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51. 发明授权

US06451944B2 Continuous, solvent-free process for making copolymers of maleic anhydride and C1−4 alkyl vinyl ether 有权
标题翻译：连续，无溶剂的马来酸酐和C 1-4烷基乙烯基醚共聚物的方法
公开(公告)号：US06451944B2
公开(公告)日：2002-09-17
申请号：US09861044
申请日：2001-05-18
申请人： Russell Biss , Jeffrey Cohen , John Zamora , Krystyna Plochocka , Jeffrey A. Lynn
发明人： Russell Biss , Jeffrey Cohen , John Zamora , Krystyna Plochocka , Jeffrey A. Lynn
IPC分类号： C08F3402
CPC分类号： C08F222/06 , C08F2/02 , C08F216/18 , Y02P20/582
摘要： A continuous, solvent-free process for obtaining solvent-free, fine white powders of high molecular weight alternating copolymers of maleic anhydride and a C1-C4 alkyl vinyl ether, without odor or taste, having the molecular structure (A—B)n, where A is maleic anhydride, B is an alkyl vinyl ether and n is an integer indicative of the molecular weight of the copolymer, which comprises feeding alkyl vinyl ether as reactant and solvent in excess over the desired 1:1 mole ratio of A:B in the copolymer, molten maleic anhydride and a free radical initiator, continuously at predetermined feeding rates into a reactor heated at a reaction temperature of about 50° to 100° C., charging the reactor and withdrawing reaction product, residual alkyl vinyl ether and initiator from the reactor at the same rate as the feed rate of reactants into the reactor simultaneously thereby maintaining a constant volume in the reactor, stripping residual alkyl vinyl ether from the reaction product, drying the copolymer obtained of any remaining traces of alkyl vinyl ether, and recycling recovered alkyl vinyl ether back into reactor as reactant and solvent.
摘要翻译：一种连续，无溶剂的方法，用于获得具有分子结构（AB）n的不含气味或味道的马来酸酐和C1-C4烷基乙烯基醚的高分子量交替共聚物的无溶剂的细白色粉末，其中A 是马来酸酐，B是烷基乙烯基醚，n是表示共聚物的分子量的整数，其包括将烷基乙烯基醚作为反应物和过量的丙烯进料到所需的1:1摩尔比的A:B中共聚物，熔融马来酸酐和自由基引发剂，以预定的进料速率连续加入到在约50℃至100℃的反应温度下加热的反应器中，将反应器和残留的烷基乙烯基醚和引发剂从反应器以与反应物进入反应器的进料速率相同的速率同时由此在反应器中保持恒定体积，从反应产物中汽提残余的烷基乙烯基醚，干燥该共聚物获得任何剩余痕量的烷基乙烯基醚的聚合物，并将回收的烷基乙烯基醚回收到反应器中作为反应物和溶剂。

52. 发明授权

US06365691B1 Continuous, solvent-free process for making terpolymers of maleic anhydride, C1-4 alkyl vinyl ether and isobutylene 有权
标题翻译：用于制备马来酸酐，C 1-4烷基乙烯基醚和异丁烯的三元共聚物的连续，无溶剂的方法
公开(公告)号：US06365691B1
公开(公告)日：2002-04-02
申请号：US09611088
申请日：2000-07-06
申请人： Russell Biss , Jeffrey Cohen , John Zamora , Krystyna Plochocka , Jeffrey A. Lynn
发明人： Russell Biss , Jeffrey Cohen , John Zamora , Krystyna Plochocka , Jeffrey A. Lynn
IPC分类号： C08F22204
CPC分类号： C08F210/10 , C08F6/001 , Y02P20/582 , C08F222/04 , C08F216/04
摘要： A continuous, solvent-free process for obtaining solvent-free, fine white powders of high molecular weight alternating terpolymers of maleic anhydride, a C1-C4 alkyl vinyl ether and isobutylene, without odor or taste.
摘要翻译：一种连续，无溶剂的方法，用于获得不含气味或味道的马来酸酐，C1-C4烷基乙烯基醚和异丁烯的高分子量交替三元共聚物的无溶剂的细白色粉末。

