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51. 发明授权

US4745426A Light measuring device for a camera 失效
标题翻译：照相机测光装置
公开(公告)号：US4745426A
公开(公告)日：1988-05-17
申请号：US913259
申请日：1986-09-30
申请人： Yasuo Suda , Akira Ishizaki
发明人： Yasuo Suda , Akira Ishizaki
IPC分类号： G02B7/34 , G03B7/099 , G03B3/00
CPC分类号： G02B7/343 , G03B7/09972
摘要： A light measuring apparatus for an exposure control for a camera including a photoelectric converter which photoelectrically converts a portion of a light beam impinging on a photoelectric conversion portion of a focus detection device, through a taking lens. The remainder of the light beam is transmitted into the optical path of the light beam so that light measuring for an exposure control is performed from the bundle of light proceeding toward the focus detection device.
摘要翻译：一种用于包括光电转换器的照相机的曝光控制的光测量装置，其通过拍摄透镜对照射在焦点检测装置的光电转换部分上的光束的一部分进行光电转换。光束的其余部分被传输到光束的光路中，从而从朝向焦点检测装置的光束执行用于曝光控制的光。

52. 发明授权

US09464281B2 Method for concentrating viruses, method for concentrating cells or bacteria, and magnetic composite 有权
标题翻译：浓缩病毒的方法，浓缩细胞或细菌的方法以及磁性复合材料
公开(公告)号：US09464281B2
公开(公告)日：2016-10-11
申请号：US12844742
申请日：2010-07-27
申请人： Yasuo Suda , Masahiro Wakao , Takashi Kodama
发明人： Yasuo Suda , Masahiro Wakao , Takashi Kodama
IPC分类号： C12N7/02 , G01N33/566 , C12N13/00 , B03C1/01 , B03C1/28 , B82Y25/00 , C12N1/20 , C12N7/00 , C12Q1/24 , G01N33/543 , H01F1/00
CPC分类号： C12N13/00 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , B82Y25/00 , C12N1/20 , C12N7/00 , C12N2760/16151 , C12Q1/24 , G01N33/54326 , H01F1/0054
摘要： A method for concentrating viruses includes applying a magnetic force to a mixture containing: sugar chain-immobilized magnetic metal nano-particles each having a structure in which a sugar chain-immobilized metal nano-particle is bound to a first magnetic nano-particle; second magnetic particles with mean particle size larger than that of the sugar chain-immobilized magnetic metal nano-particles; and a specimen. Each sugar chain-immobilized metal nano-particle has a structure where a ligand-conjugate is bound to a metal nano-particle via sulfur atoms. The ligand-conjugate has a structure where a linker compound's amino group is connected to a sugar chain having a reducing terminal. The linker compound includes, in molecules thereof, an amino group, sulfur atoms, and a hydrocarbon chain having carbon-nitrogen bonds. This allows short-time concentration of viruses in a sufficient amount almost equal to that of centrifugation concentration, allowing safely and effectively concentrating target viruses, resulting in prompt, easy, and highly sensitive detection and identification of viruses.
摘要翻译：用于浓缩病毒的方法包括：将磁力施加到含有固定有糖链的磁性金属纳米粒子的混合物，所述糖链固定的磁性金属纳米粒子具有与第一磁性纳米粒子结合的糖链固定金属纳米粒子的结构; 平均粒径大于固定链固定的金属纳米粒子的第二磁性颗粒; 和一个标本。每个糖链固定的金属纳米颗粒具有其中配体 - 共轭物通过硫原子与金属纳米颗粒结合的结构。配体 - 缀合物具有其中连接物化合物的氨基连接到具有还原末端的糖链的结构。连接体化合物在其分子中包含氨基，硫原子和具有碳 - 氮键的烃链。这允许短时间浓度的病毒足够的量几乎等于离心浓度，允许安全有效地浓缩目标病毒，导致迅速，容易和高度敏感的病毒检测和鉴定。

