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51. 发明申请

US20080089952A1 Compositions and methods for coating medical implants 审中-公开
公开(公告)号：US20080089952A1
公开(公告)日：2008-04-17
申请号：US11888674
申请日：2007-07-31
申请人： William Hunter , David Gravett , Philip Toleikis , Richard Liggins , Troy Loss
发明人： William Hunter , David Gravett , Philip Toleikis , Richard Liggins , Troy Loss
IPC分类号： A61K31/17 , A61K31/35 , A61K31/44 , A61K33/24 , A61P43/00
CPC分类号： A61L29/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L2300/404 , A61L2300/416
摘要： Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.

52. 发明申请

US20060127438A1 Compositions and methods for coating medical implants 审中-公开
公开(公告)号：US20060127438A1
公开(公告)日：2006-06-15
申请号：US11343714
申请日：2006-01-31
申请人： William Hunter , David Gravett , Philip Toleikis , Richard Liggins , Troy Loss
发明人： William Hunter , David Gravett , Philip Toleikis , Richard Liggins , Troy Loss
IPC分类号： A61K31/7072 , A61K31/7048 , A61K31/704 , A61K31/4745 , A61K31/525
CPC分类号： A61L29/16 , A61L27/34 , A61L27/54 , A61L29/085 , A61L2300/404 , A61L2300/416
摘要： Medical implants are provided which release an anthracycline, fluoropyrimidine, folic acid antagonist, podophylotoxin, camptothecin, hydroxyurea, and/or platinum complex, thereby inhibiting or reducing the incidence of infection associated with the implant.

53. 发明申请

US20070213393A1 COMPOSITIONS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS UTILIZING PROTEIN OR POLYSACCHARIDE CONTAINING ANTI-MICROTUBULE AGENTS 审中-公开
标题翻译：用于处理含有抗微生物剂的蛋白质或多糖的炎症条件的组合物和方法
公开(公告)号：US20070213393A1
公开(公告)日：2007-09-13
申请号：US11687528
申请日：2007-03-16
申请人： William Hunter , David Gravett , Richard Liggins , Philip Toleikis
发明人： William Hunter , David Gravett , Richard Liggins , Philip Toleikis
IPC分类号： A61K31/337 , A61K31/165 , A61K47/36 , A61K47/42 , C07C233/01 , C07D305/14
CPC分类号： A61K9/5161 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/1075 , A61K9/127 , A61K9/14 , A61K9/5153 , A61K9/7007 , A61K31/165 , A61K31/337 , A61K31/717 , A61K31/721 , A61K31/728 , A61K38/36 , A61K38/38 , A61K38/39 , A61K47/36 , A61K47/38 , A61K47/42 , A61K2300/00
摘要： Disclosed herein are compositions and methods for treating a variety of inflammatory conditions (e.g., inflammatory arthritis, adhesions, tumor excision sites, and fibroproliferative diseases of the eye). For example, there is provided a composition comprising a protein or polysaccharide containing dispersed (e.g., in micelle or liposome form) anti-microtubule agent, which may be formulated for administration to a patient in need thereof.
摘要翻译：本文公开了用于治疗各种炎性病症（例如炎症性关节炎，粘连，肿瘤切除部位和眼睛的纤维增生性疾病）的组合物和方法。例如，提供了包含含有分散（例如胶束或脂质体形式）抗微管剂的蛋白质或多糖的组合物，其可以配制用于给予有需要的患者。

54. 发明申请

US20130122112A1 Derivatized Hyperbranched Polyglycerols 有权
标题翻译：衍生的超支化聚甘油
公开(公告)号：US20130122112A1
公开(公告)日：2013-05-16
申请号：US13581463
申请日：2011-03-01
申请人： Helen M. Burt , Donald Brooks , Jayachandran Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
发明人： Helen M. Burt , Donald Brooks , Jayachandran Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
IPC分类号： A61K47/10 , C08G65/333
CPC分类号： A61K47/10 , A61K9/0034 , A61K9/006 , A61K9/5146 , A61K31/337 , A61K31/407 , A61K33/24 , A61K47/34 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/34 , C08G65/48 , C08G83/005 , C08G83/006 , C08G2650/54
摘要： Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C1C20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.
摘要翻译：本文提供衍生的超支化聚甘油（“dHPG”）。 dHPG包含核心，其包含用C1C20烷基链衍生的超支化聚甘油和包含至少一个与核心羟基结合的亲水取代基的壳，其中超支化聚甘油包含约1至约200摩尔的至少一个亲水取代基。 dHPG用作将药物或其他生物活性部分递送至尿路，消化道，气道，阴道腔和子宫颈以及腹膜腔以治疗诸如癌症的适应症的药剂，其可能是有用的在制备中用于治疗癌症的药物组合物的治疗或制造中，作为用于改善组织中药物摄取的预处理或共处理。此外，还提供了制备dHPG的方法。

