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51. 发明申请

US20070021494A1 3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译： 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体
公开(公告)号：US20070021494A1
公开(公告)日：2007-01-25
申请号：US11500739
申请日：2006-08-08
申请人： Arthur Taveras , Cynthia Aki , Richard Bond , Jianping Chao , Michael Dwyer , Johan Ferreira , Jianhua Chao , Younong Yu , John Baldwin , Bernd Kaiser , Ge Li , J. Merritt , Purakkattle Biju , Kingsley Nelson , Laura Rokosz , Gaifa Lai , James Jakway , Minglang Wu , Evan Hecker , Daniel Lundell , Jay Fine
发明人： Arthur Taveras , Cynthia Aki , Richard Bond , Jianping Chao , Michael Dwyer , Johan Ferreira , Jianhua Chao , Younong Yu , John Baldwin , Bernd Kaiser , Ge Li , J. Merritt , Purakkattle Biju , Kingsley Nelson , Laura Rokosz , Gaifa Lai , James Jakway , Minglang Wu , Evan Hecker , Daniel Lundell , Jay Fine
IPC分类号： A61K31/4709 , A61K31/4436 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/381 , C07D409/02 , C07D413/02 , C07D417/02
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译：公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。

52. 发明申请

US20050289555A1 Thread to thread communication 有权
标题翻译：线程线程通信
公开(公告)号：US20050289555A1
公开(公告)日：2005-12-29
申请号：US10880155
申请日：2004-06-28
申请人： Hong Jiang , Michael Dwyer
发明人： Hong Jiang , Michael Dwyer
IPC分类号： G06F9/00 , G06F9/46
CPC分类号： G06F9/542
摘要： Thread to thread communication is provided. A first thread registers with a gateway for receiving communication. Registration includes identifying a location for receiving messages. The gateway maps message payloads received from second threads to the location of the first thread. The first thread detects a payload in the location and consumes it for processing.
摘要翻译：提供线程到线程通信。第一个线程与网关注册以接收通信。注册包括识别用于接收消息的位置。网关将从第二线程接收的消息有效载荷映射到第一个线程的位置。第一个线程检测该位置中的有效载荷并将其用于处理。

53. 发明授权

US07947720B2 3,4-di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译： 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体
公开(公告)号：US07947720B2
公开(公告)日：2011-05-24
申请号：US12352781
申请日：2009-01-13
申请人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz
发明人： Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz
IPC分类号： C07D261/04 , C07D327/04 , A01N43/80 , A01N43/06
CPC分类号： C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译：公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。

54. 发明申请

US20110059958A1 MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS 有权
公开(公告)号：US20110059958A1
公开(公告)日：2011-03-10
申请号：US12744736
申请日：2009-12-03
申请人： Hidemitsu Nishida , Fumihiko Saitoh , Tomokazu Hirabayashi , Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Yan Xia
发明人： Hidemitsu Nishida , Fumihiko Saitoh , Tomokazu Hirabayashi , Samuel Chackalamannil , Tin-Yau Chan , Mariappan V. Chelliah , Martin C. Clasby , Michael Dwyer , William J. Greenlee , Yan Xia
IPC分类号： A61K31/5377 , C07D413/12 , A61P7/02 , A61P9/10 , A61P9/12 , C07D265/32 , C07D413/10
CPC分类号： C07D401/12 , C07D265/30 , C07D265/32 , C07D267/10 , C07D279/06 , C07D413/12 , C07D413/14 , C07D417/04
摘要： The present invention provides a compound of Formula (I) as described herein, or a pharmaceutically acceptable salt or a solvate thereof. The present invention also provides pharmaceutical compositions comprising one or more said compounds, and methods for using said compounds for treating or preventing a thromboses, embolisms, hypercoagulability or fibrotic changes.

