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51. 发明申请

WO2013174988A1 METHODS FOR PREDICTING AND MONITORING TREATMENT RESPONSE IN HCV- AND HCV/HIV-INFECTED SUBJECTS 审中-公开
标题翻译：预防和监测HCV感染和丙型肝炎病毒感染个体的治疗反应的方法
公开(公告)号：WO2013174988A1
公开(公告)日：2013-11-28
申请号：PCT/EP2013/060770
申请日：2013-05-24
申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ DE MONTPELLIER I , CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER
发明人： RUBBO, Pierre-Alain , REIHANI, Niloofar , TUAILLON, Edouard , VAN DE PERRE, Philippe , NAGOT, Nicolas
IPC分类号： G01N33/569 , G01N33/68
CPC分类号： G01N33/56983 , G01N33/56988 , G01N33/6863 , G01N33/6869 , G01N2333/16 , G01N2333/186 , G01N2333/522 , G01N2333/523 , G01N2333/5406 , G01N2333/5412 , G01N2333/5418 , G01N2333/5421 , G01N2800/52
摘要： The present invention relates to methods and compositions for predicting and monitoring treatment response in HCV- and HCV/HIV-infected subjects.
摘要翻译：本发明涉及用于预测和监测HCV和HCV / HIV感染受试者的治疗反应的方法和组合物。

52. 发明专利

KR20210033037A KR20210033037A - Methods and compositions for modulating th-gm cell function 审中-公开
公开(公告)号：KR20210033037A
公开(公告)日：2021-03-25
申请号：KR1020217005240A
申请日：2015-09-25
申请人： 내셔널 유니버시티 오브 싱가포르
发明人： 신-위안 푸 , 완치앙 셍 , 용리앙 장 , 팬 양
IPC分类号： G01N33/564 , A61K39/00 , C12N5/0783 , C12Q1/6883
CPC分类号： G01N33/564 , A61K31/4433 , A61K39/0008 , A61P19/02 , A61P25/00 , A61P29/00 , A61P37/00 , C12N5/0636 , C12N5/0637 , C12Q1/6883 , G01N33/6863 , G01N33/6869 , C12N2501/2307 , C12N2501/24 , C12N2501/51 , C12N2501/515 , C12N2501/60 , C12N2501/727 , C12Q2600/118 , C12Q2600/158 , G01N2333/4706 , G01N2333/535 , G01N2333/5403 , G01N2333/5418 , G01N2800/102 , G01N2800/285
摘要： 본 명세서는 IL-7/STAT5에 의해 조절되고 GM-CSF/IL-3을 분비하는 T-헬퍼 세포("T
H -GM" 세포)를 개시한다. 또한 예를 들어 염증 질환의 치료를 위해 T
H -GM 기능을 조절하기 위한 방법 및 조성물을 개시한다. 비-T
H -GM-매개된(예를 들어 TNF-α-매개된) 염증 질환과 다른, 및/또는 상기 질환 외에, T
H -GM-매개된 염증 질환(예를 들어 류머티스성 관절염)을 특이적으로 식별하기 위한 진단 및 예측 방법을 또한 제공한다.

53. 发明专利

JP2010512744A Thymic stromal phosphorus ho erythropoietin protein of the dog and the use thereof 审中-公开
公开(公告)号：JP2010512744A
公开(公告)日：2010-04-30
申请号：JP2009541349
申请日：2007-12-11
申请人：シェーリング−プラウ・リミテッド
发明人：ダニエルエム．ゴーマン， , ワールマルフィート，レネデ , ジャニーンディー．マットソン， , ムハマドエー．モーシー，
IPC分类号： C12N15/09 , A61K39/00 , A61K39/39 , A61P37/08 , C07K14/47 , C07K16/42 , C12P21/02 , G01N33/53
CPC分类号： C07K16/24 , A61K39/0005 , A61K2039/53 , A61K2039/552 , C07K14/5418 , C07K16/464 , C07K2317/33 , G01N2333/5418 , G01N2800/202
摘要：本発明は、イヌＴＳＬＰタンパク質およびこのタンパク質をコードする核酸を開示する。また、イヌＴＳＬＰタンパク質の特異的なエピトープを含むタンパク質のペプチド断片を開示する。イヌＴＳＬＰタンパク質および関連のペプチド断片は、免疫学的アッセイおよび抗ＴＳＬＰ抗体を誘発するワクチンに対する抗原として使用し得る。さらに、本発明は、イヌＴＳＬＰ遺伝子、イヌＴＳＬＰタンパク質および関連のペプチド断片を作製および使用する方法を開示する。