55. 发明申请

US20080146652A1 MICELLAR DRUG DELIVERY VEHICLES AND PRECURSORS THERETO AND USES THEREOF 审中-公开
公开(公告)号：US20080146652A1
公开(公告)日：2008-06-19
申请号：US11834498
申请日：2007-08-06
申请人： Richard Liggins , Larry Murphy , Dechi Guan
发明人： Richard Liggins , Larry Murphy , Dechi Guan
IPC分类号： A61K31/337 , A61K47/32 , A61P35/00
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/107 , A61K9/19
摘要： Anhydrous formulations are formed of a diblock copolymer (X-Y) having a hydrophilic block X comprising residues of monomer x, and a hydrophobic block Y comprising residues of monomer y; an additive selected from a polymer and an organic solvent, where the solvent is water-miscible and biocompatible, and the polymer is hydrophobic or hydrophilic and comprises residues of monomers x and/or y, the polymer optionally having a molecular weight that is less than the molecular weight of the diblock copolymer; and a drug. Upon admixture with water, the anhydrous formulations form drug delivery vehicles, preferably in micellar form. The inclusion of polymer and/or organic solvent provides for the formation of micelles at an enhanced rate, and/or provides the formation of micelles having an enhanced ability to incorporate drug(s), and/or provides the formation of micelles having advantageous physical characteristics, e.g., advantageous viscosity and/or melting point.

56. 发明授权

US09186410B2 Derivatized hyperbranched polyglycerols 有权
标题翻译：衍生的超支化聚甘油
公开(公告)号：US09186410B2
公开(公告)日：2015-11-17
申请号：US13581463
申请日：2011-03-01
申请人： Helen Burt , Donald Brooks , Jayachandran Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
发明人： Helen Burt , Donald Brooks , Jayachandran Kizhakkedathu , Richard Liggins , Dechi Guan , Lu Ye , Clement Mugabe , Alan So , Martin E. Gleave , John K. Jackson , Rajesh Kumar Kainthan
IPC分类号： A61K33/24 , C07C217/00 , C07D207/46 , A61K47/10 , A61K9/51 , A61K47/34 , C08G65/34 , C08G65/48 , C08G83/00 , C08G65/333 , A61K9/00
CPC分类号： A61K47/10 , A61K9/0034 , A61K9/006 , A61K9/5146 , A61K31/337 , A61K31/407 , A61K33/24 , A61K47/34 , A61K47/60 , C08G65/33306 , C08G65/33337 , C08G65/34 , C08G65/48 , C08G83/005 , C08G83/006 , C08G2650/54
摘要： Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with C1C20 alkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs.
摘要翻译：本文提供衍生的超支化聚甘油（“dHPG”）。 dHPG包含核心，其包含用C1C20烷基链衍生的超支化聚甘油和包含至少一个与核心羟基结合的亲水取代基的壳，其中超支化聚甘油包含约1至约200摩尔的至少一个亲水取代基。 dHPG用作将药物或其他生物活性部分递送至尿路，消化道，气道，阴道腔和子宫颈以及腹膜腔以治疗诸如癌症的适应症的药剂，其可能是有用的在制备中用于治疗癌症的药物组合物的治疗或制造中，作为用于改善组织中药物摄取的预处理或共处理。此外，还提供了制造dHPG的方法。

57. 发明申请

US20080132564A1 MICELLAR DRUG DELIVERY VEHICLES AND PRECURSORS THERETO AND USES THEREOF 审中-公开
标题翻译： MICELLAR DRUG交付车辆及其前身及其使用
公开(公告)号：US20080132564A1
公开(公告)日：2008-06-05
申请号：US11834499
申请日：2007-08-06
申请人： Richard Liggins , Larry Murphy , Dechi Guan
发明人： Richard Liggins , Larry Murphy , Dechi Guan
IPC分类号： A61K47/30 , A61K31/337
CPC分类号： A61K31/337 , A61K9/0019 , A61K9/107 , A61K9/19
摘要： Anhydrous formulations are formed of a diblock copolymer (X—Y) having a hydrophilic block X comprising residues of monomer x, and a hydrophobic block Y comprising residues of monomer y; an additive selected from a polymer and an organic solvent, where the solvent is water-miscible and biocompatible, and the polymer is hydrophobic or hydrophilic and comprises residues of monomers x and/or y, the polymer optionally having a molecular weight that is less than the molecular weight of the diblock copolymer; and a drug. Upon admixture with water, the anhydrous formulations form drug delivery vehicles, preferably in micellar form. The inclusion of polymer and/or organic solvent provides for the formation of micelles at an enhanced rate, and/or provides the formation of micelles having an enhanced ability to incorporate drug(s), and/or provides the formation of micelles having advantageous physical characteristics, e.g., advantageous viscosity and/or melting point.
摘要翻译：无水制剂由具有包含单体x的残基的亲水性嵌段X的二嵌段共聚物（X-Y）和包含单体y的残基的疏水性嵌段Y形成; 选自聚合物和有机溶剂的添加剂，其中溶剂是水可混溶和生物相容的，并且聚合物是疏水的或亲水的，并且包含单体x和/或y的残基，所述聚合物任选地具有小于二嵌段共聚物的分子量; 和一种药物。在与水混合时，无水制剂形成药物递送载体，优选以胶束形式存在。包含聚合物和/或有机溶剂提供以增强的速率形成胶束，和/或提供具有增强的引入药物的能力的胶束的形成和/或提供具有有利物理性质的胶束的形成特性，例如有利的粘度和/或熔点。

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