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51. 发明授权

US06395491B1 Method of information storage and recovery 失效
标题翻译：信息存储和恢复方法
公开(公告)号：US06395491B1
公开(公告)日：2002-05-28
申请号：US09585557
申请日：2000-06-02
申请人： Stephen P. A. Fodor , Dennis W. Solas , William J. Dower
发明人： Stephen P. A. Fodor , Dennis W. Solas , William J. Dower
IPC分类号： C12Q168
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07C229/14 , C07C229/16 , C07D263/44 , C07D317/62 , C07H19/04 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K1/047 , C07K7/06 , C07K17/06 , C07K17/14 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6834 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G01N21/6428 , G01N21/6452 , G01N21/6458 , G03F7/00 , G03F7/265 , G03F7/38 , G11C13/0014 , C12Q2535/131 , C12Q2565/626 , C12Q2563/149
摘要： The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
摘要翻译：本发明提供了用于测序，指纹和绘制生物大分子（通常为生物聚合物）的方法和装置。该方法利用多种序列特异性识别试剂，其也可用于生物样品的分类和表征其来源。

52. 发明授权

US06309822B1 Method for comparing copy number of nucleic acid sequences 失效
标题翻译：比较核酸序列拷贝数的方法
公开(公告)号：US06309822B1
公开(公告)日：2001-10-30
申请号：US08772376
申请日：1996-12-23
申请人： Stephen P. A. Fodor , Dennis W. Solas , William J. Dower
发明人： Stephen P. A. Fodor , Dennis W. Solas , William J. Dower
IPC分类号： C12Q168
CPC分类号： G11C13/0019 , B01J19/0046 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y10/00 , B82Y30/00 , C07B2200/11 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6809 , C12Q1/6816 , C12Q1/6827 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475 , G03F7/00 , G03F7/265 , G03F7/38 , G11C13/0014 , C12Q2565/501 , C12Q2539/101
摘要： The present invention provides methods for comparing and identifying differences in nucleic acid sequences using a plurality of sequence specific recognition reagents (i.e., probes comprising a nucleic acid complementary to a nucleic acid sequence in collections to be compared) bound to a solid surface.
摘要翻译：本发明提供了使用多个序列特异性识别试剂（即，包含与待比较的集合中的核酸序列互补的核酸的探针）与固体表面结合来比较和鉴定核酸序列差异的方法。

53. 发明授权

US5902723A Analysis of surface immobilized polymers utilizing microfluorescence detection 失效
标题翻译：使用微观荧光检测分析表面固定化聚合物
公开(公告)号：US5902723A
公开(公告)日：1999-05-11
申请号：US679478
申请日：1996-07-12
申请人： William J. Dower , Stephen P. A. Fodor
发明人： William J. Dower , Stephen P. A. Fodor
IPC分类号： G01N33/48 , B01J19/00 , B01J19/08 , B01L7/00 , B05D3/00 , C07B51/00 , C07B61/00 , C07C231/02 , C07C237/22 , C07H19/10 , C07H21/00 , C07K1/04 , C07K1/06 , C07K7/06 , C07K14/00 , C07K16/00 , C07K17/02 , C07K17/06 , C07K17/08 , C07K17/14 , C12M1/34 , C12Q1/68 , C40B30/04 , C40B40/06 , C40B40/10 , C40B60/14 , G01N1/30 , G01N15/14 , G01N21/64 , G01N33/53 , G01N33/533 , G01N33/536 , G01N33/541 , G01N33/543 , G01N33/566 , G01N33/58 , G01N37/00 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02
CPC分类号： B01J19/0046 , B01L7/52 , B82Y10/00 , B82Y30/00 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6804 , C12Q1/6809 , C12Q1/6816 , C12Q1/6823 , C12Q1/6837 , C12Q1/6869 , C12Q1/6874 , G03F7/00 , G03F7/26 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/0019 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C12Q2535/101 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475
摘要： Means for simultaneous parallel sequence analysis of a large number of biological polymer macromolecules. Apparatus and methods may use fluorescent labels in repetitive chemistry to determine terminal monomers on solid phase immobilized polymers. Reagents which specifically recognize terminal manomers are used to label polymers at defined positions on a solid substrate.
摘要翻译：用于同时并行序列分析大量生物聚合物大分子的方法。装置和方法可以在重复化学中使用荧光标记来测定固相固定化聚合物上的末端单体。用于特异性识别末端异构体的试剂用于在固体基质上的限定位置上标记聚合物。

