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51. 发明申请

US20120165890A1 Systems and Methods for Determining Optimal Interventricular Pacing Delays Based on Electromechanical Delays 有权
标题翻译：基于机电延迟确定最佳心室起搏延迟的系统和方法
公开(公告)号：US20120165890A1
公开(公告)日：2012-06-28
申请号：US12976419
申请日：2010-12-22
申请人： Xiaoyi Min
发明人： Xiaoyi Min
IPC分类号： A61N1/365
CPC分类号： A61N1/36585 , A61N1/3627 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/3684
摘要： Techniques are provided for use with implantable medical devices such as pacemakers for optimizing interventricular (VV) pacing delays for use with cardiac resynchronization therapy (CRT). In one example, ventricular electrical depolarization events are detected within a patient in which the device is implanted. The onset of isovolumic ventricular mechanical contraction is also detected based on cardiomechanical signals detected by the device, such as cardiogenic impedance (Z) signals, S1 heart sounds or left atrial pressure (LAP) signals. Then, an electromechanical time delay (T_QtoVC) between ventricular electrical depolarization and the onset of isovolumic ventricular mechanical contraction is determined. VV pacing delays are set to minimize the time delay to the onset of isovolumic ventricular mechanical contraction. Various techniques for identifying the onset of isovolumic ventricular contraction based on Z, S1 or LAP or other cardiomechanical signals are described. In some examples, CRT nonresponders are specifically identified and/or heart failure progression is tracked.
摘要翻译：提供技术用于可植入医疗装置，例如用于优化用于心脏再同步治疗（CRT）的室间（VV）起搏延迟）的起搏器。在一个示例中，在装置被植入的患者内检测到心室电去极化事件。基于由器械检测到的心脏机械信号，例如心源阻抗（Z）信号，S1心脏音或左心房压力（LAP）信号，也检测到等容性心室机械收缩的发作。然后，确定心室电去极化与等容性心室机械收缩发作之间的机电时间延迟（T_QtoVC）。设定VV起搏延迟以最小化等容性心室机械收缩发作的时间延迟。描述了基于Z，S1或LAP或其他心脏机械信号鉴别等容性心室收缩发作的各种技术。在一些示例中，CRT无应答者被特异性识别和/或跟踪心力衰竭进展。

52. 发明授权

US08170687B2 Implantable medical device lead incorporating insulated coils formed as inductive bandstop filters to reduce lead heating during MRI 有权
标题翻译：可植入医疗器械引线，包含形成为感应性带阻滤波器的绝缘线圈，以减少MRI期间的铅加热
公开(公告)号：US08170687B2
公开(公告)日：2012-05-01
申请号：US12537880
申请日：2009-08-07
申请人： Xiaoyi Min , Peter A. Nichols
发明人： Xiaoyi Min , Peter A. Nichols
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/086
摘要： To provide radio-frequency (RF) bandstop filtering within an implantable lead, such as a pacemaker lead, one or more segments of the tip and ring conductors of the lead are formed as insulated coils to function as inductive band stop filters. By forming segments of the conductors into insulated coils, a separate set of discrete or distributed inductors is not required, yet RF filtering is achieved to, e.g., reduce lead heating during magnetic resonance imaging (MRI) procedures. To enhance the degree of bandstop filtering at the RF signal frequencies of MRIs, additional capacitive elements are added. In one example, the ring electrode of the lead is configured to provide capacitive shunting to the tip conductor. In another example, a capacitive transition is provided between the outer insulated coil and proximal portions of the ring conductor. In still other examples, conducting polymers are provided to enhance capacitive shunting. The insulated coils may be spaced at ¼ wavelength locations.
摘要翻译：为了在诸如起搏器引线的可植入引线内提供射频（RF）带阻滤波，引线的尖端和环形导体中的一个或多个段形成为用作电感带阻滤波器的绝缘线圈。通过将导体的段形成为绝缘线圈，不需要单独的一组离散或分布式电感器，但是实现RF滤波以例如在磁共振成像（MRI）程序期间减少引线加热。为了增强MRI的RF信号频率下的带阻滤波的程度，增加了附加的电容元件。在一个示例中，引线的环形电极被配置为向尖端导体提供电容分流。在另一示例中，在外绝缘线圈和环形导体的近端部分之间提供电容性跃迁。在其它实例中，提供导电聚合物以增强电容分流。绝缘线圈可以在1/4波长位置间隔开。

