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51. 发明授权

US4627971A Osmotic device with self-sealing passageway 失效
标题翻译：渗透装置具有自密封通道
公开(公告)号：US4627971A
公开(公告)日：1986-12-09
申请号：US725832
申请日：1985-04-22
申请人： Atul D. Ayer
发明人： Atul D. Ayer
IPC分类号： A61K9/00 , A61K9/26 , A61K9/52 , A61K47/30 , A61J3/00 , A61K9/24
CPC分类号： A61K9/0004
摘要： An osmotic dispensing device is disclosed for delivering a medicine to a biological environment of use. The device comprises a semipermeable wall surrounding a compartment comprising a first layer comprising a beneficial agent formulation and a first passageway in the wall for delivering the beneficial agent formulation from the device, and a second layer of a composition comprising a hydrogel and a means for closing a second passageway formed during the manufacture of the device.
摘要翻译：公开了用于将药物递送到生物生物学环境的渗透分配装置。所述装置包括围绕隔室的半透壁，所述隔室包括第一层，所述第一层包含有益剂制剂和所述壁中的用于从所述装置输送有益剂制剂的第一通道，以及包含水凝胶和用于封闭的装置的组合物的第二层在制造装置期间形成的第二通道。

52. 发明授权

US4008719A Osmotic system having laminar arrangement for programming delivery of active agent 失效
标题翻译：渗透系统具有用于编程递送活性剂的层流布置
公开(公告)号：US4008719A
公开(公告)日：1977-02-22
申请号：US654195
申请日：1976-02-02
申请人： Felix Theeuwes , Atul D. Ayer
发明人： Felix Theeuwes , Atul D. Ayer
IPC分类号： A61F9/00 , A61K9/00 , A61K9/22 , A61M31/00
CPC分类号： A61F9/0017 , A61K9/0004
摘要： An osmotic system for delivering an agent is disclosed. The system comprises a wall surrounding a compartment and has a passageway for delivering agent from the compartment. The wall is formed of a laminae comprising a lamina consisting of a multiplicity of materials in laminar arrangement with a lamina consisting of a material or of a multiplicity of materials to provide a laminated wall that is permeable to agents and maintains its integrity during the delivery of agent. The compartment contains an agent that is soluble in an external fluid and exhibits an osmotic pressure gradient across the wall against the fluid, or the agent has limited solubility in the fluid and is mixed with an osmotically effective compound soluble in the fluid and exhibits an osmotic pressure gradient across the wall against the fluid. In operation, agent is released from the system by fluid being imbibed through the wall into the compartment at a rate controlled by the permeability of the wall and the osmotic pressure gradient across the wall producing a solution containing agent, or a solution of compound containing agent which solution in either operation is released through the passageway at a controlled and continuous rate over a prolonged period of time.
摘要翻译：公开了用于递送试剂的渗透系统。该系统包括围绕隔室的壁，并且具有用于从隔室输送药剂的通道。该壁由薄片形成，该薄片包括由层叠布置的多种材料组成的薄片，该薄片由材料或多种材料组成的薄片组成，以提供层叠壁，所述层压壁可在试剂的输送期间可渗透并保持其完整性代理商隔间含有一种可溶于外部流体的试剂，并且在整个壁上表现出与流体相对的渗透压梯度，或者该试剂在流体中的溶解度有限，并且与可溶于流体的渗透性有效化合物混合并显示出渗透性横跨壁的压力梯度相对于流体。在操作中，通过流体通过壁被吸入到隔室中的流体以由壁的渗透性和穿过壁的渗透压梯度控制的速率从系统释放，产生含溶液的试剂或含化合物的溶液任何操作中的解决方案在长时间内以受控和连续的速率通过通道释放。

