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51. 发明授权

US09244082B2 Detection and treatment of LRP4-associated neurotransmission disorders 有权
标题翻译：检测和治疗LRP4相关的神经传递障碍
公开(公告)号：US09244082B2
公开(公告)日：2016-01-26
申请号：US13452018
申请日：2012-04-20
申请人： Lin Mei , Wen-Cheng Xiong , Bin Zhang , Chengyong Shen
发明人： Lin Mei , Wen-Cheng Xiong , Bin Zhang , Chengyong Shen
IPC分类号： A61K39/395 , A61K38/00 , C07K1/00 , G01N33/68 , C12Q1/68 , G01N33/564 , G01N33/92
CPC分类号： G01N33/6896 , C07K16/28 , C07K2317/76 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/178 , G01N33/564 , G01N33/6893 , G01N33/92 , G01N2333/705 , G01N2500/04 , G01N2800/28 , G01N2800/38
摘要： The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.
摘要翻译：本发明包括用于检测神经传递或发育障碍的方法，包括但不限于对乙酰胆碱受体（AChR）和/或肌肉特异性酪氨酸激酶（MuSK）的自身抗体血清阴性的重症肌无力，所述方法包括检测与LRP4结合的自身抗体或其表位。还包括用于治疗患有神经传递障碍的个体的方法，所述方法包括在体液中检测结合LRP4的单个自身抗体或其表位，并向患者施用有效量的免疫抑制剂和/ 或另一适当的治疗方式。还包括与LRP4自身抗体结合的抗体和用于检测神经传递或发育障碍的试剂盒。

52. 发明授权

US09158117B2 Spectra shaping device for chirped pulse amplification 有权
标题翻译：用于啁啾脉冲放大的光谱整形装置
公开(公告)号：US09158117B2
公开(公告)日：2015-10-13
申请号：US12735946
申请日：2009-03-05
申请人： Ming Li , Yaping Dai , Tao Wang , Bin Zhang
发明人： Ming Li , Yaping Dai , Tao Wang , Bin Zhang
IPC分类号： G02B17/00 , G02B27/09 , G01J3/18 , G02B19/00 , G01J3/24 , G01J3/12 , H01S3/00
CPC分类号： G02B27/0944 , G01J3/1804 , G01J3/24 , G01J2003/1282 , G02B19/0023 , G02B19/0052 , G02B27/0927 , G02B27/0983 , H01S3/005
摘要： A spectra shaping apparatus for chirped pulse amplification(CPA) comprises a CTSI spectral decomposition system and a CTSI spectral synthesizing system being symmetrical, and a spectral modulating system composed of a diaphragm (10) and a plane spectra modulating reflector (5), wherein the CTSI spectral decomposition system totally expands a laser chirped pulse to a spectra plane, the spectral modulating system performs a spectra modulation on the image plane, and the CTSI spectral synthesizing system reverts the modulated spectra into the chirped pulse without distortion, thereby realizing spectra shaping. The apparatus has the feature of manufacturing easy, compacting structure, requiring less space, and cheap in cost etc., which can be different types of configuration for different circumstance application, and which can be utilized in a general laser spectrum shaping and spectrum modulation, especially for a high energy and ultra-high peak-power laser system with a large caliber and a broadband of pulse.
摘要翻译：用于啁啾脉冲放大（CPA）的光谱整形装置包括对称的CTSI光谱分解系统和CTSI光谱合成系统，以及由光阑（10）和平面光谱调制反射器（5）组成的光谱调制系统，其中 CTSI光谱分解系统将激光啁啾脉冲完全扩展到光谱平面，光谱调制系统在图像平面上进行光谱调制，CTSI光谱合成系统将调制光谱恢复为无畸变的啁啾脉冲，从而实现光谱整形。该装置具有制造容易，压实结构的特点，需要较少的空间和便宜的成本等，可以为不同情况应用的不同类型的配置，并且其可以用于一般的激光频谱整形和频谱调制，特别适用于具有大口径和宽带脉冲的高能量和超高峰值功率激光系统。

