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    • 56. 发明申请
    • Chimeric Peptides for the Regulation of GTPases
    • 嵌合肽用于调节GTP酶
    • US20120329725A1
    • 2012-12-27
    • US13584745
    • 2012-08-13
    • Yi ZhengDavid A. Williams
    • Yi ZhengDavid A. Williams
    • C07K19/00A61P35/00C12N9/14A61K38/17
    • C07K14/4706C07K2319/01C07K2319/02C07K2319/03C12N9/14C12Y306/05002
    • Chimeric peptides or fusion proteins are disclosed that include a RhoGAP activity domain and at least one specificity domain that targets a specific Rho protein. The fusion proteins can be used to inhibit any GTPase activity within a cell. The fusion proteins are particularly advantageous for the treatment of cancer. The present invention generally relates to chimeric peptides capable of regulating GTPases, and more particularly, to methods of targeting individual GTPases by using GTPase-activating proteins. Such proteins may be used for the treatment of cancers and other GTPase-related diseases. This invention relates to nucleic acid molecules and the encoded GTPase activating proteins, and variants thereof, and to the use of these molecules in the characterization, diagnosis, prevention, and treatment of cell signaling, immune, and cell proliferative disorders, particularly cancer. Disclosed herein are compounds and methods for regulating transcription of a selected gene.
    • 公开了嵌合肽或融合蛋白,其包括RhoGAP活性结构域和至少一个靶向特异性Rho蛋白的特异性结构域。 融合蛋白可用于抑制细胞内的任何GTP酶活性。 融合蛋白对癌症的治疗特别有利。 本发明一般涉及能够调节GTP酶的嵌合肽,更具体地,涉及通过使用GTP酶活化蛋白靶向各种GTP酶的方法。 这些蛋白质可用于治疗癌症和其它与GTP酶有关的疾病。 本发明涉及核酸分子和编码的GTP酶活化蛋白及其变体,以及这些分子在表征,诊断,预防和治疗细胞信号传导,免疫和细胞增殖性疾病,特别是癌症中的用途。 本文公开了用于调节所选基因转录的化合物和方法。
    • 57. 发明授权
    • Method of performance analysis for VRLA battery
    • VRLA电池性能分析方法
    • US08340934B2
    • 2012-12-25
    • US12596698
    • 2008-04-17
    • Jianhong XuLing YuanYi Zheng
    • Jianhong XuLing YuanYi Zheng
    • G01R31/36
    • G01R31/362G01R31/3648G01R31/3668H01M10/121H01M10/48
    • This invention discloses a method of performance analysis for VRLA battery which applies the method of using the float voltage dispersion ratio of the battery to evaluate the battery performance from a new perspective, and it is an online real-time test which applies several ways to evaluate the performance of the VRLA battery. According to the relevance between the dispersion of the float charge voltage of the battery and its performance, the method gets the result of the battery performance through calculating the battery float charge voltage dispersion ratio and making it relevant with the battery performance. It has small workload, convenient operation and no danger to the system when doing online testing. It also won't affect the cycle life of the VRLA battery.
    • 本发明公开了一种VRLA电池的性能分析方法,该方法采用电池的浮动电压分散比率的方法,从新的角度对电池的性能进行评估,是一种在线实时测试,采用多种方式进行评估 VRLA电池的性能。 根据电池浮充电压的偏差与其性能的关系,该方法通过计算电池浮充电压分散比并使其与电池性能相关,得到电池性能的结果。 工作量小,操作方便,在线测试时不会对系统造成危害。 它也不会影响VRLA电池的循环寿命。
    • 58. 发明授权
    • Method for manufacturing a perpendicular magnetic write head having a tapered write pole
    • 一种具有锥形写入极的垂直磁性写入头的制造方法
    • US08318031B2
    • 2012-11-27
    • US12748182
    • 2010-03-26
    • Aron PentekThomas J. A. RoucouxYi Zheng
    • Aron PentekThomas J. A. RoucouxYi Zheng
    • B44C1/22
    • G11B5/3163G11B5/1278G11B5/3116G11B5/3146G11B5/315
    • A method for manufacturing a magnetic write head having a write pole with a tapered leading edge and a tapered trailing edge. The method includes forming a non-magnetic bump player over a surface, forming a mask over the non-magnetic bump layer and performing a first ion milling to form a tapered back edge on the non-magnetic bump layer. A magnetic write pole material is then deposited over the surface and over the non-magnetic bump layer. Then a non-magnetic step structure is formed over the magnetic write pole material and an ion milling is performed to form a taper on the upper surface of the write pole. The write pole lateral dimensions can then be defined, and a non-magnetic bump formed over the tapered portion of the upper surface of the write pole. Another ion milling can then be performed to extend the taper of the surface of the write pole.
    • 一种用于制造具有带有锥形前缘和锥形后缘的写极的磁写头的方法。 所述方法包括在表面上形成非磁性碰撞播放器,在非磁性凸块层上形成掩模,并执行第一离子铣削以在非磁性凸块层上形成锥形后缘。 然后将磁性写入磁极材料沉积在表面上并在非磁性凸起层上方。 然后在磁性写入磁极材料上形成非磁性阶梯结构,并且执行离子铣削以在写入极的上表面上形成锥形。 然后可以限定写入极横向尺寸,并且在写入极的上表面的锥形部分上形成非磁性凸块。 然后可以执行另一种离子铣削来延伸写极的表面的锥度。
    • 60. 发明申请
    • Electric Machine And Oil Cooling Method For Electrical Machine
    • 电机电机及油冷方式
    • US20120235521A1
    • 2012-09-20
    • US13513019
    • 2010-01-26
    • Wei CaiYi ZhengXinglian Yuan
    • Wei CaiYi ZhengXinglian Yuan
    • H02K9/19H02K15/00
    • H02K9/19H02K9/197
    • An electrical machine comprises a casing (1), an oil inlet hole (7), an oil passage (2), oil outlet holes (3), a stator retainer (8), a casing end cover (10), a stator iron core (5), winding coils (6), slot insulations (12) and oil-guides (4). The oil passage (2) is located inside the casing (1) and links with the oil inlet hole (7) of the casing (1) and the oil outlet holes (3) of the stator retainer (8). The oil outlet holes (3) are located above the winding coils (6) and the oil-guides (4) are located between the oil outlet holes (3) and the winding coils (6). Oil entering from the oil inlet hole (7) pours onto the winding coils (6) by the guidance of the oil-guides (4) after flowing through the oil passage (2) and flowing out of the oil outlet holes (3). The winding coils of the electrical machine can be effectively cooled and the electrical machine can achieve higher thermal durability. An oil cooling method for the electrical machine is also provided.
    • 电机包括壳体(1),进油孔(7),油路(2),出油孔(3),定子保持架(8),壳体端盖(10),定子铁 (5),绕组线圈(6),槽绝缘(12)和导油器(4)。 油路(2)位于壳体(1)的内部,与壳体(1)的进油孔(7)和定子保持架(8)的排油孔(3)连结。 出油孔(3)位于绕组线圈(6)的上方,导油件(4)位于排油孔(3)和绕组线圈(6)之间。 从进油孔(7)进入的油在流经油路(2)并从出油孔(3)流出之后,通过导油件(4)的引导而在卷绕线圈(6)上倾倒。 可以有效地冷却电机的绕组线圈,并且电机可以实现更高的耐热性。 还提供了一种用于电机的油冷却方法。