专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

WO1997019699A1 DRUG COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：WO1997019699A1
公开(公告)日：1997-06-05
申请号：PCT/JP1996003450
申请日：1996-11-26
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , HASHIMOTO, Yoshimi , SHIOZAWA, Hiroyoshi , KISHIMOTO, Hideyuki , SETOGUCHI, Yoichi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： A61K45/00
CPC分类号： A61K33/08 , A61K9/0056 , A61K9/2081 , A61K45/06 , A61K31/425 , A61K31/415 , A61K31/34 , A61K2300/00
摘要： An oral solid drug composition for the therapy of digestive disorders for which diminution of gastric hydrochloric acid is effective, which improves the condition of the patient immediately after administration and retains it effect over long. It is characterized by comprising a histamine H2 receptor antagonist, a lowly neutralizing gastric antacid drug, and a highly neutralizing gastric antacid drug coated with a polymer base which is insoluble in water independently of pH.
摘要翻译：一种口服固体药物组合物，其用于治疗胃酸降低有效的消化系统疾病，其在施用后立即改善患者的状况并长期保持其效果。其特征在于包含组胺H 2受体拮抗剂，低中和胃酸抗药物，以及高分子抗胃酸药物，其涂覆有独立于pH不溶于水的聚合物基质。

52. 发明申请

WO1997019078A1 PYRIDO[2, 3-D] PYRIMIDINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF 审中-公开
标题翻译：吡咯并[2,3-D]吡啶衍生物及其药物组合物
公开(公告)号：WO1997019078A1
公开(公告)日：1997-05-29
申请号：PCT/JP1996003389
申请日：1996-11-20
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , TAKAYAMA, Kazuhisa , HISAMICHI, Hiroyuki , IWATA, Masahiro , KUBOTA, Hideki , AOKI, Motonori
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Compounds represented by general formula (I) or pharmaceutically acceptable salts thereof which have the effect of inhibiting the activity of type IV phosphodiesterases and are usable as drugs, in particular, type IV phosphodiesterase inhibitors or preventives and remedies for diseases in association with the sthenic type IV phosphodiesterase activity, in particular, respiratory diseases such as bronchial asthma. In said formula (I), X represents oxygen or sulfur; R represents lower alkyl, cycloalkyl(lower alkyl) or cycloalkyl; R represents hydrogen, halogeno, lower alkyl, halo(lower alkyl), hydroxy(lower alkyl), mercapto(lower alkyl), (lower alkoxy)(lower alkyl), (lower alkylthio)(lower alkyl), (lower alkanoyloxy)(lower alkyl), (lower alkanoylthio)(lower alkyl), (lower alkanoyl)(lower alkyl), hydroxyimino(lower alkyl), (lower alkoxyimino)(lower alkyl), cycloalkyl, aryl or lower alkanoyl; R represents hydrogen, halogeno or lower alkyl; R represents hydrogen, or lower alkyl; R represents cycloalkyl optionally substituted by the same group as R ; naphthyl optionally substituted by the same group as R ; a 5- or 6-membered monocyclic heterocycle optionally substituted by the same group as R , optionally fused with a benzene ring and having one to four heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur atoms; or a group of formula (a); and R represents halogeno, lower alkyl, halo(lower alkyl), hydroxy, lower alkoxy, cyano or nitro.
摘要翻译：具有抑制IV型磷酸二酯酶活性的通式（I）表示的化合物或其药学上可接受的盐，可用作药物，特别是IV型磷酸二酯酶抑制剂或预防药物以及与该类型相关的疾病的治疗方法 IV磷酸二酯酶活性，特别是呼吸道疾病如支气管哮喘。在所述式（I）中，X表示氧或硫; R 1表示低级烷基，环烷基（低级烷基）或环烷基; R 2表示氢，卤代低级烷基，卤代（低级烷基），羟基（低级烷基），巯基（低级烷基），（低级烷氧基）（低级烷基），（低级烷硫基）（低级烷基），（低级烷酰基）（低级烷基），（低级烷酰基）（低级烷基），羟基亚氨基（低级烷基），（低级烷氧基亚氨基）（低级烷基），环烷基，芳基或低级烷酰基。 R 3表示氢，卤代或低级烷基; R 4表示氢或低级烷基; R 5表示任选被与R 6相同的基团取代的环烷基; 任选被与R 6相同基团取代的萘基; 任选地被与R 6相同的基团取代的5-或6-元单环杂环，任选地与苯环稠合并具有一至四个选自氮，氧和硫原子的杂原子; 或一组式（a）; 和R 6表示卤代，低级烷基，卤代（低级烷基），羟基，低级烷氧基，氰基或硝基。