53. 发明申请

US20110152990A1 MRI COMPATIBLE LEAD EMPLOYING MULTIPLE MINIATURE INDUCTORS 审中-公开
标题翻译： MRI兼容多用途微电极的铅
公开(公告)号：US20110152990A1
公开(公告)日：2011-06-23
申请号：US12645252
申请日：2009-12-22
申请人： Ramez Shehada , Xiaoyi Min , Jin Zhang , Benjamin Coppola , Dave Anderson , Gene A. Bornzin , Phong D. Doan
发明人： Ramez Shehada , Xiaoyi Min , Jin Zhang , Benjamin Coppola , Dave Anderson , Gene A. Bornzin , Phong D. Doan
IPC分类号： A61N1/05 , H03H7/01
CPC分类号： A61N1/05 , A61N1/086 , H03H7/0115 , H03H2007/013
摘要： An implantable medical lead is disclosed herein. The lead includes a first electrode and a first electrical circuit. The first electrode is near a distal portion of the lead. The first electrical circuit extends through the lead to the first electrode and includes at least one conductor and a first band stop filter coupled between the distal end of the conductor and the electrode. The first band stop filter includes a first group of inductors in parallel and a second group of inductors in parallel. The first group is in series with the second group. The first group of inductors may include a self resonant L. The first group of inductors may include a self resonant tank LC. The first group of inductors may include a miniature self resonant L or miniature self resonant tank LC. The first group of inductors may include an integrated circuit of L and C components.
摘要翻译：本文公开了可植入医疗引线。引线包括第一电极和第一电路。第一电极靠近导线的远端部分。第一电路通过引线延伸到第一电极并且包括耦合在导体的远端和电极之间的至少一个导体和第一带阻滤波器。第一带阻滤波器包括并联的第一组电感器和并联的第二组电感器。第一组与第二组合作。第一组电感器可以包括自谐振L。第一组电感器可以包括自谐振槽LC。第一组电感器可以包括微型自谐振L或微型自谐振箱LC。第一组电感器可以包括L和C组件的集成电路。

54. 发明申请

US20110144722A1 MRI-COMPATIBLE IMPLANTABLE LEAD WITH IMPROVED LC RESONANT COMPONENT 审中-公开
标题翻译：具有改进的LC谐振元件的MRI兼容可植入引线
公开(公告)号：US20110144722A1
公开(公告)日：2011-06-16
申请号：US12635340
申请日：2009-12-10
申请人： Xiaoyi Min , Ingmar Viohl
发明人： Xiaoyi Min , Ingmar Viohl
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0573 , A61N1/086
摘要： An implantable lead is provided that comprises a lead body extending along a longitudinal axis. The lead body includes a distal end and a proximal end and a lumen within the lead body. The lead also includes a header assembly provided at the distal end of the lead body. The header assembly includes a tissue engaging end. The lead also includes an electrode provided on the header assembly. The electrode is configured to deliver stimulating pulses. The lead also includes an electrode conductor provided within the lumen of the lead body and extending from the electrode to the proximal end of the lead body. An LC resonant component is provided in at least one of the lead body and the header assembly. The LC resonant component comprises a capacitor having an elongated shape that extends along the longitudinal axis of the lead body. The capacitor has a core that is located about the longitudinal axis of the lead body. The LC resonant component further comprises an inductor wire wound in multiple turns about an exterior surface of the capacitor to form an inductor.
摘要翻译：提供了一种可植入引线，其包括沿着纵向轴线延伸的引线主体。引线主体包括远端和近端以及引线主体内的内腔。引线还包括设置在引线主体的远端的插头组件。头部组件包括组织接合端。引线还包括设置在插头组件上的电极。电极配置为传递刺激脉冲。引线还包括设置在引线主体的内腔内且从电极延伸到引线主体的近端的电极导体。 LC谐振元件设置在引线主体和插头组件中的至少一个中。 LC谐振元件包括具有沿引线本体的纵向轴线延伸的细长形状的电容器。电容器具有围绕引线主体的纵向轴线定位的芯。 LC谐振分量还包括围绕电容器的外表面缠绕成多圈的电感器线，以形成电感器。