53. 发明授权

US5494039A Biopsy needle insertion guide and method of use in prostate cryosurgery 失效
标题翻译：活检针插入导管及其在前列腺冷冻手术中的应用
公开(公告)号：US5494039A
公开(公告)日：1996-02-27
申请号：US93020
申请日：1993-07-16
申请人： Gary Onik , George Reyes , Larry Pottorff , Jeffrey Cohen
发明人： Gary Onik , George Reyes , Larry Pottorff , Jeffrey Cohen
IPC分类号： A61B10/00 , A61B10/02 , A61B17/00 , A61B17/34 , A61B18/02 , A61B8/00
CPC分类号： A61B17/3403 , A61B10/0241 , A61B18/02 , A61B2017/00274 , A61B2018/00547
摘要： A biopsy needle insertion guide and method of use with an ultrasound probe in medical procedures to accurately position biopsy needles in internal tissues. The insertion guide comprises a body which is removably mountable on an ultrasound probe and which comprises a clamp affixable about the probe and an elongated adjustment guide extending from the clamp in a direction perpendicular to the probe. A slide block engages the adjustment guide and is slidably adjustable therealong and a biopsy needle holder and guide assembly is carried by the slide block and is adjustably extendable from the slide block in a direction parallel to the probe. A method of use is described wherein the insertion guide is used to accurately place biopsy needles in a human prostate, the needles being then used to accurately place cryoprobes in the prostate for cryogenic surgery of the gland.
摘要翻译：活检针插入引导件和在医疗程序中使用超声波探头的方法，以将活检针准确地定位在内部组织中。插入引导件包括可移除地安装在超声波探头上并且包括可围绕探针固定的夹具的主体和沿着垂直于探针的方向从夹具延伸的细长调节引导件。滑块与调节引导件接合，并且可滑动地调节，并且活检针保持器和引导组件由滑动块承载，并且可从滑动块沿平行于探针的方向可调节地延伸。描述了一种使用方法，其中使用插入引导件将活检针精确地放置在人类前列腺中，然后使用针将准确地将冷冻探针放置在前列腺中用于腺体的低温手术。

54. 发明授权

US5437673A Closed circulation tissue warming apparatus and method of using the same in prostate surgery 失效
标题翻译：闭路循环组织加热装置及其在前列腺手术中的使用方法
公开(公告)号：US5437673A
公开(公告)日：1995-08-01
申请号：US13307
申请日：1993-02-04
申请人： John G. Baust , Zhao H. Chang , Jeffrey Cohen , Gary Onik , George Reyes
发明人： John G. Baust , Zhao H. Chang , Jeffrey Cohen , Gary Onik , George Reyes
IPC分类号： A61B17/00 , A61B18/02 , A61F7/00 , A61F7/12 , A61M25/00
CPC分类号： A61F7/12 , A61B18/02 , A61B2017/00274 , A61B2018/00547 , A61B2018/0212 , A61F2007/0054 , A61F2007/0086
摘要： The present invention is directed to a closed circulation tissue warming apparatus for use during surgery to maintain the temperature of tissues at a desired level and to a method of using the apparatus in prostate surgery particularly during transperineal cryoablation of the prostate gland in human males to maintain the temperature of the urethral tissues and thereby prevent urethral sloughing. It may also have utility where it is desired to lower the temperature of surrounding tissues, such as during laser ablation. The apparatus includes a multi-lumen catheter inserted into the urethra and connected to a fluid warming and circulation control means whereby warmed water is circulated through the lumens at a controlled flow rate and temperature. The concentric lumen structure of the catheter provides improved flow and even temperature maintenance along the length of the catheter and the urethra.
摘要翻译：本发明涉及一种封闭循环组织加热装置，用于在外科手术期间将组织的温度维持在期望的水平，以及在前列腺手术中使用该装置的方法，特别是在人类前列腺的经精囊冷冻消融期间维持尿道组织的温度，从而防止尿道脱落。在需要降低周围组织的温度的情况下，例如在激光烧蚀期间也可以具有实用性。该装置包括插入尿道并连接到流体加温和循环控制装置的多腔导管，由此温水以受控的流速和温度循环通过腔。导管的同心腔结构提供沿着导管和尿道长度的改善的流量和均匀的温度维持。

