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51. 发明授权

US07998182B2 Selective organ cooling apparatus 有权
标题翻译：选择性器官冷却装置
公开(公告)号：US07998182B2
公开(公告)日：2011-08-16
申请号：US11333986
申请日：2006-01-17
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F7/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.
摘要翻译：可以具有光滑的外表面或具有脊和凹槽的表面的血管内传热装置。该装置可以具有多个细长的关节部分，每个部分具有这样的表面。柔性接头连接相邻的细长铰接段。柔性接头可以是波纹管或柔性管。内腔设置在传热段内。内腔能够将加压工作流体输送到传热元件的远端。

52. 发明授权

US07066948B2 Selective organ cooling apparatus and method 失效
公开(公告)号：US07066948B2
公开(公告)日：2006-06-27
申请号：US10796906
申请日：2004-03-08
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F7/00
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.

53. 发明授权

US06702842B2 Selective organ cooling apparatus and method 有权
公开(公告)号：US06702842B2
公开(公告)日：2004-03-09
申请号：US10161107
申请日：2002-05-30
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F700
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.

54. 发明授权

US06582455B1 Method and device for applications of selective organ cooling 有权
公开(公告)号：US06582455B1
公开(公告)日：2003-06-24
申请号：US09621051
申请日：2000-07-21
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： The invention provides a method and device for selectively controlling the temperature of a selected organ of a patient for performance of a specified application. The method includes introducing a guide catheter into a blood vessel. The guide catheter may have a soft tip and a retaining flange, and may be used to provide treatments such as administration of thrombolytic drug therapies, stenting procedures, angiographic procedures, etc. A supply tube is provided having a heat transfer element attached to a distal end thereof. The heat transfer element having a plurality of exterior surface irregularities, these surface irregularities having a depth greater than the boundary layer thickness of flow in the feeding artery of the selected organ. The supply tube and heat transfer element may be inserted through the guide catheter to place the heat transfer element in the feeding artery of the selected organ. Turbulence is created around the surface irregularities at a distance from the heat transfer element greater than the boundary layer thickness of flow in the feeding artery, thereby creating turbulence throughout the blood flow in the feeding artery. A working fluid is circulated into the heat transfer element via the supply tube and via an internal lumen of the heat transfer element. The fluid may be circulated out of the heat transfer element via an external lumen of the heat transfer element and through the guide catheter. Heat is thereby transferred between the heat transfer element and the blood in the feeding artery to selectively control the temperature of the selected organ during or soon before or after the specified application.

55. 发明授权

US06575623B2 Guide wire having extendable contact sensors for measuring temperature of vessel walls 有权
公开(公告)号：US06575623B2
公开(公告)日：2003-06-10
申请号：US09969557
申请日：2001-10-01
申请人： Randell L. Werneth
发明人： Randell L. Werneth
IPC分类号： G01K1300
CPC分类号： A61B5/01 , A61B5/6851 , A61B5/6859 , A61B5/6885 , A61B18/02 , A61B2017/0007 , A61B2017/00084 , A61B2017/22051 , A61B2018/0262 , A61M25/09 , A61M2230/50
摘要： The present invention may be embodied in a device for detection of vulnerable plaque in a vessel based on a temperature increase of the vessel's wall. The device may be a guide wire having an extendable assembly having resilient delivery wires for placing the temperature sensor in contact with the vessel's inner wall.

56. 发明授权

US06551349B2 Selective organ cooling apparatus 有权
标题翻译：选择性器官冷却装置
公开(公告)号：US06551349B2
公开(公告)日：2003-04-22
申请号：US09815215
申请日：2001-03-22
申请人： Juan C. Lasheras , Randell L. Werneth , John D. Dobak, III
发明人： Juan C. Lasheras , Randell L. Werneth , John D. Dobak, III
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61F2007/0056 , A61F2007/126
摘要： The present invention involves a selective organ heat transfer device having a flexible coaxial catheter capable of insertion into a selected feeding artery in the vascular system of a patient. A heat transfer element is attached to a distal portion of the catheter as well as a turbulence-enhancing element which is adapted to enhance turbulent blood flow along the heat transfer element. The heat transfer element may include the turbulence-enhancing element and/or a turbulence-enhancing element may be located proximal of the heat transfer element.
摘要翻译：本发明涉及一种选择性器官传热装置，其具有能够插入患者血管系统中的选定进食动脉的柔性同轴导管。传热元件附接到导管的远端部分以及湍流增强元件，其适于增强沿着传热元件的湍流血流。传热元件可以包括湍流增强元件和/或湍流增强元件可以位于传热元件的近侧。