53. 发明授权

US09154029B2 Power supply modulation method and power supply modulator 有权
标题翻译：电源调制方式和电源调制器
公开(公告)号：US09154029B2
公开(公告)日：2015-10-06
申请号：US14005543
申请日：2011-10-24
申请人： Linguo Wang , Bin Zhang
发明人： Linguo Wang , Bin Zhang
IPC分类号： G05F1/00 , H02M3/10 , H02M3/155 , H03F1/02 , H02J1/10 , H02M1/00 , H02M3/156
CPC分类号： H02M3/10 , H02M3/155 , H02M7/483 , H02M2001/0022 , H02M2001/0045 , H02M2003/1566 , H03F1/0227
摘要： A modulation method and modulator for an envelope tracking power supply. An output of a multi-level switching regulator (202) in the envelope tracking power supply modulator is in parallel connection with an output of a linear regulator (201) via an inductor (203) and supplies power to a load. The modulation method for the envelope tracking power supply includes: generating a first control signal (209) according to the current (211) obtained from inputting a first reference level signal (206); comparing the amplitude of a second reference level signal (2061) obtained according to the first reference level signal (206) with preset amplitudes of at least three levels, and outputting a second control signal (210) according to the comparison result and the first control signal (209); the multi-level switching regulator (202) outputting a level signal of corresponding amplitude according to the second control signal (210), and loading the amplitude of the level on the inductor (203) to output an inductive current (208′); and linearly regulating the first reference level signal (206) via a linear regulator (201) to obtain a voltage output (207) to the load. The present disclosure resolves the problem of fixed rate of change of current output by the switching regulator of the envelope tracking power supply regulator and cannot adjust to different load current change rates, thus the inductive current outputted by the multi-level switching regulator can better track the load current change.
摘要翻译：一种用于包络跟踪电源的调制方法和调制器。包络跟踪电源调制器中的多电平开关调节器（202）的输出通过电感器（203）与线性调节器（201）的输出并联连接，并向负载供电。用于包络跟踪电源的调制方法包括：根据从输入第一参考电平信号（206）获得的当前（211）产生第一控制信号（209）; 将根据第一参考电平信号（206）获得的第二参考电平信号（2061）的幅度与至少三个电平的预设幅度进行比较，并且根据比较结果和第一控制输出第二控制信号（210）信号（209）; 所述多电平开关稳压器（202）根据所述第二控制信号（210）输出对应幅度的电平信号，并且将所述电平的电平加载到所述电感器（203）上以输出感应电流（208'）; 并且经由线性调节器（201）线性调节第一基准电平信号（206）以获得负载的电压输出（207）。本公开解决了由包络跟踪电源调节器的开关调节器产生的固定电流变化率的问题，并且不能适应不同的负载电流变化率，因此多电平开关调节器输出的感应电流可以更好地跟踪负载电流变化。

54. 发明申请

US20150148548A1 Silodosin Intermediate and Preparation Method Therefor 审中-公开
标题翻译：西洛昔辛中间体及其制备方法
公开(公告)号：US20150148548A1
公开(公告)日：2015-05-28
申请号：US14365638
申请日：2012-07-27
申请人： Bin Zhang , Xiaowei Hu , Pucha Yan , Xianyi Zhang , Hongjun Gao , Yuanqiang Li , Daqing Che
发明人： Bin Zhang , Xiaowei Hu , Pucha Yan , Xianyi Zhang , Hongjun Gao , Yuanqiang Li , Daqing Che
IPC分类号： C07D209/08
CPC分类号： C07D209/08 , C07F7/00 , C07F7/02 , C07F7/18 , C07F9/65397 , Y02P20/55
摘要： Disclosed are a silodosin intermediate and a preparation method thereof. The silodosin intermediate has the structure shown by the formula (A). X is hydrogen or bromide and R1 is hydrogen. The formyl group may be a group having the structure shown by the formula I. R7 is a protecting group of carboxyl, and R2 is 3-hydroxypropyl or a group having the structure shown by the formula II. W is a protecting group of hydroxyl. A compound of the formula (A) according to the present invention may further be used for preparing a compound having the structure shown by the formula (D). By means of the intermediate and the preparation method therefor provided by the present invention, high-purity optically pure silodosin can be obtained, and the optical purity is above 99%.
摘要翻译：公开了一种西洛多辛中间体及其制备方法。西洛德辛中间体具有式（A）所示的结构。 X是氢或溴，R 1是氢。甲酰基可以是具有式I所示结构的基团.R 7是羧基的保护基，R 2是3-羟丙基或具有式II所示结构的基团。 W是羟基的保护基。根据本发明的式（A）化合物还可用于制备具有式（D）所示结构的化合物。通过本发明提供的中间体及其制备方法，可以获得高纯度的光学纯的芝麻酮，光学纯度高于99％。

