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51. 发明申请

US20080269882A1 INTRAOCULAR LENS WITH ASYMMETRIC OPTICS 审中-公开
标题翻译：具不对称光学的内窥镜
公开(公告)号：US20080269882A1
公开(公告)日：2008-10-30
申请号：US11742035
申请日：2007-04-30
申请人： Michael J. Simpson , Xiaoxiao Zhang
发明人： Michael J. Simpson , Xiaoxiao Zhang
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2002/1683 , A61F2002/1696 , A61F2002/1699
摘要： In one aspect, an intraocular lens (IOL) is discloses that includes an optic having a central portion and a peripheral extension that partially surrounds the central portion. Once implanted in a patient's eye, the IOL's optic forms an image of a field of view with the peripheral extension inhibiting dysphotopsia. While in some embodiments, the peripheral extension provides focusing of light incident thereon, in other embodiments, it can include at least one textured surface for scattering the light or at least one opaque surface for preventing the light from reaching the retina. In other embodiments, the peripheral extension can include one or more translucent surface(s) for diffusing the light passing therethrough to inhibit dysphotopsia.
摘要翻译：在一个方面，公开了一种眼内透镜（IOL），其包括具有部分围绕中心部分的中心部分和外围延伸部的光学元件。一旦植入患者的眼睛，IOL的光学器件形成视野的图像，其外周延伸抑制异位斑。虽然在一些实施例中，外围延伸部提供入射到其上的光的聚焦，但在其他实施例中，其可包括用于散射光的至少一个纹理化表面或至少一个不透明表面以防止光到达视网膜。在其它实施例中，外围延伸部可以包括一个或多个半透明表面，用于扩散通过其中的光以抑制失调。

52. 发明申请

US20070182924A1 Pseudo-accommodative IOL having multiple diffractive patterns 有权
$Pseudo-accommodative IOL having multiple diffractive patterns$
标题翻译：具有多个衍射图案的假调节性IOL
公开(公告)号：US20070182924A1
公开(公告)日：2007-08-09
申请号：US11350505
申请日：2006-02-09
申请人： Xin Hong , Steve VanNoy , Xiaoxiao Zhang
发明人： Xin Hong , Steve VanNoy , Xiaoxiao Zhang
IPC分类号： G02C7/06
CPC分类号： G02C7/06 , A61F2/1618 , A61F2/1654 , G02C2202/20
摘要： In one aspect, a trifocal ophthalmic lens is disclosed that includes an optic having a surface that comprises at least one trifocal diffractive pattern and at least one bifocal diffractive pattern such that the bifocal pattern provides near and far vision and the trifocal pattern generates near, far, and intermediate vision. For example, the trifocal pattern can provide near, far, and intermediate foci such that the near and far foci are substantially coincident, respectively, with a near and a far focus of the bifocal pattern. In this manner, the trifocal and bifocal patterns collectively provide near, intermediate, and far foci (or focal regions) corresponding, respectively, to the near, intermediate and far vision.
摘要翻译：一方面，公开了一种三焦眼镜，其包括具有包括至少一个三焦衍射图案和至少一个双焦衍射图案的表面的光学元件，使得双焦点图案提供近视和远视力，并且三焦点图案生成近，远和中级视力。例如，三焦点图案可以提供近，远和中间焦点，使得近和远焦点分别与双焦点图案的近焦点和远焦点基本一致。以这种方式，三焦点和双焦点图案集中地提供分别对应于近视，中视和远视的近，中，远焦点（或焦点区域）。