53. 发明申请

WO1997011055A1 HETEROARYL-SUBSTITUTED ACRYLOYLGUANIDINE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF 审中-公开
标题翻译：异丙基取代的丙烯酰胺衍生物及其药物组合物
公开(公告)号：WO1997011055A1
公开(公告)日：1997-03-27
申请号：PCT/JP1996002696
申请日：1996-09-19
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , KIKUCHI, Kazumi , TOYOSHIMA, Akira , OKAZAKI, Toshio , TAKANASHI, Masahiro , YANAGISAWA, Isao
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D207/327
CPC分类号： C07D213/82
摘要： Heteroaryl-substituted acryloylguanidine derivatives represented by general formula (I) or their salts serving as drugs, in particular, a Na /H exchanger inhibitor and being useful as a preventive, remedy or diagnostic drug for various diseases in which the Na /H exchanger participates, for example, hypertension, arrhythmia, angina pectoris, arteriosclerosis and complications of diabetes, wherein the ring A represents an optionally substituted 5- or 6-membered heteroaryl which may be fused with one or two benzene rings; the ring B represents an optionally substituted aryl; and R1 represents hydrogen, halogeno or optionally halogenated lower alkyl.
摘要翻译：由通式（I）表示的杂芳基取代的丙烯酰基胍衍生物或其作为药物的盐，特别是Na + / H +交换剂抑制剂，可用作各种疾病的预防，补救或诊断药物，其中 Na + / H +交换体参与例如高血压，心律失常，心绞痛，动脉硬化和糖尿病并发症，其中环A表示任选被取代的可与一个或多个的稠合的5或6元杂芳基或两个苯环; 环B表示任选取代的芳基; 并且R 1表示氢，卤代或任选卤代的低级烷基。

54. 发明申请

WO1997000257A1 FUSED IMIDAZOLE DERIVATIVES AND MEDICINAL COMPOSITION THEREOF 审中-公开
标题翻译：咪唑唑衍生物及其药物组合物
公开(公告)号：WO1997000257A1
公开(公告)日：1997-01-03
申请号：PCT/JP1996001610
申请日：1996-06-13
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , YODEN, Toru , OKADA, Minoru , ISHIHARA, Tsukasa , KINOYAMA, Isao , SAKUDA, Shuichi , IDEYAMA, Yukitaka , KUDOH, Masafumi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D487/04
CPC分类号： C07D471/04 , C07D487/04 , C07D513/04
摘要： Fused imidazole derivatives represented by general formula (I) or salts thereof, wherein X represents oxygen, sulfur, methylene (-CH2-) or -NR -; Y represents methylene (-CH2) or -NR -; R and R are the same or different and each represents hydrogen or lower alkyl; and m and n are the same or different and each represents an integer of from 0 to 4, provided that m plus n is an integer of from 2 to 4. The compounds have the activity of inhibiting steroid 17-20 lyase and are efficacious in the treatment and prevention of prostatic cancer, prostatic hypertrophy, mammary cancer, mastopathy, uterus myoma, endometriosis, etc.
摘要翻译：由通式（I）表示的稠合咪唑衍生物或其盐，其中X表示氧，硫，亚甲基（-CH 2 - ）或-NR 1 - ; Y表示亚甲基（-CH 2）或-NR 2 - ; R 1和R 2相同或不同，各自表示氢或低级烷基; m和n相同或不同，并且各自表示0至4的整数，条件是m加n为2至4的整数。该化合物具有抑制类固醇17-20裂解酶的活性，并且在治疗和预防前列腺癌，前列腺肥大，乳腺癌，乳腺病，子宫肌瘤，子宫内膜异位症等。