55. 发明授权

US4951278A High-level data link control packet assembler/disassembler 失效
标题翻译：高级数据链路控制包汇编/反汇编
公开(公告)号：US4951278A
公开(公告)日：1990-08-21
申请号：US238581
申请日：1988-08-31
申请人： Jeffrey Biber , Jeffrey Cohen , John Holmbald , Zon-Hong Hsieh , Douglas Kay , Roy Spitzer
发明人： Jeffrey Biber , Jeffrey Cohen , John Holmbald , Zon-Hong Hsieh , Douglas Kay , Roy Spitzer
IPC分类号： H04L29/06
CPC分类号： H04L29/06
摘要： A data communications system has a layered communication architecture including network services protocols including a link layer and higher level protocols, and has IBM or IBM-compatible synchronous data link control (SDLC) devices including a host computer and a plurality of end user devices desiring to communicate across an X.25 packet-switching network (PSN) of the communications system. A packet assembler/disassembler (PAD) support X.25 communication across the PSN between the SDLC-utilizing host computer and the SDLC-utilizing end user device. In one embodiment, separate high level data link control (HDLC) PADs are provided at each end of the PSN operationally associated with the host computer and the plurality of end user devices, respectively. The PADS generate and respond to at least three formats of SDLC commands and responses, and, in association with their respective SDLC devices, perform at least four functions including a call setup phase, a data transfer phase, a call clearing phase, and handling of abnormal conditions. PAD means comprises qualified logical link control (QLLC) PAD means located at an end of said packet switching network for either operational association with said host computer or operational association with said plurality of end user devices. In another embodiment, a single qualified logical link control (QLLC) PAD performs functions similar to those of the HDLC PAD embodiment, except that rather than having a PAD at both ends (host end and terminal end) of a connection, a PAD is provided at only one end of the connection.
摘要翻译：数据通信系统具有包括包括链路层和更高级别协议的网络服务协议的分层通信体系结构，并且具有IBM或IBM兼容的同步数据链路控制（SDLC）设备，包括主计算机和多个最终用户设备通信通信系统的X.25分组交换网络（PSN）。分组汇编器/分解器（PAD）支持在SDLC利用主机与使用SDLC的最终用户设备之间的PSN上的X.25通信。在一个实施例中，分别在与主计算机和多个终端用户设备相关联的PSN的每一端分别提供单独的高级数据链路控制（HDLC）PAD。 PADS产生并响应至少三种格式的SDLC命令和响应，并且与其各自的SDLC设备相关联地执行至少四个功能，包括呼叫建立阶段，数据传送阶段，呼叫清除阶段以及处理异常情况。 PAD装置包括位于所述分组交换网络的末端的合格逻辑链路控制（QLLC）PAD装置，用于与所述主机计算机的操作关联或与所述多个终端用户设备的操作关联。在另一个实施例中，单个限定逻辑链路控制（QLLC）PAD执行与HDLC PAD实施例类似的功能，除了不是在连接的两端（主机端和终端）处具有PAD，而是提供PAD 在连接的一端。

56. 发明申请

US20120165813A1 RADIO FREQUENCY ABLATION DEVICE FOR THE DESTRUCTION OF TISSUE MASSES 有权
标题翻译：用于破坏组织质量的无线电频率消除装置
公开(公告)号：US20120165813A1
公开(公告)日：2012-06-28
申请号：US13323722
申请日：2011-12-12
申请人： Bruce Lee , Gordon E. Epstein , Adam Hagmann , Jeffrey Cohen
发明人： Bruce Lee , Gordon E. Epstein , Adam Hagmann , Jeffrey Cohen
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1475
摘要： The inventive ablation element comprises an elongated cannula having a proximal end and a distal end. The cannula defines an internal lumen within the cannula and a cannula axis. A plurality of conductors contained within the lumen, each of the conductors has a proximal end proximate the proximal end of the cannula, and a distal end proximate the distal end of the cannula. A plurality of ablation stylets each has a proximal end and a distal end, and each coupled at the respective proximal end of the stylet to the distal end of a respective conductor, the stylets comprise a deflectable material, the conductors together with their respective stylets being mounted for axial movement. A trocar point defined proximate the distal end of the cannula.
摘要翻译：本发明的消融元件包括具有近端和远端的细长插管。套管限定插管内的内腔和插管轴线。包含在内腔内的多个导体，每个导体具有靠近插管的近端的近端，以及靠近套管远端的远端。多个消融模具各自具有近端和远端，并且每个消融模具各自在相应的导管的相应近端处连接到相应导体的远端，所述模式包括可偏转材料，所述导体与它们各自的形式安装用于轴向移动。定位在套管远端附近的套针针点。

