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51. 发明申请

US20100022836A1 IN-BODY DEVICE HAVING A MULTI-DIRECTIONAL TRANSMITTER 有权
标题翻译：具有多方向发射器的身体设备
公开(公告)号：US20100022836A1
公开(公告)日：2010-01-28
申请号：US12530449
申请日：2008-03-07
申请人： Olivier Colliou , Timothy Robertson , Mark Zdeblick
发明人： Olivier Colliou , Timothy Robertson , Mark Zdeblick
IPC分类号： A61B1/00
CPC分类号： H01Q9/30 , A61B5/0031 , A61B5/0205 , A61B5/073 , A61B5/1104 , A61B2562/08 , H01Q1/273 , H01Q21/29
摘要： Multi-directional transmitters for in-body devices, such as implantable and ingestible devices, are provided. Aspects of the in-body multi-direction transmitters of the invention include signal transmitters configured to transmit an identifying signal in at least two different directions in an x-y plane. Embodiments of the in-body devices are configured to emit a detectable signal upon contact with a target physiological site. Also provided are methods of making and using the devices of the invention.
摘要翻译：提供用于体内装置的多向发射器，例如可植入和可摄取装置。本发明的体内多方向发射机的方面包括被配置为在x-y平面中以至少两个不同方向发射识别信号的信号发射机。身体内装置的实施例被配置为在与目标生理部位接触时发出可检测信号。还提供了制造和使用本发明的装置的方法。

52. 发明授权

US08912908B2 Communication system with remote activation 有权
标题翻译：通讯系统具有远程激活功能
公开(公告)号：US08912908B2
公开(公告)日：2014-12-16
申请号：US13180516
申请日：2011-07-11
申请人： Jeffrey Berkman , Mark Zdeblick , Patricia Johnson , Hooman Hafezi , Jonathan Withrington
发明人： Jeffrey Berkman , Mark Zdeblick , Patricia Johnson , Hooman Hafezi , Jonathan Withrington
IPC分类号： H04Q5/22 , A61J3/00 , A61B5/07 , H01Q1/27 , A61B5/053 , A61B5/03 , A61B5/145 , A61B5/00
CPC分类号： A61B5/073 , A61B5/0002 , A61B5/0008 , A61B5/036 , A61B5/0538 , A61B5/14539 , A61B5/4839 , A61B5/7285 , A61B2560/0214 , A61B2562/18 , A61J3/007 , H01Q1/273
摘要： The system of the present invention includes a conductive element, an electronic component, and a partial power source in the form of dissimilar materials. Upon contact with a conducting fluid, a voltage potential is created and the power source is completed, which activates the system. The electronic component controls the conductance between the dissimilar materials to produce a unique current signature. The system can also measure the conditions of the environment surrounding the system.
摘要翻译：本发明的系统包括不同材料形式的导电元件，电子元件和部分电源。当与导电流体接触时，产生电压电位并且电源完成，这激活了系统。电子部件控制不同材料之间的电导，以产生独特的当前签名。该系统还可以测量系统周围环境的状况。

53. 发明授权

US08419638B2 Body-associated fluid transport structure evaluation devices 有权
公开(公告)号：US08419638B2
公开(公告)日：2013-04-16
申请号：US12273503
申请日：2008-11-18
申请人： Lawrence W. Arne , Olivier Colliou , Marc Jensen , Mark Zdeblick
发明人： Lawrence W. Arne , Olivier Colliou , Marc Jensen , Mark Zdeblick
IPC分类号： A61B5/00
CPC分类号： A61B5/6876 , A61B5/04005 , A61B5/053 , A61B5/1459 , A61B5/6862 , A61F2250/0002 , A61M1/3655 , A61M1/3656 , A61M1/3661 , A61M1/3663 , A61M2025/0031 , A61M2025/0037
摘要： Implantable devices for evaluating body-associated fluid transport structures and methods for using the same are provided. In some instances, the implantable devices include an elongated structure with at least one hermetically sealed integrated circuit sensor stably associated therewith and a transmitter. The devices find use in a variety of different applications, including monitoring the function of various types of body-associated fluid transport structures, such as arteriovenous fistulae, vascular grafts, catheters, cerebrospinal fluid shunts, and implantable central venous access devices.

