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51. 发明授权

US09002452B2 Electrical therapy for diastolic dysfunction 有权
标题翻译：电疗法用于舒张功能障碍
公开(公告)号：US09002452B2
公开(公告)日：2015-04-07
申请号：US10703398
申请日：2003-11-07
申请人： Rodney W. Salo , Matthew Salo
发明人： Rodney W. Salo , Matthew Salo
IPC分类号： A61N1/365 , A61N1/362
CPC分类号： A61N1/3627 , A61N1/36514
摘要： Pacing pulses are delivered to one or more cardiac regions to improve diastolic performance in patients having diastolic dysfunction and/or heart failure. A cardiac pacing system executes a pacing algorithm using a parameter indicative of the diastolic performance as an input. The pacing pulses excite the one or more cardiac regions to redistribute the loading on the ventricular wall during diastole, thereby improving the diastolic performance by lowering the degree of cardiac wall motion dyssynchrony associated with diastolic dysfunction.
摘要翻译：将起搏脉冲输送到一个或多个心脏区域以改善具有舒张功能障碍和/或心力衰竭的患者的舒张性能。心脏起搏系统使用表示舒张性能的参数作为输入来执行起搏算法。起搏脉冲激发一个或多个心脏区域以在舒张期期间重新分布心室壁上的负荷，从而通过降低与舒张功能障碍相关的心脏壁运动不同步的程度来改善舒张性能。

52. 发明授权

US08103326B2 Device for monitoring fluid status 有权
标题翻译：用于监测流体状态的装置
公开(公告)号：US08103326B2
公开(公告)日：2012-01-24
申请号：US12098644
申请日：2008-04-07
申请人： Robert J. Sweeney , Julio C. Spinelli , Rodney W. Salo
发明人： Robert J. Sweeney , Julio C. Spinelli , Rodney W. Salo
IPC分类号： A61B5/00
CPC分类号： A61B5/0538 , A61B5/053 , A61B5/14535 , A61N1/36521
摘要： A technique for determining a patient's hematocrit by an electrical impedance measurement is described. An implantable device may be configured to utilize the technique in order to assess a cardiac patient's fluid status. In order to determine the hematocrit, the electrical impedance of the blood is measured and mapped by a mapping function to a corresponding hematocrit value.
摘要翻译：描述了通过电阻抗测量来确定患者的血细胞比容的技术。可植入装置可被配置为利用该技术来评估心脏病人的流体状态。为了确定血细胞比容，测量血液的电阻抗并通过映射函数映射到相应的血细胞比容值。

53. 发明授权

US08090442B2 Apparatus and method for spatially and temporally distributing cardiac electrical stimulation 有权
标题翻译：空间和时间分布心脏电刺激的装置和方法
公开(公告)号：US08090442B2
公开(公告)日：2012-01-03
申请号：US11931718
申请日：2007-10-31
申请人： Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
发明人： Rodney W. Salo , Julio C. Spinelli , Bruce H. KenKnight
IPC分类号： A61N1/368
CPC分类号： A61N1/368 , A61N1/3622 , A61N1/3627
摘要： A cardiac electro-stimulatory device and method for operating same in which stimulation pulses are distributed among a plurality of electrodes fixed at different sites of the myocardium in order to reduce myocardial hypertrophy brought about by repeated pacing at a single site and/or increase myocardial contractility. In order to spatially and temporally distribute the stimulation, the pulses are delivered through a switchable pulse output configuration during a single cardiac cycle, with each configuration comprising one or more electrodes fixed to different sites in the myocardium.
摘要翻译：一种心脏电刺激装置及其操作方法，其中刺激脉冲分布在固定在心肌不同部位的多个电极之间，以便通过在单个部位重复起搏而引起的心肌肥大和/或增加心肌收缩力。为了空间和时间地分布刺激，脉冲在单个心动周期期间通过可切换的脉冲输出配置递送，每个配置包括一个或多个电极固定在心肌中的不同部位。

54. 发明授权

US08060219B2 Epicardial patch including isolated extracellular matrix with pacing electrodes 失效
标题翻译：心外膜包括分离的细胞外基质与起搏电极
公开(公告)号：US08060219B2
公开(公告)日：2011-11-15
申请号：US11017627
申请日：2004-12-20
申请人： Jeffrey Ross , John Kim , Rodney W. Salo , Ronald W. Heil, Jr. , Randy Westlund
发明人： Jeffrey Ross , John Kim , Rodney W. Salo , Ronald W. Heil, Jr. , Randy Westlund
IPC分类号： A61N1/05
CPC分类号： A61N1/0587 , A61N1/0568 , A61N1/059
摘要： An epicardial patch includes an extracellular matrix (ECM) and a plurality of electrodes. The isolated ECM is configured for epicardial attachment over a myocardial region including an injured area to control post-injury remodeling of the myocardial region. The plurality of electrodes is configured for delivering electrical stimulation to enhance the effect of the isolated ECM in remodeling control by altering workload and stress on the myocardial region.
摘要翻译：心外膜贴片包括细胞外基质（ECM）和多个电极。分离的ECM被配置用于在包括受伤区域的心肌区域上的心外膜附着以控制心肌区域的损伤后重建。多个电极被配置为通过改变心肌区域上的工作负荷和压力来传递电刺激以增强孤立的ECM在重塑控制中的作用。