55. 发明申请

WO1996036346A1 WATER-SOLUBLE EXTRACT ORIGINATING IN FEATHER COCKSCOMB 审中-公开
标题翻译：水溶性提取物在鱼类食品中的定位
公开(公告)号：WO1996036346A1
公开(公告)日：1996-11-21
申请号：PCT/JP1996001275
申请日：1996-05-15
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , TAKAHASHI, Tooru , HASE, Koji , NAMBA, Tsuneo
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： A61K35/78
CPC分类号： A61K36/21 , A23L33/105 , A61K2300/00
摘要： A water-soluble extract extracted and isolated from feather cockscomb (Celosia argentea, L.), which is a plant belonging to the family Amaranthaceae, and a medicinal composition or a food additive containing this extract as the active ingredient. The extract contains 90 to 99 % by weight of polysaccharides and 1 to 10 % by weight of proteins, exerts depressive effects on toxic hepatopathy caused by alcohol and drugs and immune hepatopathy caused by viruses, etc. and thus is useful as a preventive or remedy for hepatopathy.
摘要翻译：从作为属于苋属科的植物的羽毛鸡冠（Celosia argentea，L.）提取和分离的水溶性提取物和含有该提取物作为有效成分的药物组合物或食品添加剂。提取物含有90〜99重量％的多糖和1〜10重量％的蛋白质，对由酒精和药物引起的中毒性肝病和由病毒引起的免疫性肝病等产生抑制作用，因此可用作预防或补救用于肝病。

56. 发明申请

WO1996006843A1 NOVEL NAPHTHYRIDINE DERIVATIVE AND MEDICINAL COMPOSITION THEREOF 审中-公开
标题翻译：新型萘啶衍生物和药物组合物
公开(公告)号：WO1996006843A1
公开(公告)日：1996-03-07
申请号：PCT/JP1995001700
申请日：1995-08-28
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , TAKAYAMA, Kazuhisa , IWATA, Masahiro , OKAMOTO, Yoshinori , AOKI, Motonori , NIWA, Akira , ISOMURA, Yasuo
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： A 1,8-naphthyridine derivative represented by general formula (I), and salt, hydrate and solvate thereof: the compound inhibits type IV phosphodiesterases and is useful as a preventive or remedy for respiratory diseases, inflammatory diseases, systemic or local joint diseases, proliferative diseases, inflammations accompanying organ transplantation, diseases associated with urination, and diseases wherein tumor necrosis factors (TNF) and other cytokines, such as IL-1 or IL-2, participate.
摘要翻译：由通式（I）表示的1,8-萘啶衍生物及其盐，水合物和溶剂化物：该化合物抑制IV型磷酸二酯酶，并且可用作呼吸系统疾病，炎性疾病，全身或局部关节疾病的预防或治疗，增殖性疾病，伴随器官移植的炎症，与排尿有关的疾病，以及肿瘤坏死因子（TNF）和其它细胞因子如IL-1或IL-2参与的疾病。

57. 发明申请

WO1995034218A1 FEED CONTAINING CRUDE DRUG 审中-公开
标题翻译：饲料中含有原药
公开(公告)号：WO1995034218A1
公开(公告)日：1995-12-21
申请号：PCT/JP1995001186
申请日：1995-06-14
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , KOJIMA, Yasuhiko , TAKAHASHI, Tooru
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： A23K01/14
CPC分类号： A61K36/185 , A23K10/30 , A23K20/10 , A23K50/30 , A61K36/286 , A61K36/355 , A61K36/42 , A61K36/48 , A61K36/68 , A61K2300/00
摘要： Mixed feed or feed additive containing pumpkin seed, common plantain and Japanese honeysuckle, and optionally containing other crude drugs such as safflower, licorice, peristerion, dandelion, houttuynia herb, and chrysanthemun flower. Cow, pig, chicken and amberjack can be fed with this feed or additive compounded with other marketed feed, thereby improving the resistance to diseases of the fed animals, keeping them healthy, and further improving the meat or egg quality.
摘要翻译：含有南瓜种子，普通车前草和日本金银花的混合饲料或饲料添加剂，以及任选地含有其他生药如红花，甘草，紫苏，蒲公英，鱼腥草和菊花。奶牛，猪，鸡肉和黄连素可以喂食与其他市售饲料混合的饲料或添加剂，从而提高对饲养动物的抗病能力，保持健康，进一步提高肉类或鸡蛋质量。