54. 发明授权

US08412347B2 Methods and apparatus for leads for implantable devices 有权
标题翻译：用于植入式装置的引线的方法和装置
公开(公告)号：US08412347B2
公开(公告)日：2013-04-02
申请号：US12514045
申请日：2009-04-29
申请人： Mark Zdeblick
发明人： Mark Zdeblick
IPC分类号： A61N1/00
CPC分类号： A61N1/056 , A61N1/048 , A61N1/0488 , A61N1/378
摘要： A charge pump is provided in the same integrated circuit chip as a control means which permits selectively connecting any of one or more electrodes with conductors along a lead. The charge pump derives about two volts from a one-volt supply, and becomes stable within a few tens of microseconds. The charge pump may be composed of three doublers—the first generating timing signals for the second and third doublers, with the second and third doublers working out of phase with each other.
摘要翻译：电荷泵设置在与控制装置相同的集成电路芯片中，该控制装置允许选择性地将一个或多个电极中的任一个与导体沿导线连接。电荷泵从一伏电源产生约两伏特，并在几十微秒内稳定。电荷泵可以由三个倍增器组成，即第二和第三倍增器的第一产生定时信号，第二和第三倍增器彼此相位异相。

55. 发明申请

US20120277813A1 Pacing and Stimulation Apparatus and Methods 审中-公开
标题翻译：起搏和刺激装置和方法
公开(公告)号：US20120277813A1
公开(公告)日：2012-11-01
申请号：US13536702
申请日：2012-06-28
申请人： Mark Zdeblick
发明人： Mark Zdeblick
IPC分类号： A61N1/36
CPC分类号： A61N1/36146 , A61N1/056 , A61N1/36185 , A61N1/3686
摘要： System, device and method of variable pacing and stimulation are provided. In one example device, one or more lead integrated circuits may programmably control one or more variability parameters. One or more electrodes may provide electrical stimulation. Each electrode may be individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter. Electrodes may be intentionally shorted together during time intervals that fall between times of stimulus, so as to dissipate potentials that might otherwise persist and cause electrode degradation.
摘要翻译：提供可变起搏和刺激的系统，装置和方法。在一个示例性设备中，一个或多个引线集成电路可编程地控制一个或多个可变性参数。一个或多个电极可以提供电刺激。每个电极可以由至少一个引线集成电路单独寻址并由至少一个可变性参数控制。在刺激时间之间的时间间隔内，电极可能被故意地短路在一起，以消散可能会持续并导致电极降解的电位。

56. 发明申请

US20120022341A1 Two-Wrist Data Gathering System 有权
标题翻译：双腕数据采集系统
公开(公告)号：US20120022341A1
公开(公告)日：2012-01-26
申请号：US13260081
申请日：2011-01-28
申请人： Mark Zdeblick
发明人： Mark Zdeblick
IPC分类号： A61B5/00
CPC分类号： A61B5/0408 , A61B5/061 , A61B5/07 , A61B5/681 , A61J7/0481 , A61J2200/30 , A61J2205/60 , A61K9/20 , G06F19/00 , G06F19/3456 , H04B13/005
摘要： Sensing is carried out from locations at considerable remove from the stomach. Cooperating sensor electronics are placed at each of two wrists of the patient. The potential discomfort and inconvenience of an abdominal patch are reduced or eliminated. And alternative power sources become available.
摘要翻译：从相当大的胃部移除的位置进行感测。合作的传感器电子设备放置在患者的两只手腕的每一个上。减轻或消除腹部贴片的潜在不适和不便。并且替代电源变得可用。