55. 发明授权

US07765386B2 Scalable parallel pipeline floating-point unit for vector processing 有权
标题翻译：用于矢量处理的可扩展并行流水线浮点单元
公开(公告)号：US07765386B2
公开(公告)日：2010-07-27
申请号：US11237548
申请日：2005-09-28
申请人： David D. Donofrio , Michael Dwyer
发明人： David D. Donofrio , Michael Dwyer
IPC分类号： G06F9/00
CPC分类号： G06F9/3885 , G06F9/3851 , G06F15/8061
摘要： An embodiment of the present invention is a technique to perform floating-point operations for vector processing. An input queue captures a plurality of vector inputs. A scheduler dispatches the vector inputs. A plurality of floating-point (FP) pipelines generates FP results from operating on scalar components of the vector inputs dispatched from the scheduler. An arbiter and assembly unit arbitrates use of output section and assembles the FP results to write to the output section.
摘要翻译：本发明的一个实施例是用于执行向量处理的浮点运算的技术。输入队列捕获多个向量输入。调度器调度向量输入。多个浮点（FP）流水线从对调度器调度的向量输入的标量分量进行操作生成FP结果。仲裁器和装配单元仲裁使用输出部分并组装FP结果以写入输出部分。

56. 发明申请

US20100009736A1 Word Game 审中-公开
标题翻译：文字游戏
公开(公告)号：US20100009736A1
公开(公告)日：2010-01-14
申请号：US12170726
申请日：2008-07-10
申请人： Michael Dwyer
发明人： Michael Dwyer
IPC分类号： A63F13/00
CPC分类号： A63F9/0098 , A63F2009/186
摘要： A word game and method of playing the word game comprising providing a main word or phrase (“Theme Word”), and a group of existing words (“Puzzle Words”), wherein each letter from the Theme Word is used once to form a different word (“Solved Word”) when added to a Puzzle Word. In an embodiment, multiple letters from the Theme Word may be added to a single Puzzle Word to form a single Solved Word. The letters from the Theme Word may be added anywhere to the Puzzle Word in order to form a new Solved Word. In an embodiment, the order of the letters in Puzzle Word may not be changed. In another embodiment the letter from the Theme Word may not be added to the end of the Puzzle Word. The game will be considered solved when all of the letters of the Theme Word have been successfully combined once with a Puzzle Word such that each letter has been used with a Puzzle Word to form a Solved Word.
摘要翻译：一种单词游戏和玩游戏的方法，包括提供主要词或短语（“主题词”）和一组现有单词（“拼图词”），其中来自主题词的每个字母被使用一次以形成加入谜语时，不同的单词（“解决的词”）。在一个实施例中，来自主题词的多个字母可以被添加到单个拼图词中以形成单个解决词。主题词中的字母可以添加到拼图词的任何地方，以形成一个新的解决词。在一个实施例中，拼图Word中的字母的顺序可以不被改变。在另一个实施例中，主题词的字母可能不会添加到拼图词的末尾。当所有主题词的所有字母已经用拼图Word成功地组合一次时，该游戏将被解决，使得每个字母已经与拼图Word一起使用以形成解决的词。

57. 发明申请

US20070074009A1 Scalable parallel pipeline floating-point unit for vector processing 有权
标题翻译：用于矢量处理的可扩展并行流水线浮点单元
公开(公告)号：US20070074009A1
公开(公告)日：2007-03-29
申请号：US11237548
申请日：2005-09-28
申请人： David Donofrio , Michael Dwyer
发明人： David Donofrio , Michael Dwyer
IPC分类号： G06F9/44
CPC分类号： G06F9/3885 , G06F9/3851 , G06F15/8061
摘要： An embodiment of the present invention is a technique to perform floating-point operations for vector processing. An input queue captures a plurality of vector inputs. A scheduler dispatches the vector inputs. A plurality of floating-point (FP) pipelines generates FP results from operating on scalar components of the vector inputs dispatched from the scheduler. An arbiter and assembly unit arbitrates use of output section and assembles the FP results to write to the output section.
摘要翻译：本发明的一个实施例是用于执行向量处理的浮点运算的技术。输入队列捕获多个向量输入。调度器调度向量输入。多个浮点（FP）流水线从对调度器调度的向量输入的标量分量进行操作生成FP结果。仲裁器和装配单元仲裁使用输出部分并组装FP结果以写入输出部分。