54. 发明公开

EP3198007A1 METHODS AND COMPOSITIONS FOR MODULATING TH-GM CELL FUNCTION 有权
标题翻译：调节TH-GM细胞功能的方法和组合物
公开(公告)号：EP3198007A1
公开(公告)日：2017-08-02
申请号：EP15843971.1
申请日：2015-09-25
申请人： National University of Singapore
发明人： FU, Xin-yuan , SHENG, Wanqiang , ZHANG, Yongliang , YANG, Fan
IPC分类号： C12N5/0783 , C12Q1/68 , G01N33/53 , A61P37/00
CPC分类号： G01N33/564 , A61K31/4433 , A61K39/0008 , C12N5/0636 , C12N5/0637 , C12N2501/2307 , C12N2501/24 , C12N2501/51 , C12N2501/515 , C12N2501/60 , C12N2501/727 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , G01N33/6863 , G01N33/6869 , G01N2333/4706 , G01N2333/535 , G01N2333/5403 , G01N2333/5418 , G01N2800/102 , G01N2800/285
摘要： Disclosed herein is a T-helper cell (“TH-GM” cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating TH-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying TH-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-TH-GM-mediated (e.g., TNF-α-mediated) inflammatory disorders, are also provided.
摘要翻译：本文公开了受IL-7 / STAT5调节并分泌GM-CSF / IL-3的T辅助细胞（“TH-GM”细胞）。还公开了用于调节TH-GM功能以治疗例如炎性病症的方法和组合物。与非TH-GM介导的（例如TNF-α介导的）炎性病症不同和/或除了TH-GM介导的（例如TNF-α介导的）炎性病症之外，用于特异性鉴定TH-GM介导的炎性病症（例如类风湿性关节炎）的诊断和预后方法是还提供。

55. 发明公开

EP2955196A1 Antibodies directed against CD127 审中-公开
标题翻译： Gegen CD127 gerichteteAntikörper
公开(公告)号：EP2955196A1
公开(公告)日：2015-12-16
申请号：EP15305078.6
申请日：2015-01-23
申请人： Effimune
发明人： Poirier, Nicolas , Mary, Caroline , Vanhove, Bernard
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94 , G01N33/5041 , G01N33/6854 , G01N2333/5418 , G01N2333/70546 , G01N2333/7155 , G01N2500/00
摘要： The invention relates to antibodies directed against CD127, the alpha chain of the interleukin 7 (IL-7) receptor IL-7R), and whichi have antagonist properties for IL-7-IL-7R interaction, may present cytotoxic activity against CD127 positive cells but do not increase the maturation of dendritic cells (DCs) induced by TSLP, a cytokine also using CD127 as part of its receptor. Alternatively, or in addition, these antibodies do not induce the internalization of CD127 and/or inhibit the IL7-induced internalization of CD127. According to another aspect of the invention antibodies are provided which recognize a human CD127 epitope comprising the human CD127 sequences of SEQ ID No: 110 and/or SEQ ID No: 111. The antibodies of the invention are suitable for use in order to remedy to a condition diagnosed in a human patient which results from pathogenesis related to lymphopoiesis, when IL-7 signalling pathways provide contribution to said pathogenesis, especially when an increase in the maturation, more precisely the upregulation of costimulatory molecules, of dendritic cells is undesirable.
摘要翻译：本发明涉及针对CD127，白细胞介素7（IL-7）受体IL-7R的α链）及其具有IL-7-IL-7R相互作用的拮抗剂性质的抗体可能对CD127阳性细胞具有细胞毒活性但不会增加由TSLP诱导的树突状细胞（DC）的成熟，细胞因子也使用CD127作为其受体的一部分。或者或另外，这些抗体不诱导CD127的内化和/或抑制IL7诱导的CD127内化。根据本发明的另一方面，提供了抗体，其识别包含SEQ ID No：110和/或SEQ ID No：111的人CD127序列的人CD127表位。本发明的抗体适用于补救特别是当IL-7信号通路对所述发病机制作出贡献时，特别是当树突状细胞的共刺激分子的上调增加是不期望的时，特别是当增加成熟度时，由患有淋巴细胞生成的发病机制导致的人类患者诊断出的症状。

56. 发明公开

EP2649449A2 BIOMARKERS FOR TUBERCULOSIS AND HIV/AIDS 审中-公开
标题翻译：生物标记结核病和艾滋病毒/艾滋病
公开(公告)号：EP2649449A2
公开(公告)日：2013-10-16
申请号：EP11877185.6
申请日：2011-12-09
申请人： Steyn, Andries J.C. , Crossman, David K. , Henostroza, German , Kimerling, Michael
发明人： Steyn, Andries J.C. , Crossman, David K. , Henostroza, German , Kimerling, Michael
IPC分类号： G01N33/569 , G01N33/68 , C12Q1/04 , G06F17/00
CPC分类号： G01N33/5695 , G01N33/56988 , G01N33/6863 , G01N33/6869 , G01N2333/35 , G01N2333/49 , G01N2333/523 , G01N2333/525 , G01N2333/535 , G01N2333/5412 , G01N2333/5415 , G01N2333/5418 , G01N2333/5434 , G01N2333/55 , G01N2333/70503 , G01N2333/70546 , G01N2333/715 , G01N2800/60 , G06F19/10 , G06F19/18
摘要： Described herein is a diagnostic test that identifies circulating biomarkers for the differentiation and classification of the pathogenesis of TB and/or HIV in a population.