57. 发明授权

US08055345B2 Self-referencing communication in implantable devices 有权
标题翻译：植入式设备中的自参考通信
公开(公告)号：US08055345B2
公开(公告)日：2011-11-08
申请号：US12202150
申请日：2008-08-29
申请人： Haifeng Li , Mark Zdeblick , Lawrence Arne , Yafei Bi , Nilay Jani , Jonathan Withrington
发明人： Haifeng Li , Mark Zdeblick , Lawrence Arne , Yafei Bi , Nilay Jani , Jonathan Withrington
IPC分类号： A61N1/00
CPC分类号： A61N1/37288 , A61N1/025
摘要： Various aspects of the present invention enable robust, reliable control functionality for effectors present on intraluminal, e.g., vascular leads, as well as other types of implantable devices. Aspects of the invention include implantable integrated circuits that have self-referencing and self-clocking signal encoding, and are capable of bidirectional communication. Also provided by the invention are effector assemblies that include the integrated circuits, as well as implantable medical devices, e.g., pulse generators that include the same, as well as systems and kits thereof and methods of using the same, e.g., in pacing applications, including cardiac resynchronization therapy (CRT) applications.
摘要翻译：本发明的各个方面对存在于管腔内（例如血管引线）以及其它类型的可植入装置的效果器提供了鲁棒且可靠的控制功能。本发明的方面包括具有自参考和自时钟信号编码并且能够进行双向通信的可植入集成电路。本发明还提供了包括集成电路的效应器组件以及可植入的医疗装置，例如包括其的脉冲发生器，以及其系统和套件，以及使用该装置的方法，例如在起搏应用中，包括心脏再同步治疗（CRT）应用。

58. 发明申请

US20110034964A1 Integrated Circuit Implementation and Fault Control System, Device, and Method 有权
标题翻译：集成电路实现与故障控制系统，设备及方法
公开(公告)号：US20110034964A1
公开(公告)日：2011-02-10
申请号：US12920086
申请日：2009-02-27
申请人： Yafei Bi , Haifeng Li , Mark Zdeblick , Todd Thompson , Robert Leichner
发明人： Yafei Bi , Haifeng Li , Mark Zdeblick , Todd Thompson , Robert Leichner
IPC分类号： A61N1/08 , A61N1/362 , A61N1/05 , A61N1/39
CPC分类号： A61N1/05 , A61N1/025 , A61N1/37 , A61N1/378
摘要： Apparatus and methods enable robust, reliable control for implantable medical devices, including cardiac pacemakers, defibrillators and cardiac resynchronization devices. Integrated circuits in the devices have minimized interfaces, can derive power from the interface signals, and have high voltage and latch-up protection. A device lead has a power generation circuit and a switching circuit using cascaded PMOS transistors for operating with a stable voltage despite fluctuations in the supplied voltage. The lead has control electronics that provide a very low impedance between an electrode and a lead conductor during most of the duration of a pacing pulse, but during a brief initial portion of the pacing pulse, provide a very high impedance to permit charging up a power supply that is local to the control electronics. A method of stabilizing the external impedance and a system for fault detection and fault recovery for an implantable device are also provided.
摘要翻译：装置和方法能够对可植入医疗装置（包括心脏起搏器，除颤器和心脏再同步装置）进行可靠的，可靠的控制。器件中的集成电路具有最小化的接口，可以从接口信号中获取功率，并具有高电压和闭锁保护。器件引线具有发电电路和使用级联PMOS晶体管的开关电路，用于尽管工作电压的波动以稳定的电压工作。引线具有控制电子学，其在起搏脉冲的大部分持续时间期间在电极和引线导体之间提供非常低的阻抗，但是在起搏脉冲的短暂初始部分期间，提供非常高的阻抗以允许充电电力供应是本地控制电子产品。还提供了一种稳定外部阻抗的方法和用于可植入装置的故障检测和故障恢复系统。

