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51. 发明授权

US09421543B2 Hydrodynamic filter unit, hydrodynamic filter including the hydrodynamic filter unit, and method of filtering target material by using the hydrodynamic filter unit and the hydrodynamic filter 有权
标题翻译：流体动力过滤器单元，包括流体动力过滤器单元的流体动力过滤器，以及通过使用流体动力过滤器单元和流体动力过滤器过滤目标材料的方法
公开(公告)号：US09421543B2
公开(公告)日：2016-08-23
申请号：US13434252
申请日：2012-03-29
申请人： Minseok S. Kim , Won-ho Lee , Sun-soo Kim , Jin-hoon Kim , Jeong-gun Lee , Tae-seok Sim
发明人： Minseok S. Kim , Won-ho Lee , Sun-soo Kim , Jin-hoon Kim , Jeong-gun Lee , Tae-seok Sim
IPC分类号： B01D33/00 , B01D15/00 , B01D33/41 , B01D37/00 , B82Y99/00 , B01L3/00
CPC分类号： B01L3/502753 , B01L3/502761 , B01L2200/0652 , B01L2300/0816 , B01L2400/086
摘要： A hydrodynamic filter unit includes an inlet channel connected to a fluid chamber, into which a fluid including a target material is introduced, and a plurality of outlet channels connected to the fluid chamber, through which the fluid is discharged. A filtering method includes introducing a fluid including a target material into the hydrodynamic filter unit through the inlet channel, capturing the target material in the hydrodynamic filter unit, and discharging a remaining part of the fluid outside of the hydrodynamic filter unit through an outlet channel.
摘要翻译：流体动力过滤器单元包括连接到流体室的入口通道，包括目标材料的流体被引入到该流体室中，以及连接到流体室的多个出口通道，流体被排出。过滤方法包括通过入口通道将包括目标材料的流体引入到流体动力过滤器单元中，捕获流体动力过滤器单元中的目标材料，以及通过出口通道将流体动力过滤器单元外剩余部分排出。

52. 发明授权

US08846322B2 Method and kit for isolating target cell 有权
标题翻译：用于分离靶细胞的方法和试剂盒
公开(公告)号：US08846322B2
公开(公告)日：2014-09-30
申请号：US13582931
申请日：2011-03-07
申请人： Jong-myeon Park , Jeong-gun Lee
发明人： Jong-myeon Park , Jeong-gun Lee
IPC分类号： G01N33/53 , G01N33/574 , G01N33/543 , G01N33/569
CPC分类号： G01N33/57492 , C07K16/30 , C07K17/08 , G01N33/543 , G01N33/54313 , G01N33/54353 , G01N33/56966 , G01N33/574 , G01N33/57484 , Y10T428/2982
摘要： Provided are a method and kit for isolating a target cell by using particles comprising polymers having positive charge and negative charge and at least one antibody bound to polymers. The target cell in the biological sample may be efficiently isolated and detected by using a method and kit according to an exemplary embodiment.
摘要翻译：提供了通过使用包含具有正电荷和负电荷的聚合物的颗粒和与聚合物结合的至少一种抗体来分离靶细胞的方法和试剂盒。通过使用根据示例性实施方案的方法和试剂盒可以有效地分离和检测生物样品中的靶细胞。

53. 发明申请

US20130052664A1 METHOD AND KIT FOR ISOLATING TARGET CELL 有权
标题翻译：用于分离目标细胞的方法和工具包
公开(公告)号：US20130052664A1
公开(公告)日：2013-02-28
申请号：US13582931
申请日：2011-03-07
申请人： Jong-myeon Park , Jeong-gun Lee
发明人： Jong-myeon Park , Jeong-gun Lee
IPC分类号： G01N33/574 , C08G73/04 , C08F12/08 , C08F228/02 , G01N33/566 , C12M1/34
CPC分类号： G01N33/57492 , C07K16/30 , C07K17/08 , G01N33/543 , G01N33/54313 , G01N33/54353 , G01N33/56966 , G01N33/574 , G01N33/57484 , Y10T428/2982
摘要： Provided are a method and kit for isolating a target cell by using particles comprising polymers having positive charge and negative charge and at least one antibody bound to polymers. The target cell in the biological sample may be efficiently isolated and detected by using a method and kit according to an exemplary embodiment.
摘要翻译：提供了通过使用包含具有正电荷和负电荷的聚合物的颗粒和与聚合物结合的至少一种抗体来分离靶细胞的方法和试剂盒。通过使用根据示例性实施方案的方法和试剂盒可以有效地分离和检测生物样品中的靶细胞。

