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51. 发明申请

US20030092163A1 Probiotic bifidobacterium strains 审中-公开
标题翻译：益生菌双歧杆菌菌株
公开(公告)号：US20030092163A1
公开(公告)日：2003-05-15
申请号：US10201940
申请日：2002-07-25
发明人： John Kevin Collins , Gerald Christopher O'Sullivan , Liam O'Mahony , Fergus Shanahan , Barry Kiely
IPC分类号： C12N001/20 , C12N001/21
CPC分类号： C12N1/20 , A23L33/135 , A23Y2300/00 , A23Y2300/55 , A61K35/745 , C12R1/02
摘要： A Bifidobacterium strain, AH208, AH209, AH210, AH211, AH212 or AH214 or mutants or variants thereof are useful in the prophylaxis and/or treatment of inflammatory activity especially undesirable gastrointestinal inflammatory activity, such as inflammatory bowel disease or irritable bowel syndrome.
摘要翻译：双歧杆菌菌株，AH208，AH209，AH210，AH211，AH212或AH214或其突变体或变体可用于预防和/或治疗炎性活动，特别是不期望的胃肠炎症活动，例如炎性肠病或肠易激综合征。

52. 发明授权

US6096528A Thermotolerant and high acetic acid-producing Acetobacter bacterium 有权
标题翻译：耐热和高醋酸生产的醋杆菌细菌
公开(公告)号：US6096528A
公开(公告)日：2000-08-01
申请号：US370784
申请日：1999-08-05
申请人： Shu-Fen Lu , Fwu-Ling Lee , Han-Ken Chen
发明人： Shu-Fen Lu , Fwu-Ling Lee , Han-Ken Chen
IPC分类号： C12P7/54 , C12N1/20 , C07C53/08 , C07C53/10
CPC分类号： C12R1/02 , C12P7/54
摘要： The present invention relates to a thermotolerant bacterium, designated as Acetobacter sp. I14-2, with high production of acetic acid which was isolated from spoiled banana in Taiwan. The present invention also relates to compositions containing the new species and methods for acetic acid production.
摘要翻译：本发明涉及一种耐热细菌，称为醋杆菌属（Accetobacter sp。）。 I14-2，高产量的乙酸，从台湾被宠坏的香蕉中分离出来。本发明还涉及含有新物质和乙酸生产方法的组合物。

53. 发明授权

US5962278A Cellulose-producing bacteria 失效
标题翻译：纤维素生产菌
公开(公告)号：US5962278A
公开(公告)日：1999-10-05
申请号：US973757
申请日：1998-02-03
申请人： Takayasu Tsuchida , Naoto Tonouchi , Akira Seto , Yukiko Kojima , Masanobu Matsuoka , Fumihiro Yoshinaga
发明人： Takayasu Tsuchida , Naoto Tonouchi , Akira Seto , Yukiko Kojima , Masanobu Matsuoka , Fumihiro Yoshinaga
IPC分类号： C12P19/04 , C12R1/02 , C12N1/20
CPC分类号： C12R1/02 , C12P19/04 , Y10S435/823
摘要： This invention relates to a microorganism that is capable of producing a cellulosic product (referred to hereinafter as a "cellulose-producing bacterium") and belongs to a novel subspecies which is substantialy negative or very slightly positive in oxidation of acetates and lactates. This invention also relates to novel saccharide analog-resistant strains, amino acid analog-resistant strains and levan sucrase-defective strains.Further, this invention relates to a method for the production of cellulosic material (bacterial cellulose: "BC"), which comprises culturing these novel bactria and to bacterial cellulose which may be thus obtained.A larger amount of bacterial cellulose may be produced by culturing Acetobacter xylinum subsp. nonacetoxidans, the present resistant strains and the levan sucrase-defective strains, which have been derived and bred from the cellulose-producing bacteria, than by culturing the BPR 2001 strain in the medium containing especially sucrose or glucose as carbon sources.
摘要翻译： PCT No.PCT / JP97 / 00514 Sec。 371日期1998年2月3日 102（e）日期1998年2月3日PCT 1997年2月24日提交PCT公布。出版物WO97 / 40135 日期1997年10月30日本发明涉及一种能够生产纤维素产品（以下称为“纤维素生产菌”）的微生物，属于新陈代谢，其在乙酸酯的氧化中具有显着的负性或非常微量的阳性和乳酸盐。本发明还涉及新型糖类似物抗性菌株，氨基酸类似物抗性菌株和levan蔗糖酶缺陷菌株。此外，本发明涉及一种生产纤维素材料（细菌纤维素“BC”）的方法，该方法包括培养这些新型细菌和可得到的细菌纤维素。可以通过培养木醋杆菌（Subst。）来生产更多的细菌纤维素。通过在特别是蔗糖或葡萄糖作为碳源的培养基中培养BPR 2001菌株，从纤维素生产细菌中衍生和繁殖的本发明的耐药菌株，本发明的抗性菌株和levan蔗糖酶缺陷菌株。

