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51. 发明授权

US5310650A Method and device for improved reaction kinetics in nucleic acid hybridizations 失效
标题翻译：用于改善核酸杂交反应动力学的方法和装置
公开(公告)号：US5310650A
公开(公告)日：1994-05-10
申请号：US925322
申请日：1992-08-04
申请人： Michael E. McMahon , Julian Gordon
发明人： Michael E. McMahon , Julian Gordon
IPC分类号： B01L3/00 , C12Q1/68 , C12Q1/70 , G01N30/38 , G01N30/60 , G01N30/92 , G01N33/558 , G01N37/00
CPC分类号： G01N33/558 , B01L3/5023 , C12Q1/6834 , C12Q1/6876 , C12Q1/689 , C12Q1/701 , B01L2300/0825 , B01L2300/087 , B01L2400/0406 , G01N30/38 , G01N30/6065 , G01N30/92 , Y10S435/81
摘要： The present invention relates to methods and test strips for performing nucleic acid hybridizations on a porous chromatographic material having the capacity for rapid chromatographic solvent transport of non-immobilized reagents and reactive solution components by means of a selected chromatographic solvent. The strip includes a first end or contact site, at which chromatographic solvent transport begins, a second end, at which chromatographic solvent transport ends, and at least one zone positioned between the first and second ends. The zone is impregnated with a capture nucleotide sequence which is immobilized against solvent transport and which is capable of hybridization with a complementary nucleotide sequence or probe so as to render it immobilized in the capture zone. The strip may further include a probe zone between the first end and the capture zone, wherein a labeled probe is impregnated such that it is mobilized by the solvent and transported to the capture zone where hybridization can occur. Interfering sample components and unhybridized nucleic acids are cleared from the capture zone by chromatographic solvent transport to form an inherent wash.
摘要翻译：本发明涉及用于在多孔层析材料上进行核酸杂交的方法和测试条，该多孔层析材料具有通过选择的色谱溶剂快速色谱溶剂转运非固定化试剂和反应溶液组分的能力。条带包括开始色谱溶剂转移的第一端或接触位置，色谱溶剂输送结束的第二端和位于第一端和第二端之间的至少一个区。该区域被捕获核苷酸序列浸渍，该捕获核苷酸序列固定化以抵抗溶剂转运并且能够与互补核苷酸序列或探针杂交，以使其固定在捕获区中。条带还可以包括在第一端和捕获区之间的探针区，其中标记的探针被浸渍，使得其被溶剂移动并被运送到可以发生杂交的捕获区。干扰样品组分和未杂交的核酸通过色谱溶剂转移从捕获区域中清除，形成固有的洗涤液。

52. 发明授权

US4743539A Specific antibody to the native form of 2'5'-oligonucleotides, the method of preparation and the use as reagents in immunoassays or for binding 2'5-oligonucleotides in biological systems 失效
标题翻译：对2'5'-寡核苷酸的天然形式的特异性抗体，制备方法和用作免疫测定中的试剂或用于在生物系统中结合2'5-寡核苷酸
公开(公告)号：US4743539A
公开(公告)日：1988-05-10
申请号：US672266
申请日：1984-11-09
申请人： Julian Gordon , Michael A. Minks
发明人： Julian Gordon , Michael A. Minks
IPC分类号： A61K39/00 , A61K39/395 , C07K14/435 , C07K16/00 , C07K16/44 , C07K19/00 , C12P21/00 , C12Q1/00 , C12Q1/48 , C12Q1/68 , G01N33/531 , C08G77/04 , G01N33/53 , G01N33/577
CPC分类号： C07K16/44 , C12Q1/48 , C12Q1/6804 , G01N33/531 , Y10S435/81 , Y10S435/948 , Y10S436/808 , Y10S530/808 , Y10S530/81
摘要： A new specific antibody to 5'-terminal mono-, di- or triphosphorylated (2'-5')adenyl-adenosine oligonucleotides and a method of producing it have been found. The antibody can be used for the quantitative analysis of the oligonucleotides mentioned above in any one of the well known methods of immunological analysis.
摘要翻译： PCT No.PCT / EP84 / 00062 Sec。 371日期1984年11月9日 102（e）1984年11月9日PCT PCT Fils 3月6日，PCT PCT。第WO84 / 03444号公报日期：1984年9月13日。已经发现了一种新的5'-末端单，二磷酸化或三磷酸化（2'-5'）腺苷 - 腺苷寡核苷酸的特异性抗体及其生产方法。抗体可以用于任何一种众所周知的免疫学分析方法的上述寡核苷酸的定量分析。