55. 发明申请

US20110125240A1 BIOCOMPATIBLE INDUCTOR FOR IMPLANTABLE LEAD AND METHOD OF MAKING SAME 审中-公开
标题翻译：用于可植入铅的生物电解电容器及其制造方法
公开(公告)号：US20110125240A1
公开(公告)日：2011-05-26
申请号：US12622847
申请日：2009-11-20
申请人： Yong D. Zhao , Xiaoyi Min , Virote Indravudh , Ingmar Viohl , J. Christopher Moulder , Kevin L. Morgan , Phong D. Doan
发明人： Yong D. Zhao , Xiaoyi Min , Virote Indravudh , Ingmar Viohl , J. Christopher Moulder , Kevin L. Morgan , Phong D. Doan
IPC分类号： A61N1/05
CPC分类号： A61N1/0573 , A61N1/086
摘要： A biocompatible inductor for an implantable medical lead is disclosed herein. In one embodiment the biocompatible inductor may include a biocompatible bobbin and a wire wound about a barrel of the biocompatible bobbin to form a coil. The wire may include an electrically conductive core, an electrically conductive biocompatible jacket extending over the core, and a coating of high dielectric strength insulation material extending over the jacket. Additionally, the biocompatible inductor may include medical adhesive located in gaps within the coil and a polyester shrink tube covering the coil.
摘要翻译：本文公开了用于可植入医疗引线的生物相容性电感器。在一个实施方案中，生物相容性感应器可以包括生物相容的线轴和缠绕在生物相容线圈架的筒上的线以形成线圈。线可以包括导电芯，在芯上延伸的导电生物相容性护套，以及在护套上延伸的高介电强度绝缘材料的涂层。此外，生物相容性电感器可以包括位于线圈内的间隙中的医用粘合剂和覆盖线圈的聚酯收缩管。

56. 发明授权

US07949411B1 Epicardial lead 有权
标题翻译：心外膜导联
公开(公告)号：US07949411B1
公开(公告)日：2011-05-24
申请号：US11626132
申请日：2007-01-23
申请人： Michael Yang , Sheldon Williams , Wenbo Hou , Kevin L. Morgan , Xiaoyi Min
发明人： Michael Yang , Sheldon Williams , Wenbo Hou , Kevin L. Morgan , Xiaoyi Min
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/057
摘要： Embodiments include electrical leads and methods of using electrical leads that may be used for delivering both cardioversion/defibrillation signals and pacing signals and sensing to target tissue. Some of these embodiments may also be used to sense and transmit electrical signals from target tissue. Some electrical lead embodiments are configured to be delivered into a patient's intrapericardial space by non-invasive methods.
摘要翻译：实施例包括电引线和使用电引线的方法，其可以用于将心律转复/除颤信号和起搏信号以及感测传送到目标组织。这些实施例中的一些也可以用于感测和传输来自目标组织的电信号。一些电引线实施例被配置为通过非侵入性方法递送到患者的心包内空间。

57. 发明授权

US07917216B1 Multi-site pacing for atrial tachyarrhythmias 有权
标题翻译：多节段起搏用于房性快速性心律失常
公开(公告)号：US07917216B1
公开(公告)日：2011-03-29
申请号：US11458649
申请日：2006-07-19
申请人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
发明人： Kyungmoo Ryu , Jong Gill , Xiaoyi Min , Annapurna Karicherla , Gene A. Bornzin
IPC分类号： A61N1/18
CPC分类号： A61N1/3622 , A61N1/0587 , A61N1/3686
摘要： Tachyarrhythmia is treated by applying anti-tachycardia pacing through at least one multi-site electrode set located on, in or around the heart. The electrode set is arranged and located such that an electrical activation pattern having a wave-front between substantially flat and concave is generated through a reentrant circuit associated with the tachyarrhythmia. The electrode set may be one of a plurality of predefined, multi-site electrode sets located on, in or around the atria. Alternatively, the electrode set may be formed using at least two selectable electrodes located on, in or around the atria.
摘要翻译：通过应用抗心动过速起搏通过位于心脏内或心脏周围的至少一个多位点电极组来治疗快速性心律失常。电极组被布置和定位成使得通过与快速性心律失常相关联的折返电路产生具有基本上平坦和凹陷之间的波前的电激活模式。电极组可以是位于心房内或周围的多个预定义的多位点电极组之一。或者，可以使用位于心房内或周围的至少两个可选择电极来形成电极组。