53. 发明申请

US20120165358A1 CONTROLLED RELEASE FORMULATIONS OF OPIOID AND NONOPIOID ANALGESICS 审中-公开
标题翻译：阿片类和非诺贝特药物的控制释放配方
公开(公告)号：US20120165358A1
公开(公告)日：2012-06-28
申请号：US13300380
申请日：2011-11-18
申请人： Evangeline Cruz , Atul D. Ayer , Brenda J. Pollock , Carmelita Garcia , Sherry Li , Alfredo M. Wong , Lawrence G. Hamel , Cheri Enders Klein , Yihong Qiu , Ye Huang
发明人： Evangeline Cruz , Atul D. Ayer , Brenda J. Pollock , Carmelita Garcia , Sherry Li , Alfredo M. Wong , Lawrence G. Hamel , Cheri Enders Klein , Yihong Qiu , Ye Huang
IPC分类号： A61K31/485 , A61P25/04 , A61P29/00
CPC分类号： A61K9/2086 , A61K9/0004 , A61K9/209 , A61K9/4808 , A61K9/5084 , A61K31/00 , A61K31/16 , A61K31/165 , A61K31/167 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： Sustained release dosage forms for twice daily oral dosing to a human patient for providing relief from pain are provided. The sustained release dosage form comprises an immediate release component and a sustained release component, wherein the immediate release component and the sustained release component collectively contain a therapeutically effective amount of an opioid analgesic and a therapeutically effective amount of nonopioid analgesic. In a preferred embodiment, the nonopioid analgesic is acetaminophen and the opioid analgesic is hydrocodone and pharmaceutically acceptable salts thereof, and in preferred embodiments, the pharmaceutically acceptable salt is bitartrate. The dosage forms produce plasma profiles in a patient characterized by a Cmax for hydrocodone of between about 0.6 ng/mL/mg to about 1.4 ng/mL/mg and an AUC for hydrocodone of between about 9.1 ng*hr/mL/mg to about 19.9 ng*hr/mL/mg (per mg hydrocodone bitartrate administered) and a Cmax for acetaminophen of between about 2.8 ng/mL/mg and 7.9 ng/mL/mg and an AUC for acetaminophen of between about 28.6 ng*hr/mL/mg and about 59.1 ng*hr/mL/mg (per mg acetaminophen administered) after a single dose.
摘要翻译：提供了持续释放剂型，每天两次口服给予患者以缓解疼痛。持续释放剂型包括速释组分和持续释放组分，其中速释组分和持续释放组分共同含有治疗有效量的阿片样镇痛剂和治疗有效量的非阿片类止痛剂。在优选的实施方案中，非阿片类镇痛剂是对乙酰氨基酚，阿片类镇痛剂是氢可酮及其药学上可接受的盐，并且在优选的实施方案中，药学上可接受的盐是酒石酸氢盐。剂型在患者中产生血浆曲线，其特征在于氢可酮的C max为约0.6ng / mL / mg至约1.4ng / mL / mg，氢可酮的AUC为约9.1ng * hr / mL / mg至约 19.9ng * hr / mL / mg（每毫克给予的氢可酮酮可乐酮），对乙酰氨基酚的C max为约2.8ng / mL / mg至7.9ng / mL / mg，对乙酰氨基酚的AUC为约28.6ng * hr / mL / mg和约59.1ng * hr / mL / mg（施用每mg对乙酰氨基酚）。

54. 发明授权

US06110499A Phenytoin therapy 失效
公开(公告)号：US06110499A
公开(公告)日：2000-08-29
申请号：US119382
申请日：1998-07-20
申请人： Padmaja Shivanand , Zahedeh Hatamkhany , Barbara F. Laidlaw , Atul D. Ayer
发明人： Padmaja Shivanand , Zahedeh Hatamkhany , Barbara F. Laidlaw , Atul D. Ayer
IPC分类号： A61K9/00 , A61K31/4166 , A61K9/24
CPC分类号： A61K9/0004 , A61K31/4166
摘要： A therapeutic composition, a dosage form and a method are disclosed for administering phenytoin indicated for the management of epilepsy.

55. 发明授权

US6096339A Dosage form, process of making and using same 失效
标题翻译：剂型，制作及使用过程
公开(公告)号：US6096339A
公开(公告)日：2000-08-01
申请号：US826642
申请日：1997-04-04
申请人： Atul D. Ayer , Andrew Lam , Judy A. Magruder , Lawrence G. Hamel , Patrick S. L. Wong
发明人： Atul D. Ayer , Andrew Lam , Judy A. Magruder , Lawrence G. Hamel , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22 , A61K9/24
CPC分类号： A61K9/0004
摘要： The invention disclosed pertains to a dosage form comprising an agent formulation comprising drug and pharmaceutical carrier of cooperating particle size and means for dispensing the agent formulation from the dosage form.
摘要翻译：所公开的本发明涉及包含药物制剂的剂型，其包含具有协调粒径的药物和药物载体以及用于从剂型分配药剂制剂的装置。