58. 发明申请

WO1995029891A1 N-(3-PYRROLIDINYL)BENZAMIDE DERIVATIVE 审中-公开
标题翻译： N-（3-吡咯烷基）苯甲酰胺衍生物
公开(公告)号：WO1995029891A1
公开(公告)日：1995-11-09
申请号：PCT/JP1995000818
申请日：1995-04-26
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , OHMORI, Junya , MAENO, Kyoichi , HIDAKA, Kazuyuki , NAKATO, Kazuhiro , SAKAMOTO, Shuichi , TSUKAMOTO, Shin-ichi
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D207/14
CPC分类号： C07D207/14
摘要： An N-(3-pyrrolidinyl)benzamide derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof and a medicine containing the same, having a potent and selective antagonism against dopamine D3 and/or D4 receptors and useful as a psychotropic agent, schizophrenia remedy, and so forth. In said formula, R represents hydrogen, lower alkyl, aralkyl, or three- to eight-membered cycloalkyl or cycloalkyl-lower alkyl; R represents four- to sixteen-membered bi- or tricyclic bridged hydrocarbon group; R represents lower alkoxy, amino, or mono- or di(lower alkyl)amino; R represents hydrogen, halogen, optionally hydroxylated lower alkyl, lower alkoxy, cyano, nitro, amino, mono- or di(lower alkyl)amino, acyl or -S(O)m-R ; R represents lower alkyl, amino or mono- or di(lower alkyl)amino; m represents 0, 1 or 2; X represents a bond, -O-, -S(O)n-, -NH- or -CONH-; and n represents 0, 1 or 2; provided when R represents cycloalkyl, the case where X represents -CONH-, R represents lower alkoxy and R represents halogen is excepted.
摘要翻译：由通式（I）表示的N-（3-吡咯烷基）苯甲酰胺衍生物或其药学上可接受的盐和含有它们的药物，具有对多巴胺D3和/或D4受体的有效和选择性拮抗作用并用作精神药物，精神分裂症补救等等。在所述式中，R 1表示氢，低级烷基，芳烷基或三至八元环烷基或环烷基 - 低级烷基; R 2表示四至十六元的二环或三环桥连烃基; R 3表示低级烷氧基，氨基或单或二（低级烷基）氨基; R 4表示氢，卤素，任选羟基化的低级烷基，低级烷氧基，氰基，硝基，氨基，单或二（低级烷基）氨基，酰基或-S（O）m -R 5。 R 5表示低级烷基，氨基或一或二（低级烷基）氨基; m表示0,1或2; X表示键，-O - ， - S（O）n - ， - NH-或-CONH-; n表示0,1或2; 当R 1表示环烷基时，其中X表示-CONH-，R 3表示低级烷氧基，R 4表示卤素的情况除外。

