专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

51. 发明申请

WO2008096136A1 COMBINATIONS WITH A MUSCARINIC RECEPTOR ANTAGONIST 审中-公开
标题翻译：与一种MUSCARINIC受体拮抗剂的组合
公开(公告)号：WO2008096136A1
公开(公告)日：2008-08-14
申请号：PCT/GB2008/000415
申请日：2008-02-06
申请人： ARGENTA DISCOVERY LTD , ASTRAZENECA AB , DIXON, John , ERIKSSON, Tomas , HANSSON, John , MENSONIDES-HARSEMA, Marguerite , MO, John , FINCH, Harry
发明人： DIXON, John , ERIKSSON, Tomas , HANSSON, John , MENSONIDES-HARSEMA, Marguerite , MO, John , FINCH, Harry
IPC分类号： A61K31/421 , A61K31/4468 , A61P11/06
CPC分类号： A61K31/4468 , A61K31/421 , A61K2300/00
摘要： The invention provides a pharmaceutical product, kit or composition comprising a first active ingredient which is a selected muscarinic receptor antagonist, and a second active ingredient which is selected from a phosphodiesterase inhibitor, a modulator of chemokine receptor function, an inhibitor of kinase function, a protease inhibitor, a steroidal glucocorticoid receptor agonist, a non-steroidal glucocorticoid receptor agonist and a purinoceptor antagonist, of use in the treatment of respiratory diseases such as chronic obstructive pulmonary disease and asthma.
摘要翻译：本发明提供了包含选自毒蕈碱受体拮抗剂的第一活性成分和选自磷酸二酯酶抑制剂，趋化因子受体功能调节剂，激酶功能抑制剂，第二活性成分蛋白酶抑制剂，类固醇糖皮质激素受体激动剂，非类固醇糖皮质激素受体激动剂和嘌呤受体拮抗剂，用于治疗呼吸系统疾病如慢性阻塞性肺疾病和哮喘。

