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    • 54. 发明授权
    • Quinolinomorphinane derivatives and medicinal use thereof
    • 喹啉吗啡烷衍生物及其医药用途
    • US06172078B2
    • 2001-01-09
    • US09194538
    • 1999-01-13
    • Hiroshi NagaseYoshifumi ImamuraHiroshi OhnoMasanobu KaneedaSusumu MatsudaYasushi Miyauchi
    • Hiroshi NagaseYoshifumi ImamuraHiroshi OhnoMasanobu KaneedaSusumu MatsudaYasushi Miyauchi
    • C07D51500
    • C07D489/00
    • The present invention provides a quinolinomorphinan derivative or a pharmacologically acceptable acid addition salt thereof, and an agent for curing or preventing cerebral disorders composed of the derivative and salt thereof, which is represented by the following formula (I): (wherein R1 represents cyclopropylmethyl or the like; R2 and R3 independently represent hydroxy, methoxy, or the like; R4 represents hydrogen, methyl, amino or the like; and (R5)m represents hydrogen, substituted benzo, or the like. The compounds of the present invention prevent damages of the cerebral nerve cells and are useful as medicine for curing or preventing various cerebral diseases such as cerebral stroke, traumatic cerebral diseases, cerebral edema, and cerebral neurodegenerative diseases. The compounds of the present invention also ameliorate the after-effects of these diseases and prevent the recurrence of these diseases by inhibiting various ischemic, hemorrhagic or traumatic cerebral disorders, and damages of the cerebral nerve cells caused by various nerve degenerations.
    • 本发明提供喹啉吗啡喃衍生物或其药理学上可接受的酸加成盐,以及由下式(I)表示的用于治疗或预防由其衍生物和盐组成的脑病的药剂:(其中R1表示环丙基甲基或 R 2和R 3独立地表示羟基,甲氧基等; R 4表示氢,甲基,氨基等;(R 5)m表示氢,取代的苯并或类似物,本发明化合物可以防止损害 的脑神经细胞,可用作治疗或预防各种脑疾病如脑中风,创伤性脑疾病,脑水肿和脑神经变性疾病的药物,本发明的化合物还可以改善这些疾病的后遗症和 通过抑制各种缺血性,出血性或创伤性脑病,预防这些疾病的复发,以及d 大脑神经细胞由各种神经变性引起的药物。