54. 发明授权

US07855069B2 Method and apparatus for the rapid disruption of cells or viruses using micro magnetic beads and laser 有权
标题翻译：使用微磁珠和激光快速破坏细胞或病毒的方法和装置
公开(公告)号：US07855069B2
公开(公告)日：2010-12-21
申请号：US11253541
申请日：2005-10-19
申请人： Jeong-gun Lee , Young-nam Kwon , Young-a Kim , Myo-yong Lee , Shin-i Yoo , Yeon-ja Cho , Kwang-ho Cheong , Chang-eun Yoo , Seung-yeon Yang
发明人： Jeong-gun Lee , Young-nam Kwon , Young-a Kim , Myo-yong Lee , Shin-i Yoo , Yeon-ja Cho , Kwang-ho Cheong , Chang-eun Yoo , Seung-yeon Yang
IPC分类号： C12M1/42 , C12M1/33
CPC分类号： C12M47/06 , B01F11/0266 , B01F13/0059 , B01L3/502761 , B01L2300/0816 , C12N1/066 , C12N13/00
摘要： A method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser are provided. According to the method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser, cell lysis within 40 seconds is possible, the apparatus can be miniaturized using a laser diode, a DNA purification step can be directly performed after a disruption of cells or viruses, and a solution containing DNA can be transferred to a subsequent step after cell debris and beads to which inhibitors of a subsequent reaction are attached are removed with an electromagnet. In addition, by means of the cell lysis chip, an evaporation problem is solved, vibrations can be efficiently transferred to cells through magnetic beads, a microfluidics problem on a rough surface is solved by hydrophobically treating the inner surface of the chip, and the cell lysis chip can be applied to LOC.
摘要翻译：提供了使用微磁珠和激光快速破坏细胞或病毒的方法和装置。根据使用微磁珠和激光快速破坏细胞或病毒的方法和装置，可以在40秒内进行细胞裂解，使用激光二极管可以使装置小型化，DNA纯化步骤可以直接在细胞或病毒的破坏以及含有DNA的溶液可以转移到随后的步骤中，随后的反应的抑制剂与细胞碎片和珠子一起用电磁铁去除。另外，通过细胞裂解芯片，解决了蒸发问题，可以通过磁珠将振动有效地转移到细胞中，通过疏水处理芯片的内表面和细胞来解决粗糙表面上的微流体问题裂解芯片可应用于LOC。

55. 发明授权

US07531138B2 Device and method for rapidly lysing cells or viruses 失效
标题翻译：用于快速裂解细胞或病毒的装置和方法
公开(公告)号：US07531138B2
公开(公告)日：2009-05-12
申请号：US11560890
申请日：2006-11-17
申请人： Su-hyeon Kim , Jeong-gun Lee
发明人： Su-hyeon Kim , Jeong-gun Lee
IPC分类号： B01L3/00 , G01N1/00 , C12M1/00
CPC分类号： C12M47/06 , B01L3/5027 , C12N1/066 , C12N13/00 , G01N1/44 , Y10T137/2496 , Y10T436/25
摘要： A cell lysis device for lysing cells or viruses, comprising a cell lysis tube having a sample inlet; a pump connected to the cell lysis tube for transferring a sample into the tube; a sealing unit for reversibly sealing a specific region of the tube; and a laser source for generating a laser is provided. Further, a method of lysing cells or viruses using the cell lysis device is provided. The method comprises introducing a sample containing cells or viruses and optionally magnetic beads to the cell lysis tube through the sample inlet; transferring the sample to a specific region in the cell lysis tube by means of the pump; temporarily sealing the region of the cell lysis tube where the sample is placed with the sealing unit; irradiating the sample with the laser; removing the sealing unit from the cell lysis tube; and discharging the sample from the cell lysis tube by means of the pump.
摘要翻译：一种用于裂解细胞或病毒的细胞裂解装置，包括具有样品入口的细胞裂解管; 连接到细胞裂解管的泵，用于将样品转移到管中; 用于可逆地密封管的特定区域的密封单元; 并提供用于产生激光的激光源。此外，提供了使用细胞裂解装置裂解细胞或病毒的方法。该方法包括通过样品入口将含有细胞或病毒的样品和任选的磁珠引入细胞裂解管; 通过泵将样品转移到细胞裂解管中的特定区域; 用密封单元临时密封放置样品的细胞溶解管的区域; 用激光照射样品; 从细胞裂解管中取出密封单元; 并通过泵从细胞裂解管排出样品。