54. 发明授权

US5871928A Methods for nucleic acid analysis 失效
标题翻译：核酸分析方法
公开(公告)号：US5871928A
公开(公告)日：1999-02-16
申请号：US873034
申请日：1997-06-11
申请人： Stephen P. A. Fodor , Dennis W. Solas , William J. Dower
发明人： Stephen P. A. Fodor , Dennis W. Solas , William J. Dower
IPC分类号： B01J19/00 , C07B61/00 , C07H19/10 , C07H21/00 , C07K1/04 , C07K17/06 , C07K17/14 , C12Q1/68 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/14 , G03F7/00 , G03F7/26 , G03F7/38 , G11C13/02 , C07H21/02 , C07H21/04 , C12P19/34
CPC分类号： G11C13/0019 , B01J19/0046 , B82Y10/00 , B82Y30/00 , C07H19/10 , C07H21/00 , C07K1/042 , C07K1/045 , C07K17/06 , C07K17/14 , C12Q1/6816 , G03F7/00 , G03F7/265 , G03F7/38 , G11C13/0014 , G11C13/02 , B01J2219/00315 , B01J2219/00432 , B01J2219/00434 , B01J2219/00436 , B01J2219/00459 , B01J2219/00468 , B01J2219/00475 , B01J2219/005 , B01J2219/00527 , B01J2219/00529 , B01J2219/00531 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00641 , B01J2219/00648 , B01J2219/00659 , B01J2219/00689 , B01J2219/00695 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , C07B2200/11 , C40B40/06 , C40B40/10 , C40B60/14 , G01N15/1475
摘要： The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classification of biological samples, and to characterize their sources.
摘要翻译：本发明提供了用于测序，指纹和绘制生物大分子（通常为生物聚合物）的方法和装置。该方法利用多种序列特异性识别试剂，其也可用于生物样品的分类和表征其来源。

55. 发明授权

US5830851A Methods of administering peptides that bind to the erythropoietin receptor 失效
标题翻译：给予与促红细胞生成素受体结合的肽的方法
公开(公告)号：US5830851A
公开(公告)日：1998-11-03
申请号：US484631
申请日：1995-06-07
申请人： Nicholas C. Wrighton , William J. Dower , Ray S. Chang , Arun K. Kashyap
发明人： Nicholas C. Wrighton , William J. Dower , Ray S. Chang , Arun K. Kashyap
IPC分类号： A61K38/00 , C07K14/505 , A61K38/04 , C07K7/04 , C12N15/00
CPC分类号： C07K14/505 , A61K38/00
摘要： Peptides of 10 to 40 or more amino acid residues in length and having the sequence X.sub.3 X.sub.4 X.sub.5 GPX.sub.6 TWX.sub.7 X.sub.8 (SEQ ID NO:252) where each amino acid is indicated by standard one letter abbreviation; X.sub.3 is C; X.sub.4 is R, H, L, or W; X.sub.5 is M, F, or I; X.sub.6 is independently selected from any one of the 20 genetically coded L-amino acids; X.sub.7 is D, E, I, L, or V; and X.sub.8 is C, which bind and activate the erythropoietin receptor (EPO-R) or otherwise act as an EPO agonist, and methods for their use.
摘要翻译：长度为10至40个或更多个氨基酸残基并具有序列X3X4X5GPX6TWX7X8（SEQ ID NO：252）的肽，其中每个氨基酸由标准单字母缩写表示; X3是C; X4是R，H，L或W; X5是M，F或I; X6独立地选自20个遗传编码的L-氨基酸中的任一个; X7是D，E，I，L或V; X8是C，其结合并激活促红细胞生成素受体（EPO-R）或以其它方式作为EPO激动剂，以及它们使用的方法。

