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51. 发明申请

US20070280612A1 Method and apparatus for fiberscope 有权
公开(公告)号：US20070280612A1
公开(公告)日：2007-12-06
申请号：US11798483
申请日：2007-05-14
申请人： Patrick Treado , Matthew Nelson , Joseph Demuth
发明人： Patrick Treado , Matthew Nelson , Joseph Demuth
IPC分类号： G02B6/04 , G01J3/00 , G01J3/44 , G01N21/47 , G01N21/55 , G02B6/02
CPC分类号： A61B1/00165 , A61B1/043 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/021 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0291 , G01J3/32 , G01J3/44 , G01J2003/1213 , G01N21/33 , G01N21/359 , G01N21/474 , G01N21/645 , G01N21/65 , G01N2021/3155 , G01N2021/4742 , G01N2021/6419 , G01N2021/6421 , G01N2021/6484 , G01N2021/656 , G02B6/06 , G02B6/29398 , G02B23/2423 , G02B23/2469
摘要： The disclosure generally relates to a method and apparatus for a fiberscope. In one embodiment, the disclosure relates to a chemical imaging fiberscope for imaging and collecting optical spectra from a sample having at least one illumination fiber for transmitting light from a first an a second light source to a distal end of a fiberscope; a dichroic mirror disposed at said distal end of the fiberscope such that light from said first light source passes substantially straight through said mirror and light of a predetermined wavelength from said second light source is substantially reflected by said mirror toward said sample to thereby illuminate said sample; and at least one collection fiber for receiving light from said illuminated sample and transmitting the received light to an optical device.

52. 发明申请

US20070086004A1 Method for detection of pathogenic microorganisms 有权
标题翻译：检测病原微生物的方法
公开(公告)号：US20070086004A1
公开(公告)日：2007-04-19
申请号：US11440846
申请日：2006-05-25
申请人： John Maier , Charles Gardner , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe
发明人： John Maier , Charles Gardner , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6486 , G01J3/02 , G01J3/0218 , G01J3/2823 , G01J3/44 , G01N21/31 , G01N21/33 , G01N21/359 , G01N21/645 , G01N21/6456 , G01N21/6458 , G01N21/65 , G01N2021/1736 , G01N2021/6421 , G01N2021/6423 , G01N2021/656
摘要： A method for the detection and identification of pathogenic microorganisms using Raman scattered light and emitted light. The method may include passing the Raman scattered light and emitted light through a FAST fiber array spectral translator.
摘要翻译：使用拉曼散射光和发射光检测和鉴定病原微生物的方法。该方法可以包括使拉曼散射光和发射光通过FAST光纤阵列光谱转换器。

53. 发明申请

US20070086003A1 Method for detection of pathogenic microorganisms 有权
公开(公告)号：US20070086003A1
公开(公告)日：2007-04-19
申请号：US11440845
申请日：2006-05-25
申请人： John Maier , Charles Gardner , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe
发明人： John Maier , Charles Gardner , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/6486 , G01J3/02 , G01J3/0218 , G01J3/2823 , G01J3/44 , G01N21/31 , G01N21/33 , G01N21/359 , G01N21/645 , G01N21/6456 , G01N21/6458 , G01N21/65 , G01N2021/1736 , G01N2021/6421 , G01N2021/6423 , G01N2021/656
摘要： A method for the detection and identification of pathogenic microorganisms using Raman scattered light and transmitted light in the near infrared spectral region. The method may include passing the Raman scattered light and transmitted light through a FAST fiber array spectral translator.

54. 发明申请

US20060209301A1 Method and apparatus for compact spectrometer for fiber array spectral translator 有权
标题翻译：用于光纤阵列光谱转换器的紧凑型光谱仪的方法和装置
公开(公告)号：US20060209301A1
公开(公告)日：2006-09-21
申请号：US11366531
申请日：2006-03-03
申请人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
发明人： Charles Gardner , John Maier , Matthew Nelson , Robert Schweitzer , Patrick Treado , G. Vanni , Julianne Wolfe , Joseph Demuth , Jason Neiss , Chenhui Wang
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01J3/44 , G01J3/02 , G01J3/0205 , G01J3/0218 , G01J3/0224 , G01J3/0237 , G01J3/0256 , G01J3/0264 , G01J3/0272 , G01J3/0283 , G01J3/0291 , G01J3/10 , G01J3/26 , G01J3/32 , G01J3/36 , G01J3/447 , G01N21/65 , G01N2201/0846
摘要： The disclosure relates to a portable system having a fiber array spectral translator (“FAST”) for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an image of all or part of the sample using Raman shifted light from the sample, and analyzing the Raman shifted light for patterns characteristic of one or more hazardous agents.
摘要翻译：本公开涉及一种具有光纤阵列光谱转换器（“FAST”）的便携式系统，用于获得具有第一和第二空间尺寸的样品的空间准确的波长分辨图像，所述第一和第二空间尺寸可用于通过照射来检测危险物质具有光的样品，使用来自样品的拉曼移动光形成全部或部分样品的图像，并且分析拉曼偏移光以获得一种或多种危险剂的特征。