53. 发明授权

US08765384B2 Carbohydrate-ligand conjugates and their application for the analysis of carbohydrate-protein interaction 有权
标题翻译：碳水化合物 - 配体结合物及其在碳水化合物 - 蛋白质相互作用分析中的应用
公开(公告)号：US08765384B2
公开(公告)日：2014-07-01
申请号：US10590045
申请日：2005-02-18
申请人： Yasuo Suda
发明人： Yasuo Suda
IPC分类号： G01N33/53 , G01N33/532 , G01N33/553
CPC分类号： G01N33/52 , C07H15/04 , G01N33/531 , G01N2400/00
摘要： A novel ligand conjugate which is effectively utilizable for analyzing a function of a protein; a ligand-supporting object; and a method of analyzing a protein. The ligand conjugate has a structure which comprises: a linker compound having a structure represented by the following General Formula (1): (wherein n and p each is an integer of 0 to 6) in which X is a structure comprising one, two, or three hydrocarbon derivative chains which have an aromatic amino group at the end and may have a carbon-nitrogen bond in the main chain, Y is a hydro-carbon structure containing one or more sulfur atoms, and Z is a straight-chain structure comprising a carbon-carbon bond or carbon-oxygen bond; and a sugar which has a reducing end and is bonded to the linker compound through the aromatic amino group.
摘要翻译：一种新颖的配体结合物，可有效用于分析蛋白质的功能; 配体支持物; 和分析蛋白质的方法。配体缀合物具有以下结构：包含具有以下通式（1）表示的结构的连接体化合物：（其中n和p各自为0〜6的整数），其中，X为包含1〜或在末端具有芳香族氨基并且在主链中可具有碳 - 氮键的三个烃衍生物链，Y是含有一个或多个硫原子的氢碳结构，Z是直链结构，包括碳 - 碳键或碳 - 氧键; 和具有还原性末端并通过芳香族氨基与连接体化合物键合的糖。

54. 发明申请

US20110169997A1 SOLID-STATE IMAGE SENSING ELEMENT AND IMAGE SENSING APPARATUS 有权
标题翻译：固态图像感应元件和图像感应装置
公开(公告)号：US20110169997A1
公开(公告)日：2011-07-14
申请号：US13119336
申请日：2009-11-11
申请人： Akihiko Nagano , Ichiro Onuki , Makoto Takamiya , Makoto Oikawa , Yoshitaka Hashimoto , Fumihiro Kajimura , Yasuo Suda
发明人： Akihiko Nagano , Ichiro Onuki , Makoto Takamiya , Makoto Oikawa , Yoshitaka Hashimoto , Fumihiro Kajimura , Yasuo Suda
IPC分类号： H04N5/225
CPC分类号： H01L27/14627 , G02B3/0056 , G02B5/003 , G02B5/005 , G02B5/201 , G02B7/346 , H01L27/14623 , H04N5/23212 , H04N5/3696 , H04N9/045
摘要： An image sensor that output a signal for detecting a focus state of a photographing lens. The image sensor includes a microlens; a light-receiving pixel; a first focus state detection pixel pair for outputting a focus state detection signal, in which aperture areas of the first focus state detection pixel pair are small in comparison to the light-receiving pixel; and a second focus state detection pixel pair for outputting a focus state detection signal, in which aperture areas of the second focus state detection pixel pair are small in comparison to the light-receiving pixel, wherein the second focus state detection pixel pair is arranged at a position that is shifted by a predetermined amount relative to each aperture position, with respect to the microlens of the first focus state detection pixel pair.
摘要翻译：输出用于检测拍摄镜头的聚焦状态的信号的图像传感器。图像传感器包括微透镜; 光接收像素; 第一焦点状态检测像素对，用于输出聚焦状态检测信号，其中第一焦点状态检测像素对的开口面积与光接收像素相比较小; 以及第二焦点状态检测像素对，用于输出焦点状态检测信号，其中第二聚焦状态检测像素对的开口面积与光接收像素相比较小，其中第二聚焦状态检测像素对布置在相对于第一聚焦状态检测像素对的微透镜相对于每个孔径位置偏移预定量的位置。