53. 发明授权

US09618431B2 Electrokinetic device for capturing assayable agents in a dielectric fluid 有权
公开(公告)号：US09618431B2
公开(公告)日：2017-04-11
申请号：US12955150
申请日：2010-11-30
申请人： Julian Gordon , Prasanthi Gandhi
发明人： Julian Gordon , Prasanthi Gandhi
IPC分类号： G01N1/40
CPC分类号： G01N1/40 , G01N1/2202 , G01N1/2273 , G01N2001/245 , G01N2001/4038 , G01N2015/0046 , Y10T436/255
摘要： Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. In one embodiment, the agents are directed electrokinetically to the sample collection assay device with no intermediate transfer steps. The agents are directed by creation of an electrokinetic potential well, which will effect their capture on to an assay device. Environmental agents such as biowarfare agents, pathogens, allergens or pollutants are collected autonomously on to the assay device, without any human intervention. The dielectric fluid medium, such as air, is sampled by electrokinetic propulsion with no moving parts or optionally, by transporting the dielectric fluid by a fan, pump or by breath. A further embodiment for collection of pathogen samples entails breathing into a tube where the sample is exposed to an electric plasma in the neighborhood of a high voltage electrode or electrodes, further transported by the breath through a potential well created at a sample collection device, where charge particles are electroprecipitated. The dielectric fluid medium may further include non-conductive liquids, such as oils. Oils may be sampled for the presence of contaminants, contaminating organisms or bio-degrading organisms.

54. 发明申请

US20140206034A1 ELECTROKINETIC DEVICE FOR CAPTURING ASSAYABLE AGENTS IN A DIELECTRIC FLUID 有权
标题翻译：用于在电介质流体中捕获测定剂的电动装置
公开(公告)号：US20140206034A1
公开(公告)日：2014-07-24
申请号：US13747820
申请日：2013-01-23
申请人： Julian Gordon , Prasanthi Gandhi
发明人： Julian Gordon , Prasanthi Gandhi
IPC分类号： C12Q1/24
CPC分类号： C12Q1/24 , G01N1/2202
摘要： Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. The agents are directed by creation of an electrokinetic potential well, which will affect their capture on to an assay device. The dielectric fluid medium, such as air, is sampled by electrokinetic propulsion with no moving parts or optionally, by transporting the dielectric fluid by a fan, pump or by breath.
摘要翻译：描述电动装置和方法的目的是从介电流体介质中收集可分析试剂。电动流动可以通过在高电压电极中使用等离子体产生并由此带电粒子在电压梯度中的传输来诱导。药剂通过产生电动势阱来引导，这将影响它们捕获到测定装置上。诸如空气的电介质流体介质通过没有移动部件的电动推进进行采样，或者可选地，通过风扇，泵或呼吸传送电介质流体。

55. 发明授权

US08560621B2 Method and system of automating data capture from electronic correspondence 有权
公开(公告)号：US08560621B2
公开(公告)日：2013-10-15
申请号：US13309385
申请日：2011-12-01
申请人： Jai Rawat , Silvia Doundakova , Oswald Dominic D'sa , Julian Gordon , Renuka Kulkarni , Vijayasankar Dhanapal , Srinivas Gubbala , Santhosh Raman , Rajiv Anand
发明人： Jai Rawat , Silvia Doundakova , Oswald Dominic D'sa , Julian Gordon , Renuka Kulkarni , Vijayasankar Dhanapal , Srinivas Gubbala , Santhosh Raman , Rajiv Anand
IPC分类号： G06F15/16
CPC分类号： H04L51/12 , G06F17/2705 , G06F17/30876 , G06Q10/107 , G06Q40/12 , H04L51/14 , H04L67/306
摘要： A method and system of automating capture of electronic data provide a user with an effective universal Internet identity and e-mail address, comprehensive e-mail filtering and forwarding services, and e-receipt identification and data extraction. Detailed user e-mail preferences data stored at a central server may be selectively altered such that incoming correspondence is redirected in accordance with the user's preferences. Computer program code at the central server parses incoming e-mail header information and data content, selectively extracts data from identified types of correspondence, and forwards extracted data in accordance with user preferences data. Additional computer program code may manipulate the extracted data in accordance with format requirements and display the manipulated data to a user in a desired format.