59. 发明申请

WO1995024399A1 5-HT3 RECEPTOR AGONIST, NOVEL THIAZOLE DERIVATIVE, AND INTERMEDIATE THEREFOR 审中-公开
标题翻译： 5-HT3受体激动剂，新型噻唑衍生物及其中间体
公开(公告)号：WO1995024399A1
公开(公告)日：1995-09-14
申请号：PCT/JP1995000385
申请日：1995-03-09
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , IWAOKA, Kiyoshi , ANAN, Hideki , IMANISHI, Naoki , KAZUTA, Kenichi , KOSHIO, Hiroyuki , SUZUKI, Takeshi , ITAHANA, Hirotsune , ITO, Hiroyuki , MIYATA, Keiji , OHTA, Mitsuaki
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D277/28
CPC分类号： C07D277/60 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/08 , C07D487/04 , C07D487/08 , C07D513/04 , Y02P20/55
摘要： A 5-HT3 receptor agonist containing a thiazole derivative represented by general formula (I) as the active ingredient, a specified compound useful as a 5-HT3 receptor agonist, and a specified thioamide derivative useful as an intermediate therefor, wherein ring A represents one of the following rings which may be substituted by at least one substituent selected from the group consisting of halogen, lower alkyl and lower alkoxy: (1) a benzene ring, and (2) a 5- or 6-membered unsaturated heterocycle having one or two heteroatoms selected from among nitrogen, oxygen and sulfur; one of L and L represents a single bond, and the other of them is absent, or represents C1-C4 alkylene or C2-C5 alkenylene; R represents a group represented by any of general formulae: (1), (2), (3) and (4); L represents lower alkylene; L represents a single bond or lower alkylene; R and R represent each independently hydrogen, lower alkyl or an amino-protecting group; R represents hydrogen, lower alkyl, oxo or optionally protected amino; R is absent, or represents hydrogen, lower alkyl, aralkyl or an amino-protecting group; ring B represents one of the following rings which are either monocyclic or bicyclic and may bear an oxygen atom(s): (1) a nitrogenous saturated heterocycle bearing four to sixteen ring atoms, and (2) a nitrogenous heterocycle having a double bond and bearing four to sixteen ring atoms: and ring D represents a saturated carbocycle bearing four to eight ring atoms; provided the nitrogen atom of R may form an unsubstituted quaternary ammonium salt.
摘要翻译：含有由通式（I）表示的噻唑衍生物作为活性成分的5-HT 3受体激动剂，可用作5-HT 3受体激动剂的特定化合物和用作其中间体的特定硫代酰胺衍生物，其中环A表示1 可以被选自卤素，低级烷基和低级烷氧基的至少一个取代基取代的以下环：（1）苯环，和（2）具有一个或多个的一个或多个的5-或6-元不饱和杂环，选自氮，氧和硫的两个杂原子; L 1和L 2之一表示单键，另一个不存在，或表示C1-C4亚烷基或C2-C5亚烯基; R表示由通式（1），（2），（3）和（4）中的任一个表示的基团。 L 3表示低级亚烷基; L 4代表单键或低级亚烷基; R 1和R 2各自独立地表示氢，低级烷基或氨基保护基; R 3表示氢，低级烷基，氧代或任选保护的氨基; R 4不存在，或表示氢，低级烷基，芳烷基或氨基保护基; 环B表示单环或双环的以下环之一，并且可以带有氧原子：（1）具有4至16个环原子的含氮饱和杂环，和（2）具有双键的含氮杂环和具有四至十六个环原子：环D表示带有四至八个环原子的饱和碳环; 条件是R的氮原子可以形成未取代的季铵盐。

60. 发明申请

WO1994026737A1 IMIDAZOLYLQUINOXALINEDIONE DERIVATIVE AND PHARMACEUTICAL COMPOSITION THEREOF 审中-公开
标题翻译：咪唑啉酮衍生物及其药物组合物
公开(公告)号：WO1994026737A1
公开(公告)日：1994-11-24
申请号：PCT/JP1994000758
申请日：1994-05-11
申请人： YAMANOUCHI PHARMACEUTICAL CO., LTD. , SAKAMOTO, Shuichi , SHISHIKURA, Jun-ichi , IWATA, Masahiro , OKADA, Masamichi , SASAMATA, Masao
发明人： YAMANOUCHI PHARMACEUTICAL CO., LTD.
IPC分类号： C07D403/04
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08
摘要： An imidazolylquinoxalinedione derivative, represented by general formula (I), useful as a glutamate receptor antagonist, a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the same as the active ingredient, wherein R represents hydrogen or lower alkyl; R represents hydrogen or hydroxy; X represents -O-, -NR - or -S(O)n-; R represents hydrogen or lower alkyl; n represents 0, 1 or 2; A represents a direct bond or lower alkylene; and R represents (1) lower alkyl, (2) carboxy, or (3) phenyl, cycloalkyl or mono- or bicyclic heterocyclic group wherein the heteroatom(s) is(are) N and/or S, each of which may be substituted.
摘要翻译：用作谷氨酸受体拮抗剂的通式（I）表示的咪唑并喹喔啉二酮衍生物及其药学上可接受的盐，以及含有该活性成分的药物组合物，其中R 1表示氢或低级烷基; R 2表示氢或羟基; X表示-O-，-NR 4 - 或-S（O）n - ; R 4代表氢或低级烷基; n表示0,1或2; A表示直接键或低级亚烷基; 并且R 3表示（1）低级烷基，（2）羧基或（3）苯基，环烷基或单环或双环杂环基，其中杂原子为（或）N和/或S，可以被替代。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式