55. 发明申请

US20110117602A1 HUMAN ANTIBODY CAPABLE OF INDUCING APOPTOSIS 审中-公开
标题翻译：人类抗体可诱导疫苗
公开(公告)号：US20110117602A1
公开(公告)日：2011-05-19
申请号：US12743739
申请日：2008-11-18
申请人： Yuji Ito , Masanori Baba , Naomichi Arima , Yasuo Suda , Toshihiro Nakashima , Masaharu Torikai
发明人： Yuji Ito , Masanori Baba , Naomichi Arima , Yasuo Suda , Toshihiro Nakashima , Masaharu Torikai
IPC分类号： C07K16/30 , C07H21/04 , C12N15/63 , C12P21/00
CPC分类号： C07K16/005 , C07K16/2833 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , G01N33/57484
摘要： A human antibody that has a specific reactivity with multiple tumor cell lines including ATL cells and possesses both safety and therapeutic efficacy and a fragment of said antibody are provided. A human antibody and a fragment of said antibody that may recognize HLA-DR β chain expressed on the surface of tumor cells were obtained. In particular, it was found that a dimer of scFv (diabody) of said antibody may induce potent apoptosis in cells expressing the HLA-DR β chain. The antibody and a fragment of said antibody obtained in accordance with the present invention are useful for a detection reagent, a diagnostic and a medicament for protection or treatment of cancers including ATL and/or viral infectious diseases.
摘要翻译：提供了与多种肿瘤细胞系（包括ATL细胞）具有特异性反应性并具有安全性和治疗功效以及所述抗体片段的人类抗体。可以识别HLA-DR和bgr的人抗体和所述抗体的片段; 获得在肿瘤细胞表面表达的链。特别地，发现所述抗体的scFv（双抗体）的二聚体可能在表达HLA-DR和bgr的细胞中诱导有效的凋亡; 链。根据本发明获得的抗体和所述抗体的片段可用于检测试剂，诊断剂和用于保护或治疗包括ATL和/或病毒感染性疾病的癌症的药物。

56. 发明授权

US07838549B2 Linker compound, ligand conjugate, and production methods thereof 有权
标题翻译：接头化合物，配体缀合物及其制备方法
公开(公告)号：US07838549B2
公开(公告)日：2010-11-23
申请号：US10588612
申请日：2005-02-04
申请人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel , Masahiro Wakao
发明人： Yasuo Suda , Akio Arano , Shoichi Kusumoto , Michael Sobel , Masahiro Wakao
IPC分类号： A61K31/385 , C07D409/14
CPC分类号： C07H15/04 , C07D339/04 , G01N33/54353
摘要： The present invention provides a novel linker compound which minimizes any nonspecific hydrophobic interactions and is capable of easily adjusting the length to a disulfide group subjected to metal bond to thereby enable effective formation of a metal-sulfur bond; novel ligand conjugate and ligand carrier, and a process for producing them. The linker compound is of a structure represented by the following general formula (1) where a, b, d, e are independently an integer of 0 to 6. X has a structure serving as a multi-branched structure moiety including three or more hydrocarbon derivative chains, wherein the hydrocarbon derivative chains each include an aromatic amino group at an end thereof, and may or may not include a carbon-nitrogen bond in a main chain thereof. The ligand conjugate includes the linker compound having a sugar molecule introduced therein.
摘要翻译：本发明提供了一种新的接头化合物，其使任何非特异性疏水相互作用最小化，并且能够容易地将长度调节至经受金属键的二硫键，从而有效形成金属 - 硫键; 新型配体结合物和配体载体，及其制备方法。连接体化合物为下述通式（1）所示的结构，其中a，b，d，e独立地为0〜6的整数。X具有作为多支链结构部分的结构，包含三个以上的烃衍生链，其中所述烃衍生物链各自在其末端包括芳族氨基，并且在其主链中可以包括或不包括碳 - 氮键。配体缀合物包括其中引入糖分子的连接体化合物。