53. 发明授权

US07029497B2 Accommodative intraocular lens 有权
标题翻译：适应性眼内镜
公开(公告)号：US07029497B2
公开(公告)日：2006-04-18
申请号：US10442771
申请日：2003-05-21
申请人： Xiaoxiao Zhang , Yin Yang
发明人： Xiaoxiao Zhang , Yin Yang
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1618 , A61F2/1629 , A61F2/1645 , A61F2/1648 , A61F2002/1681
摘要： A single optic accommodative lens. The lens includes a non-circular ring with radial dimensions that are different in at least two meridians. The radial dimension of vertical meridian of the lens approximates the natural diameter of the capsular bag. The optic of the lens is connected to the ring at the vertical meridian by a pair of haptics.
摘要翻译：单个光学调节镜头。透镜包括具有在至少两个子午线上不同的径向尺寸的非圆形环。透镜的垂直子午线的径向尺寸近似于囊袋的天然直径。透镜的光学元件通过一对触觉件连接到垂直子午线上的环。

54. 发明申请

US20050209692A1 Accommodative intraocular lens system 有权
标题翻译：适应性眼内透镜系统
公开(公告)号：US20050209692A1
公开(公告)日：2005-09-22
申请号：US10805921
申请日：2004-03-22
申请人： Xiaoxiao Zhang
发明人： Xiaoxiao Zhang
IPC分类号： A61F2/16
CPC分类号： A61F2/1629 , A61F2/1648 , A61F2/1694 , A61F2002/1681
摘要： A two optic accommodative lens system. The first lens in the system is fixed in the anterior chamber of an eye. The second lens in the system includes a non-circular ring with radial dimensions that are different in at least two meridians and implanted in the posterior chamber of an eye within the capsular bag. The radial dimension of vertical meridian of the lens approximates the natural diameter of the capsular bag. The optic of the second lens is connected to the ring at the vertical meridian by two or more of haptics. The radial dimension of horizontal meridian of the second lens is slightly larger than the natural diameter of the capsular bag.
摘要翻译：一个两个光学调节透镜系统。系统中的第一个镜片固定在眼睛的前房。系统中的第二透镜包括具有径向尺寸的非圆形环，其在至少两个子午线上不同，并且植入在囊袋内的眼睛的后室中。透镜的垂直子午线的径向尺寸近似于囊袋的天然直径。第二透镜的光学元件通过两个或更多个触觉件在垂直子午线处连接到环。第二透镜的水平子午线的径向尺寸略大于囊袋的天然直径。

55. 发明授权

US06941813B2 Noninvasive pressure sensing assembly 有权
标题翻译：无创压力传感组件
公开(公告)号：US06941813B2
公开(公告)日：2005-09-13
申请号：US10610087
申请日：2003-06-30
申请人： Mikhail Boukhny , Xiaoxiao Zhang
发明人： Mikhail Boukhny , Xiaoxiao Zhang
IPC分类号： G01L9/00
CPC分类号： G01L9/0076 , G01L9/0077
摘要： An optical noninvasive pressure sensing assembly capable of accurately indicating relatively minute pressure changes. The present invention generally includes a light source, such as a Light Emitting Diode (LED) or normal room illumination, positioned to reflected light off of a surface of a membrane. The membrane is in contact with the fluid in which the pressure is to be measured so that changes in the pressure in the fluid cause movement of the membrane. A charge coupling device (CCD) camera captures light reflected off of the membrane and the reflected light is analyzed to determine the relative movement of the membrane based on the change in the pattern of the reflected light.
摘要翻译：一种能够准确地指示相对较小的压力变化的光学非侵入式压力感测组件。本发明通常包括诸如发光二极管（LED）或正常室内照明的光源，其定位成从膜的表面反射光。膜与要测量压力的流体接触，使得流体中的压力变化引起膜的移动。电荷耦合器件（CCD）相机捕获从膜反射的光，并且基于反射光的图案的变化来分析反射光以确定膜的相对运动。