58. 发明申请

US20060101256A1 Looping instructions for a single instruction, multiple data execution engine 审中-公开
标题翻译：单条指令的循环指令，多个数据执行引擎
公开(公告)号：US20060101256A1
公开(公告)日：2006-05-11
申请号：US10969731
申请日：2004-10-20
申请人： Michael Dwyer , Hong Jiang
发明人： Michael Dwyer , Hong Jiang
IPC分类号： G06F9/44
CPC分类号： G06F9/30058 , G06F9/325 , G06F9/3885 , G06F9/3887
摘要： According to some embodiments, looping instructions are provided for a Single Instruction, Multiple Data (SIMD) execution engine. For example, when a first loop instruction is received at an execution engine information in an n-bit loop mask register may be copied to an n-bit wide, m-entry deep loop stack.
摘要翻译：根据一些实施例，为单指令多数据（SIMD）执行引擎提供循环指令。例如，当在执行引擎处接收到第一循环指令时，可将n位循环屏蔽寄存器中的信息复制到n位宽的m入口深循环堆栈。

59. 发明申请

US20050289329A1 Conditional instruction for a single instruction, multiple data execution engine 审中-公开
标题翻译：单条指令的条件指令，多数据执行引擎
公开(公告)号：US20050289329A1
公开(公告)日：2005-12-29
申请号：US10879460
申请日：2004-06-29
申请人： Michael Dwyer , Hong Jiang , Thomas Piazza
发明人： Michael Dwyer , Hong Jiang , Thomas Piazza
IPC分类号： G06F9/38 , G06F15/00
CPC分类号： G06F9/3887 , G06F9/30036 , G06F9/30072 , G06F9/3885
摘要： According to some embodiments, a conditional Single Instruction, Multiple Data instruction is provided. For example, a first conditional instruction may be received at an n-channel SIMD execution engine. The first conditional instruction may be evaluated based on multiple channels of associated data, and the result of the evaluation may be stored in an n-bit conditional mask register. A second conditional instruction may then be received at the execution engine and the result may be copied from the conditional mask register to an n-bit wide, m-entry deep conditional stack.
摘要翻译：根据一些实施例，提供了条件单指令，多数据指令。例如，可以在n信道SIMD执行引擎处接收第一条件指令。可以基于相关数据的多个信道来评估第一条件指令，并且可以将评估结果存储在n位条件掩码寄存器中。然后可以在执行引擎处接收第二条件指令，并且可以将结果从条件屏蔽寄存器复制到n位宽的m入口深条件堆栈。

60. 发明授权

US06903131B2 3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists 失效
标题翻译： 3,4-二取代的马来酰亚胺化合物作为CXC趋化因子受体拮抗剂
公开(公告)号：US06903131B2
公开(公告)日：2005-06-07
申请号：US10269775
申请日：2002-10-11
申请人： Arthur G. Taveras , Michael Dwyer , Johan A. Ferreira , Viyyoor M. Girijavallabhan , Jianping Chao , John J. Baldwin , J. Robert Merritt , Ge Li
发明人： Arthur G. Taveras , Michael Dwyer , Johan A. Ferreira , Viyyoor M. Girijavallabhan , Jianping Chao , John J. Baldwin , J. Robert Merritt , Ge Li
IPC分类号： A61K31/337 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/4155 , A61K31/4192 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/56 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/55 , A61K39/395 , A61K45/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/10 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/28 , A61P27/02 , A61P31/04 , A61P31/18 , A61P31/20 , A61P31/22 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/44 , C07D207/456 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
CPC分类号： C07D207/456 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要： Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译：公开了式（I）化合物或其药学上可接受的盐或溶剂化物。该化合物可用于治疗趋化因子介导的疾病，例如急性和慢性炎症性疾病和癌症。

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