57. 发明申请

US20080316353A1 IMAGE TAKING APPARATUS AND LENS APPARATUS 有权
标题翻译：图像拍摄装置和镜头装置
公开(公告)号：US20080316353A1
公开(公告)日：2008-12-25
申请号：US12188385
申请日：2008-08-08
申请人： Yasuo Suda
发明人： Yasuo Suda
IPC分类号： H04N5/232
CPC分类号： G03B13/36 , G03B19/12 , H04N5/2253 , H04N5/23212
摘要： An image taking apparatus which can perform a focusing operation quickly is described. The image taking apparatus comprises a light splitting unit which splits a light flux from the image-taking lens into a plurality of light fluxes, a view finder optical system for observing an object image formed by the light flux from the image-taking lens, an image pickup element which photoelectrically converts the object image to an electric signal and a focus detection unit for detecting the focusing state of the image-taking lens according to a phase difference detection system. Here, the light splitting unit changes between a first state in which the light flux is directed to the view finder optical system and the focus detection unit and a second state in which the light flux is directed to the image pickup element and the focus detection unit.
摘要翻译：描述能够快速进行聚焦操作的摄像装置。图像摄取装置包括将来自摄像镜头的光束分解成多个光束的分光单元，用于观察由摄像镜头的光束形成的被摄体图像的取景器光学系统，将物体图像光电转换成电信号的摄像元件和用于根据相位差检测系统检测摄像镜头的聚焦状态的焦点检测单元。这里，分光单元在光束被引导到取景器光学系统和焦点检测单元的第一状态和光束被引导到图像拾取元件的第二状态和焦点检测单元之间变化。

58. 发明授权

US07414664B2 Image taking apparatus and lens apparatus 失效
标题翻译：摄像装置和镜头装置
公开(公告)号：US07414664B2
公开(公告)日：2008-08-19
申请号：US10770437
申请日：2004-02-04
申请人： Yasuo Suda
发明人： Yasuo Suda
IPC分类号： H04N5/225 , G03B7/099 , G03B19/12 , G03B13/00 , G02B7/28
CPC分类号： G03B13/36 , G03B19/12 , H04N5/2253 , H04N5/23212
摘要： An image taking apparatus performs a focusing operation quickly and includes a light splitting unit which splits a light flux from an image-taking lens into a plurality of light fluxes, a view finder optical system observing an object image formed by the light flux from the lens, an image pickup element which photoelectrically converts the object image to an electrical signal and a focus detector detecting the focusing state of the lens according to a phase difference detector. Here, the light splitting unit changes between a first state for directing the light flux to the view finder optical system and the focus detector, a second state for directing the light flux to the image pickup element and the focus detector, and a third state in which the light flux is directed only to the image pickup element.
摘要翻译：摄像装置快速进行聚焦操作，并且包括将来自摄像镜头的光束分解成多个光束的分光单元，观察由来自透镜的光束形成的物体图像的取景器光学系统，将对象图像光电转换成电信号的图像拾取元件和根据相位差检测器检测透镜的聚焦状态的聚焦检测器。这里，分光单元在用于将光束引导到取景器光学系统和焦点检测器的第一状态之间改变，用于将光束引导到图像拾取元件和焦点检测器的第二状态，以及第三状态光通量仅被引导到图像拾取元件。

