会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 52. 发明公开
    • NEUE LEUKOTRIEN-B 4?-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
    • 新白三烯B 4?的衍生物,生产与应用,药物的方法
    • EP0741687A1
    • 1996-11-13
    • EP94905714.0
    • 1994-01-27
    • SCHERING AKTIENGESELLSCHAFT
    • SKUBALLA, WernerBUCHMANN, BerndHEINDL, JosefFRÖHLICH, WolfgangEKERDT, RolandGIESEN, Claudia
    • C07D521A61K31A61K47A61P1A61P17A61P29A61P35A61P43C07C43C07C59C07C67C07C69C07C235C07C311C07C323
    • C07C59/72C07C59/62C07C69/708C07C235/08C07C2601/14
    • Described are pharmacologically active leukotriene B4 derivatives of general formula (I) in which R1 is CH2OH, CH3, CF3, COOR4 or CONR5R6, R2 is H or an organic-acid group with 1 to 15 C-atoms, R3 is H, a C1-C14 alkyl group, optionally with one or more substituents, a C3-C10 cycloalkyl group, a C6-C10 aryl group optionally substituted, independently of each other, with one or more halogen, phenyl, C1-C4 alkyl, C1-C4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carbonyl, carboxyl or hydroxy groups or R3 is a 5- to 6-membered aromatic heterocyclic ring with at least one hetero atom, R4 is H, C1-C10 alkyl, C3-C10 cycloalkyl, a C6-C10 aryl group optionally substituted with 1 to 3 halogen, phenyl, C1-C4 alkyl, C1-C4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxyl or hydroxy groups or R4 is CH2-CO-(C6-C10) aryl or a 5- to 6-membered ring with at least one hetero atom, A is a trans, trans-CH=CH-CH=CH, a -CH2CH2-CH=CH- or a tetramethylene group, B is a straight-chain or branched-chain C1-C10 alkylene group, which may be substituted with fluorine, or the group (a), D is a direct bond, oxygen, sulphur, -C C- or -CH=CR7 or, together with B, may also form a direct bond, R5 and R6 which may be the same or different, are H or C1-C4 alkyl, or R6 is H and R5 is C1-C15 alkanoyl or R8SO2-, R5 and R6 being optionally substituted with OH, R7 is H, C1-C5 alkyl, chlorine or bromine, R8 is defined in the same way as R3, n is 2 to 5 plus, when R4 is hydrogen, salts of these compounds with physiologically tolerated bases, as well as their cyclo-dextrin clathrates.
    • PCT号 PCT / EP94 / 00216秒。 371日期1996年11月8日二段。 102(e)中的日期1996年11月8日提交的PCT 1994年1月27日的PCT公布。 号 WO95 / 20564的PCT公布。 日期8月3日,通式1995Pharmacologically活性白三烯B4衍生物I,(I)中有所描述,其中R 1 darstellt CH 2 OH,CH 3,CF 3,COOR 4,CONR 5 R 6,或R 2ħdarstellt或有机酸基与1 -15℃原子,R3象征H; C1-C14烷基,C3-C10环烷基,任选substituiertem单或多; C6-C10芳基,彼此独立地,任选地单独使用或substituiertem被卤素,苯基,C1-C4烷基,C1-C4烷氧基,氟甲基,氯甲基,三氟甲基,羰基,羧基或羟基相乘; 或具有至少1个杂原子,R 4指的是氢,C1-C10烷基,C3-C10环烷基的5-至6-元芳族杂环; C6-C10芳基任选地被1-3个卤,苯基,C1-C4烷基,C1-C4烷氧基,氟甲基,氯甲基,三氟甲基,羧基或羟基取代; CH2-CO-(C6-C10)芳基或者具有至少1个杂原子的5至6元环,A象征反,反 - CH = CH-CH = CH,-CH 2 CH 2一个-CH = CH-或一个 四亚甲基,乙象征一个C1-C10的直链或支链亚烷基,任选地其可以被氟或组 D表示直接键,氧,硫,-C 3BOND C-,-CH被取代 = CR7,或连同B可因此意味着直接的键,R 5和R 6相同或不同,并且表示H或C1-C4烷基或R 6表示H且R 5 darstellt C1-C15烷酰基或R8SO2,以及与任选substituiertem OH,R7手段H,C1-C5烷基,氯,溴,R8的含义同R 3,n是2-5,和,如果R4指的是氢,及其与生理上相容的碱及其环糊精笼形物的盐。
    • 53. 发明授权
    • LEUKOTRIEN-B 4?-DERIVATIVE, VERFAHREN ZU IHRER HERSTELLUNG UND ARZNEIMITTEL
    • 奥地利维多利亚州4星级酒店ARZNEIMITTEL VERFAHREN ZU IHRER HERSTELLUNG
    • EP0614457B1
    • 1996-08-21
    • EP92923741.0
    • 1992-11-19
    • SCHERING AKTIENGESELLSCHAFT
    • SKUBALLA, WernerBUCHMANN, BerndHEINDL, JosefFRÖHLICH, WolfgangEKERDT, RolandGIESEN, Claudia
    • C07C405/00
    • C07C405/0058C07C2601/04C07C2601/18C07D309/30