55. 发明授权

US08918397B2 Clustering customers 有权
标题翻译：聚集客户
公开(公告)号：US08918397B2
公开(公告)日：2014-12-23
申请号：US13561468
申请日：2012-07-30
申请人： Heng Cao , Jin Dong , Jacqueline Giang Huong Morris , Ming Xie , Wen Jun Yin , Bin Zhang
发明人： Heng Cao , Jin Dong , Jacqueline Giang Huong Morris , Ming Xie , Wen Jun Yin , Bin Zhang
IPC分类号： G06F17/30 , G06Q30/02
CPC分类号： G06Q30/02
摘要： A computer implemented method for clustering customers includes receiving a source set of customer records, wherein each customer record represents one customer, and each customer record includes at least one data attribute, and each data attribute has an attribute value; pre-processing the source set of customer records to generate a pre-processed set of customer records; executing a clustering algorithm on the pre-processed set of customer records to group the pre-processed set of customer records into clusters of a pre-defined number. The pre-processing comprises: determining the type of a customer in the source set of customer records; using a type attribute value to indicate the type of the customer in its customer record; normalizing data attribute values and type attribute values; weighting to the data attribute values and the type attribute values respectively to obtain weighted attribute values of the data attribute and weighted attribute values of the type attribute.
摘要翻译：用于聚类客户的计算机实现方法包括接收客户记录的源集合，其中每个客户记录表示一个客户，并且每个客户记录包括至少一个数据属性，并且每个数据属性具有属性值; 预处理客户记录的源集合以生成预处理的一组客户记录; 在预处理的客户记录集上执行聚类算法，以将预处理的客户记录集合分组成预定义数量的集群。预处理包括：确定客户记录源组中客户的类型; 使用类型属性值来指示客户记录中客户的类型; 归一化数据属性值和类型属性值; 分别对数据属性值和类型属性值进行加权，以获得类型属性的数据属性和加权属性值的加权属性值。

56. 发明授权

US08871114B2 Phosphor compositions and methods of making the same 有权
标题翻译：荧光粉组合物及其制备方法
公开(公告)号：US08871114B2
公开(公告)日：2014-10-28
申请号：US13586677
申请日：2012-08-15
申请人： Hiroaki Miyagawa , Bin Zhang , James Chienchung Shih
发明人： Hiroaki Miyagawa , Bin Zhang , James Chienchung Shih
IPC分类号： C09K11/77 , H05B33/14
CPC分类号： C09K11/7774 , C09K11/7721 , F21V9/30 , G21K5/00 , H01L33/502 , H05B33/14
摘要： Disclosed herein are emissive ceramic elements having low amounts of certain trace elements. Applicants have surprisingly found that a lower internal quantum efficiency (IQE) may be attributed to specific trace elements that, even at very low amounts (e.g., 50 ppm or less), can cause significant deleterious effects on IQE. In some embodiments, the emissive ceramic element includes a garnet host material and an amount of Ce dopant. The emissive ceramic element may, in some embodiments, have an amount of Na in the composition less than about 67 ppm, an amount of Mg in the composition less than about 23 ppm, or an amount of Fe in the composition less than about 21 ppm.
摘要翻译：本文公开了具有少量某些微量元素的发光陶瓷元件。申请人惊奇地发现，较低的内部量子效率（IQE）可归因于特定的微量元素，甚至在非常低的量（例如，50ppm或更少）下也可能对IQE产生显着的有害影响。在一些实施例中，发射陶瓷元件包括石榴石主体材料和一定量的Ce掺杂剂。在一些实施方案中，发光陶瓷元件可以具有小于约67ppm的组成中的Na的量，组合物中的Mg的量小于约23ppm，或组合物中的Fe的量小于约21ppm 。