54. 发明授权

US5268274A Methods and nucleic acid sequences for the expression of the cellulose synthase operon 失效
标题翻译：用于表达纤维素合成酶操纵子的方法和核酸序列
公开(公告)号：US5268274A
公开(公告)日：1993-12-07
申请号：US689008
申请日：1991-04-22
申请人： Arie Ben-Bassat , Roger D. Calhoon , Anna L. Fear , David H. Gelfand , James H. Meade , Rony Tal , Hing Wong , Moshe Benziman
发明人： Arie Ben-Bassat , Roger D. Calhoon , Anna L. Fear , David H. Gelfand , James H. Meade , Rony Tal , Hing Wong , Moshe Benziman
IPC分类号： C07K14/195 , C12N1/21 , C12N9/10 , C12N9/88 , C12N15/52 , C12N15/54 , C12N15/72 , C12N15/74 , C12N15/00 , C12P19/04
CPC分类号： C12N9/1059 , C07K14/195 , C12N15/52 , C12N15/72 , C12N15/74 , C12N9/88 , C12R1/02 , Y10S435/823
摘要： Nucleic acid sequences encoding the bacterial cellulose synthase operon derived from Acetobacter are disclosed. Methods for isolating the genes, vectors containing the genes, and transformed hosts useful for the expression of recombinant bacterial cellulose synthase or production of cellulose are also described.
摘要翻译：公开了编码源自醋杆菌的细菌纤维素合成酶操纵子的核酸序列。还描述了分离基因的方法，含有该基因的载体和用于表达重组细菌纤维素合成酶或纤维素生产的转化宿主。

55. 发明授权

US5079162A Reticulated cellulose and methods and microorganisms for the production thereof 失效
标题翻译：网状纤维素及其生产方法和微生物
公开(公告)号：US5079162A
公开(公告)日：1992-01-07
申请号：US196496
申请日：1988-05-19
申请人： Arie Ben-Bassat , Robert Bruner , Sharon Shoemaker , Yehoshua Aloni , Harry Wong , Donald C. Johnson , Amar N. Neogi
发明人： Arie Ben-Bassat , Robert Bruner , Sharon Shoemaker , Yehoshua Aloni , Harry Wong , Donald C. Johnson , Amar N. Neogi
IPC分类号： A61L15/28 , C12P19/04
CPC分类号： C12R1/02 , A61L15/28 , C12P19/04 , Y10S435/823
摘要： A method and media for producing bacterial cellulose under agitated culture conditions resulting in sustained production over an average of 70 hours of at least 0.1 g/liter per hour are achieved. A unique reticulated cellulose product is produced using the methods and conditions claimed, and may be in the form of a sheet characterized by substantial resistance to densification and great tensile strength when produced by sheet forming means.Strains of Acetobacter that are stable under agitated culture conditions and that exhibit substantially reduced gluconic and keto-gluconic acids production are described.
摘要翻译：在搅拌培养条件下生产细菌纤维素的方法和介质，得到平均70小时至少0.1g /升/小时的持续生产。使用所要求保护的方法和条件制备独特的网状纤维素产品，并且可以是以片材成形方法制造时特征为显着的致密化抗拉强度的片材的形式。描述了在搅拌培养条件下稳定并且显示出显着降低的葡萄糖酸和酮 - 葡萄糖酸生产的醋杆菌菌株。

56. 发明授权

US4950597A Modification of cellulose normally synthesizied by cellulose-producing microorganisms 失效
标题翻译：纤维素生产微生物通常合成的纤维素的改性
公开(公告)号：US4950597A
公开(公告)日：1990-08-21
申请号：US198784
申请日：1988-05-25
申请人： Inder M. Saxena , Eric M. Roberts , R. Malcolm Brown, Jr.
发明人： Inder M. Saxena , Eric M. Roberts , R. Malcolm Brown, Jr.
IPC分类号： C12P19/04
CPC分类号： C12R1/02 , C12P19/04 , Y10S435/822 , Y10S435/823
摘要： The present invention involves a process for screening for and isolating spontaneously occurring or induced cellulose II-producing microorganisms. The process comprises a series of steps in various embodiments. Initially, cellulose-producing microorganisms from a first culture are plated out on a nutrient agar plate. The nutrient agar plate is then incubated to facilitate formation of colonies from single microorganisms. Samples of liquid nutrient medium are then inoculated with microorganisms from colonies having a smooth configuration, as compared to the usual rough colony configuration. The inoculated samples are then aerobically incubated to facilitate microorganism proliferation and pellicle formation. From these incubated samples are selected microorganisms, which, after a cultivation period, have proliferated but not formed a pellicle. Said selected microorganisms produce cellulose II instead of the cellulose I produced by pellicle-forming organisms.
摘要翻译：本发明涉及用于筛选和分离自发产生或诱导的产生纤维素II的微生物的方法。该方法包括各种实施方案中的一系列步骤。最初，将来自第一培养物的产生纤维素的微生物铺在营养琼脂平板上。然后培养营养琼脂平板以促进从单一微生物形成菌落。与通常的粗殖群配置相比，液体营养培养基的样品接种具有平滑构型的菌落的微生物。然后将接种的样品有氧培养以促进微生物增殖和防护薄膜组织。从这些孵育的样品中选出微生物，其在培养期后已增殖但未形成防护薄膜。所述选择的微生物产生纤维素II，而不是由防护薄膜组织生物体产生的纤维素I。

