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51. 发明授权

US06274705B1 Antithrombotic azacycloalkylalkanoyl peptides and pseudopeptides 失效
标题翻译：抗血栓形成的氮杂环烷基烷酰基肽和假肽
公开(公告)号：US06274705B1
公开(公告)日：2001-08-14
申请号：US09137998
申请日：1998-08-21
申请人： Scott I. Klein , Bruce F. Molino
发明人： Scott I. Klein , Bruce F. Molino
IPC分类号： C07K5083
CPC分类号： C07K5/0806 , C07K5/06026
摘要： The present invention relates to azacycloalkylalkanoyl peptides and pseudopeptides which inhibit platelet aggregation and thrombus formation thereby being useful in the prevention and treatment of thrombosis associated with disease states such as myocardial infarction, stroke, peripheral arterial disease, and disseminated intravascular coagulation, to methods for the prevention or treatment of thrombosis in a mammal in need of such therapy comprising the administration of a therapeutically effective amount of such compounds, and to pharmaceutical compositions comprising such compounds.
摘要翻译：本发明涉及抑制血小板聚集和血栓形成的氮杂环烷基烷酰基肽和假肽，从而可用于预防和治疗与诸如心肌梗塞，中风，外周动脉疾病和弥散性血管内凝血之类的疾病状态相关的血栓形成，用于预防或治疗需要这种治疗的哺乳动物的血栓形成，包括施用治疗有效量的这些化合物，以及包含这些化合物的药物组合物。

52. 发明授权

US5064814A Anti-thrombotic peptide and pseudopeptide derivatives 失效
标题翻译：抗血栓肽和假肽衍生物
公开(公告)号：US5064814A
公开(公告)日：1991-11-12
申请号：US505286
申请日：1990-04-05
申请人： Scott I. Klein , Bruce F. Molino
发明人： Scott I. Klein , Bruce F. Molino
IPC分类号： A61K38/00 , C07K5/02
CPC分类号： C07K5/0205 , C07K5/0202 , A61K38/00
摘要： Disclosed are novel peptide and pseudopeptide derivatives and phrmaceutical compositions thereof that inhibit platelet aggregation and thrombus formation in mammalian blood.
摘要翻译：公开了抑制哺乳动物血液中血小板聚集和血栓形成的新型肽和假肽衍生物及其药物组合物。