58. 发明申请

US20110034979A1 IMPLANTABLE MEDICAL DEVICE LEAD INCORPORATING INSULATED COILS FORMED AS INDUCTIVE BANDSTOP FILTERS TO REDUCE LEAD HEATING DURING MRI 有权
标题翻译：可塑性医疗器械引线包含作为电感式带状过滤器形成的绝缘线圈，以减少MRI中的引线加热
公开(公告)号：US20110034979A1
公开(公告)日：2011-02-10
申请号：US12537880
申请日：2009-08-07
申请人： Xiaoyi Min , Peter A. Nichols
发明人： Xiaoyi Min , Peter A. Nichols
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N1/086
摘要： To provide radio-frequency (RF) bandstop filtering within an implantable lead, such as a pacemaker lead, one or more segments of the tip and ring conductors of the lead are formed as insulated coils to function as inductive band stop filters. By forming segments of the conductors into insulated coils, a separate set of discrete or distributed inductors is not required, yet RF filtering is achieved to, e.g., reduce lead heating during magnetic resonance imaging (MRI) procedures. To enhance the degree of bandstop filtering at the RF signal frequencies of MRIs, additional capacitive elements are added. In one example, the ring electrode of the lead is configured to provide capacitive shunting to the tip conductor. In another example, a capacitive transition is provided between the outer insulated coil and proximal portions of the ring conductor. In still other examples, conducting polymers are provided to enhance capacitive shunting. The insulated coils may be spaced at ¼ wavelength locations.
摘要翻译：为了在诸如起搏器引线的可植入引线内提供射频（RF）带阻滤波，引线的尖端和环形导体中的一个或多个段形成为用作电感带阻滤波器的绝缘线圈。通过将导体的段形成为绝缘线圈，不需要单独的一组离散或分布式电感器，但是实现RF滤波以例如在磁共振成像（MRI）程序期间减少引线加热。为了增强MRI的RF信号频率下的带阻滤波的程度，增加了附加的电容元件。在一个示例中，引线的环形电极被配置为向尖端导体提供电容分流。在另一示例中，在外绝缘线圈和环形导体的近端部分之间提供电容性跃迁。在其它实例中，提供导电聚合物以增强电容分流。绝缘线圈可以在1/4波长位置间隔开。

59. 发明申请

US20110022112A1 SYSTEMS AND METHODS FOR DETERMINING VENTRICULAR PACING SITES FOR USE WITH MULTI-POLE LEADS 有权
标题翻译：用于确定多通道导管使用的透水性场地的系统和方法
公开(公告)号：US20110022112A1
公开(公告)日：2011-01-27
申请号：US12639881
申请日：2009-12-16
申请人： Xiaoyi Min
发明人： Xiaoyi Min
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684
摘要： Techniques are provided for use by implantable medical devices for controlling multi-site left ventricular (MSLV) pacing using a multi-pole left ventricular (LV) lead. In various examples, a reduced number of “V sense”, “RV pace”, and “LV pace” tests are performed to determine preferred or optimal interventricular pacing delays (VV) for use with MSLV pacing. Additionally, techniques are described for sorting the order by which LV sites are to be paced during MSLV pacing. Furthermore, techniques are described for detecting and addressing circumstances where AV/PV delays are longer than corresponding AR/PR delays during MSLV.
摘要翻译：提供技术用于可植入医疗装置，以使用多极左心室（LV）引线来控制多部位左心室（MSLV）起搏。在各种示例中，执行减少数量的“V感觉”，“RV步速”和“LV步调”测试以确定用于MSLV起搏的优选或最佳心室起搏延迟（VV）。另外，描述了用于排序在MSLV起搏期间LV站点要起搏的顺序的技术。此外，描述了用于检测和寻址在MSLV期间AV / PV延迟大于相应的AR / PR延迟的情况的技术。

60. 发明授权

US07850616B1 Determination of diastolic heart failure 有权
标题翻译：舒张性心力衰竭的测定
公开(公告)号：US07850616B1
公开(公告)日：2010-12-14
申请号：US11154064
申请日：2005-06-15
申请人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Falkenberg Eric
发明人： Jong Gill , Xiaoyi Min , Gene A. Bornzin , Falkenberg Eric
IPC分类号： A61B5/021 , A61B5/0225
CPC分类号： A61B5/0215 , A61B5/042 , A61B5/0464 , A61B5/053 , A61B7/00 , A61N1/36578
摘要： An exemplary method includes detecting a change in state of a cardiac valve, detecting elongation of the left ventricle substantially along its major axis, determining a time difference between the change in state of the cardiac valve and the elongation of the left ventricle and, based at least in part on the time difference, deciding whether a diastolic abnormality exists. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：示例性方法包括检测心脏瓣膜的状态变化，检测左心室基本上沿其长轴的伸长，确定心脏瓣膜状态变化与左心室伸长之间的时间差，并基于至少部分地基于时间差，决定是否存在舒张异常。还公开了其它示例性方法，装置，系统等。

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