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51. 发明申请

US20110090613A1 APPARATUS AND METHOD FOR SUBSTRATE CLAMPING IN A PLASMA CHAMBER 有权
标题翻译：用于在等离子体室中衬底夹紧的装置和方法
公开(公告)号：US20110090613A1
公开(公告)日：2011-04-21
申请号：US12950105
申请日：2010-11-19
申请人： Ganesh Balasubramanian , Amit Bansal , Eller Y. Juco , Mohamad Ayoub , Hyung-Joon Kim , Karthik Janakiraman , Sudha Rathi , Deenesh Padhi , Martin Jay Seamons , Visweswaren Sivaramakrishnan , Bok Hoen Kim , Amir Al-Bayati , Derek R. Witty , Hichem M'Saad , Anton Baryshnikov , Chiu Chan , Shuang Liu
发明人： Ganesh Balasubramanian , Amit Bansal , Eller Y. Juco , Mohamad Ayoub , Hyung-Joon Kim , Karthik Janakiraman , Sudha Rathi , Deenesh Padhi , Martin Jay Seamons , Visweswaren Sivaramakrishnan , Bok Hoen Kim , Amir Al-Bayati , Derek R. Witty , Hichem M'Saad , Anton Baryshnikov , Chiu Chan , Shuang Liu
IPC分类号： H01L21/683 , H01L21/66 , G01R27/02
CPC分类号： H01L21/6831 , C23C16/52 , H01J37/32431 , H01L21/67069 , H01L21/67253
摘要： The present invention generally provides methods and apparatus for monitoring and maintaining flatness of a substrate in a plasma reactor. Certain embodiments of the present invention provide a method for processing a substrate comprising positioning the substrate on an electrostatic chuck, applying an RF power between the an electrode in the electrostatic chuck and a counter electrode positioned parallel to the electrostatic chuck, applying a DC bias to the electrode in the electrostatic chuck to clamp the substrate on the electrostatic chuck, and measuring an imaginary impedance of the electrostatic chuck.
摘要翻译：本发明通常提供了用于监测和维持等离子体反应器中的基板的平坦度的方法和装置。本发明的某些实施例提供了一种处理衬底的方法，包括将衬底定位在静电吸盘上，在静电吸盘中的电极与平行于静电吸盘的对置电极之间施加RF功率，将DC偏压施加到静电卡盘中的电极将基板夹在静电卡盘上，并测量静电卡盘的虚拟阻抗。

52. 发明申请

US20080113971A1 PYRAZOLE COMPOUNDS AS PROTEIN KINASE INHIBITORS 审中-公开
标题翻译：吡咯化合物作为蛋白激酶抑制剂
公开(公告)号：US20080113971A1
公开(公告)日：2008-05-15
申请号：US11958229
申请日：2007-12-17
申请人： Cathleen Hanau , Serena Mershon , Matthew Graneto , Marvin Meyers , Ingrid Buchler , Shridhar Hegde , Kun Wu , Shuang Liu
发明人： Cathleen Hanau , Serena Mershon , Matthew Graneto , Marvin Meyers , Ingrid Buchler , Shridhar Hegde , Kun Wu , Shuang Liu
IPC分类号： A61K31/551 , A61K31/498 , C07D487/04
CPC分类号： C07D471/04 , C07D401/04 , C07D401/14 , C07D471/14 , C07D487/04 , C07D513/04 , C07D519/00
摘要： Compounds are described which inhibit mitogen activated protein kinase-activated protein kinase-2 (MK-2). Methods of making such compounds are described, as well as a method of using them for the inhibition of MK-2, and for the prevention or treatment of a disease or disorder that is mediated by TNFα, where the method involves administering to the subject an MK-2 inhibiting compound of the present invention. Pharmaceutical compositions and kits which contain the present MK-2 inhibiting compounds are also described.
摘要翻译：描述了抑制丝裂原活化蛋白激酶活化蛋白激酶-2（MK-2）的化合物。描述了制备这些化合物的方法，以及使用它们用于抑制MK-2的方法，以及用于预防或治疗由TNFα介导的疾病或病症的方法，其中所述方法涉及对受试者施用本发明的MK-2抑制化合物。还描述了含有本发明的MK-2抑制化合物的药物组合物和试剂盒。