57. 发明公开

EP2585827A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
标题翻译：方法和组合物诊断和预后肾损伤和肾功能衰竭的
公开(公告)号：EP2585827A1
公开(公告)日：2013-05-01
申请号：EP11798516.8
申请日：2011-06-23
申请人： Astute Medical, Inc.
发明人： ANDERBERG, Joseph , GRAY, Jeff , MCPHERSON, Paul , NAKAMURA, Kevin , KAMPF, James, Patrick
IPC分类号： G01N33/48 , G01N33/53
CPC分类号： G01N33/6893 , G01N2333/475 , G01N2333/49 , G01N2333/52 , G01N2333/521 , G01N2333/54 , G01N2333/5418 , G01N2333/71 , G01N2333/7155 , G01N2333/96494 , G01N2800/347 , G01N2800/50 , G01N2800/52 , G01N2800/56
摘要： The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect MMP9:TIMP2 complex and optionally further a kidney injury marker of Thymic stromal lymphopoietin, Vascular endothelial growth factor receptor 1, C-C motif chemokine 1, C-C motif chemokine 17, C-C motif chemokine 21, C-C motif chemokine 27, FLT-3 Ligand, Immunoglobulin G subclass 3, Interleukin-1 receptor type I, Interleukin-20, Interleukin-29, Interleukin-7, Platelet-derived growth factor A/B dimer, Platelet-derived growth factor A/A dimer, and as diagnostic and prognostic biomarkers in renal injuries.

58. 发明公开

EP2252325A2 TREATMENT OF POMPE DISEASE WITH SPECIFIC PHARMACOLOGICAL CHAPERONES AND MONITORING TREATMENT USING SURROGATE MARKERS 审中-公开
标题翻译：治疗克罗恩热泵在某些药理伴侣监测和治疗的替代指标
公开(公告)号：EP2252325A2
公开(公告)日：2010-11-24
申请号：EP09720946.4
申请日：2009-03-12
申请人： Amicus Therapeutics, Inc.
发明人： WUSTMAN, Brandon , DO, Hung, V.
IPC分类号： A61K38/47
CPC分类号： G01N33/6893 , G01N33/5091 , G01N2333/49 , G01N2333/515 , G01N2333/5412 , G01N2333/5418 , G01N2333/5421 , G01N2800/042 , G01N2800/52
摘要： Provided is a method of monitoring the treatment of Pompe disease with specific pharmacological chaperones using systemic and/or cellular surrogate markers.

59. 发明申请

WO2018223001A1 PREDICTIVE FACTORS FOR TIMING OF WOUND CLOSURE 审中-公开
公开(公告)号：WO2018223001A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035612
申请日：2018-06-01
申请人： THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.
发明人： ELSTER, Eric A. , SCHOBEL-MCHUGH, Seth A. , GAUCHER, Beverly J. , LISBOA, Filipe A.
IPC分类号： G01N33/68 , G01N33/50 , C12Q1/68
CPC分类号： G01N33/6869 , G01N2333/5412 , G01N2333/5418 , G01N2333/5421 , G01N2333/5428
摘要： The present invention relates to methods for treating an open wound. The levels of certain cytokines in serum and wound effluent from a human subject with an open wound are compared to cytokine levels in persons whose wounds were closed successfully or failed to close. The wound is surgically closed if the cytokines levels and wound history of the human subject are favorable. Alternatively, the wound is left open and additional biological samples are analyzed at a later date.

60. 发明申请

WO2013186562A1 BIOMARKERS FOR PSYCHOTIC DISORDERS, LIKE DEPRESSION AND ANXIETY DISORDER 审中-公开
标题翻译：心理障碍的生物标志物，像抑郁症和恶心病
公开(公告)号：WO2013186562A1
公开(公告)日：2013-12-19
申请号：PCT/GB2013/051550
申请日：2013-06-12
申请人： CAMBRIDGE ENTERPRISE LIMITED , STICHTING VU-VUMC
发明人： BAHN, Sabine , SCHWARZ, Emanuel , PENNIX, Brenda , VOGELZANGS, Nicole
IPC分类号： G01N33/68
CPC分类号： G01N33/6869 , G01N33/573 , G01N33/68 , G01N33/6863 , G01N33/6866 , G01N2333/435 , G01N2333/525 , G01N2333/54 , G01N2333/5403 , G01N2333/5406 , G01N2333/5409 , G01N2333/5412 , G01N2333/5418 , G01N2333/5421 , G01N2333/5428 , G01N2333/55 , G01N2333/555 , G01N2333/57 , G01N2333/96494 , G01N2800/30 , G01N2800/301
摘要： The invention relates to biomarkers and a method of diagnosing or monitoring depression, anxiety disorder or other psychotic disorder.
摘要翻译：本发明涉及生物标志物和诊断或监测抑郁症，焦虑障碍或其它精神病症的方法。

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