59. 发明授权

US06893941B2 Semiconductor device and its manufacture method 失效
标题翻译：半导体器件及其制造方法
公开(公告)号：US06893941B2
公开(公告)日：2005-05-17
申请号：US10630680
申请日：2003-07-31
申请人： Yasuo Suda
发明人： Yasuo Suda
IPC分类号： H01L27/146 , H01L31/0203 , H01L31/0216 , H01L31/0232 , H01L21/30
CPC分类号： H01L27/14685 , H01L27/14618 , H01L27/14625 , H01L27/14627 , H01L31/0203 , H01L31/02164 , H01L31/02325 , H01L31/02327 , H01L2224/48091 , H01L2224/48227 , H01L2924/00014
摘要： A semiconductor device formed by cutting a first substrate and a second substrate bonded together by a spacer, wherein: the spacer is disposed at an end of the first substrate after cutting; the second substrate is a semiconductor wafer formed with a light reception element or elements; and the first substrate has an optical element or an optical element set for converging light on the light reception element or elements. A method of manufacturing such a semiconductor device. A semiconductor device manufacture method includes: a step of detecting a warp of a semiconductor substrate; a step of holding the semiconductor substrate on a base under a condition that the warp is removed; a step of bonding an opposing substrate to the semiconductor substrate; and a step of cutting the opposing substrate, wherein the opposing substrate bonded to the semiconductor substrate is set with a size corresponding to the warp of the semiconductor substrate or with a gap to an adjacent opposing substrate.
摘要翻译：一种半导体器件，其通过切割通过间隔物结合在一起的第一基板和第二基板而形成，其中：所述间隔件设置在所述第一基板的切割后的端部; 第二基板是形成有光接收元件的半导体晶片; 并且第一基板具有用于在光接收元件上会聚光的光学元件或光学元件组。一种制造这种半导体器件的方法。半导体器件制造方法包括：检测半导体衬底的翘曲的步骤; 在去除翘曲的条件下将半导体衬底保持在基底上的步骤; 将相对基板接合到半导体基板的步骤; 以及切割对置基板的步骤，其中，将与半导体基板结合的对置基板的尺寸设定为与半导体基板的翘曲相对应的尺寸或与相邻的相对基板的间隙。

60. 发明授权

US06882368B1 Image pickup apparatus 失效
标题翻译：摄像设备
公开(公告)号：US06882368B1
公开(公告)日：2005-04-19
申请号：US09604743
申请日：2000-06-28
申请人： Yasuo Suda
发明人： Yasuo Suda
IPC分类号： H04N9/04 , H04N5/225
CPC分类号： H04N9/045 , H04N5/3415
摘要： An image pickup apparatus is provided having first and second image pickup portions for receiving at least first and second distinct wavelength components of object light, respectively, and first and second optical systems for guiding the first and second wavelength components to the first and second image pickup portions, respectively, via different optical paths. The first and second optical systems are formed to have respective shapes so that the focal length of the first optical system with regard to the first wavelength component is equal to the focal length of the second optical system with regard to the second wavelength component. When a virtual object distance, as defined as set forth herein, an interval between optical axes of the first and second optical systems is set such that a change in an interval between object images of the first and second wavelength components received by the first and second image pickup portions, respectively, between when an object exists at the virtual object distance and when it exists at infinity is smaller than a pixel pitch of the image pickup portions multiplied by two.
摘要翻译：一种图像拾取装置，具有分别用于分别接收物体光的至少第一和第二不同波长分量的第一和第二图像拾取部分，以及用于将第一和第二波长分量引导到第一和第二图像拾取器的第一和第二光学系统分别经由不同的光路。第一和第二光学系统形成为具有各自的形状，使得第一光学系统相对于第一波长分量的焦距等于第二光学系统相对于第二波长分量的焦距。当如本文所述定义的虚拟对象距离被设置为第一和第二光学系统的光轴之间的间隔，使得由第一和第二光学系统接收的第一和第二波长分量的对象图像之间的间隔的变化分别在物体存在于虚拟对象距离处和当其存在于无限远处时的图像拾取部分小于图像拾取部分的像素间距乘以2。

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