53. 发明申请

US20070088033A1 Diaryl Substituted Pyridinones 审中-公开
标题翻译：二芳基取代的吡啶酮
公开(公告)号：US20070088033A1
公开(公告)日：2007-04-19
申请号：US11531492
申请日：2006-09-13
申请人： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
发明人： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
IPC分类号： A61K31/53 , A61K31/506 , A61K31/497 , A61K31/4439 , A61K31/4545 , A61K31/4709 , C07D417/02 , C07D403/02 , C07D401/02
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， >和R 5＆gt;在本文中定义。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

54. 发明申请

US20060211694A1 Diaryl substituted pyridinones 失效
标题翻译：二芳基取代的吡啶酮
公开(公告)号：US20060211694A1
公开(公告)日：2006-09-21
申请号：US11226556
申请日：2005-09-14
申请人： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
发明人： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
IPC分类号： A61K31/53 , A61K31/506 , A61K31/498 , A61K31/497 , A61K31/501 , A61K31/4439 , A61K31/4747 , A61K31/4709 , A61K31/4412
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， >和R 5＆gt;在本文中定义。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

55. 发明授权

US07067540B2 Substituted pyridinones 有权
标题翻译：取代的吡啶酮
公开(公告)号：US07067540B2
公开(公告)日：2006-06-27
申请号：US10367987
申请日：2003-02-14
申请人： Balekudru Devadas , John Walker , Shaun R. Selness , Terri L. Boehm , Richard C. Durley , Rajesh Devraj , Brian S. Hickory , Paul V. Rucker , Kevin D. Jerome , Heather M. Madsen , Edgardo Alvira , Michele A. Promo , Radhika M. Blevis-Bal , Laura D. Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey S. Shieh , Aruna Sambandam , Shuang Liu , Ian L. Scott , Kevin F. McGee
发明人： Balekudru Devadas , John Walker , Shaun R. Selness , Terri L. Boehm , Richard C. Durley , Rajesh Devraj , Brian S. Hickory , Paul V. Rucker , Kevin D. Jerome , Heather M. Madsen , Edgardo Alvira , Michele A. Promo , Radhika M. Blevis-Bal , Laura D. Marruto , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey S. Shieh , Aruna Sambandam , Shuang Liu , Ian L. Scott , Kevin F. McGee
IPC分类号： A61K31/44 , C07D213/02 , C07D401/02
CPC分类号： C07D213/64 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/79 , C07D213/84 , C07D213/85 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D409/14 , C07D413/10
摘要： Disclosed are compounds Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式I化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， >和R 5＆gt;在本文中定义。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

56. 发明申请

US20050176775A1 Substituted pyridinones 审中-公开
标题翻译：取代的吡啶酮
公开(公告)号：US20050176775A1
公开(公告)日：2005-08-11
申请号：US10918826
申请日：2004-08-13
申请人： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marrufo , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
发明人： Balekudru Devadas , John Walker , Shaun Selness , Terri Boehm , Richard Durley , Rajesh Devraj , Brian Hickory , Paul Rucker , Kevin Jerome , Heather Madsen , Edgardo Alvira , Michele Promo , Radhika Blevis-Bal , Laura Marrufo , Jeff Hitchcock , Thomas Owen , Win Naing , Li Xing , Huey Shieh , Aruna Sambandam , Shuang Liu , Ian Scott , Kevin McGee
IPC分类号： A61K20060101 , A61K31/4412 , A61K31/4415 , A61K31/4439 , A61P29/00 , C07D211/86 , C07D213/64 , C07D213/69 , C07D213/70 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/80 , C07D213/84 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04 , C07D41/02
CPC分类号： C07D213/69 , C04B35/632 , C07D213/64 , C07D213/70 , C07D213/73 , C07D213/80 , C07D215/22 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/06 , C07D413/10 , C07D417/04
摘要： Disclosed are compounds of Formula I and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, and R5 are defined herein. These compounds are useful for treating diseases and conditions caused or exacerbated by unregulated p38 MAP Kinase and/or TNF activity. Pharmaceutical compositions containing the compounds, methods of preparing the compounds and methods of treatment using the compounds are also disclosed.
摘要翻译：公开了式I的化合物及其药学上可接受的盐，其中R 1，R 2，R 3，R 4， SUB＆gt;和R 5＆gt;在本文中定义。这些化合物可用于治疗由不受调节的p38 MAP激酶和/或TNF活性引起或加重的疾病和病症。还公开了含有化合物的药物组合物，制备化合物的方法和使用该化合物的治疗方法。