    • Leukotriene-B4 derivatives have the formula (I), in which R1 stands for CH¿2?OH, CH3, CF3, COOR?5, CONR6R7, or R1¿ represents together with R2 a carbonyl group; R?2 and R3¿ are different or the same and stand for H or an organic acid residue with 1-15 C atoms; R4 stands for H, C¿1?-C10-alkyl, possibly substituted one or several times by chlorine or bromine, C3-C10-cycloalkyl, a C6-C10-aryl residue possibly independently substituted one or several times by chlorine, bromine, phenyl, C1-C4-alkyl, C1-C4-alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxy or hydroxy or a 5-6 membered aromatic heterocyclic ring with at least 1 heteroatom; R?5¿ stands for hydrogen, C¿1?-C10-alkyl, C3-C10-cycloalkyl, an aryl residue possibly substituted by 1-3 chlorine, bromine, phenyl, C1-C4-alkyl, C1-C4-alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxy or hydroxy, CH2-CO-(C6-C10)aryl or a 5-6 membered ring with at least 1 heteroatom; A stands for a trans, trans-CH=CH-CH=CH, -CH2CH2-CH=CH- or a tetramethylene group; B stands for a straight or branched chain C1-C10alkylene group, possibly substituted with fluorine or the group (a); D is a direct bond, oxygen, sulphur, -C=C-, -CH=CR?8¿ or it may represent together with B a direct bond; R?6 and R7¿ are different or the same and stand for H or C¿1?-C4-alkyl or R?7¿ stands for H and R6 stands for C¿1?-C10-alkanoyl or C1-C10-alkansulphonyl; R?8¿ stands for H, C¿1?-C5-alkyl, chlorine, bromine; m stands for the digits 1 or 4 and n equals 3-5. Also disclosed are the salts of these derivates with physiologically tolerable bases, when R?5¿ stands for hydrogen, and their cyclodextrine clathrates.
    • PCT No.PCT / EP92 / 02653 Sec。 371日期:1994年5月27日 102(e)日期1994年5月27日PCT提交1992年11月19日PCT公布。 公开号WO93 / 11105 日本6月10日,1993.Leukotriene-B4衍生物式Ⅰ(Ⅰ)它们与生理上相容的碱和它们的环糊精包合物的盐被描述。
    • 54. 发明授权
    • NEUE LEUKOTRIEN-B 4?-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
    • 新白三烯B 4?的衍生物,生产与应用,药物的方法。
    • EP0529022B1
    • 1995-09-27
    • EP92905138.1
    • 1992-02-24
    • SCHERING AKTIENGESELLSCHAFT
    • SKUBALLA, WernerBUCHMANN, BerndHEINDL, JosefFRÖHLICH, WolfgangEKERDT, RolandGIESEN, Claudia
    • C07C405/00C07D309/30
    • C07C69/007C07C33/12C07C59/46C07C69/732C07C405/00
    • The invention discloses new leukotriene B4 derivatives of formula (I), wherein R1 stands for CH¿2?OH, CH3, CF3, COOR?5, CONR6R7, or R1¿ together with R2 stands for a carbonyl group, R?2 and R3¿ are the same or different and stand for H or an organic acid residue containing 1 to 15 carbon atoms, R4 stands for H, C¿1?-C10 alkyl, possibly substituted one or more times by chlorine or bromine, C3-C10 cycloalkyl, a C6-C10 aryl residue possibly substituted one or more times by chlorine, bromine or phenyl, C1-C4 alkyl, C1-C4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxy or hydroxy, or a 5- or 6-membered aromatic heterocyclic ring with at least one heteroatom, R?5¿ stands for hydrogen, C¿1?-C10 alkyl, C3-C10 cycloalkyl, a C6-C10 aryl residue possibly substituted one to three times by chlorine, bromine or phenyl, C1-C4 alkyl, C1-C4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxy or hydroxy, CH2-CO-(C6-C10) aryl or a 5- or 6-membered ring with at least one heteroatom, A stands for a trans,trans-CH=CH-CH=CH, a -CH2CH2-CH=CH- or a tetramethylene group, B stands for a C1-C10 straight-chain or branched-chain alkylene group, possibly substituted by fluorine, or the group of formula (a), D stands for a direct bond, oxygen, sulphur, -C=C-, -CH=CR8 or, together with B, for a direct bond, R6 and R7 are the same or different and stand for H or C1-C4 alkyl or R7 stands for H and R6 stands for C1-C10 alkanoyl or C1-C10 alkanesulphonyl, R8 stands for H, C1-C5 alkyl, chlorine or bromine, n is equal to 3 to 5 and, when R5 stands for hydrogen, their salts with physiologically tolerable bases and their cyclodextrin clathrates.