57. 发明授权

US06491716B2 Method and device for applications of selective organ cooling 有权
标题翻译：选择性器官冷却应用的方法和装置
公开(公告)号：US06491716B2
公开(公告)日：2002-12-10
申请号：US09246788
申请日：1999-02-09
申请人： John D. Dobak III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61B2018/0212 , A61B2018/0262 , A61F2007/0056 , A61F2007/126
摘要： The invention provides a method and device for heating or cooling a surrounding fluid in a feeding vessel. The device includes a catheter assembly capable of insertion to a selected feeding vessel in the vascular system of a patient. The assembly includes a heat transfer element at a distal end of the catheter assembly, the heat transfer element having a plurality of exterior surface irregularities shaped and arranged to create turbulence in a surrounding fluid, the surface irregularities having a depth at least equal to the boundary layer thickness of flow of the surrounding fluid in the feeding vessel. The assembly also includes a supply catheter to deliver a working fluid to an interior of the heat transfer element, a return catheter to return a working fluid from the interior of the heat transfer element, and a drug delivery catheter running substantially parallel to the axis of the catheter assembly. The method includes selectively controlling the temperature of a selected volume of blood in a patient by introducing a catheter assembly into a blood vessel feeding a selected volume of blood in a patient and delivering a working fluid through a supply catheter in the catheter assembly and returning the working fluid through a return catheter in the catheter assembly. Heat is transferred between a heat transfer element forming a distal end of the catheter assembly and the volume of blood in the feeding vessel. A liquid, such as a drug, is delivered through a drug delivery catheter to the volume of blood in the feeding vessel.
摘要翻译：本发明提供一种用于加热或冷却进料容器中的周围流体的方法和装置。该装置包括能够插入患者血管系统中的选定进料容器的导管组件。所述组件包括在所述导管组件的远端处的传热元件，所述传热元件具有多个外表面凹凸，其形状和布置成在周围流体中产生湍流，所述表面凹凸具有至少等于所述边界的深度进料容器中周围流体的流动层厚度。该组件还包括供应导管，用于将工作流体输送到传热元件的内部;返回导管，用于从工作流体从传热元件的内部返回;以及药物输送导管，其基本上平行于导管组件。该方法包括通过将导管组件引入供给患者中选定体积的血液的血管中并通过导管组件中的供应导管输送工作流体来选择性地控制患者体内所选体积的血液的温度，工作流体通过导管组件中的返回导管。在形成导管组件的远端的传热元件和进料容器中的血液体积之间传递热量。诸如药物的液体通过药物输送导管递送到进料容器中的血液体积。

58. 发明授权

US06464716B1 Selective organ cooling apparatus and method 有权
标题翻译：选择性器官冷却装置及方法
公开(公告)号：US06464716B1
公开(公告)日：2002-10-15
申请号：US09607799
申请日：2000-06-30
申请人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
发明人： John D. Dobak, III , Juan C. Lasheras , Randell L. Werneth
IPC分类号： A61F700
CPC分类号： A61B18/02 , A61B2017/00292 , A61B2018/0212 , A61F7/12 , A61F2007/0056 , A61F2007/126 , A61M25/00 , A61M25/0023 , A61M2025/0004 , A61M2025/006 , A61M2205/3606
摘要： An endovascular heat transfer device which can have a smooth exterior surface, or a surface with ridges and grooves. The device can have a plurality of elongated, articulated segments, with each having such a surface. A flexible joint connects adjacent elongated, articulated segments. The flexible joints can be bellows or flexible tubes. An inner lumen is disposed within the heat transfer segments. The inner lumen is capable of transporting a pressurized working fluid to a distal end of the heat transfer element.
摘要翻译：可以具有光滑的外表面或具有脊和凹槽的表面的血管内传热装置。该装置可以具有多个细长的关节部分，每个部分具有这样的表面。柔性接头连接相邻的细长铰接段。柔性接头可以是波纹管或柔性管。内腔设置在传热段内。内腔能够将加压工作流体输送到传热元件的远端。