57. 发明授权

US06869590B2 Labeled macrophage scavenger receptor antagonists for imaging atherosclerosis and vulnerable plaque 失效
公开(公告)号：US06869590B2
公开(公告)日：2005-03-22
申请号：US10080974
申请日：2002-02-22
申请人： David Scott Edwards , Shuang Liu
发明人： David Scott Edwards , Shuang Liu
IPC分类号： C07D213/89 , A61K9/08 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/20 , A61K47/22 , A61K47/46 , A61K49/00 , A61K49/04 , A61K51/00 , A61K51/04 , C07C235/64 , C07F1/08 , C07F13/00 , A61M36/14
CPC分类号： A61K51/0497
摘要： Detectably labeled macrophage scavenger receptor antagonists useful for the diagnosis and monitoring of various cardiovascular diseases including but not limited to atherosclerosis, vulnerable plaque, coronary artery disease, renal disease, thrombosis, transient ischemia due to clotting, stroke, myocardial infarction, organ transplant, organ failure and hypercholesterolemia.

58. 发明申请

US20050010038A1 Chelants and macrocyclic metal complex radiopharmaceuticals thereof 失效
标题翻译：螯合剂及其大环金属络合物放射性药物
公开(公告)号：US20050010038A1
公开(公告)日：2005-01-13
申请号：US10864792
申请日：2004-06-09
申请人： Shuang Liu
发明人： Shuang Liu
IPC分类号： A61K51/04 , A61K51/08 , C07D213/81 , C07D213/82 , C07F9/58 , C07F13/00 , C07F5/00
CPC分类号： C07F13/005 , A61K51/0478 , A61K51/0482 , C07D213/81 , C07D213/82 , C07F9/58
摘要： Chelants and macrocyclic metal complexes thereof, methods of preparing the chelants and macrocyclic metal complexes, and radiopharmaceutical compositions comprising the macrocyclic metal complexes are disclosed. Methods of using the macrocyclic metal complexes as radiopharmaceuticals for the diagnosis of cardiovascular disorders, infectious diseases and cancer are also disclosed. Chelants as bifunctional chelators (BFCs) for the radiolabeling of target-specific biomolecules, such as proteins, peptides, peptidomimetics, non-peptide receptor ligands, enzyme inhibitors, and enzyme substrates are disclosed. Methods of using macrocyclic metal complexes containing the chelant-biomolecule conjugates as target-specific diagnostic radiopharmaceuticals that selectively localize at sites of disease and allow an image to be obtained of the loci using gamma scintigraphy are disclosed. Methods of use of the radiopharmaceuticals as imaging agents for the diagnosis of cardiovascular disorders, such as thromboembolic disease or atherosclerosis, infectious disease and cancer are further disclosed.
摘要翻译：公开了螯合剂及其大环金属络合物，制备螯合剂和大环金属配合物的方法，以及包含大环金属络合物的放射性药物组合物。还公开了将大环金属络合物用作放射性药物用于诊断心血管疾病，感染性疾病和癌症的方法。公开了用于靶标特异性生物分子例如蛋白质，肽，肽模拟物，非肽受体配体，酶抑制剂和酶底物的放射性标记的双功能螯合剂（BFC）的螯合剂。公开了使用含有螯合剂 - 生物分子共轭物的大环金属络合物作为靶向特异性诊断放射性药物的方法，其在疾病部位选择性定位并允许使用γ闪烁扫描获得基因座的图像。进一步公开了使用放射性药物作为诊断心血管疾病如血栓栓塞性疾病或动脉粥样硬化，感染性疾病和癌症的显像剂的方法。