56. 发明授权

US08764822B2 Method of calculating the required power of a toric implant 有权
标题翻译：计算复曲面植入物所需功率的方法
公开(公告)号：US08764822B2
公开(公告)日：2014-07-01
申请号：US12328092
申请日：2008-12-04
申请人： Blake Harris , James Hoffman , Xin Hong , Xiaoxiao Zhang , Warren E. Hill
发明人： Blake Harris , James Hoffman , Xin Hong , Xiaoxiao Zhang , Warren E. Hill
IPC分类号： A61F2/14
CPC分类号： A61F2/1645 , A61F2/142 , A61F2240/001 , G02C7/028
摘要： A method for calculating the required power of a toric implant by using both the measured pre-operative corneal astigmatism and the predicted surgically-induced post-operative astigmatism. The surgically-induced post-operative astigmatism is predicted using power vector analysis of the surgical technique employed by the surgeon. Such a method provides a more accurate method of calculating the required post-operative refractive power of the implant. The method can be implemented manually, but preferably is automated by implementation on a computer through appropriate software.
摘要翻译：通过使用测量的术前角膜散光和预测的手术引起的术后散光来计算复曲面植入物所需功率的方法。使用外科医生使用的手术技术的功率矢量分析来预测手术引起的术后散光。这种方法提供了计算植入物所需的术后屈光力的更精确的方法。该方法可以手动实现，但是优选地通过在计算机上通过适当的软件实现自动化。

57. 发明申请

US20120290085A1 EXTENDED DEPTH OF FOCUS (EDOF) LENS TO INCREASE PSEUDO-ACCOMMODATION BY UTILIZING PUPIL DYNAMICS 有权
标题翻译：聚焦深度（EDOF）镜头通过利用PUPIL动态增加PSEUDO-ACCOMMODATION
公开(公告)号：US20120290085A1
公开(公告)日：2012-11-15
申请号：US13562143
申请日：2012-07-30
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang , Michael Simpson , Myoung Choi , Yan Zhang
IPC分类号： A61F2/16
CPC分类号： G02C7/044 , A61F2/1613 , G02C7/042
摘要： In one aspect, the present invention provides an ophthalmic lens (e.g., an IOL) that includes an optic having an anterior surface and a posterior surface disposed about an optical axis. At least one of the surfaces (e.g., the anterior surface) has a profile characterized by superposition of a base profile and an auxiliary profile. The auxiliary profile can include an inner region, an outer region and a transition region between the inner and the outer regions, where an optical path difference across the transition region (i.e., the optical path difference between the inner and the outer radial boundaries of the transition region) corresponds to a non-integer fraction (e.g., ½) of a design wavelength (e.g., a wavelength of about 550 nm).
摘要翻译：一方面，本发明提供一种眼科镜片（例如，IOL），其包括具有围绕光轴设置的前表面和后表面的光学元件。至少一个表面（例如，前表面）具有由基体轮廓和辅助轮廓叠加来表征的轮廓。辅助轮廓可以包括内部区域，外部区域和内部区域和外部区域之间的过渡区域，其中穿过过渡区域的光程差（即，内部和外部径向边界之间的光程差）过渡区域）对应于设计波长（例如，约550nm的波长）的非整数分数（例如，1/2）。

58. 发明授权

US07998198B2 Accommodative IOL with dynamic spherical aberration 有权
标题翻译：适应性IOL具有动态球面像差
公开(公告)号：US07998198B2
公开(公告)日：2011-08-16
申请号：US12365609
申请日：2009-02-04
申请人： Robert Angelopoulos , Xin Hong , Xiaoxiao Zhang , Mutlu Karakelle
发明人： Robert Angelopoulos , Xin Hong , Xiaoxiao Zhang , Mutlu Karakelle
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2/1629 , A61F2/1637 , A61F2/1648
摘要： The present invention is generally directed to accommodative intraocular lenses (IOLs) that exhibit a dynamic spherical aberration as a function of accommodative power. By way of example, in one aspect, the present invention provides an intraocular lens (IOL) having an anterior optical element, a posterior optical element, and a mechanism for coupling the anterior and posterior elements so as to allow axial movement of those elements relative to one another for providing accommodation when the lens is implanted in a patient's eye. Each of the anterior and the posterior elements includes at least one aspherical surface, where the asphericities of the surfaces are adapted to provide a combined spherical aberration that varies with accommodation.
摘要翻译：本发明通常涉及作为调节功率的函数的动态球面像差的调节性眼内透镜（IOL）。作为示例，在一个方面，本发明提供了一种具有前光学元件，后部光学元件和用于联接前部元件和后部元件的机构的眼内透镜（IOL），以允许这些元件相对于轴向移动当镜片植入患者眼睛时，提供住宿。前部和后部元件中的每一个包括至少一个非球面，其中表面的非球面度适于提供随调节而变化的组合球面像差。