55. 发明申请

US20060051036A1 Method and apparatus for fiberscope 有权
公开(公告)号：US20060051036A1
公开(公告)日：2006-03-09
申请号：US10956044
申请日：2004-10-04
申请人： Patrick Treado , Matthew Nelson , Joseph Demuth
发明人： Patrick Treado , Matthew Nelson , Joseph Demuth
IPC分类号： G02B6/06 , G01J3/44
CPC分类号： A61B1/00165 , A61B1/043 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01J3/02 , G01J3/021 , G01J3/0218 , G01J3/0256 , G01J3/0264 , G01J3/0291 , G01J3/32 , G01J3/44 , G01J2003/1213 , G01N21/33 , G01N21/359 , G01N21/474 , G01N21/645 , G01N21/65 , G01N2021/3155 , G01N2021/4742 , G01N2021/6419 , G01N2021/6421 , G01N2021/6484 , G01N2021/656 , G02B6/06 , G02B6/29398 , G02B23/2423 , G02B23/2469
摘要： The disclosure generally relates to a method and apparatus for a fiberscope. In one embodiment, the disclosure relates to a chemical imaging fiberscope for imaging and collecting optical spectra from a sample having at least one illumination fiber for transmitting light from a first an a second light source to a distal end of a fiberscope; a dichroic mirror disposed at said distal end of the fiberscope such that light from said first light source passes substantially straight through said mirror and light of a predetermined wavelength from said second light source is substantially reflected by said mirror toward said sample to thereby illuminate said sample; and at least one collection fiber for receiving light from said illuminated sample and transmitting the received light to an optical device.

56. 发明申请

US20060019409A1 Spectroscopic methods for component particle analysis 有权
公开(公告)号：US20060019409A1
公开(公告)日：2006-01-26
申请号：US11091126
申请日：2005-03-28
申请人： Matthew Nelson , Patrick Treado , Jason Attanucci
发明人： Matthew Nelson , Patrick Treado , Jason Attanucci
IPC分类号： G06K9/00 , G01N33/543 , G01N33/551
CPC分类号： G06K9/00127
摘要： The invention relates to methods of assessing one or more geometric properties of a particle of a substance using an infrared spectroscopic property of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures containing both particles of the substance and other materials.

57. 发明申请

US20060001867A1 Method and apparatus for spectral modulation compensation 有权
标题翻译：光谱调制补偿的方法和装置
公开(公告)号：US20060001867A1
公开(公告)日：2006-01-05
申请号：US10879632
申请日：2004-06-30
申请人： John Maier , Jason Neiss , Shona Stewart , Matthew Nelson , Joseph Demuth , Patrick Treado
发明人： John Maier , Jason Neiss , Shona Stewart , Matthew Nelson , Joseph Demuth , Patrick Treado
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , G01J3/0297 , G01J3/44 , G01N2021/656
摘要： The embodiments disclosed herein generally relate to identifying and removing background noise in spectroscopic imaging of a sample. Because white-light has essentially constant intensity at every wavelength, background noise caused by white light can be identified and removed from spectroscopic measurements including Raman spectroscopy. Thus, once the Raman spectrum for a sample is obtained, it may be corrected to remove the white-light dispersive spectrum in accordance with the embodiments disclosed herein.
摘要翻译：本文公开的实施例通常涉及在样本的光谱成像中识别和去除背景噪声。因为白光在每个波长处具有基本恒定的强度，所以可以从包括拉曼光谱的光谱测量中识别和去除由白光引起的背景噪声。因此，一旦获得样品的拉曼光谱，就可以根据本文公开的实施方案来校正其去除白光色散谱。