53. 发明授权

US4859672A Pyrido[2,3-d]pyrimidinone and imidazo[4,5-b]pyrimidinone 失效
标题翻译：吡啶并[2,3-d]嘧啶酮和咪唑并[4,5-b]嘧啶酮
公开(公告)号：US4859672A
公开(公告)日：1989-08-22
申请号：US925008
申请日：1986-10-29
申请人： Alfred P. Spada , Henry F. Campbell , Donald E. Kuhla , William L. Studt , William C. Faith , Bruce F. Molino
发明人： Alfred P. Spada , Henry F. Campbell , Donald E. Kuhla , William L. Studt , William C. Faith , Bruce F. Molino
IPC分类号： C07D475/02 , A61K31/435 , A61K31/44 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/519 , A61K31/53 , A61K31/55 , A61P37/04 , C07D471/04 , C07D475/00 , C07D487/04
CPC分类号： C07D475/00 , C07D471/04
摘要： Compounds useful for increasing cardiotonic contractility in humans or other animals and pharmaceutical compositions including these compounds are disclosed. The compounds have the general structure ##STR1## wherein: A is ##STR2## and R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.8, R.sub.10, R.sub.11, R.sub.12, R.sub.14, R.sub.15, R.sub.16, R.sub.17, R.sub.18, R.sub.19, R.sub.20, R.sub.21, R.sub.22, R.sub.23 and R.sub.24 are H, lower alkyl of 1-4 carbon atoms, phenyl, substituted phenyl, phenyl lower alkyl of 1-4 carbon atoms or substituted phenyl lower alkyl of 1-4 carbon atoms;wherein the substituted phenyl group is substituted by one or more of lower alkyl, lower alkoxy, amino, lower alkyl amino, lower alkyl mercapto, hydroxy, hydroxy lower alkyl, acetoxy, benzyloxy, phenoxy, lower alkyl sulfinyl or lower alkyl sulfonyl;R.sub.13 is H, lower alkyl of 1-4 carbon atoms, alkoxy lower alkyl of 1-4 carbon atoms, hydroxy lower alkyl of 1-5 carbon atoms, amino, carbamoyl, cyano, lower alkyl carbamoyl of 1-4 carbon atoms, formyl, amino lower alkyl of 1-4 carbon atoms, carboxy, carbalkoxy, or tetrazolyl;R.sub.3 and R.sub.4 together may form =O;R.sub.16 and R.sub.17 together may form a carbon-carbon bond;n is 0 or 1; andO is 0 or 1.
摘要翻译：公开了可用于增加人或其他动物的强心收缩性的化合物和包括这些化合物的药物组合物。这些化合物具有通用结构，其中：A为 + TR ，R1，R2，R3，R4，R8，R10，R11，R12，R14，R15，R16，R17，R18， R 20，R 21，R 22，R 23和R 24是H，1-4个碳原子的低级烷基，苯基，取代的苯基，1-4个碳原子的苯基低级烷基或1-4个碳原子的取代的苯基低级烷基; 其中取代的苯基被一个或多个低级烷基，低级烷氧基，氨基，低级烷基氨基，低级烷基巯基，羟基，羟基低级烷基，乙酰氧基，苄氧基，苯氧基，低级烷基亚磺酰基或低级烷基磺酰基取代。 R13为H，1-4个碳原子的低级烷基，1-4个碳原子的烷氧基低级烷基，1-5个碳原子的羟基低级烷基，氨基，氨基甲酰基，氰基，1-4个碳原子的低级烷基氨基甲酰基，，1-4个碳原子的氨基低级烷基，羧基，烷氧羰基或四唑基; R3和R4一起可以形成= O; R 16和R 17一起可以形成碳 - 碳键; n为0或1; O为0或1。

54. 发明申请

US20110003832A1 NEW CAPPED Pyrazinoylguanidine SODIUM CHANNEL BLOCKERS 有权
标题翻译：新CAPPED吡嗪酰胍胍SODIUM通道阻断剂
公开(公告)号：US20110003832A1
公开(公告)日：2011-01-06
申请号：US12876615
申请日：2010-09-07
申请人： Michael R. JOHNSON , Bruce F. Molino , Bruce Sargent , Jianzhong Zhang
发明人： Michael R. JOHNSON , Bruce F. Molino , Bruce Sargent , Jianzhong Zhang
IPC分类号： A61K31/4965 , C07D241/30 , A61P11/00 , A61P1/02 , A61P9/12 , A61P15/02
CPC分类号： C07D241/26 , A61K31/495 , A61K31/50 , A61K45/06
摘要： The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
摘要翻译：本发明涉及钠通道阻断剂。本发明还包括使用这些本发明的钠通道阻断剂的各种治疗方法。

55. 发明授权

US07696165B2 Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders 失效
标题翻译：使用环孢菌素炔类似物来预防或治疗病毒性疾病
公开(公告)号：US07696165B2
公开(公告)日：2010-04-13
申请号：US11391020
申请日：2006-03-28
申请人： Bruce F. Molino
发明人： Bruce F. Molino
IPC分类号： A61K38/12
CPC分类号： A61K38/13
摘要： The present invention relates to methods of preventing or treating a mammal with a viral-induced disorder. The method involves administering to the mammal a therapeutically effective amount of a compound represented by Formula I, as shown below: or a pharmaceutically acceptable salt thereof, with X, R0, and R1 defined herein, under conditions effective to prevent or treat the viral-induced disorder.
摘要翻译：本发明涉及用病毒诱导的病症预防或治疗哺乳动物的方法。该方法包括在有效预防或治疗病毒感染的条件下向哺乳动物施用治疗有效量的由式I表示的化合物，如下所示：或其药学上可接受的盐，与本文定义的X，R 0和R 1，诱发障碍。