57. 发明授权

US08828531B2 Emissive ceramic materials having a dopant concentration gradient and methods of making and using the same 有权
标题翻译：具有掺杂剂浓度梯度的发光陶瓷材料及其制造和使用方法
公开(公告)号：US08828531B2
公开(公告)日：2014-09-09
申请号：US13306797
申请日：2011-11-29
申请人： Guang Pan , Hiroaki Miyagawa , Hironaka Fujii , Bin Zhang , Rajesh Mukherjee , Toshitaka Nakamura , Amane Mochizuki
发明人： Guang Pan , Hiroaki Miyagawa , Hironaka Fujii , Bin Zhang , Rajesh Mukherjee , Toshitaka Nakamura , Amane Mochizuki
IPC分类号： B32B3/26 , B32B18/00 , C09K11/00 , C09K11/80 , C09K11/77 , C04B35/638 , C04B35/44 , C04B35/626 , H01L33/50
CPC分类号： C09K11/7774 , B32B18/00 , C04B35/44 , C04B35/6261 , C04B35/62665 , C04B35/6268 , C04B35/638 , C04B38/00 , C04B2111/807 , C04B2235/3225 , C04B2235/3229 , C04B2235/3418 , C04B2235/441 , C04B2235/5409 , C04B2235/6025 , C04B2235/604 , C04B2235/6562 , C04B2235/6565 , C04B2235/6581 , C04B2235/661 , C04B2235/663 , C04B2235/75 , C04B2235/764 , C04B2235/9646 , C04B2235/9653 , C04B2235/9661 , C04B2237/343 , C04B2237/582 , C04B2237/586 , C04B2237/704 , C09K2211/182 , H01L33/502 , H01L33/505 , H01L51/52 , Y10T428/249953 , Y10T428/249961 , Y10T428/24997 , Y10T428/24999 , C04B38/0655
摘要： Disclosed herein are emissive ceramic materials having a dopant concentration gradient along a thickness of a yttrium aluminum garnet (YAG) region. The dopant concentration gradient may include a maximum dopant concentration, a half-maximum dopant concentration, and a slope at or near the half-maximum dopant concentration. The emissive ceramics may, in some embodiments, exhibit high internal quantum efficiencies (IQE). The emissive ceramics may, in some embodiments, include porous regions. Also disclosed herein are methods of make the emissive ceramic by sintering an assembly having doped and non-doped layers.
摘要翻译：本文公开了具有沿钇铝石榴石（YAG）区域的厚度的掺杂剂浓度梯度的发射陶瓷材料。掺杂剂浓度梯度可以包括最大掺杂剂浓度，半最大掺杂剂浓度以及在半最大掺杂剂浓度处或附近的斜率。在一些实施例中，发射陶瓷可表现出高的内部量子效率（IQE）。在一些实施例中，发光陶瓷可以包括多孔区域。本文还公开了通过烧结具有掺杂层和非掺杂层的组件来制造发光陶瓷的方法。

58. 发明申请

US20140227042A1 CONSTANT-RESISTANCE AND LARGE DEFORMATION ANCHOR CABLE AND CONSTANT-RESISTANCE DEVICE 有权
标题翻译：不间断电阻和大型变形锚索和恒电阻装置
公开(公告)号：US20140227042A1
公开(公告)日：2014-08-14
申请号：US14126289
申请日：2011-06-13
申请人： Manchao He , Zhigang Tao , Bin Zhang , Xiaojie Yang
发明人： Manchao He , Zhigang Tao , Bin Zhang , Xiaojie Yang
IPC分类号： E21D21/00
CPC分类号： E21D21/0033 , E02D5/80 , E21D21/02
摘要： A constant-resistance and large deformation anchor cable and a constant-resistance device are provided. The constant-resistance and large deformation anchor cable comprises cables (7), an anchoring device (13), a loading plate (12) and clipping sheets (4). The upper end of cables (7) is fixed on the anchoring device (13) and the loading plate (12) by clipping sheets (4). The constant-resistance and large deformation anchor cable also comprises a constant-resistance device, and the constant-resistance device comprises a sleeve (8) and a constant-resistance body (5). The sleeve (8) is a straight tube. The constant-resistance body is conical, and the diameter of the lower end of the constant-resistance body is bigger than the diameter of the upper end of the constant-resistance body. The inner diameter of the sleeve (8) is smaller than the diameter of the lower end of the constant-resistance body. A cuneiform part is arranged on inner wall of the lower end of the sleeve (8), and the constant-resistance body (5) is arranged on the cuneiform part. The strength of constant-resistance body (5) is higher than the strength of the sleeve (8), thus the sleeve (8) generates plastic deforming and the shape of the constant-resistance body (5) is not changed, when the constant-resistance body (5) moves in the sleeve (8). The lower end of the cables (7) is fixed on the constant-resistance body (5). The constant-resistance and large deformation anchor cable and the constant-resistance device have the properties of constant-resistance and preventing fracture, and can detect and early warn the all process of the activity of the landslides and the causative fault.
摘要翻译：提供恒电阻大变形锚索和恒电阻装置。恒电阻和大变形锚索包括电缆（7），锚固装置（13），装载板（12）和夹板（4）。电缆（7）的上端通过夹板（4）固定在锚固装置（13）和装载板（12）上。恒电阻和大变形锚索还包括恒电阻装置，并且恒电阻装置包括套筒（8）和恒定电阻体（5）。套筒（8）是直管。恒定电阻体是圆锥形的，恒定电阻体的下端的直径大于恒定电阻体的上端的直径。套筒（8）的内径小于恒定电阻体的下端的直径。楔形部分布置在套筒（8）的下端的内壁上，并且恒定阻力体（5）布置在楔形部分上。恒定电阻体（5）的强度高于套筒（8）的强度，因此套筒（8）产生塑性变形，恒定电阻体（5）的形状不变，当常数电阻体（5）在套筒（8）中移动。电缆（7）的下端固定在恒定电阻体（5）上。恒电阻大变形锚索和恒电阻装置具有抗电阻性能好，防止断裂的特点，可以检测并预警山体滑坡活动的全过程和原因。

