专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

US20080319493A1 Biocompatible electroplated interconnection bonding method and electronics package suitable for implantation 有权
标题翻译：生物相容性电镀互连接合方法和电子封装适合植入
公开(公告)号：US20080319493A1
公开(公告)日：2008-12-25
申请号：US11821327
申请日：2007-06-21
申请人： Dao Min Zhou , James Singleton Little , Robert J. Greenberg
发明人： Dao Min Zhou , James Singleton Little , Robert J. Greenberg
IPC分类号： A61N1/00 , H05K3/46
CPC分类号： H05K3/361 , A61N1/02 , A61N1/36046 , C25D3/567 , C25D3/62 , C25D5/02 , C25D5/18 , C25D5/56 , H05K3/32 , H05K2203/0723
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue. The present invention is directed to a device comprising a substrate containing at least one contact, a flexible assembly containing at least one pad, and electroplated bonding between said contact and said pad that bonds said substrate and said flexible assembly together. The present invention is directed to a method of bonding for implantation a substrate to a flexible assembly, said method comprising the steps of: aligning said substrate and said flexible assembly, whereby there is a common alignment for a contact on said substrate and contact pads on said flexible assembly, and electroplating bonding between said contacts and said pads, thereby bonding said flexible assembly to said substrate.
摘要翻译：本发明涉及一种将气密密封的电子封装结合到电极或柔性电路的方法，以及所得的电子封装，其适于植入生物组织，例如用于视网膜或皮层电极阵列，以使视力恢复到某些非目标人士。电气密封的电子封装通过电镀生物相容性材料（例如铂或金）直接结合到柔性电路或电极上，有效地形成电镀铆钉形连接，其将柔性电路连接到电子封装。所得到的电子装置是生物相容的并且适合长期植入生物体组织。本发明涉及一种装置，其包括含有至少一个接触件的基板，包含至少一个焊盘的柔性组件以及在所述接触件和所述焊盘之间的电镀接合，将所述基板和所述柔性组件接合在一起。本发明涉及一种用于将衬底植入到柔性组件中的接合方法，所述方法包括以下步骤：对准所述衬底和所述柔性组件，由此存在用于所述衬底上的接触和所述衬底上的接触焊盘的共同对准所述柔性组件，以及所述触头和所述焊盘之间的电镀接合，从而将所述柔性组件粘合到所述衬底上。

52. 发明授权

US07228181B2 Retinal prosthesis with side mounted inductive coil 有权
标题翻译：视网膜假体与侧面安装的感应线圈
公开(公告)号：US07228181B2
公开(公告)日：2007-06-05
申请号：US10820240
申请日：2004-04-06
申请人： Robert J. Greenberg , Da-Yu Chang , Rajat Agrawal , Brian V. Mech , Mark S. Humayun , James Singleton Little , Kevin Wilkin
发明人： Robert J. Greenberg , Da-Yu Chang , Rajat Agrawal , Brian V. Mech , Mark S. Humayun , James Singleton Little , Kevin Wilkin
IPC分类号： A61N1/08
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/3787
摘要： The invention is a retinal prosthesis with an inductive coil mounted to the side of the eye by means of a strap around the eye. This allows for close coupling to an external coil and movement of the entire implanted portion with movement of the eye ball.
摘要翻译：本发明是一种视网膜假体，其具有通过围绕眼睛的带安装到眼睛侧面的感应线圈。这允许与外部线圈紧密耦合并且随着眼球的移动而移动整个植入部分。

53. 发明授权

US07846285B2 Biocompatible electroplated interconnection bonding method and electronics package suitable for implantation 有权
标题翻译：生物相容性电镀互连接合方法和电子封装适合植入
公开(公告)号：US07846285B2
公开(公告)日：2010-12-07
申请号：US11924722
申请日：2007-10-26
申请人： Dao Min Zhou , James Singleton Little , Robert J. Greenberg
发明人： Dao Min Zhou , James Singleton Little , Robert J. Greenberg
IPC分类号： H05K3/46
CPC分类号： H05K3/361 , A61N1/02 , A61N1/36046 , C25D3/567 , C25D3/62 , C25D5/02 , C25D5/18 , C25D5/56 , H05K3/32 , H05K2203/0723
摘要： The invention is directed to a method of bonding a hermetically sealed electronics package to an electrode or a flexible circuit and the resulting electronics package that is suitable for implantation in living tissue, such as for a retinal or cortical electrode array to enable restoration of sight to certain non-sighted individuals. The hermetically sealed electronics package is directly bonded to the flex circuit or electrode by electroplating a biocompatible material, such as platinum or gold, effectively forming a plated rivet-shaped connection, which bonds the flex circuit to the electronics package. The resulting electronic device is biocompatible and is suitable for long-term implantation in living tissue.
摘要翻译：本发明涉及一种将气密密封的电子封装结合到电极或柔性电路的方法，以及所得的电子封装，其适于植入生物组织，例如用于视网膜或皮层电极阵列，以使视力恢复到某些非目标人士。密封电子封装通过电镀生物相容性材料（例如铂或金）直接结合到柔性电路或电极上，有效地形成电镀铆钉形连接，其将柔性电路连接到电子封装。所得到的电子装置是生物相容的并且适合长期植入生物体组织。

