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51. 发明申请

US20160115221A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNODEFICIENCY 有权
公开(公告)号：US20160115221A1
公开(公告)日：2016-04-28
申请号：US14790872
申请日：2015-07-02
申请人： ADMA Biologics, Inc.
发明人： Adam S. Grossman , Jerrold B. Grossman , James Mond , Dov A. Goldstein
IPC分类号： C07K16/06 , C07K16/12 , C07K16/10
CPC分类号： C07K16/06 , A61K39/155 , A61K39/39516 , A61K39/42 , A61K45/06 , A61K2039/507 , C07K16/08 , C07K16/10 , C07K16/1009 , C07K16/1027 , C07K16/1203 , C07K16/1232 , C07K16/1242 , C07K16/1271 , C07K16/1275 , C07K16/1282 , C07K16/1285 , C07K16/1289 , C07K2317/10 , C07K2317/21 , C07K2317/31 , C07K2317/76 , G01N33/6854 , Y02A50/466 , Y02A50/469
摘要： The present invention relates to compositions and methods for the treatment of immunodeficiency (e.g., primary immunodeficiency disease). In particular, the invention provides human plasma immunoglobulin compositions containing select antibody titers specific for a plurality of respiratory pathogens, methods of identifying human donors and donor samples for use in the compositions, methods of manufacturing the compositions, and methods of utilizing the compositions (e.g., for prophylactic administration and/or therapeutic treatment (e.g., passive immunization (e.g., immune-prophylaxis))).

52. 发明申请

US20150335751A1 AQEOUS COMPOSITION COMPRISING AT LEAST ONE PROTEIN AND ONE SOLUBILIZING AGENT, PREPARATION THEREOF AND USES THEREOF 审中-公开
标题翻译：包含至少一种蛋白质和一种溶解剂的组合物，其制备方法及其用途
公开(公告)号：US20150335751A1
公开(公告)日：2015-11-26
申请号：US14712328
申请日：2015-05-14
申请人： ADOCIA
发明人： Rémi SOULA
IPC分类号： A61K47/22 , A61K9/00 , A61K47/18 , A61K38/28 , C07K16/00
CPC分类号： A61K47/12 , A61K9/0019 , A61K9/08 , A61K38/00 , A61K39/39516 , A61K39/39591 , A61K47/183 , A61K47/22 , C07K16/06 , C07K2317/21
摘要： A liquid composition which has, in an aqueous medium, one or more protein(s) and one or more solubilizing agent(s) chosen from anionic compounds of non-saccharide structure, the structure of which contains at least one aromatic nucleus having at least 6 ring members and at least one carboxylic acid group in salified form, and which has, in its acid form, a molar mass between 130 and 500 g/mol. A process for solubilizing one or more protein(s), wherein at least one solubilizing agent chosen from anionic compounds of non-saccharide structure, the structure of which contains at least one aromatic nucleus having at least 6 ring members and at least one carboxylic acid group in salified form, and which has, in its acid form, a molar mass between 130 and 500 g/mol, is added to an aqueous protein preparation in order to solubilize the protein is also provided.
摘要翻译：一种液体组合物，其在水性介质中具有一种或多种蛋白质和一种或多种选自非糖结构的阴离子化合物的增溶剂，其结构含有至少一个具有至少一个芳香族核心 6个环成员和至少一个成盐形式的羧酸基团，其酸形式的摩尔质量为130-500g / mol。一种用于溶解一种或多种蛋白质的方法，其中至少一种增溶剂选自非糖结构的阴离子化合物，其结构含有至少一个具有至少6个环成员的芳香核和至少一个羧酸并且为了溶解蛋白质，还提供了以成盐形式并且以其酸形式将130至500g / mol的摩尔质量加入到蛋白质水溶液制剂中。