56. 发明授权

US5427908A Recombinant library screening methods 失效
标题翻译：重组文库筛选方法
公开(公告)号：US5427908A
公开(公告)日：1995-06-27
申请号：US517659
申请日：1990-05-01
申请人： William J. Dower , Steven E. Cwirla
发明人： William J. Dower , Steven E. Cwirla
IPC分类号： C07K14/00 , C07K16/00 , C07K19/00 , C12N1/21 , C12N7/00 , C12N15/09 , C12N15/10 , C12P21/02 , C12P21/08 , C12Q1/68 , C12R1/92 , C40B40/02 , G01N33/53 , G01N33/531 , C12N5/00 , C12N15/13
CPC分类号： C40B40/02 , C07K16/00 , C07K16/005 , C12N15/1037
摘要： Nucleotide sequences encoding proteins of interest are isolated from DNA libraries using bacteriophage to link the protein to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest and inserted into or adjacent to a coat protein of a bacteriophage vector, or into a sequence encoding a protein which may be linked by means of a ligand to a phage coat protein. By employing affinity purification techniques the phage particles containing sequences encoding the desired protein may be selected and the desired nucleotide sequences obtained therefrom. Thus, for example, novel proteins such as monoclonal antibodies may be produced and conventional hybridoma technology avoided.
摘要翻译：使用噬菌体从DNA文库中分离编码感兴趣的蛋白质的核苷酸序列，以将蛋白质与编码它的序列连接。从编码感兴趣的蛋白质的细胞和插入到噬菌体载体的外壳蛋白中或邻近的蛋白质制备DNA文库，或者将其编码为可通过配体与噬菌体外壳蛋白连接的蛋白质的序列。通过使用亲和纯化技术，可以选择含有编码所需蛋白质的序列的噬菌体颗粒和从其获得的所需核苷酸序列。因此，例如，可以产生新的蛋白质，例如单克隆抗体，并避免常规的杂交瘤技术。

57. 发明授权

US5186800A Electroporation of prokaryotic cells 失效
标题翻译：原核细胞的电穿孔
公开(公告)号：US5186800A
公开(公告)日：1993-02-16
申请号：US493253
申请日：1990-03-14
申请人： William J. Dower
发明人： William J. Dower
IPC分类号： C12M3/00 , C12N13/00 , C12N15/64 , C12N15/87
CPC分类号： C12N15/87 , C12M35/02 , C12N13/00 , C12N15/64
摘要： Electroporation of prokaryotic cells is achieved by the application of high-intensity electric fields of short duration to reversibly permeabilize the cell walls. Preferably, the field strength of the applied will be at least about 5 kV/cm and the duration of the exposure will be in the range from 2 to 20 msec. Macromolecules may be introduced to the cells or obtained from the cells during this period of cell wall permeability. Most commonly, the method will be utilized for transformation of the cells with nucleic acids. Very high transformation efficiencies in the range from 10.sup.9 to 10.sup.10 cells/.mu.g and transformation frequencies approaching 80% and above have been achieved.
摘要翻译：通过应用短时间的高强度电场来可逆地渗透细胞壁来实现原核细胞的电穿孔。优选地，施加的场强将为至少约5kV / cm，并且曝光的持续时间将在2至20毫秒的范围内。在细胞壁渗透期间，大分子可以被引入细胞或从细胞获得。最通常地，该方法将用于用核酸转化细胞。转化效率达到109〜1010个/ g，转化率达到80％以上。