54. 发明申请

US20080283417A1 Process for Cathodic Protection of Electrode Materials 有权
标题翻译：电极材料阴极保护工艺
公开(公告)号：US20080283417A1
公开(公告)日：2008-11-20
申请号：US11924349
申请日：2007-10-25
申请人： Dao Min Zhou , Amy Hines , James Singleton Little , Robert J. Greenberg
发明人： Dao Min Zhou , Amy Hines , James Singleton Little , Robert J. Greenberg
IPC分类号： C23F13/00
CPC分类号： C23F13/00 , A61N1/05 , A61N1/08 , C23F13/02
摘要： The present invention relates to a process for cathodic protection of electrode or electrode materials wherein negative bias is applied on the electrode. the negative bias is obtained by asymmetric current pulse. The asymmetric current pulse is obtained by performing negative phase with higher amplitude. The asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The asymmetric current pulse is obtained by performing negative phase with higher amplitude and with wider pulse width than that of the anodic phase. The present invention further relates to a process for cathodic protection of electrode or electrode materials, wherein negative bias is applied on the electrode, wherein the negative bias is obtained by asymmetric current pulse, wherein the asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.
摘要翻译：本发明涉及对电极或电极材料进行阴极保护的方法，其中负电极施加在电极上。负偏压通过不对称电流脉冲获得。通过执行具有较高振幅的负相来获得非对称电流脉冲。通过执行具有比阳极相宽的脉冲宽度的负相来获得非对称电流脉冲。通过执行具有更高幅度和宽于脉冲宽度的阳极相的负相位获得非对称电流脉冲。本发明还涉及一种用于对电极或电极材料进行阴极保护的方法，其中在电极上施加负偏压，其中通过不对称电流脉冲获得负偏压，其中非对称电流脉冲通过执行具有更宽的负相脉冲宽度大于阳极相。通过脉冲串获得更宽的脉冲宽度。

55. 发明授权

US09974953B2 Method and apparatus to provide safety checks for neural stimulation 有权
公开(公告)号：US09974953B2
公开(公告)日：2018-05-22
申请号：US13430356
申请日：2012-03-26
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/36 , A61N1/08 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： An apparatus for controlling the stimulation of neural tissue which includes a neural stimulator, an input device for providing input to the neural stimulator for neural stimulation, at least one electrode electrically connected to and driven by the neural stimulator and suitable to stimulate neural tissue, a device capable of determining a charge per phase by calculating a discrete integral of the wave form of the input for the at least one electrode, a calculating device for comparing the charge per phase to a predetermined maximum and determining a reduced stimulation for the at least one electrode by the amount necessary not to exceed the predetermined maximum for the at least one electrode, and a current pulse generator for stimulating the neural tissue according to the reduced stimulation level.

56. 发明授权

US08423151B2 Method and apparatus to provide safety checks for neural stimulation 有权
标题翻译：提供神经刺激安全检查的方法和装置
公开(公告)号：US08423151B2
公开(公告)日：2013-04-16
申请号：US11926057
申请日：2007-10-28
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/08 , A61N1/18
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue in not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes as continued use may result in neural and further electrode damage. Systems and stimulator control mechanisms to prevent damage to neural tissue.
摘要翻译：在电刺激神经组织中，重要的是防止过度刺激和不平衡刺激，这将导致对神经组织，电极或两者的损伤。至关重要的是神经组织不会受到高于安全阈值的任何直流或交流电流的影响。此外，重要的是识别有缺陷的电极，因为继续使用可能导致神经和电极损坏。系统和刺激物控制机制，以防止损伤神经组织。

57. 发明授权

US08170682B2 Method and apparatus to provide safety checks for neural stimulation 有权
标题翻译：提供神经刺激安全检查的方法和装置
公开(公告)号：US08170682B2
公开(公告)日：2012-05-01
申请号：US11927391
申请日：2007-10-29
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译：本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。本公开中提出的装置包括能够执行所公开的方法的电路和系统。

58. 发明授权

US09913985B2 Method and apparatus to provide safety checks for neural stimulation 有权
公开(公告)号：US09913985B2
公开(公告)日：2018-03-13
申请号：US11413771
申请日：2006-04-28
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： In electrically stimulating neural tissue it is important to prevent over stimulation and unbalanced stimulation which would cause damage to the neural tissue, the electrode, or both. It is critical that neural tissue in not subjected to any direct current or alternating current above a safe threshold. Further, it is important to identify defective electrodes as continued use may result in neural and further electrode damage. The present invention presents system and stimulator control mechanisms to prevent damage to neural tissue.

59. 发明申请

US20120185015A1 Method and Apparatus to Provide Safety Checks for Neural Stimulation 有权
标题翻译：提供神经刺激安全检查的方法和装置
公开(公告)号：US20120185015A1
公开(公告)日：2012-07-19
申请号：US13430356
申请日：2012-03-26
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61F9/08 , A61N1/36
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to a test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译：本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。本公开中提出的装置包括能够执行所公开的方法的电路和系统。

60. 发明授权

US08060216B2 Method and apparatus to provide safety checks for neural stimulation 有权
标题翻译：提供神经刺激安全检查的方法和装置
公开(公告)号：US08060216B2
公开(公告)日：2011-11-15
申请号：US11796433
申请日：2007-04-27
申请人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
发明人： Robert Jay Greenberg , Kelly Hobart McClure , James Singleton Little , Rongqing Dai , Arup Roy , Richard Agustin Castro , John Reinhold , Kea-Tiong Tang , Sumit Yadav , Chunhong Zhou , Dao Min Zhou , Pishoy Maksy
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： Electronic neural tissue stimulators for controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to a test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译：用于控制电刺激水平的电子神经组织刺激器，以防止损伤神经组织。本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。本公开中提出的装置包括能够执行所公开的方法的电路和系统。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式