53. 发明申请

US20130156751A1 TREATMENT OF DISEASES 审中-公开
标题翻译：治疗疾病
公开(公告)号：US20130156751A1
公开(公告)日：2013-06-20
申请号：US13544026
申请日：2012-07-09
申请人： Bryan Youl
发明人： Bryan Youl
IPC分类号： A61K39/395
CPC分类号： A61K35/16 , A61K9/0021 , A61K39/39516 , C07K14/005 , C07K16/06 , C07K16/10 , C07K16/2833 , C12N2740/16022
摘要： Methods of treatment of various non-demyelinating and demyelinating neural disorders are provided, comprising administering a serum composition obtained from a goat after challenge with an immunogen. Also provided are methods of treatment of certain autoimmune disorders using such a composition.
摘要翻译：提供了治疗各种非脱髓鞘和脱髓鞘神经障碍的方法，包括用免疫原施用从攻击后的山羊获得的血清组合物。还提供了使用这种组合物治疗某些自身免疫性疾病的方法。

54. 发明申请

US20120294951A1 USE OF GOAT SERUM FOR VETERINARY TREATMENT 失效
标题翻译：使用高血压进行兽医治疗
公开(公告)号：US20120294951A1
公开(公告)日：2012-11-22
申请号：US13562863
申请日：2012-07-31
申请人： Graham Joseph Peck , Juliette Peck
发明人： Graham Joseph Peck , Juliette Peck
IPC分类号： A61K35/16 , A61P11/00
CPC分类号： A61K39/39516 , A61K38/00 , A61K39/42 , A61K2039/505 , C07K16/06 , C07K16/1045 , C07K16/2833 , C07K2317/20
摘要： Methods for veterinary treatment of mammals are described, for treatment of conditions having an inflammatory component. The methods are particularly suited to treatment of cats, dogs, or horses.
摘要翻译：描述了哺乳动物的兽医治疗方法，用于治疗具有炎性成分的病症。这些方法特别适用于治疗猫，狗或马。

55. 发明申请

US20090148564A1 IMMUNOGLOBULIN AND FATTY ACIDS 有权
标题翻译：免疫球蛋白和脂肪酸
公开(公告)号：US20090148564A1
公开(公告)日：2009-06-11
申请号：US12065770
申请日：2006-09-08
申请人： Jens Kristian Munk , Gunner Jacobsen , Karl Jorgen Jensen , Frank Bonlokke Andersen
发明人： Jens Kristian Munk , Gunner Jacobsen , Karl Jorgen Jensen , Frank Bonlokke Andersen
IPC分类号： A23K1/16 , A23K1/18
CPC分类号： A61K39/39516 , A23K20/147 , A23K20/158 , A23K50/30 , A23L33/12 , A23L33/19 , Y10S426/805 , Y10S426/807
摘要： The present invention relates to a composition comprising 0.1-10 w/w % immunoglobulin (Ig), 4-14 w/w % saturated fatty acids, 4-14 w/w % mono-unsaturated fatty acids and 0-5 w/w % poly-unsaturated fatty acids, wherein the weight percentages are based on the content of dry matter in the composition. In particular it relates to the use of said composition as a feed and/or a food composition.
摘要翻译：本发明涉及包含0.1-10w / w％免疫球蛋白（Ig），4-14w / w％饱和脂肪酸，4-14w / w％单不饱和脂肪酸和0-5w / w ％多不饱和脂肪酸，其中重量百分数是基于组合物中干物质的含量。特别地，其涉及所述组合物作为饲料和/或食物组合物的用途。