56. 发明申请

US20130029408A1 INTEGRATED SYSTEM FOR SAMPLING AND ANALYSIS 有权
标题翻译：用于采样和分析的集成系统
公开(公告)号：US20130029408A1
公开(公告)日：2013-01-31
申请号：US13559911
申请日：2012-07-27
申请人： Julian Gordon
发明人： Julian Gordon
IPC分类号： C12M1/34 , C12M1/42
CPC分类号： B03C3/366 , B03C3/12 , B03C3/41 , B03C3/47 , B03C2201/26 , G01N1/2273 , G01N1/40 , G01N33/497 , G01N2001/2285
摘要： There is disclosed a device for determination of a sample from a dielectric fluid medium for a bio-specific assay device, comprising: a sampling device and a biosensor, wherein the sampling device concentrates a sample from dielectric medium by electrically focusing the sample on to a capture element and wherein said biosensor is fluidically linked to said capture element thus providing sampling and determination in a unitary device.
摘要翻译：公开了一种用于测定来自用于生物特异性测定装置的介电流体介质的样品的装置，包括：采样装置和生物传感器，其中采样装置通过将样品电聚焦到捕获元件，并且其中所述生物传感器与所述捕获元件流体连接，从而在单一设备中提供采样和确定。

57. 发明申请

US20120079049A1 METHOD AND SYSTEM OF AUTOMATING DATA CAPTURE FROM ELECTRONIC CORRESPONDENCE 有权
标题翻译：电子相关数据采集的方法与系统
公开(公告)号：US20120079049A1
公开(公告)日：2012-03-29
申请号：US13309385
申请日：2011-12-01
申请人： Jai Rawat , Silvia Doundakova , Oswald Dominic D'sa , Julian Gordon , Renuka Kulkarni , Vijayasankar Dhanapal , Srinivas Gubbala , Santhosh Raman , Rajiv Anand
发明人： Jai Rawat , Silvia Doundakova , Oswald Dominic D'sa , Julian Gordon , Renuka Kulkarni , Vijayasankar Dhanapal , Srinivas Gubbala , Santhosh Raman , Rajiv Anand
IPC分类号： G06F15/16
CPC分类号： H04L51/12 , G06F17/2705 , G06F17/30876 , G06Q10/107 , G06Q40/12 , H04L51/14 , H04L67/306
摘要： A method and system of automating capture of electronic data provide a user with an effective universal Internet identity and e-mail address, comprehensive e-mail filtering and forwarding services, and e-receipt identification and data extraction. Detailed user e-mail preferences data stored at a central server may be selectively altered such that incoming correspondence is redirected in accordance with the user's preferences. Computer program code at the central server parses incoming e-mail header information and data content, selectively extracts data from identified types of correspondence, and forwards extracted data in accordance with user preferences data. Additional computer program code may manipulate the extracted data in accordance with format requirements and display the manipulated data to a user in a desired format.
摘要翻译：自动捕获电子数据的方法和系统为用户提供有效的通用互联网身份和电子邮件地址，全面的电子邮件过滤和转发服务，以及电子收据识别和数据提取。可以选择性地改变存储在中央服务器处的详细用户电子邮件偏好数据，使得根据用户偏好重定向传入对应。中央服务器上的计算机程序代码解析输入的电子邮件头信息和数据内容，从识别的对应类型中选择性地提取数据，并根据用户偏好数据转发提取的数据。附加的计算机程序代码可以根据格式要求来操纵所提取的数据，并以期望的格式将操纵的数据显示给用户。

58. 发明授权

US08038944B1 Electrokinetic device for capturing assayable agents in a dielectric fluid 有权
标题翻译：用于在介电流体中捕获分析试剂的电动装置
公开(公告)号：US08038944B1
公开(公告)日：2011-10-18
申请号：US13028495
申请日：2011-02-16
申请人： Julian Gordon , Prasanthi Gandhi
发明人： Julian Gordon , Prasanthi Gandhi
IPC分类号： G01N27/00
CPC分类号： G01N1/40 , G01N1/2202 , G01N1/2273 , G01N2001/245 , G01N2001/4038 , G01N2015/0046 , Y10T436/255
摘要： Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. In one embodiment, the agents are directed electrokinetically to the sample collection assay device with no intermediate transfer steps. The agents are directed by creation of an electrokinetic potential well, which will effect their capture on to an assay device. Environmental agents such as biowarfare agents, pathogens, allergens or pollutants are collected autonomously on to the assay device, without any human intervention. The dielectric fluid medium, such as air, is sampled by electrokinetic propulsion with no moving parts or optionally, by transporting the dielectric fluid by a fan, pump or by breath. A further embodiment for collection of pathogen samples entails breathing into a tube where the sample is exposed to an electric plasma in the neighborhood of a high voltage electrode or electrodes, further transported by the breath through a potential well created at a sample collection device, where charge particles are electroprecipitated. The dielectric fluid medium may further include non-conductive liquids, such as oils. Oils may be sampled for the presence of contaminants, contaminating organisms or bio-degrading organisms.
摘要翻译：描述电动装置和方法的目的是从介电流体介质中收集可分析试剂。电动流动可以通过在高电压电极中使用等离子体产生并由此带电粒子在电压梯度中的传输来诱导。在一个实施方案中，将试剂电动定向于样品采集测定装置，无中间转移步骤。这些试剂通过产生电动势阱来引导，这将影响其捕获到测定装置上。环境试剂如生物灭菌剂，病原体，过敏原或污染物被自动收集到测定装置上，无需人为干预。诸如空气的电介质流体介质通过没有移动部件的电动推进进行采样，或者可选地，通过风扇，泵或呼吸传送电介质流体。用于收集病原体样品的另一实施例需要呼吸到管中，其中样品暴露于高压电极或电极附近的电等离子体，并进一步通过呼吸运送通过样品收集装置产生的潜在井，其中电荷颗粒被电沉积。介电流体介质还可以包括非导电液体，例如油。可能为污染物，污染生物体或生物降解生物体的存在而对油进行采样。