56. 发明申请

US20060051248A1 Microfluidic bio sample processing apparatus capable of being assembled 审中-公开
标题翻译：能够组装的微流体生物样品处理装置
公开(公告)号：US20060051248A1
公开(公告)日：2006-03-09
申请号：US11221176
申请日：2005-09-07
申请人： Hye-jung Cho , Jeong-gun Lee , Sang-Kyun Kang , Sang-chae Kim , Tae-gyun Kim , Jae-yong Lee
发明人： Hye-jung Cho , Jeong-gun Lee , Sang-Kyun Kang , Sang-chae Kim , Tae-gyun Kim , Jae-yong Lee
IPC分类号： B01L3/00
CPC分类号： B01L3/502715 , B01J2219/00286 , B01J2219/00495 , B01J2219/00605 , B01J2219/00659 , B01J2219/00677 , B01J2219/00722 , B01J2219/0081 , B01J2219/00831 , B01J2219/00833 , B01J2219/00873 , B01J2219/00889 , B01J2219/0097 , B01L2200/027 , B01L2200/028 , B01L2200/04 , B01L2300/0816 , B01L2400/0487
摘要： Disclosed is a microfluidic bio sample processing apparatus including a processing module configured for processing the bio sample and having a hole through which the processed bio sample, a solution for processing the bio sample or both flow, a board having a flowing channel connected with the hole so as to allow the bio sample, the solution for processing the bio sample or both to flow between processing modules and a bonding feature for bonding the processing module with the board. The processing modules are configured to be assembled and/or disassembled onto or from the board so that the processing apparatus is adapted to various kinds of bio samples having different processing steps.
摘要翻译：公开了一种微流体生物样品处理设备，其包括处理模块，该处理模块被配置用于处理生物样品并具有孔，经处理的生物样品，用于处理生物样品或两者的流体的溶液通过该孔流动，具有与孔连接的流动通道的板以便允许生物样品，用于处理生物样品或两者的溶液在处理模块之间流动，以及用于将处理模块与板接合的结合特征。处理模块被配置为在板上或从板上组装和/或拆卸，使得处理装置适用于具有不同处理步骤的各种生物样品。

57. 发明授权

US08658359B2 Method and apparatus for disrupting cells and purifying nucleic acid using a single chip 有权
标题翻译：使用单个芯片破坏细胞并纯化核酸的方法和装置
公开(公告)号：US08658359B2
公开(公告)日：2014-02-25
申请号：US13079926
申请日：2011-04-05
申请人： In-ho Lee , Jun-hong Min , Young-rok Kim , Jae-ho You , Chang-eun Yoo , Jeong-gun Lee , Ki-woong Han
发明人： In-ho Lee , Jun-hong Min , Young-rok Kim , Jae-ho You , Chang-eun Yoo , Jeong-gun Lee , Ki-woong Han
IPC分类号： C12Q1/68 , C12P19/34 , C07H21/00
CPC分类号： C12Q1/68 , C12M47/06 , C12N15/1006
摘要： Provided herein is a method and apparatus for disrupting cells and purifying nucleic acids in a single chip. The method comprises irradiating a chip with a laser beam, wherein the chip comprises a solid support on which a cell lysis enhancing metal oxide layer, and a cell binding metal oxide layer have been deposited.
摘要翻译：本文提供了在单个芯片中破坏细胞并纯化核酸的方法和装置。该方法包括用激光束照射芯片，其中芯片包括其上沉积有细胞裂解增强金属氧化物层和细胞结合金属氧化物层的固体支持物。