57. 发明授权

US4863565A Sheeted products formed from reticulated microbial cellulose 失效
标题翻译：由网状微生物纤维素形成的片状产品
公开(公告)号：US4863565A
公开(公告)日：1989-09-05
申请号：US196127
申请日：1988-05-19
申请人： Donald C. Johnson , Amar N. Neogi
发明人： Donald C. Johnson , Amar N. Neogi
IPC分类号： A61L15/28 , C12P19/04
CPC分类号： C12R1/02 , A61L15/28 , C12P19/04 , Y10S428/913 , Y10S435/823 , Y10T428/2922 , Y10T428/2965
摘要： A method and media for producing bacterial cellulose under agitated culture conditions resulting in sustained production over an average of 70 hours of at least 0.1 g/liter per hour are achieved. A unique reticulated cellulose product is produced using the methods and conditions claimed, and may be in the form of a sheet characterized by substantial resistance to densification and great tensile strength when produced by sheet forming means.Strains of Acetobacter that are stable under agitated culture conditions and that exhibit substantially reduced gluconic and keto-gluconic acids production are described.
摘要翻译：在搅拌培养条件下生产细菌纤维素的方法和介质，得到平均70小时至少0.1g /升/小时的持续生产。使用所要求保护的方法和条件制备独特的网状纤维素产品，并且可以是以片材成形方法制造时特征为显着的致密化抗拉强度的片材的形式。描述了在搅拌培养条件下稳定并且显示出显着降低的葡萄糖酸和酮 - 葡萄糖酸生产的醋杆菌菌株。

58. 发明申请

US20180258454A1 Bioresorbable Exopolysaccharides 审中-公开
公开(公告)号：US20180258454A1
公开(公告)日：2018-09-13
申请号：US15912680
申请日：2018-03-06
申请人： DePuy Synthes Products, Inc.
发明人： Douglas D. Buechter
IPC分类号： C12P19/04 , C12N9/12 , C12N1/20 , A61L27/20 , C08L5/00 , C12R1/02
CPC分类号： C12P19/04 , A61L27/20 , C07K14/32 , C08L5/00 , C08L2201/06 , C08L2203/02 , C12N1/20 , C12N9/1029 , C12N9/1205 , C12N9/90 , C12R1/02 , C12Y207/01059
摘要： The present disclosure is directed to microorganisms that are genetically modified to express at least one exogenous enzyme involved in D-glucosamine uptake and metabolism. Methods for the production of an exopolysaccharide are also disclosed. The exopolysaccharide comprises N-acetylglucosamine and D-glucose and may be used as a bioresorbable implant for soft tissue repair, replacement, or augmentation.

59. 发明申请

US20180112177A1 Preparation of Microbial Cellulose 审中-公开
公开(公告)号：US20180112177A1
公开(公告)日：2018-04-26
申请号：US15793175
申请日：2017-10-25
申请人： The Government of the United States of America, as represented by the Secretary of the Navy
发明人： Scott Walper , Michael A. Daniele , Jonathan D. Yuen
IPC分类号： C12N1/22 , C12R1/02 , C12P19/04 , A61K47/38
CPC分类号： C12N1/22 , A61K47/38 , C12P19/04 , C12R1/02
摘要： The properties of microbial pellicles are tuned by adjusting the physical culture conditions. A culture of Gluconacetobacter xylinus can be grown in a liquid growth media having a surface exposed to air so that a basal pellicle of microbial cellulose forms on the surface. Feeding the culture by adding additional liquid growth media at the surface, thereby submerging the basal pellicle; and then allowing the culture to grow again forms a second pellicle of microbial cellulose.

60. 发明授权

US09040281B2 Method for producing aliphatic carboxylic acids 有权
标题翻译：脂肪族羧酸的制造方法
公开(公告)号：US09040281B2
公开(公告)日：2015-05-26
申请号：US14232724
申请日：2012-07-13
申请人： Irene Finnegan
发明人： Irene Finnegan
IPC分类号： C12N9/08 , C12P7/64 , C12N9/02 , C12P7/40 , C12N1/20 , C12P7/52 , C12P7/54 , C12R1/02
CPC分类号： C12P7/6409 , C12N1/20 , C12N9/0008 , C12P7/40 , C12P7/52 , C12P7/54 , C12P7/6436 , C12R1/02 , Y02P20/52
摘要： The invention relates to a micro-organism comprising a hydrogenase enzyme system which is capable of converting carbon dioxide into formic acid and a second enzyme system which is capable of converting formic acid into aliphatic carboxylic acids having a chain length of five or more carbon atoms. Also described are various methods for producing oil, as well as other aspects of the invention.
摘要翻译：本发明涉及包含能够将二氧化碳转化为甲酸的氢化酶系统和能够将甲酸转化为链长为5个或更多个碳原子的脂肪族羧酸的第二酶体系的微生物。还描述了用于生产油的各种方法以及本发明的其它方面。

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