56. 发明授权

US5925015A Nutritional support system 失效
标题翻译：营养支持系统
公开(公告)号：US5925015A
公开(公告)日：1999-07-20
申请号：US859627
申请日：1997-05-20
申请人： Richard G. Weyers , Atul D. Ayer , Brenda J. Pollock , Brian L. Barclay , Ernest S. Quan
发明人： Richard G. Weyers , Atul D. Ayer , Brenda J. Pollock , Brian L. Barclay , Ernest S. Quan
IPC分类号： A61M5/168 , A61J15/00 , A61K9/00 , A61M5/14 , A61M37/00
CPC分类号： A61M5/1409 , A61J15/00 , A61J15/008 , A61K9/0004 , A61M2205/6063 , A61M5/1407
摘要： A nutritional system is disclosed, for delivering a colorant dye to a nutritional fluid that flows through the nutritional system.
摘要翻译：公开了用于将着色剂染料递送到流过营养系统的营养液体的营养系统。

57. 发明授权

US5330762A Tandospiaine antidepressive therapy 失效
标题翻译：坦度螺酮抗抑郁药治疗
公开(公告)号：US5330762A
公开(公告)日：1994-07-19
申请号：US10086
申请日：1993-01-27
申请人： Atul D. Ayer , Dana Ridzon
发明人： Atul D. Ayer , Dana Ridzon
IPC分类号： A61K9/00 , A61K9/52 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/506 , A61K47/34 , A61P25/20 , A61P25/24 , A61P25/26 , A61K9/24
CPC分类号： A61K31/496 , A61K31/495 , A61K31/505 , A61K31/506 , A61K9/0004
摘要： A dosage form is provided for administering a drug of the formula ##STR1## to a patient to produce an anxiolytic benefit in the patient.
摘要翻译：提供给患者施用式“IMAGE”的药物以在患者中产生抗焦虑益处的剂型。

58. 发明授权

US4915953A Dosage form for delivering acetaminophen or phenylpropanolamine 失效
标题翻译：用于递送对乙酰氨基酚或苯丙醇胺的剂型
公开(公告)号：US4915953A
公开(公告)日：1990-04-10
申请号：US312556
申请日：1989-02-21
申请人： Maureen L. Jordan , Atul D. Ayer , Paul R. Magruder , David E. Edgren
发明人： Maureen L. Jordan , Atul D. Ayer , Paul R. Magruder , David E. Edgren
IPC分类号： A61K9/00
CPC分类号： A61K9/0004
摘要： A dosage form is disclosed comprising a wall that surrounds a compartment with an exit means in the wall. The compartment comprises a first or fast releasing lamina and a second or short releasing lamina that are delivered through the exit means over two different periods of time.
摘要翻译：公开了一种剂型，其包括围绕隔室的壁，壁上具有出口装置。隔室包括第一或快速释放层和经由出口装置在两个不同时间段内输送的第二或短释放层。

59. 发明授权

US4915952A Composition comprising drug, HPC, HPMC and PEO 失效
标题翻译：组合物包含药物，HPC，HPMC和PEO
公开(公告)号：US4915952A
公开(公告)日：1990-04-10
申请号：US310167
申请日：1989-02-15
申请人： Atul D. Ayer , Lawrence G. Hamel
发明人： Atul D. Ayer , Lawrence G. Hamel
IPC分类号： A61K9/00 , A61K9/22 , A61K31/44
CPC分类号： A61K9/0004 , A61K31/44
摘要： A dosage form is disclosed for delivering the beneficial drugs pseudoephedrine and brompheniramine to a biological environment of use.
摘要翻译：公开了用于将有益药物伪麻黄碱和溴苯那敏递送到生物生物学环境的剂型。

60. 发明授权

US4847093A Dosage form with means for governing rate of gas formation 失效
标题翻译：用于形成气体排放率的方法
公开(公告)号：US4847093A
公开(公告)日：1989-07-11
申请号：US668761
申请日：1986-06-19
申请人： Atul D. Ayer , Patrick S. L. Wong
发明人： Atul D. Ayer , Patrick S. L. Wong
IPC分类号： A61K9/00 , A61K9/22
CPC分类号： A61K9/0004
摘要： An osmotic device is disclosed comprising a release rate controlling wall that surrounds a carbon dioxide generating compound.
摘要翻译：公开了一种渗透装置，其包括围绕产生二氧化碳的化合物的释放速率控制壁。

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