59. 发明授权

US06416733B1 Radiopharmaceuticals for imaging infection and inflammation 失效
标题翻译：用于成像感染和炎症的放射性药物
公开(公告)号：US06416733B1
公开(公告)日：2002-07-09
申请号：US08943659
申请日：1997-10-03
申请人： John A. Barrett , Edward H. Cheesman , Thomas D. Harris , Shuang Liu , Milind Rajopadhye , Michael Sworin
发明人： John A. Barrett , Edward H. Cheesman , Thomas D. Harris , Shuang Liu , Milind Rajopadhye , Michael Sworin
IPC分类号： A61K5100
CPC分类号： A61K51/0497 , A61K51/0455 , A61K51/0478 , C07C59/90 , C07D213/64 , C07D213/71 , C07D213/77 , C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07F13/005
摘要： The present invention provides novel radiopharmaceuticals useful for the diagnosis of infection and inflammation, reagents and kits useful for preparing the radiopharmaceuticals, methods of imaging sites of infection and/or inflammation in a patient, and methods of diagnosing diseases associated with infection or inflammation in patients in need of such diagnosis. The radiopharmaceuticals bind in vivo to the leukotriene B4 (LTB4) receptor on the surface of leukocytes which accumulate at the site of infection and inflammation. The reagents provided by this invention are also useful for the treatment of diseases associated with infection and inflammation.
摘要翻译：本发明提供了可用于诊断感染和炎症的新型放射性药物，可用于制备放射性药物的试剂和试剂盒，成像患者感染和/或炎症部位成像方法以及诊断患者感染或炎症相关疾病的方法需要这样的诊断。放射性药物在体内结合白细胞表面的白细胞三烯B4（LTB4）受体，其在感染和炎症部位积聚。本发明提供的试剂也可用于治疗与感染和炎症相关的疾病。

60. 发明授权

US06403054B1 Ternary ligand complexes useful as radiopharmaceuticals 失效
标题翻译：用作放射性药物的三元配体配合物
公开(公告)号：US06403054B1
公开(公告)日：2002-06-11
申请号：US08864586
申请日：1997-05-28
申请人： Shuang Liu
发明人： Shuang Liu
IPC分类号： A61K5104
CPC分类号： C07F13/005 , A61K51/0478 , C07D213/77 , C07D213/82 , C07F9/5045
摘要： The present invention provides novel radiopharmaceuticals useful for imaging the heart, brain, lungs, liver or kidneys, kits useful for preparing the radiopharmaceuticals, and methods of imaging the heart, brain, lungs, liver or kidneys in a patient in need of such imaging. The radiopharmaceuticals are comprised of technetium or rhenium radionuclide complexes of a ternary ligand system: one hydrazido or diazenido ligand, one aminoalcohol ligand, and one pi-acid ligand selected from phosphines, arsines, and imine nitrogen-containing heterocycles. The radiopharmaceuticals have the formula, ML1L2L3, wherein the variables are as defined herein.
摘要翻译：本发明提供了可用于对心脏，脑，肺，肝或肾进行成像的新型放射性药物，可用于制备放射性药物的试剂盒，以及在需要这种成像的患者中对心脏，脑，肺，肝或肾进行成像的方法。放射性药物由三元配体体系的锝或铼放射性核素配合物组成：一个肼基或二氮烯酸配体，一个氨基醇配体和一个选自膦，胂和亚胺含氮杂环的一个配位体。放射性药物具有式ML1L2L3，其中变量如本文所定义。

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