56. 发明授权

US07632807B2 Cyclosporin alkynes and their utility as pharmaceutical agents 有权
标题翻译：环孢菌素炔及其作为药剂的作用
公开(公告)号：US07632807B2
公开(公告)日：2009-12-15
申请号：US12046854
申请日：2008-03-12
申请人： Bruce F. Molino , Zhicai Yang
发明人： Bruce F. Molino , Zhicai Yang
IPC分类号： A61K38/12 , A61K39/39
CPC分类号： C07K7/645 , A61K38/00
摘要： The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, and R1 defined herein.
摘要翻译：本发明的化合物由式I中所示的化学结构或其药学上可接受的盐以本文定义的X，R0和R1表示。

57. 发明申请

US20080176863A1 CAPPED PYRAZINOYLGUANIDINE SODIUM CHANNEL BLOCKERS 审中-公开
公开(公告)号：US20080176863A1
公开(公告)日：2008-07-24
申请号：US12049946
申请日：2008-03-17
申请人： Michael R. JOHNSON , Bruce F. Molino , Jianzhong Zhang , Bruce Sargent
发明人： Michael R. JOHNSON , Bruce F. Molino , Jianzhong Zhang , Bruce Sargent
IPC分类号： A61K31/4965 , C07D405/02 , C07D241/02
摘要： The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.
摘要翻译：本发明涉及钠通道阻断剂。本发明还包括使用这些本发明的钠通道阻断剂的各种治疗方法。

58. 发明授权

US07368451B2 Capped pyrazinoylguanidine sodium channel blockers 有权
公开(公告)号：US07368451B2
公开(公告)日：2008-05-06
申请号：US11211660
申请日：2005-08-26
申请人： Michael R. Johnson , Bruce F. Molino , Jianzhong Zhang , Bruce Sargent
发明人： Michael R. Johnson , Bruce F. Molino , Jianzhong Zhang , Bruce Sargent
IPC分类号： A61K31/4965 , C07D401/00 , C07D403/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D241/26 , A61K31/4965 , A61K31/497 , C07D241/32 , C07D403/12 , C07D413/12 , C07D417/12 , C07D473/00 , C07D473/16
摘要： The present invention relates to sodium channel blockers. The present invention also includes a variety of methods of treatment using these inventive sodium channel blockers.

59. 发明授权

US07361636B2 Cyclosporin alkynes and their utility as pharmaceutical agents 失效
标题翻译：环孢菌素炔及其作为药剂的作用
公开(公告)号：US07361636B2
公开(公告)日：2008-04-22
申请号：US11232293
申请日：2005-09-21
申请人： Bruce F. Molino , Zhicai Yang
发明人： Bruce F. Molino , Zhicai Yang
IPC分类号： A61K38/12
CPC分类号： C07K7/645 , A61K38/00
摘要： The compounds of the present invention are represented by the chemical structure found in Formula I: or a pharmaceutically acceptable salt thereof, with X, R0, and R1 defined herein.
摘要翻译：本发明的化合物由式I所示的化学结构或其药学上可接受的盐与本文定义的X，R 0和R 1表示。

60. 发明授权

US5162336A Tetrahydro-pyrido-indoles as cholecystokinin and gastrin antagonists 失效
标题翻译：作为选择性蛋白和胃蛋白酶拮抗剂的四氢吡喃葡萄糖苷
公开(公告)号：US5162336A
公开(公告)日：1992-11-10
申请号：US573514
申请日：1990-08-24
申请人： Bruce F. Molino , Paul R. Darkes , William R. Ewing
发明人： Bruce F. Molino , Paul R. Darkes , William R. Ewing
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Disclosed are tetrahydro-pyrido-indoles having the general formula ##STR1## which are antagonists towards the neuropeptides cholexystokinin and gastrin processing valuable activities for the treatment of cholecystokinin or gastrin-related disorders of the gastrointestinal, central nervous and appetite regulatory systems and their pharmaceutical compositions and processes for their preparation.
摘要翻译：公开了具有通式为“IMAGE”的四氢吡啶并吲哚，它们是拮抗神经肽胆碱酯酶和胃泌素处理胃肠，中枢神经和食欲调节系统的缩胆囊肿或胃泌素相关病症的有价值的活性及其药物组合物及其制备方法。

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