56. 发明申请

US20080206246A1 POLYPEPTIDES WITH ENHANCED ANTI-INFLAMMATORY AND DECREASED CYTOTOXIC PROPERTIES AND RELATING METHODS 审中-公开
标题翻译：具有增强抗炎和降低细胞毒性的多肽和相关方法
公开(公告)号：US20080206246A1
公开(公告)日：2008-08-28
申请号：US11957015
申请日：2007-12-14
申请人： Jeffrey V. Ravetch , Falk Nimmerjahn , Yoshikatsu Kaneko
发明人： Jeffrey V. Ravetch , Falk Nimmerjahn , Yoshikatsu Kaneko
IPC分类号： A61K39/00 , C07K16/00 , A61K38/00 , C07K14/00
CPC分类号： C07K16/06 , A61K39/39516 , A61K2039/505 , C07K16/00 , C07K2317/41 , C07K2317/52 , C07K2317/71
摘要： The invention provides a polypeptide containing at least one IgG Fc region, wherein said at least one IgG Fc region is glycosylated with at least one galactose moiety connected to a respective terminal sialic acid moiety by a α2,6 linkage, and wherein said polypeptide having a higher anti-inflammatory activity as compared to an unpurified antibody.
摘要翻译：本发明提供了含有至少一个IgG Fc区的多肽，其中所述至少一个IgG Fc区用至少一个通过α2,6连接于相应末端唾液酸部分的半乳糖部分糖基化，并且其中所述多肽具有与未纯化抗体相比具有更高的抗炎活性。

57. 发明授权

US5770196A Modified antibody variable domains and therapeutic uses thereof 失效
标题翻译：修饰抗体可变结构域及其治疗用途
公开(公告)号：US5770196A
公开(公告)日：1998-06-23
申请号：US472788
申请日：1995-06-07
申请人： Gary M. Studnicka
发明人： Gary M. Studnicka
IPC分类号： C12N15/09 , A61K9/08 , A61K9/12 , A61K9/19 , A61K9/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/14 , A61P7/06 , A61P9/04 , A61P17/06 , A61P17/12 , A61P19/02 , A61P21/04 , A61P25/00 , A61P27/02 , A61P29/00 , A61P31/04 , A61P37/02 , C07K1/107 , C07K14/00 , C07K16/00 , C07K16/18 , C07K16/28 , C07K16/46 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/13 , C12P21/08 , C12R1/91 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/68 , G06F19/16 , G06F19/18 , G06F19/22 , C07K14/705 , C07K14/725
CPC分类号： C07K16/467 , A61K39/395 , A61K39/39516 , C07K16/2866 , C07K16/2896 , C07K16/465 , G01N33/6854 , G06F19/16 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2317/74 , C07K2319/00 , G06F19/18 , G06F19/22 , Y10S514/825 , Y10S514/866
摘要： Methods are described for identifying the amino acid residues of an antibody variable domain which may be modified without diminishing the native affinity of the domain for antigen while reducing its immunogenicity with respect to a heterologous species and for preparing so modified antibody variable domains which are useful for administration to heterologous species. Antibody variable regions prepared by the methods of the invention are also described.
摘要翻译：描述了用于鉴定可以修饰的抗体可变结构域的氨基酸残基的方法，而不降低其对抗原的结构域的天然亲和力，同时降低其对异源物种的免疫原性，并且用于制备如此修饰的抗体可变结构域，其可用于对异源物种的管理。还描述了通过本发明的方法制备的抗体可变区。

58. 发明授权

US5258177A IgA preparation and process of making the same 失效
标题翻译： IgA制备和制备相同的过程
公开(公告)号：US5258177A
公开(公告)日：1993-11-02
申请号：US804403
申请日：1991-12-10
申请人： Yahiro Uemura , Sunnie Park , Raja R. Mamidi , Charles M. Heldebrandt
发明人： Yahiro Uemura , Sunnie Park , Raja R. Mamidi , Charles M. Heldebrandt
IPC分类号： A61K39/395 , C07K16/06
CPC分类号： C07K16/065 , A61K39/39516 , Y10S424/804 , Y10S530/831 , Y10S530/861
摘要： A method of preparing an IgA rich preparation comprising exposing a plasma fraction to an amino acid, organic salt or inorganic salt with optional chromatographic treatment yielding a product suitable for use in medical conditions treatable with IgA.
摘要翻译：一种制备富含IgA的制剂的方法，包括用可选的色谱处理将血浆级分暴露于氨基酸，有机盐或无机盐，产生适合用于可用IgA治疗的医学状况的产物。

