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51. 发明申请

US20150231194A1 BIOTECHNOLOGICAL PRODUCTION OF CYANOPHYCIN DIPEPTIDES 有权
标题翻译：生物技术生产CYANOPHYCIN DIPPTID
公开(公告)号：US20150231194A1
公开(公告)日：2015-08-20
申请号：US14619161
申请日：2015-02-11
申请人： WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER
发明人： Ahmed SALLAM , Alexander Steinbüchel
IPC分类号： A61K38/05 , A23L1/305 , A23L1/29 , C12N9/48
CPC分类号： A61K38/05 , A23K20/147 , A23L33/18 , A23L33/30 , A23V2002/00 , A61K38/164 , C12N9/485 , C12N9/52 , C12P21/06 , C12Y304/15006 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.
摘要翻译：本发明涉及一种通过使用CGPase降解聚合物制剂，特别适用于所述方法的CGP酶，将来自氰磷霉素（CGP）或CGP样聚合物制剂的二肽组合物酶促生产的方法和使用氰霉素 CGP）或CGP样聚合物或其片段，特别是通过上述方法获得的二肽组合物作为药物组合物，药物或作为食品或饲料替代物。

52. 发明授权

US08980845B2 Biotechnological production of cyanophycin dipeptides 有权
标题翻译：生物技术生产的蓝藻素二肽
公开(公告)号：US08980845B2
公开(公告)日：2015-03-17
申请号：US12995762
申请日：2009-06-15
申请人： Ahmed Sallam , Alexander Steinbüchel
发明人： Ahmed Sallam , Alexander Steinbüchel
IPC分类号： C07K5/06 , C07K4/04 , C12P13/04 , A61K38/05 , C12P21/06 , A23K1/16 , A23L1/305 , A61K38/16 , C12N9/52
CPC分类号： A61K38/05 , A23K20/147 , A23L33/18 , A23L33/30 , A23V2002/00 , A61K38/164 , C12N9/485 , C12N9/52 , C12P21/06 , C12Y304/15006 , Y02A50/473 , Y02A50/481
摘要： The present invention relates to a process for the enzymatic production of a dipeptide composition from a cyanophycin (CGP) or CGP-like polymer preparation by degrading the polymer preparation with an CGPase, a CGPase particularly adapted for said process, and the use of cyanophycin (CGP) or CGP-like polymers or fragments thereof, notably a dipeptide composition obtained by the process as defined above, as pharmaceutical composition, medicament, or as food or feed substitute.
摘要翻译：本发明涉及一种通过使用CGPase降解聚合物制剂，特别适用于所述方法的CGP酶，将来自氰磷霉素（CGP）或CGP样聚合物制剂的二肽组合物酶促生产的方法和使用氰霉素 CGP）或CGP样聚合物或其片段，特别是通过上述方法获得的二肽组合物作为药物组合物，药物或作为食品或饲料替代物。

53. 发明授权

US08912342B2 Pyrazole synthesis by coupling of carboxylic acid derivatives and enamines 有权
标题翻译：吡唑通过羧酸衍生物和烯胺的偶联合成
公开(公告)号：US08912342B2
公开(公告)日：2014-12-16
申请号：US13759107
申请日：2013-02-05
申请人： Westfaelische Wilhelms Universitaet Muenster
发明人： Frank Glorius , Mamta Suri
IPC分类号： C07D231/12 , C07D231/14 , C07D405/04
CPC分类号： C07D231/14 , C07D231/12 , C07D405/04
摘要： A method of synthesizing Pyrazoles by means of the oxidative conversion of Enamines with suitable N-containing carboxylic acid derivatives in the presence of copper ions and 2-picolinic acid derivatives is provided.
摘要翻译：提供了一种通过在铜离子和2-吡啶甲酸衍生物存在下用适当的含有N的羧酸衍生物对Enamine进行氧化转化来合成吡唑的方法。

54. 发明公开

US20230342596A1 OPTICAL MATRIX MULTIPLICATION UNIT FOR AN OPTOELECTRONIC SYSTEM FOR FORMING AN ARTIFICIAL NEURAL NETWORK 审中-公开
公开(公告)号：US20230342596A1
公开(公告)日：2023-10-26
申请号：US18044650
申请日：2021-09-14
申请人： WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER
发明人： Wolfram PERNICE , Johannes FELDMANN
IPC分类号： G06N3/067 , G06E3/00
CPC分类号： G06N3/0675 , G06E3/001
摘要： An optical matrix multiplication unit for an optoelectronic system can be used to form an artificial neural network, having N input waveguides, M output waveguides and a plurality of matrix multiplication unit cells for signal processing of optical signals of one each of the N input waveguides and for transferring the processed signals into one each of the M output waveguides, wherein each of the matrix multiplication unit cells is allocated to one of the input waveguides and one of the output waveguides and undertakes a unique allocation between said two allocated waveguides. Each of the matrix multiplication unit cells has, for signal processing and signal transfer, a directional coupler, having an electrooptical modulator for transmission control of the directional coupler, interconnected between the allocated input waveguide and the allocated output waveguide.