55. 发明授权

US07953485B2 Therapy control based on the rate of change of intracardiac impedance 有权
标题翻译：基于心内阻抗变化率的治疗控制
公开(公告)号：US07953485B2
公开(公告)日：2011-05-31
申请号：US12105219
申请日：2008-04-17
申请人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
发明人： Rodney W. Salo , Joseph M. Pastore , Jeffrey E. Stahmann , Jesse W. Hartley
IPC分类号： A61N1/362
CPC分类号： A61N1/36521 , A61N1/30
摘要： A system comprising a medical device that includes an impedance measurement circuit adapted to be coupled to implantable electrodes to obtain an intracardiac impedance signal between electrodes, a therapy circuit operable to deliver a therapy to a subject, and a controller circuit coupled to the impedance measurement circuit and the therapy circuit. The controller circuit determines a time rate of change of the intracardiac impedance signal and adjusts at least one parameter related to therapy in a manner that alters the rate of change.
摘要翻译：一种包括医疗装置的系统，该医疗装置包括阻抗测量电路，该阻抗测量电路适于耦合到可植入电极以获得电极之间的心内阻抗信号，可操作以将治疗递送给受试者的治疗电路，以及耦合到所述阻抗测量电路和治疗电路。控制器电路确定心内阻抗信号的时间变化率，并且以改变变化率的方式调节与治疗相关的至少一个参数。

56. 发明授权

US07949394B2 Using implanted sensors for feedback control of implanted medical devices 有权
标题翻译：使用植入式传感器对植入式医疗设备进行反馈控制
公开(公告)号：US07949394B2
公开(公告)日：2011-05-24
申请号：US12778779
申请日：2010-05-12
申请人： Rodney W. Salo , Abhijeet V. Chavan
发明人： Rodney W. Salo , Abhijeet V. Chavan
IPC分类号： A61N1/365
CPC分类号： A61N1/36564 , A61N1/3621 , A61N1/3925
摘要： A system and method for administering a therapeutic treatment to the heart includes a pressure sensor positioned in the pulmonary artery, an implantable medical device located remotely from the sensor, and communication means for communicating pressure data from the pressure sensor to the implantable medical device. The system includes a control module operatively coupled to the implantable medical device. The control module is adapted for comparing the pulmonary arterial pressure data to a pre-programmed value, adjusting an operating parameter of the implantable medical device based on the relationship of the pulmonary arterial pressure to the pre-programmed value, and repeating this process until the relationship between the pulmonary arterial pressure data and the pre-programmed value is such that no adjustment is necessary.
摘要翻译：用于向心脏施用治疗性治疗的系统和方法包括定位在肺动脉中的压力传感器，远离传感器定位的可植入医疗装置，以及用于将来自压力传感器的压力数据传送到可植入医疗装置的连通装置。该系统包括可操作地耦合到可植入医疗装置的控制模块。控制模块适于将肺动脉压数据与预编程值进行比较，基于肺动脉压与预编程值的关系来调整可植入医疗装置的操作参数，并重复该过程直到肺动脉压数据与预编程值之间的关系使得不需要调整。

57. 发明授权

US07922663B2 Implantable ultrasound system for maintaining vessel patency and perfusion 有权
标题翻译：用于维持血管通畅和灌注的植入式超声系统
公开(公告)号：US07922663B2
公开(公告)日：2011-04-12
申请号：US11903735
申请日：2007-09-24
申请人： Binh C. Tran , Abhi Chavan , Rodney W. Salo , Jonathan Kwok
发明人： Binh C. Tran , Abhi Chavan , Rodney W. Salo , Jonathan Kwok
IPC分类号： A61B8/00
CPC分类号： A61B17/2202 , A61B2017/22027
摘要： An apparatus comprising an implantable acoustic transducer, an acoustic transducer interface circuit communicatively coupled to the acoustic transducer, and a controller circuit communicatively coupled to the acoustic transducer interface circuit. The controller is configured to, in response to receiving an indication of a patient condition associated with a development of a blood vessel obstruction, initiate delivery of acoustic energy that mitigates the blood vessel obstruction. Other systems and methods are described.
摘要翻译：包括可植入声学换能器，通信地耦合到声换能器的声换能器接口电路以及通信地耦合到声换能器接口电路的控制器电路的装置。控制器被配置为响应于接收到与血管阻塞的发展相关联的患者状况的指示，启动缓解血管阻塞的声能的传递。描述了其他系统和方法。