58. 发明授权

US08590710B2 Target particles-separating device and method using multi-orifice flow fractionation channel 有权
$Target particles-separating device and method using multi-orifice flow fractionation channel$
标题翻译：目标颗粒分离装置和使用多孔流量分馏通道的方法
公开(公告)号：US08590710B2
公开(公告)日：2013-11-26
申请号：US13156630
申请日：2011-06-09
申请人： Tae-seok Sim , Jeong-gun Lee , Hyo-il Jung , Ki-ho Kwon
发明人： Tae-seok Sim , Jeong-gun Lee , Hyo-il Jung , Ki-ho Kwon
IPC分类号： B07C5/00
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/0652 , B01L2300/087 , B01L2400/0487
摘要： A device separating target particles in a fluid sample includes first through third multi-orifice flow fractionation (“MOFF”) channels, each including a multi-orifice segment with an inlet and an outlet at opposite ends, and an alternating series of contraction channels and expansion chambers interconnected in a lengthwise direction; a first separation unit including a first separation channel which is interconnected in fluid communication with a center region of the outlet of the first MOFF channel, and first branch channels which are interconnected in fluid communication with sidewall regions of the outlet of the first MOFF channel, and respectively with inlets of the second and third MOFF channels; and buffer inlets which are connected to the inlets of the second and third MOFF channels and through which a buffer flows into the second and third MOFF channels.
摘要翻译：分离流体样品中的目标颗粒的装置包括第一至第三多孔流动分馏（“MOFF”）通道，每个通道包括具有相对端的入口和出口的多孔段，以及交替的一系列收缩通道和膨胀室沿长度方向互相连接; 第一分离单元，其包括与第一MOFF通道的出口的中心区域流体连通的第一分离通道和与第一MOFF通道的出口的侧壁区域流体连通地互连的第一分支通道，并分别具有第二和第三MOFF通道的入口; 以及连接到第二和第三MOFF通道的入口并且缓冲器通过其流入第二和第三MOFF通道的缓冲器入口。

59. 发明申请

US20130122577A1 KIT INCLUDING SEQUENCE SPECIFIC BINDING PROTEIN AND METHOD AND DEVICE FOR DETERMINING NUCLEOTIDE SEQUENCE OF TARGET NUCLEIC ACID 审中-公开
标题翻译：包含序列特异性结合蛋白的试剂盒和用于测定靶核酸核酸序列的方法和装置
公开(公告)号：US20130122577A1
公开(公告)日：2013-05-16
申请号：US13577418
申请日：2011-02-07
申请人： Joo-won Rhee , Su-hyeon Kim , Jeong-gun Lee , Mi-jeong Song
发明人： Joo-won Rhee , Su-hyeon Kim , Jeong-gun Lee , Mi-jeong Song
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/5308 , Y10S977/774 , Y10S977/92 , C12Q2522/101 , C12Q2563/107
摘要： Provided are kits for determining a nucleotide sequence of a target nucleic acid, the kit including at least one sequence specific binding protein and a detectable tag. In accordance with a kit for determining a nucleotide sequence of a target nucleic acid according to one exemplary embodiment and a method and device for determining a nucleotide sequence of a target nucleic acid, the nucleotide sequence of the target nucleic acid may be more efficiently determined.
摘要翻译：提供了用于确定靶核酸的核苷酸序列的试剂盒，该试剂盒包括至少一种序列特异性结合蛋白和可检测标签。根据一个示例性实施方案的用于确定靶核酸的核苷酸序列的试剂盒以及用于确定靶核酸的核苷酸序列的方法和装置，可以更有效地确定靶核酸的核苷酸序列。

60. 发明授权

US07955801B2 Method and apparatus for disrupting cells and purifying nucleic acid using a single chip 有权
标题翻译：使用单个芯片破坏细胞并纯化核酸的方法和装置
公开(公告)号：US07955801B2
公开(公告)日：2011-06-07
申请号：US11639794
申请日：2006-12-15
申请人： In-ho Lee , Jun-hong Min , Young-rok Kim , Jae-ho You , Chang-eun Yoo , Jeong-gun Lee , Ki-woong Han
发明人： In-ho Lee , Jun-hong Min , Young-rok Kim , Jae-ho You , Chang-eun Yoo , Jeong-gun Lee , Ki-woong Han
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/68 , C12M47/06 , C12N15/1006
摘要： Provided herein is a method and apparatus for disrupting cells and purifying nucleic acids in a single chip. The method comprises irradiating a chip with a laser beam, wherein the chip comprises a solid support on which a cell lysis enhancing metal oxide layer, and a cell binding metal oxide layer have been deposited.
摘要翻译：本文提供了在单个芯片中破坏细胞并纯化核酸的方法和装置。该方法包括用激光束照射芯片，其中芯片包括其上沉积有细胞裂解增强金属氧化物层和细胞结合金属氧化物层的固体支持物。

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