59. 发明授权

US08731007B2 Digital microwave radio link with a variety of ports 有权
标题翻译：数字微波无线电链路与各种端口
公开(公告)号：US08731007B2
公开(公告)日：2014-05-20
申请号：US12684756
申请日：2010-01-08
申请人： Idan Bar-Sade , Eliezer Pasternak , John Park , Bin Zhang
发明人： Idan Bar-Sade , Eliezer Pasternak , John Park , Bin Zhang
IPC分类号： H04J3/02
CPC分类号： H04L1/0002 , H04L1/0015 , H04L1/0057 , H04L1/203 , H04L12/46 , H04L27/0014 , H04L27/2273
摘要： A microwave radio terminal capable of multiple gigabits/sec bit rate is provided. The radio terminal may use QAM modulation, including the two lowest modulation formats of BPSK and QPSK. The serial bit stream, including forward error correction (FEC) and all other overhead, is prepared in a digital circuit, such as a filed programmable gate array (FPGA) and is output serially, using SERDES devices inside the FPGA, as two separate channels known as “I-channel” and “Q-channel”.
摘要翻译：提供能够具有多吉比特/秒比特率的微波无线电终端。无线终端可以使用包括BPSK和QPSK两种最低调制格式的QAM调制。包括前向纠错（FEC）和所有其他开销的串行比特流在诸如现有可编程门阵列（FPGA）的数字电路中准备，并且使用FPGA内部的SERDES设备串行地输出，作为两个单独的通道被称为“I-channel”和“Q-channel”。

60. 发明申请

US20130335496A1 Printer having Skewed Transfix Roller to Reduce Torque Disturbances 有权
标题翻译：具有倾斜转印辊的打印机可减少扭矩干扰
公开(公告)号：US20130335496A1
公开(公告)日：2013-12-19
申请号：US13495483
申请日：2012-06-13
申请人： Roger G. Leighton , Michael F. Leo , Bin Zhang , Joannes N.M. deJong
发明人： Roger G. Leighton , Michael F. Leo , Bin Zhang , Joannes N.M. deJong
IPC分类号： B41J2/01
CPC分类号： B41J2/0057
摘要： An inkjet offset printer includes an imaging drum and a transfix roller skewed with respect to and defining a continuously applied or an uninterrupted nip with the imaging drum to reduce torque disturbances and media wrinkling issues. Acoustic and physical disturbances resulting from a sheet of recording media entering and leaving the nip are reduced or eliminated.
摘要翻译：喷墨偏移打印机包括成像鼓和变倍辊，其相对于成像鼓倾斜并限定与成像鼓的连续施加或不间断的辊隙，以减少扭矩扰动和介质起皱问题。减少或消除由进入和离开辊隙的记录介质片引起的声学和物理扰动。

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