59. 发明授权

US5913871A Balloon modification for improved stent fixation and deployment 失效
标题翻译：球囊修改用于改进支架固定和部署
公开(公告)号：US5913871A
公开(公告)日：1999-06-22
申请号：US723084
申请日：1996-09-25
申请人： Randell L. Werneth , John J. Bridgeman , Gary E. Currie
发明人： Randell L. Werneth , John J. Bridgeman , Gary E. Currie
IPC分类号： A61F2/06 , A61F2/84 , A61M29/00
CPC分类号： A61F2/958 , A61M25/1027 , A61F2002/9583 , A61M2025/1086 , A61M2025/1088
摘要： An intravascular catheter system and method of manufacture for implanting a radially expandable stent within a body vessel. The catheter system comprises a shaft defining an inflation lumen in fluid communication with a balloon on the distal end of the shaft. A stent is mounted coaxially upon a balloon. The balloon has ridges impressed in the outline of the stent for at least a portion of the stent. The ridges are sized to receive the stent so as to cause the balloon to expand evenly and the stent to deploy uniformly. In an alternative embodiment the balloon may additionally have a polymeric surface layer exhibiting a higher coefficient of friction than the underlying material against the stent material. The surface layer may be provided as a high friction polymeric coating on a formed balloon or as a coaxial extrusion of a high friction polymeric material over the underlying balloon tubing material. In a further embodiment the balloon may have the polymeric surface layer exhibiting a higher coefficient of friction than the underlying material against the stent material but without the ridges.
摘要翻译：一种血管内导管系统和用于在体内容器内植入可径向扩张的支架的制造方法。该导管系统包括一个轴，该轴限定与轴的远端上的球囊流体连通的充气腔。支架同轴安装在气球上。气囊在至少一部分支架的支架轮廓上留下了凹凸。脊的尺寸被设计成接收支架，以使球囊均匀地膨胀，支架均匀地展开。在替代实施例中，球囊可另外具有聚合物表面层，该聚合物表面层具有比相对于支架材料的下面的材料更高的摩擦系数。表面层可以作为高度摩擦的聚合物涂层提供在形成的气囊上或作为高摩擦聚合物材料在下面的气囊管材料上的同轴挤出。在另一个实施方案中，气囊可以具有聚合物表面层，其表现出比针对支架材料的下面的材料更高的摩擦系数，但没有脊。

60. 发明授权

US5653691A Thickened inner lumen for uniform stent expansion and method of making 失效
标题翻译：增厚的内腔，用于均匀的支架扩张和制造方法
公开(公告)号：US5653691A
公开(公告)日：1997-08-05
申请号：US637959
申请日：1996-04-25
申请人： Garry Eugene Rupp , Randell L. Werneth , Perfecta P. Tilos
发明人： Garry Eugene Rupp , Randell L. Werneth , Perfecta P. Tilos
IPC分类号： A61F2/06 , A61F2/84 , A61M25/00 , A61M25/10 , A61M29/00
CPC分类号： A61M25/1036 , A61F2/958 , A61M25/0009 , A61M25/0023 , A61M25/10 , A61F2002/9522 , A61F2002/9586
摘要： An intravascular catheter system for implanting a radially expandable stent within a body vessel including a catheter comprising an inner lumen tube, an inflation lumen tube, an inflatable balloon and at least one free standing built-up layer affixed to the outer diameter of the inner lumen tube, the built-up layer being internal to the balloon. A stent is mounted coaxially upon the balloon, the built-up layer extends coaxially within the stent but does not extend beyond the proximal and distal ends of the stent. The built-up layer is sufficiently thick as to cause the balloon to expand evenly and the stent to deploy uniformly. The method of manufacturing the built-up layer includes forming the layer from shrink wrap tubing or alternatively forming the layer from molded ultraviolet light curing adhesive.
摘要翻译：一种用于在体内容器内植入可径向扩张的支架的血管内导管系统，包括导管，其包括内腔管，充气管腔，可充气球囊和固定到内腔外径的至少一个独立组合层管内，积聚层位于气球内部。支架同轴地安装在气囊上，积层在支架内同轴延伸，但不延伸超出支架的近端和远端。堆积层足够厚，使气囊均匀膨胀，支架均匀分布。制造堆积层的方法包括从收缩包裹管形成层或者从成型的紫外光固化粘合剂形成层。

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