57. 发明申请

US20090086203A1 Method for Correlating Spectroscopic Measurements with Digital Images of Contrast Enhanced Tissue 有权
标题翻译：将光谱测量与对比增强组织的数字图像相关联的方法
公开(公告)号：US20090086203A1
公开(公告)日：2009-04-02
申请号：US12329688
申请日：2008-12-08
申请人： Jeffrey Cohen , John S. Maier
发明人： Jeffrey Cohen , John S. Maier
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/02 , G01J3/0264 , G01J3/0289 , G01J3/0291 , G01N21/6458 , G01N21/6486 , G01N21/65 , G01N21/658 , G01N2021/6417 , G01N2021/6423 , G01N2021/656
摘要： A system and method of correlating Raman measurements with digital images of a sample so to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed from the field of view, the sample is treated with a contrast enhancing agent. The treated sample is repositioned in the spectroscopic device's field of view and a digital image of the treated sample is obtained. The spectroscopic data set is linked with the digital image by defining a transformation to map the image spatial coordinates of the digital image to the spectral spatial coordinates of the spectroscopic data. For the spectroscopic data set of the sample, the database is searched to identify a spectroscopic data set, of a known sample having well characterized pathology, which matches the sample's spectroscopic data set.
摘要翻译：将拉曼测量与样本的数字图像相关联的系统和方法，以对样本的疾病状态进行分类。对于位于分光装置的视野中的样品获得光谱数据集。从样品中取出样品后，用对比度增强剂处理样品。经处理的样品在分光装置的视野中重新定位，并获得处理过的样品的数字图像。通过定义将数字图像的图像空间坐标映射到光谱数据的光谱空间坐标的变换，光谱数据集与数字图像相关联。对于样本的光谱数据集，搜索数据库以识别具有良好表征的病理学的已知样品的光谱数据集，其与样品的光谱数据集相匹配。

58. 发明授权

US5458022A Bicycle pedal range adjusting device 失效
标题翻译：自行车踏板范围调节装置
公开(公告)号：US5458022A
公开(公告)日：1995-10-17
申请号：US151968
申请日：1993-11-15
申请人： Raymond Mattfeld , Jeffrey Cohen
发明人： Raymond Mattfeld , Jeffrey Cohen
IPC分类号： A63B22/06 , B62M3/02 , G05G1/14
CPC分类号： B62M3/02 , A63B2022/0623 , A63B2208/12 , Y10T74/2164
摘要： A device is provided for range adjusting bicycle pedals in a bicycle having a frame with a crank hub, a drive sprocket and drive chain. The device consists of a crank axle extending through the crank hub, with the drive sprocket mounted on the crank axle to operate the drive chain. A pair of crank arms extend in opposite directions from the crank axle. A pair of pedals are provided. A structure is for mounting each pedal in an adjustable manner to each crank arm, so as to change the distance of the pedals to the crank axle. Someone who cannot fit on a standard bicycle properly, such as a child, an adult and an elderly person that has limited knee, hip and ankle movement, can still pedal the bicycle. In addition, status-post surgical patients would also benefit from the range adjusting device. In a modification the crank arms are adjustable to the crank axle instead of the pedals to the crank arms.
摘要翻译：提供了一种用于在具有带有曲柄毂，驱动链轮和驱动链的框架的自行车中用于范围调节自行车踏板的装置。该装置包括一个延伸穿过曲柄毂的曲柄轴，驱动链轮安装在曲柄轴上以操作驱动链。一对曲柄臂从曲柄轴向相反方向延伸。提供一对踏板。一种结构用于以可调节的方式将每个踏板安装到每个曲柄臂上，以便改变踏板与曲柄轴的距离。无法适应标准自行车的人，例如膝盖，髋关节和脚踝运动有限的儿童，成年人和老年人，仍然可以踩踏自行车。此外，状态后手术患者也将受益于范围调整装置。在一个修改中，曲柄臂可以调节到曲柄轴而不是曲柄臂的踏板。