59. 发明授权

US07738958B2 Methods and apparatus for enhancing cardiac pacing 有权
标题翻译：用于增强心脏起搏的方法和装置
公开(公告)号：US07738958B2
公开(公告)日：2010-06-15
申请号：US11680509
申请日：2007-02-28
申请人： Mark Zdeblick , Joseph M. Ruggio
发明人： Mark Zdeblick , Joseph M. Ruggio
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61B5/02028 , A61B5/02055 , A61B5/0215 , A61B5/02158 , A61B5/026 , A61B5/14535 , A61B5/14539 , A61B5/1459 , A61B5/6883 , A61N1/3627 , A61N1/36528 , A61N1/3655 , A61N1/36557 , A61N1/36564 , A61N1/36571 , A61N1/36585 , A61N1/3682 , A61N1/3684
摘要： Methods, apparatus and systems for enhancing cardiac pacing generally provide for measuring at least one cardiac characteristic, calculating at least one cardiac performance parameter based on the measured characteristic(s), and adjusting at least one functional parameter of a cardiac pacing device. Devices may include at least one catheter (such as a multiplexed catheter with one or more sensors and/or actuators), at least one implant (such as a sensor implantable in a heart wall), or a combination of both. Various cardiac performance parameters and/or pacing device performance parameters may be weighted, and the parameters and their respective weights may be used to determine one or more adjustments to be made to the pacing device. In some instances, the adjustments are made automatically.
摘要翻译：用于增强心脏起搏的方法，装置和系统通常提供测量至少一个心脏特征，基于所测量的特征来计算至少一个心脏性能参数，以及调整心脏起搏装置的至少一个功能参数。装置可以包括至少一个导管（例如具有一个或多个传感器和/或致动器的多路导管），至少一个植入物（例如可植入心脏壁的传感器）或两者的组合。可以对各种心脏性能参数和/或起搏装置性能参数进行加权，并且可以使用参数及其各自的权重来确定对起搏装置进行的一项或多项调整。在某些情况下，会自动进行调整。

60. 发明申请

US20100131023A1 IMPLANTABLE MEDICAL DEVICES COMPRISING CATHODIC ARC PRODUCED STRUCTURES 审中-公开
标题翻译：包含阴极弧生产结构的可植入医疗器械
公开(公告)号：US20100131023A1
公开(公告)日：2010-05-27
申请号：US12305894
申请日：2007-06-21
申请人： Benedict James Costello , Marc Jensen , Mark Zdeblick , Jeremy Frank , Vladimer Gelfandbein , Lawrence Arne
发明人： Benedict James Costello , Marc Jensen , Mark Zdeblick , Jeremy Frank , Vladimer Gelfandbein , Lawrence Arne
IPC分类号： A61N1/05 , C23C14/34
CPC分类号： C23C14/0641 , C04B35/56 , C04B35/5611 , C04B35/5626 , C04B35/58 , C04B38/0022 , C04B2111/00793 , C04B2111/0081 , C04B2111/00836 , C04B2111/00844 , C23C14/0635 , C23C14/0664 , C23C14/325 , H01J37/32055
摘要： Implantable medical devices that include cathodic arc produced structures are provided. Cathodic arc produced structures of the invention may be thick, stress-free metallic structures that have configurations heretofore not available in implantable medical devices. In yet other embodiments, the structures may be crenulated or porous layers. Also provided are methods of producing implantable medical devices as well as systems for practicing the subject methods.
摘要翻译：提供了包括阴极电弧产生结构的植入式医疗设备。本发明的阴极电弧产生的结构可以是厚的，无应力的金属结构，其具有以前在植入式医疗装置中不可用的构造。在其他实施例中，结构可以是经过弯曲的或多孔的层。还提供了生产可植入医疗装置的方法以及用于实施本发明方法的系统。

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