草药化学成分
公开(公告)号：US20030118676A1
公开(公告)日：2003-06-26
申请号：US10013133
申请日：2001-12-07
发明人： Janaswamy Madhusudana Rao , Pullela Venkata Srinivas , Jhillu Singh Yadav , Kondapuram Vijaya Raghavan , A.K. Saxena , M. Shanmugavel , Himani Kampasi , Gulam Nabi Qazi
IPC分类号： A61K035/78 , A61K031/05
CPC分类号： A61K31/05 , A61K36/13
摘要： The present invention relate to a novel synergistic composition of lignans exhibiting anticancer activities for breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate cancer obtained from the plant extract of Cedrus deodra, said composition comprising_of (null)-Matairesinol in the range of 9 to 13% by weight, (null)-Wikstromol in the range of 75 to 79% by weight, Dibenzylbutyrolactol in the range of 7 to 11% by weight, and Unidentified material in the range of 2.6 to 3% by weight; further, the synergistic composition of lignan is used in combination with pharmaceutically acceptable carriers for inhibiting growth of various human cancer cell lines selected from breast, cervix, neuroblastoma, colon, liver, lung, mouth, ovary and prostate tissues.
摘要翻译：本发明涉及从Cedrus deodra植物提取物获得的乳腺，子宫颈，成神经细胞瘤，结肠，肝，肺，口腔，卵巢和前列腺癌的抗癌活性的新型协同组合物，所述组合物包含（ - ） - 马塔瑞诺醇（ - ） - 维生素C在75至79重量％的范围内，二苄基丁内酯的范围为7至11重量％，不明物质的范围为2.6至3重量％重量此外，木酚素的协同组合与药学上可接受的载体组合使用，用于抑制选自乳腺，子宫颈，成神经细胞瘤，结肠，肝，肺，口，卵巢和前列腺组织的各种人类癌细胞系的生长。

55. 发明申请

US20030100514A1 Method of inhibiting overactivity of phagocytes or lymphocytes in an individual 有权
标题翻译：抑制个体吞噬细胞或淋巴细胞过度活跃的方法
公开(公告)号：US20030100514A1
公开(公告)日：2003-05-29
申请号：US09991971
申请日：2001-11-26
发明人： Markku Ahotupa , John Eriksson , Lauri Kangas , Mikko Unkila , Janne Komi , Merja Perala , Helena Korte
IPC分类号： A61K031/365 , A61K031/05
CPC分类号： A61K31/05 , A61K31/365
摘要： This invention relates to a method of inhibiting the overactivity of phagocytes or lymphocytes in an individual by administering to said individual an effective amount of a lignan, wherein i) the phagocytes are neutrophils and the lignan is hydroxymatairesinol or matairesinol or mixtures thereof, or ii) the phagocytes are cells of myeloid origin and the lignan is enterolactone or hydroxymatairesinol or mixtures thereof, or iii) the lymphocytes are T-lymphocytes and the lignan is hydroxymatairesinol, matairesinol or enterolactone or mixtures thereof. Furthermore, this invention concerns a method of treating or preventing an acute ischemia-reperfusion injury or a chronic condition, caused by overactivity of phagocytes or lymphocytes in an individual, said method comprising decreasing the activity of phagocytes in an individual by administering to said individual an effective amount of a lignan.
摘要翻译：本发明涉及一种通过向所述个体施用有效量的木脂素来抑制个体中吞噬细胞或淋巴细胞的过度活性的方法，其中i）吞噬细胞是嗜中性粒细胞，并且所述木酚素是羟基亚麻醇或马来亚硫醇或其混合物，或ii）吞噬细胞是骨髓来源的细胞，木脂素是肠内酯或羟基亚麻苦醇或其混合物，或iii）淋巴细胞是T淋巴细胞，木脂素是羟基亚麻醇，马来西林或肠内酯或其混合物。此外，本发明涉及一种治疗或预防由个体吞噬细胞或淋巴细胞的过度活动引起的急性缺血再灌注损伤或慢性病症的方法，所述方法包括通过向所述个体施用个体来减少吞噬细胞的活性有效量的木脂素。

56. 发明申请

US20030092719A1 Methods and kits for treating depression or preventing deterioration of cognitive function 审中-公开
标题翻译：治疗抑郁症或预防认知功能恶化的方法和试剂盒
公开(公告)号：US20030092719A1
公开(公告)日：2003-05-15
申请号：US10132907
申请日：2002-04-24
发明人： Wesley W. Day , Andrew G. Lee , David D. Thompson , Charles D. Petrie
IPC分类号： A61K031/505 , A61K031/517 , A61K031/47 , A61K031/4709 , A61K031/4439 , A61K031/05
CPC分类号： A61K45/06 , A61K31/05 , A61K31/4439 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/505 , A61K31/517 , A61K31/55 , A61K2300/00
摘要： The present invention provides methods and kits for treating depression, perimenopausal depression, schizophrenia, anxiety, panic attacks, binge eating, social phobia, or preventing deterioration of cognitive function by administering to a patient in need thereof a therapeutically effect amount of an estrogen agonist/antagonist of formula I 1
摘要翻译：本发明提供了治疗抑郁症，围绝经期抑郁症，精神分裂症，焦虑症，惊恐发作，暴饮暴食，社交恐惧症或通过对有需要的患者施用治疗有效量的雌激素激动剂/ 式I的拮抗剂