59. 发明授权

US07879089B2 Correction of higher order aberrations in intraocular lenses 有权
标题翻译：矫正眼内透镜高阶像差
公开(公告)号：US07879089B2
公开(公告)日：2011-02-01
申请号：US11435905
申请日：2006-05-17
申请人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang
发明人： Xin Hong , Mutlu Karakelle , Xiaoxiao Zhang
IPC分类号： A61F2/16
CPC分类号： A61F2/141 , A61B3/0025 , A61F2/1637 , A61F2240/001 , A61F2240/008
摘要： In one aspect, the present invention provides a method of designing an intraocular lens (IOL) to address variations of at least one ocular parameter in a population of patient eyes. The method can include establishing at least one eye model in which the ocular parameter can be varied over a range exhibited by the population. The eye model can be employed to evaluate a plurality of IOL designs in correcting visual acuity for eyes in the patient population. An IOL design that provides a best fit for visual performance over at least a portion of the parameter range can then be selected.
摘要翻译：一方面，本发明提供一种设计眼内透镜（IOL）以解决患者眼睛中的至少一个眼睛参数的变化的方法。该方法可以包括建立至少一个眼睛模型，其中眼睛参数可以在群体表现的范围上变化。可以使用眼睛模型来评估多个IOL设计，以校正患者群体中的眼睛的视力。然后可以选择提供最适合视觉性能的IOL设计，至少部分参数范围。

60. 发明申请

US20110022170A1 Truncated diffractive intraocular lenses 审中-公开
$Truncated diffractive intraocular lenses$
标题翻译：截断的衍射眼内透镜
公开(公告)号：US20110022170A1
公开(公告)日：2011-01-27
申请号：US12847214
申请日：2010-07-30
申请人： Michael J. Simpson , Mutlu Karakelle , Stephen J. Van Noy , Xiaoxiao Zhang , Xin Hong , Jihong Xie
发明人： Michael J. Simpson , Mutlu Karakelle , Stephen J. Van Noy , Xiaoxiao Zhang , Xin Hong , Jihong Xie
IPC分类号： A61F2/16 , G02C7/02 , G02C7/06
CPC分类号： A61F2/1654 , A61F2/1618 , G02C7/042 , G02C7/044 , G02C2202/20
摘要： In one aspect, the present invention provides a method of designing a diffractive ophthalmic lens (e.g., an intraocular lens (IOL)) that includes providing an optic having an anterior refractive surface and a posterior refractive surface, wherein the optic provides a far-focus power (e.g., in a range of about 18 to about 26 Diopters (D)). A truncated diffractive structure can be disposed on at least one of the surfaces for generating a near-focus add power (e.g., in a range of about 3 D to about 4 D). And the diffractive structure can be adjusted so as to obtain a desired distribution of optical energy between the near and far foci for a range of pupil sizes.
摘要翻译：一方面，本发明提供了一种设计衍射眼用透镜（例如，眼内透镜（IOL））的方法，其包括提供具有前折射表面和后折射表面的光学元件，其中所述光学元件提供远焦点功率（例如，在约18至约26屈光度（D）的范围内）。截面的衍射结构可以设置在至少一个表面上，用于产生近焦点添加功率（例如，在约3D至约4D的范围内）。并且可以调整衍射结构，以便在一定范围的瞳孔尺寸之间获得近焦点和远焦点之间期望的光能分布。

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