58. 发明申请

US20050277118A1 Methods for identifying subjects at risk of melanoma and treatments thereof 审中-公开
标题翻译：鉴别患有黑素瘤风险的受试者及其治疗方法
公开(公告)号：US20050277118A1
公开(公告)日：2005-12-15
申请号：US10661966
申请日：2003-09-11
申请人： Richard Roth , Matthew Nelson , Andreas Braun
发明人： Richard Roth , Matthew Nelson , Andreas Braun
IPC分类号： A61B20060101 , A61K31/7105 , A61K38/45 , A61K48/00 , A61P35/00 , C07H21/00 , C07H21/04 , C12N9/12 , C12N15/54 , C12Q1/48 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： Provided herein are methods for identifying risk of melanoma in a subject, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating melanoma, and therapeutic methods for treating melanoma in a subject. These embodiments are based upon an analysis of polymorphic variations in a BRAF nucleic acid, which has a nucleotide sequence exemplified by SEQ ID NO:1.
摘要翻译：本文提供用于鉴定受试者中黑素瘤风险的方法，用于实施该方法的试剂和试剂盒，用于鉴定治疗黑素瘤的候选治疗剂的方法，以及用于治疗受试者中黑素瘤的治疗方法。这些实施方案基于具有SEQ ID NO：1示例的核苷酸序列的BRAF核酸中的多态性变异的分析。

59. 发明申请

US20050272043A1 Methods for identifying risk of breast cancer and treatments thereof 审中-公开
公开(公告)号：US20050272043A1
公开(公告)日：2005-12-08
申请号：US10857780
申请日：2004-05-27
申请人： Richard Roth , Andreas Braun , Stefan Kammerer , Matthew Nelson , Rikard Reneland , Carolyn Hoyal-Wrightson
发明人： Richard Roth , Andreas Braun , Stefan Kammerer , Matthew Nelson , Rikard Reneland , Carolyn Hoyal-Wrightson
IPC分类号： C12Q20060101 , C12Q1/68
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/156 , C12Q2600/172
摘要： Provided herein are methods for identifying risk of breast cancer in a subject and/or a subject at risk of breast cancer, reagents and kits for carrying out the methods, methods for identifying candidate therapeutics for treating breast cancer, and therapeutic methods for treating breast cancer in a subject. These embodiments are based upon an analysis of polymorphic variations in nucleotide sequences within the human genome.

60. 发明授权

US08994934B1 System and method for eye safe detection of unknown targets 有权
标题翻译：眼睛安全检测未知目标的系统和方法
公开(公告)号：US08994934B1
公开(公告)日：2015-03-31
申请号：US13373333
申请日：2011-11-10
申请人： Matthew Nelson , Patrick Treado , Robert Schweitzer , Robert D'Agostino
发明人： Matthew Nelson , Patrick Treado , Robert Schweitzer , Robert D'Agostino
IPC分类号： G01N21/00 , G01N33/00 , G01J3/02
CPC分类号： G01N33/0057 , G01J3/02 , G01J3/027 , G01J3/44 , G01J5/0846 , G01J5/0859 , G01J2005/0077 , H04N5/23219
摘要： The present disclosure provides for a system and method for detecting and identifying unknown targets. At least one region of interest comprising an unknown target in a sample scene may be targeted using SWIR spectroscopic techniques. A region of interest may be surveyed to thereby determine whether or not a human is present. This surveying may be achieved my assessing LWIR data, data acquired from motion sensors, and combinations thereof. If no human is present in a region of interest, the region may be interrogated using Raman spectroscopic techniques to thereby obtain a Raman data set representative of the region of interest. This Raman data set may be assessed to thereby identify said unknown target. This assessment may be achieved by comparing the Raman data set to a reference data sets in a reference database, where each reference data set is associated with a known target.
摘要翻译：本公开提供了用于检测和识别未知目标的系统和方法。可以使用SWIR光谱技术来对包含样本场景中的未知目标的至少一个感兴趣区域进行定位。可以调查感兴趣的区域，从而确定人是否存在。本次测量可能会实现我对LWIR数据的评估，运动传感器获取的数据及其组合。如果感兴趣区域中没有人存在，则可以使用拉曼光谱技术询问该区域，从而获得表示感兴趣区域的拉曼数据集。可以评估该拉曼数据集，从而识别所述未知目标。可以通过将拉曼数据集与参考数据库中的参考数据集进行比较来实现该评估，其中每个参考数据集与已知目标相关联。

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