57. 发明申请

US20030086986A1 Ophthalmic, pharmaceutical and other healthcare preparations with naturally occurring plant compounds, extracts and derivatives 审中-公开
标题翻译：具有天然植物化合物，提取物和衍生物的眼科，制药和其他保健制剂
公开(公告)号：US20030086986A1
公开(公告)日：2003-05-08
申请号：US10117533
申请日：2002-04-04
发明人： Chris De Bruijn , F. Richard Christ , Anthony J. Dziabo , Joseph Vigh
IPC分类号： A61K035/78 , A61K031/235 , A61K031/05
CPC分类号： A61K31/155 , A61K9/0048 , A61K31/05 , A61K31/11 , A61K31/192 , A61K31/4166 , A61K31/7048 , A61L12/08 , A61L12/14 , A61L12/143 , C11D3/0078 , C11D3/382 , C11D7/44 , A61K2300/00
摘要： A number of discrete, isolated and well-characterized natural plant compounds show antimicrobial activity when used for topical applications in the ophthalmic, skin care, oral care, pharmaceutical, medical device, heath care products or similar preparations for topical application. Of particular interest are Allantoin, Berberine, Bilberry extract, Caffeic Acid Phenethyl Ether, Chlorogenic Acid, Cranberry Extract, Elderberry Extract, Ferulic Acid, Green Tea Extract, Grape Seed Extract, Hydroxytyrosol, Oleuropein, Olive Leaf Extract, Pine Bark Extract, Pomegranate Extract, Pycnogenol, Quercetin, Resveratrol, and Tart Cherry Extract. Oleuropein, and Pomegranate Extract, either alone or in combination, is extremely effective. Allantoin, can be used to enhance the efficacy of synthetic chemical disinfecting/preservative agents as well as to mitigate the cytotoxicity of some synthetic chemical disinfecting/preservative agents.
摘要翻译：当用于眼科，皮肤护理，口腔护理，制药，医疗器械，护理产品或用于局部应用的类似制剂时，许多离散，分离和良好表征的天然植物化合物显示出抗微生物活性。特别感兴趣的是尿囊素，小檗碱，越桔提取物，咖啡酸苯乙醚，绿原酸，蔓越莓提取物，接骨木提取物，阿魏酸，绿茶提取物，葡萄籽提取物，羟基酪醇，橄榄精，橄榄叶提取物，松树皮提取物，石榴提取物，碧萝芷，槲皮素，白藜芦醇和挞樱桃提取物。橄榄精和石榴提取物，单独或组合，是非常有效的。尿囊素可用于提高合成化学消毒/防腐剂的功效，并减轻某些合成化学消毒/防腐剂的细胞毒性。

58. 发明申请

US20030060484A1 Hepatitis a viricide 有权
标题翻译：肝炎杀戮
公开(公告)号：US20030060484A1
公开(公告)日：2003-03-27
申请号：US10168442
申请日：2002-09-18
发明人： Friedrich Von Rheinbaben , Holger Biering , Klaus-Peter Bensemir , Sabine Glaeser
IPC分类号： A61K031/47 , A61K031/44 , A61K031/425 , A61K031/4035 , A61K031/05 , A61K031/045
CPC分类号： A01N31/02 , A01N47/44 , A01N2300/00
摘要： The invention relates to agents which combat the hepatitus A virus, containing only minimal amounts of chlorine-containing and/or chlorine cleaving active ingredients, or none of said substances. The inventions also relates to the use of these agents and to a method for their production.
摘要翻译：本发明涉及与仅含有最少量含氯和/或氯裂解活性成分或不含所述物质的肝病A病毒相抗衡的药剂。本发明还涉及这些试剂的使用及其生产方法。

59. 发明申请

US20030053968A1 Compositions for the treatment of pigmentation disorders and methods for their manufacture 有权
公开(公告)号：US20030053968A1
公开(公告)日：2003-03-20
申请号：US09864083
申请日：2001-05-23
发明人： Mitchell S. Wortzman , Philip J. Gordon , Eugene H. Gans , Bhiku G. Patel
IPC分类号： A61K007/135 , A61K007/021 , A61K031/375 , A61K031/05
CPC分类号： A61Q19/02 , A61K8/23 , A61K8/347 , A61K8/676 , A61K31/02 , A61K31/20 , A61K31/34 , A61K31/375 , A61K45/06 , Y10S514/844 , Y10S514/846 , A61K2300/00
摘要： The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. Protected retinoid may be added to these compositions for additional skin benefit effects.

60. 发明申请

US20030004211A1 Carbohydrate modifying agent and drinks containing the modifying agent 审中-公开
标题翻译：碳水化合物改性剂和含有改性剂的饮料
公开(公告)号：US20030004211A1
公开(公告)日：2003-01-02
申请号：US10155314
申请日：2002-05-22
发明人： Frank Corsini , Richard L. Kozlenko , Joe A. Vinson
IPC分类号： A61K031/353 , A61K031/7048 , A61K031/715 , A61K031/198 , A61K031/05
CPC分类号： A23L2/66 , A23C9/13 , A23L2/52 , A23L2/54 , A23L33/105 , A23L33/15 , A23L33/16 , A23L33/175 , A23L33/185 , A23L33/21 , A23L33/22 , A23V2002/00 , A23V2250/5062 , A23V2250/2116 , A23V2250/214 , A23V2250/2106 , A23V2250/1642 , A23V2250/708 , A23V2250/5488 , A23V2250/0622
摘要： The present invention provides a composition that modulates the rate of sugar absorption and/or metabolism in a subject to whom the composition is administered. The composition includes active soluble fiber, one or more polyphenolic compounds, and a source of amino acids. The composition may be used dry in formulating foodstuffs and beverages. In a preferred embodiment, the composition is a component of a finished beverage, such as a carbonated soft drink.
摘要翻译：本发明提供调节施用组合物的受试者中糖吸收和/或代谢速率的组合物。组合物包括活性可溶性纤维，一种或多种多酚化合物和氨基酸来源。组合物可以在配制食品和饮料中干燥使用。在优选的实施方案中，组合物是成品饮料的组分，例如碳酸软饮料。

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