58. 发明授权

US07869881B2 Baroreflex stimulator with integrated pressure sensor 有权
标题翻译：具有集成压力传感器的Baroreflex刺激器
公开(公告)号：US07869881B2
公开(公告)日：2011-01-11
申请号：US10745921
申请日：2003-12-24
申请人： Imad Libbus , Rodney W. Salo
发明人： Imad Libbus , Rodney W. Salo
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/36057 , A61N1/36564
摘要： An aspect relates to an implantable medical device. An embodiment of the device comprises a pulse generator, sensor circuitry, a lead, and a controller. The pulse generator generates baroreflex stimulation pulses. The lead is adapted to be electrically connected to the pulse generator and to the sensor circuitry. The lead includes an electrode to distribute the baroreflex stimulation pulses to a baroreflex site and a pressure sensor to provide a signal indicative of blood pressure to the sensor circuitry. The controller is connected to the pulse generator and the sensor circuitry. The controller adapted to adjust the baroreflex stimulation pulses based on the blood pressure. Other aspects are provided herein.
摘要翻译：一个方面涉及可植入医疗装置。该装置的实施例包括脉冲发生器，传感器电路，引线和控制器。脉冲发生器产生压力反射刺激脉冲。引线适于电连接到脉冲发生器和传感器电路。引线包括用于将压力反射刺激脉冲分布到压力反射部位的电极和压力传感器，以向传感器电路提供指示血压的信号。控制器连接到脉冲发生器和传感器电路。控制器适于基于血压调节压力反射刺激脉冲。本文提供了其他方面。

59. 发明申请

US20100274306A1 METHOD AND APPARATUS FOR DEVICE CONTROLLED GENE EXPRESSION FOR CARDIAC PROTECTION 失效
标题翻译：用于设备控制的基因表达用于心脏保护的方法和装置
公开(公告)号：US20100274306A1
公开(公告)日：2010-10-28
申请号：US12830534
申请日：2010-07-06
申请人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
发明人： Joseph M. Pastore , Jeffrey Ross , Tamara Colette Baynham , Rodney W. Salo , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61M37/00 , A61N1/00
CPC分类号： A61N1/3627 , A61K48/0083 , A61N1/36514
摘要： A gene regulatory system detects ischemia events and is capable of delivering a biologic therapy in response to the detection of an ischemic event or the reception of a command. The biologic therapy protects the heart from ischemic damage by regulating the expression of an exogenously introduced gene product. In one embodiment, the gene regulatory system includes an implantable system that emits at least one gene regulatory signal in response to the detection of the ischemic event or the reception of the command. The gene regulatory signal directly or indirectly regulates gene expression of the gene product.
摘要翻译：基因调控系统检测缺血事件，并且能够响应于缺血事件的检测或命令的接收而递送生物疗法。生物治疗通过调节外源基因产物的表达来保护心脏免于缺血性损伤。在一个实施方案中，基因调控系统包括可植入系统，其可以响应于缺血事件的检测或命令的接收而发射至少一个基因调节信号。基因调控信号直接或间接调控基因产物的基因表达。

60. 发明授权

US07764995B2 Method and apparatus to modulate cellular regeneration post myocardial infarct 失效
标题翻译：调节心肌梗塞后细胞再生的方法和装置
公开(公告)号：US07764995B2
公开(公告)日：2010-07-27
申请号：US10862716
申请日：2004-06-07
申请人： Steven D. Girouard , Jeffrey Ross , Rodney W. Salo
发明人： Steven D. Girouard , Jeffrey Ross , Rodney W. Salo
IPC分类号： A61N1/36
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2205/3523 , A61M2205/3561 , A61M2210/125 , A61M2230/00 , A61N1/36585
摘要： A system delivers cardiac pacing therapy and chemical and/or biological therapy to modulate myocardial tissue growth in a heart after myocardial infarction (MI). The system includes an agent delivery device to release one or more agents to an MI region to modulate myocardial tissue growth in that region, and a cardiac rhythm management (CRM) device to deliver pacing pulses to enhance the effects of the one or more agents by altering myocardial wall stress and cardiac workload. In one embodiment, the system is an implantable system including an implantable agent delivery device and an implantable CRM device.
摘要翻译：系统提供心脏起搏治疗和化学和/或生物治疗以调节心肌梗塞（MI）后心脏中的心肌组织生长。该系统包括用于将一个或多个药剂释放到MI区域以调节该区域中的心肌组织生长的药剂递送装置，以及心律管理（CRM）装置，以递送起搏脉冲以增强一种或多种药剂的作用改变心肌壁压力和心脏工作量。在一个实施例中，该系统是包括可植入药剂输送装置和可植入CRM装置的可植入系统。

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