59. 发明授权

US06100099A Test strip having a diagonal array of capture spots 失效
标题翻译：具有捕获点对角阵列的测试条
公开(公告)号：US06100099A
公开(公告)日：2000-08-08
申请号：US181245
申请日：1998-10-28
申请人： Julian Gordon , Joanell Hoijer , Cynthia Jou , James Rhoads
发明人： Julian Gordon , Joanell Hoijer , Cynthia Jou , James Rhoads
IPC分类号： C07K14/47 , C12N15/10 , C12Q1/68 , G01N33/558 , G01N33/533
CPC分类号： C12Q1/6862 , C07K14/4712 , C12N15/10 , C12Q1/6813 , C12Q1/6883 , G01N33/558 , C12Q2600/156 , C12Q2600/16 , Y10S436/807 , Y10S436/81
摘要： The invention relates to multiplex ligase chain reaction (LCR). Two or more putative target sequences are selected. For each one, a set of four probes is used simultaneously to amplify the putative sequence if it is present in the sample. Preferably, all the amplicons are labeled with a common label/hapten and, for each different target, with a unique label/hapten. The invention also relates to an immunochromatographic strip device and method employing a diagonal array of capture spots.
摘要翻译：本发明涉及多重连接酶链反应（LCR）。选择两个或多个推定的靶序列。对于每一个，如果样品中存在，则同时使用一组四个探针来放大推定序列。优选地，所有扩增子用公共标记/半抗原标记，并且对于每个不同的靶标，用唯一的标记/半抗原标记。本发明还涉及使用捕获点的对角线阵列的免疫色谱条带装置和方法。

60. 发明授权

US5976824A Method and apparatus for collecting a cell sample from a liquid specimen 失效
标题翻译：从液体样品中收集细胞样品的方法和装置
公开(公告)号：US5976824A
公开(公告)日：1999-11-02
申请号：US744228
申请日：1996-11-05
申请人： Julian Gordon
发明人： Julian Gordon
IPC分类号： G01N33/48 , B01D29/01 , B01D35/02 , B01J3/00 , B01L3/00 , C12M1/26 , C12N15/09 , C12Q1/24 , C12Q1/68 , G01N1/00 , G01N1/04 , G01N1/10 , G01N1/28 , G01N1/40 , G01N33/483 , G01N33/53 , C12Q1/02 , B01D29/05 , B01D39/18 , C12M1/12
CPC分类号： G01N1/405 , B01J3/006 , B01L3/502 , B01L3/5025 , B01L3/50255 , B01L3/5635 , G01N1/4077 , G01N33/53 , G01N2001/007 , G01N2001/4088 , Y10T436/25375 , Y10T436/255
摘要： A method and apparatus for collecting a binding member of interest from a liquid specimen utilizes a collection receptacle in which the specimen is deposited, with an affinity-filter media being place in communication with a discharge port in the collection receptacle and a transfer device for drawing specimen from the collection receptacle and through the filter for capturing the binding member of interest. The collection receptacle, affinity-filter media and carrier therefor and the transfer device may be supplied in kit form for use in a clinical environment. A hypobaric vessel may be used and the transfer device and this vessel may also serve as a disposal receptacle for the liquid specimen passed through the filter media.
摘要翻译：用于从液体样本收集感兴趣的结合构件的方法和装置利用其中沉积样本的收集容器，其中亲和过滤介质与收集容器中的排出端口连通，以及用于绘制的传送装置来自收集容器的样本和用于捕获感兴趣的结合构件的过滤器。收集容器，亲和过滤介质及其载体以及转移装置可以以套件形式提供，以用于临床环境。可以使用低压容器，并且转移装置和该容器也可以用作通过过滤介质的液体样品的处理容器。

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