59. 发明申请

US20070167838A1 System and method for a Raman and/or fluorescence colposcope 审中-公开
标题翻译：用于拉曼和/或荧光阴道镜的系统和方法
公开(公告)号：US20070167838A1
公开(公告)日：2007-07-19
申请号：US11595977
申请日：2006-11-13
申请人： Hugh Hubble , Jeffrey Cohen
发明人： Hugh Hubble , Jeffrey Cohen
IPC分类号： A61B1/06 , A61B6/00
CPC分类号： A61B1/303 , A61B1/043 , A61B5/0071 , A61B5/0075 , A61B5/0084
摘要： A colposcope and a method of using a colposcope which integrates both visual imaging capability and Raman imaging and/or fluorescence imaging is disclosed. In an embodiment, two sets of optics may be positioned within the housing of a colposcope to allow for both visual and Raman imaging. A Raman data set may be produced which may include a Raman image or a Raman spectrum of a cell, tissue, or a cancer cell, for example. Additionally, the use of one or more lasers for imaging and/or treatment is disclosed. A Raman imaging colposcope according to one embodiment of the present disclosure may be used to identify a cancer cell in vivo, giving a physician a tool to diagnose cervical cancer in his office. This instrument would also be of low cost and easy to operate.
摘要翻译：公开了阴道镜和使用集成了视觉成像能力和拉曼成像和/或荧光成像的阴道镜的方法。在一个实施例中，两组光学器件可以位于阴道镜的壳体内，以允许视觉和拉曼成像。可以产生可以包括例如细胞，组织或癌细胞的拉曼图像或拉曼光谱的拉曼数据集。另外，公开了一种或多种用于成像和/或治疗的激光器的使用。根据本公开的一个实施方案的拉曼成像阴道镜可用于体内鉴定癌细胞，给予医师在其办公室诊断子宫颈癌的工具。该仪器的成本低，易于操作。

60. 发明申请

US20070016183A1 Radio frequency ablation device for the destruction of tissue masses 有权
标题翻译：射频消融装置用于破坏组织块
公开(公告)号：US20070016183A1
公开(公告)日：2007-01-18
申请号：US11173928
申请日：2005-07-01
申请人： Bruce Lee , Gordon Epstein , Adam Hagmann , Jeffrey Cohen
发明人： Bruce Lee , Gordon Epstein , Adam Hagmann , Jeffrey Cohen
IPC分类号： A61B18/04
CPC分类号： A61B18/1477 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1475
摘要： The inventive ablation element comprises an elongated cannula having a proximal end and a distal end. The cannula defines an internal lumen within the cannula and a cannula axis. A plurality of conductors contained within the lumen, each of the conductors has a proximal end proximate the proximal end of the cannula, and a distal end proximate the distal end of the cannula. A plurality of ablation stylets each has a proximal end and a distal end, and each coupled at the respective proximal end of the stylet to the distal end of a respective conductor, the stylets comprise a deflectable material, the conductors together with their respective stylets being mounted for axial movement. A trocar point defined proximate the distal end of the cannula. A deflection surface positioned between the trocar point and the proximal end of the cannula, the deflection surface being configured and positioned to deflect, in response to axial movement of the stylets in a direction from the proximate end of the cannula to the distal end of the cannula, at least some of the stylets laterally with respect to the cannula axis in different directions along substantially straight paths, the paths defining an ablation volume.
摘要翻译：本发明的消融元件包括具有近端和远端的细长插管。套管限定插管内的内腔和插管轴线。包含在内腔内的多个导体，每个导体具有靠近套管近端的近端，以及靠近套管远端的远端。多个消融模具各自具有近端和远端，并且每个消融模具各自在相应的导管的相应近端处连接到相应导体的远端，所述模式包括可偏转材料，所述导体与它们各自的形式安装用于轴向移动。定位在套管远端附近的套针针点。定位在套管针点和套管近端之间的偏转表面，所述偏转表面被构造和定位成响应于沿着插管的近端到所述插管的远端的方向的轴向移动而偏转插管，沿着基本上直的路径在不同方向上相对于插管轴线横向的至少一些样式，所述路径限定消融体积。

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