59. 发明申请

WO2014182631A1 TREATMENT OF ALZHEIMER'S DISEASE SUBPOPULATIONS WITH POOLED IMMUNOGLOBULIN G 审中-公开
标题翻译：治疗阿尔茨海默病患者血液中游离脂肪酸G
公开(公告)号：WO2014182631A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/036848
申请日：2014-05-05
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
发明人： GELMONT, David, M. , SINGER, Julia , FRITSCH, Sandor , SCHWARZ, Hans-Peter
IPC分类号： A61K39/00
CPC分类号： C07K16/18 , A61K38/47 , A61K39/39516 , A61K2039/505 , C07K16/06 , C07K16/065 , G01N33/6896
摘要： The present invention provides, among other aspects, methods for the treatment of Alzheimer's disease in a subject in need thereof, the method including administration of a therapeutically effective amount of a pooled human immunoglobulin G (IgG) composition to a subject with moderately severe Alzheimer's disease, a subject carrying an ApoE4 allele, or both, where the amount of pooled human IgG is from 300 mg/kg to 800 mg/kg body weight of the subject per two week period, and where the amount is administered in one or more doses during the two week period after initiation of a therapeutic regimen. Also provided, are methods for selecting a treatment regimen for a subject with Alzheimer's disease, including diagnosing the severity of the Alzheimer's disease, determining if the subject carries an APOE4 allele, or both, and assigning a treatment regimen including administration of pooled human immunoglobulin G and/or an anti-beta amyloid monoclonal antibody.
摘要翻译：除其他方面外，本发明还提供了在有需要的受试者中治疗阿尔茨海默氏病的方法，所述方法包括将治疗有效量的合并的人免疫球蛋白G（IgG）组合物给予具有中等严重阿尔茨海默病的受试者，携带ApoE4等位基因或两者的受试者，其中合并的人IgG的量为每两周一次的受试者体重为300mg / kg至800mg / kg，并且其中以一个或多个剂量在开始治疗方案后的两周期间。还提供了用于选择阿尔茨海默氏病患者的治疗方案的方法，包括诊断阿尔茨海默氏病的严重程度，确定受试者是否携带APOE4等位基因，或两者，以及分配治疗方案，包括给予合并的人免疫球蛋白G 和/或抗β淀粉样蛋白单克隆抗体。

60. 发明申请

WO2009117085A1 COMBINATIONS AND METHODS FOR SUBCUTANEOUS ADMINISTRATION OF IMMUNE GLOBULIN AND HYALURONIDASE 审中-公开
标题翻译：免疫球蛋白和羟丙酸钠的免疫应答的组合和方法
公开(公告)号：WO2009117085A1
公开(公告)日：2009-09-24
申请号：PCT/US2009/001670
申请日：2009-03-16
申请人： BAXTER HEALTHCARE, S.A. , BAXTER INTERNATIONAL, INC. , HALOZYME, INC. , SCHIFF, Richard , LEIBL, Heinz , FROST, Gregory, I.
发明人： SCHIFF, Richard , LEIBL, Heinz , FROST, Gregory, I.
IPC分类号： A61K39/395 , A61K38/47 , C07K16/06 , C12N9/26 , A61P37/00
CPC分类号： C07K16/06 , A61K38/00 , A61K39/39516 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C12N9/2408 , Y02A50/466 , A61K2300/00
摘要： Provided are combinations, compositions and kits containing a immune globulin (IG) composition and a soluble hyaluronidase composition formulated for subcutaneous administration. Such products can be used in methods of treating IG- treatable diseases or conditions. Also provided are methods for subcutaneous administration of immune globulin whereby the dosing regimen is substantially the same as for intravenous administration of the same dosage for treatment of the same IG-treatable disease or condition.
摘要翻译：提供了含有免疫球蛋白（IG）组合物和配制用于皮下给药的可溶性透明质酸酶组合物的组合，组合物和试剂盒。这些产品可用于治疗IG可治疗疾病或病症的方法。还提供了用于皮下施用免疫球蛋白的方法，其中给药方案与用于治疗相同的IG可治疗疾病或病症的相同剂量的静脉内施用基本相同。

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