58. 发明申请

US20130012685A1 NOVEL PEPTIDES THAT BIND TO THE ERYTHROPOIETIN RECEPTOR 审中-公开
标题翻译：与蛋白激酶受体结合的新肽
公开(公告)号：US20130012685A1
公开(公告)日：2013-01-10
申请号：US13541420
申请日：2012-07-03
申请人： Christopher P. Holmes , Qun Yin , Genet Zemede , Ashok Bhandari , Yaohua S. Dong , David Tumelty , Guy Lalonde , Brian T. Frederick , Anjan Chakrabarti , Palani Balu , Peter J. Schatz , Nicholas C. Wrighton , William J. Dower
发明人： Christopher P. Holmes , Qun Yin , Genet Zemede , Ashok Bhandari , Yaohua S. Dong , David Tumelty , Guy Lalonde , Brian T. Frederick , Anjan Chakrabarti , Palani Balu , Peter J. Schatz , Nicholas C. Wrighton , William J. Dower
IPC分类号： C07K7/00 , C07K14/00
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to peptide compounds that are agonists of the erythropoietin receptor (EPO-R). The invention further relates to therapeutic methods using such peptide compounds to treat disorders associated with insufficient or defective red blood cell production. Pharmaceutical compositions, which comprise the peptide compounds of the invention, are also provided.
摘要翻译：本发明涉及作为促红细胞生成素受体（EPO-R）的激动剂的肽化合物。本发明还涉及使用这种肽化合物治疗与不充分或有缺陷的红细胞生成相关的疾病的治疗方法。还提供了包含本发明的肽化合物的药物组合物。

59. 发明申请

US20100137255A1 CREATINE PHOSPHATE ANALOG PRODRUGS, COMPOSITIONS AND USES THEREOF 失效
标题翻译： CREATINE PHOSPHATE ANALOG PRODRUGS，COMPOSITIONS AND USES THEREOF
公开(公告)号：US20100137255A1
公开(公告)日：2010-06-03
申请号：US12699471
申请日：2010-02-03
申请人： Noa Zerangue , Qingzhi Gao , William J. Dower
发明人： Noa Zerangue , Qingzhi Gao , William J. Dower
IPC分类号： A61K31/675 , C07F9/09 , A61P9/00 , A61P9/04
CPC分类号： C07F9/2458 , A01N1/0226 , C07F9/6506
摘要： Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate analogs, or pharmaceutical compositions thereof are disclosed.
摘要翻译：肌酸磷酸酯类似物的膜可渗透前体药物，包含磷酸肌酸类似物的膜可渗透前体药物的药物组合物，以及治疗疾病如缺血，心力衰竭和神经变性疾病的方法，包括施用磷酸肌酸类似物的前药或其药物组合物。

60. 发明授权

US07683043B2 Creatine phosphate analog prodrugs, compositions and uses thereof 失效
标题翻译：肌酸磷酸酯类似物前药，其组合物和用途
公开(公告)号：US07683043B2
公开(公告)日：2010-03-23
申请号：US11810980
申请日：2007-06-06
申请人： Noa Zerangue , Qingzhi Gao , William J. Dower
发明人： Noa Zerangue , Qingzhi Gao , William J. Dower
IPC分类号： A61K31/66 , C07F9/02
CPC分类号： C07F9/2458 , A01N1/0226 , C07F9/6506
摘要： Membrane permeable prodrugs of creatine phosphate analogs, pharmaceutical compositions comprising membrane permeable prodrugs of creatine phosphate analogs, and methods of treating diseases such as ischemia, heart failure, and neurodegenerative disorders comprising administering prodrugs of creatine phosphate analogs, or pharmaceutical compositions thereof are disclosed.
摘要翻译：肌酸磷酸酯类似物的膜可渗透前体药物，包含磷酸肌酸类似物的膜可渗透前体药物的药物组合物，以及治疗疾病如缺血，心力衰竭和神经变性疾病的方法，包括施用磷酸肌酸类似物的前药或其药物组合物。

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