55. 发明申请

US20220220441A1 RAPID AND DETERMINISTIC GENERATION OF MICROGLIA FROM HUMAN PLURIPOTENT STEM CELLS 有权
公开(公告)号：US20220220441A1
公开(公告)日：2022-07-14
申请号：US17613927
申请日：2020-05-27
申请人： Westfälische Wilhelms-Universität Münster
发明人： Matthias Pawlowski , Anna Martina Speicher
IPC分类号： C12N5/079 , C07K14/53 , C07K14/54
摘要： The present invention relates to a method for the production of microglia from stem cells comprising the steps of a) targeted insertion of a nucleotide sequence encoding a transcriptional regulator protein into a first genomic safe harbour site; and b) targeted insertion of the coding sequence of the transcription factor PU.1 (SEQ ID NO: 1) into a second genomic safe harbour site, wherein the gene is operably linked to an inducible promoter, which is regulated by the transcriptional regulator protein; expression of PU.1 (SEQ ID NO: 2); and culturing the stem cells received from steps a) and b) with exposure to at least one growth factor or small molecule that mimics signaling during at least one stage of embryonic development of microglia or adult microglia proliferation, differentiation or polarization. Further, the present invention relates to the microglia obtained by the methods of the present invention and various uses thereof.

56. 发明授权

US11253570B2 S100A8/S100A9-induced immunotolerance in newborn subjects 有权
公开(公告)号：US11253570B2
公开(公告)日：2022-02-22
申请号：US16347907
申请日：2017-11-06
申请人： Westfälische Wilhelms-Universität Münster , Medizinische Hochschule Hannover (MHH)
发明人： Dorothee Viemann , Johannes Roth , Thomas Vogl
IPC分类号： A61K38/17 , A61P29/00 , G01N33/96 , G01N33/68
摘要： The present application provides for the use of S100A8 or S100A9 homodimer or S100A8/A9 heterodimer in the prevention or treatment of a NF-κB-associated postnatal inflammatory disorder in a newborn subject. Moreover, the present invention relates to a pharmaceutical composition comprising S100A8 or S100A9 homodimer or S100A8/A9 heterodimer and an in vitro method for evaluating the risk of a newborn subject for developing a NF-κB-associated postnatal inflammatory disorder.

57. 发明申请

US20210261478A1 Process For Synthesizing Fluorinated Cyclic Aliphatic Compounds 有权
公开(公告)号：US20210261478A1
公开(公告)日：2021-08-26
申请号：US16498372
申请日：2018-02-23
申请人： WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER
发明人： Mario Patrick Wiesenfeldt , Frank Glorius , Zackaria Nairoukh
IPC分类号： C07B35/02 , C07F7/18 , C07C67/303 , C07F5/02 , C07C269/06 , C07C17/354 , C07C41/20 , C07D209/08 , C07D211/76 , C07D307/79 , C07J1/00 , B01J31/22
摘要： The present invention relates to a novel method for producing fluorinated cycloaliphatic compounds from the analogous aromatic compounds by hydrogenation with an Rh-carbene catalyst system.

58. 发明授权

US10406215B2 Cell-penetrating bacterial E3-ubiqitin-ligases for use in immunotherapy 有权
公开(公告)号：US10406215B2
公开(公告)日：2019-09-10
申请号：US15022827
申请日：2014-09-22
申请人： Westfälische Wilhelms-Universität Münster
发明人： Marie-Luise Lubos , Alexander Schmidt , Christian Rueter
IPC分类号： A61K38/53 , C07K14/25 , C07K14/255 , C12N9/00 , A61K38/16
摘要： The present invention relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunomodulatory domains thereof, for use in immunotherapy. The present invention further relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunomodulatory domains thereof, for delivering cargo molecules into eukaryotic cells.

59. 发明申请

US20180074054A1 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE 审中-公开
公开(公告)号：US20180074054A1
公开(公告)日：2018-03-15
申请号：US15565318
申请日：2016-04-08
申请人： ASTUTE MEDICAL, INC. , UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , WESTFÄLISCHE WILHELMS-UNIVERSITÄT MÜNSTER
发明人： Paul McPherson , John A. Kellum, Jr. , Alexander Zarbock
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , G01N33/6893 , G01N2333/4745 , G01N2333/8146 , G01N2800/347 , G01N2800/50
摘要： It is an object of the present invention to provide methods for assessing the efficacy of a remote ischemic preconditioning procedure though the measurement of urinary TIMP-2 and IGFBP7 concentrations.

60. 发明授权

US08030629B2 Adaptive X-ray optics 失效
标题翻译：自适应X射线光学
公开(公告)号：US08030629B2
公开(公告)日：2011-10-04
申请号：US12520551
申请日：2007-12-06
申请人： Zacharias Helmut , Martin Silles
发明人： Zacharias Helmut , Martin Silles
IPC分类号： G21K1/06 , H01L31/0232 , G01N23/20
CPC分类号： G21K1/06 , G02B26/0825 , G21K2201/062
摘要： The invention relates to an adaptive optical device for the reflection of impinging radiation, the adaptive optical device comprising at least one actuator and at least one partially reflective volume. The at least one partially reflective volume has a first surface that is oriented to the impinging radiation. The at least one partially reflective volume is at least partially deformable by said at least one actuator such that the impinging radiation is reflected at the at least one partially reflective volume substantially in accordance with Bragg's law. Further, the invention relates to a method and apparatus for controlling the shape of an adaptive optical device.
摘要翻译：本发明涉及用于反射入射辐射的自适应光学装置，所述自适应光学装置包括至少一个致动器和至少一个部分反射体积。至少一个部分反射体积具有被定向到入射辐射的第一表面。所述至少一个部分反射体积可由所述至少一个致动器至少部分地变形，使得所述入射辐射基本上根据布拉格定律在所述至少一个部分反射体积处反射。此外，本发明涉及一种用于控制自适应光学装置的形状的方法和装置。

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