52. 发明申请

WO2007007057A1 ANTAGONISTS OF SNS SODIUM CHANNELS 审中-公开
标题翻译： SNS钠通道的拮抗剂
公开(公告)号：WO2007007057A1
公开(公告)日：2007-01-18
申请号：PCT/GB2006/002523
申请日：2006-07-07
申请人： VERNALIS (R & D) LIMITED , HAMLYN, Richard , CALLIS, David , EARNSHAW, Christopher, Geoffrey , FINCH, Harry , HUCKSTEP, Mike , LYNCH, Rosemary , MELLOR, Sarah
发明人： HAMLYN, Richard , CALLIS, David , EARNSHAW, Christopher, Geoffrey , FINCH, Harry , HUCKSTEP, Mike , LYNCH, Rosemary , MELLOR, Sarah
IPC分类号： A61K31/397 , A61P23/00
CPC分类号： A61K31/397
摘要： Compounds of the formula (I), and pharmaceutically acceptable salts thereof, are found to be antagonists of SNS sodium channels. They are therefore useful as analgesic and neuroprotective agents, formula (I): R 1 represents: (a) -L-A or -L' -A' wherein L represents a bond or a C 1- C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl moiety, A represents a phenyl, 5- to 10-membered heteroaryl, C 3 -C 6 carbocyclyl or 5- to 10-membered heterocyclyl group, L' represents a C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl moiety, and A' represents -Het-A or -X-A wherein Het represents -O-, -S- or -NR'-, and X represents -CO-, -SO-, -SO 2 -, -CO-O-, -CO-S-, -CONR'-, -O-CO-, -S-CO- or -NR'-CO-, wherein R' represents hydrogen or C 1 -C 6 alkyl; (b) -L-CR(A)(A') or -L-CR(A)(L-A) wherein R is hydrogen or C 1 1-C 4 alkyl, A' is as defined above, each L is the same or different and is as defined above and each A' is the same or different and is as defined above; (c) -L-A-A' or -L-A-L-A wherein A' and L are as defined above and each A is the same or different and is as defined above; or (d) -A-Z-A wherein Z is -Het-L'-, -X-L'-, -L'-Het- or -L'-X-, wherein Het, L' and X are as defined above and each A is the same or different and is as defined above; J represents -NR 5 -, -O- or a direct bond; R 5 represents hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; R 4 is represents hydrogen, C 1 -C 6 alkyl, C 2 -C 6 alkenyl or C 2 -C 6 alkynyl; and either R 2 represents -L-A, -L-A’, -L-A-A’, -L-A-L-A, -L-CR(A)(L-A), -L- CR(A)(A’) or -L-CR(A)(L") wherein L" is -Het-L', -X-L', -CONH 2 or -CO 2 H, and wherein A', Het, X and R are as defined above, each L is the same or different and is as defined above, each A is the same or different and is as defined above and R 3 represents hydrogen, C 1 -C 6 alkyl C 2 -C 6 alkynyl or (CO)-L', wherein L is as defined above or R 2 and R 3 form, together with the nitrogen to which they are attached, a 5-to 10-membered heteroaryl or 5-to 10-membered heterocyclyl ring.
摘要翻译：发现式（I）化合物及其药学上可接受的盐是SNS钠通道的拮抗剂。因此，它们可用作止痛和神经保护剂，式（I）：R 1表示：（a）-LA或-L'-A'，其中L表示键或C 1 C 6 -C 6烷基，C 2 -C 6亚烯基或C 2 -C 6亚烷基或C 2 -C 6亚烷基 C 6炔基部分，A表示苯基，5至10元杂芳基，C 3 -C 6碳环基或5至10元杂环基基团，L'表示C 1 -C 6烷基，C 2 -C 6亚烷基或C 1 -C 6烷基， A'表示-Het-A或-XA，其中Het表示-O - ， - S-或-NR'-，X表示 -CO - ， - SO - ， - SO 2 - ， - CO-O-，-CO-S-，-CONR'-，-O-CO-，-S-CO-或 - NR'-CO-，其中R'表示氢或C 1 -C 6烷基; （b）-L-CR（A）（A'）或-L-CR（A）（LA）其中R是氢或C 1〜烷基，A'如上所定义，每个L相同或不同，如上所定义，每个A'相同或不同，如上所定义; （c）-L-A-A'或-L-A-L-A其中A'和L如上所定义，并且每个A相同或不同，如上所定义; 或（d）-AZA，其中Z是-Het-L'-，-X-L' - ，-L'-Het-或-L'-X-，其中Het，L'和X如上所定义， A相同或不同，如上所述; J表示-NR 5 - ，-O-或直接键; R 5表示氢，C 1 -C 6烷基，C 2 -C 6烷基，C 1 -C 6烷基，链烯基或C 2 -C 6 -C 6炔基; R 4表示氢，C 1 -C 6烷基，C 2 -C 6烷基，C 1 -C 6烷基，C 1 -C 6烷基， / SUB链烯基或C 2 -C 6炔基; 并且R 2表示-LA，-L-A'，-LA-A'，-LALA，-L-CR（A）（LA），-L-CR（A）（A '）或-L-CR（A）（L“）其中L”是-Het-L'，-X-L'，-CONH 2或-CO 2 H，其中A'，Het，X和R如上所定义，每个L相同或不同，如上所定义，每个A相同或不同，如上所定义，R 3， / SO 2表示氢，C 1 -C 6烷基C 2 -C 6炔基或（CO） -L'，其中L如上定义或R 2和R 3形式与它们所连接的氮一起形成5至10元杂芳基或5至10元杂环基环。

53. 发明申请

WO2006082412A2 MULTIMERS OF HETEROCYCLIC COMPOUNDS AND THEIR USE 审中-公开
标题翻译：多元醇的杂环化合物及其用途
公开(公告)号：WO2006082412A2
公开(公告)日：2006-08-10
申请号：PCT/GB2006/000361
申请日：2006-02-03
申请人： ARGENTA DISCOVERY LTD , FINCH, Harry , EDWARDS, Christine , RAY, Nicholas, Charles , O'CONNOR, Elizabeth, Anne , FITZGERALD, Mary, F.
发明人： FINCH, Harry , EDWARDS, Christine , RAY, Nicholas, Charles , O'CONNOR, Elizabeth, Anne , FITZGERALD, Mary, F.
IPC分类号： C07D239/22 , C07D401/12 , C07D403/14 , A61K31/513 , A61P9/00
CPC分类号： C07D239/22 , A61K31/513 , A61K47/55 , C07D401/12 , C07D403/14
摘要： A compound of formula (I): M-L-M, wherein L is a linker and each M is independently a group of formula (II): is useful in therapy, e.g. of respiratory diseases.
摘要翻译：式（I）的化合物：M-L-M，其中L是连接体，每个M独立地是式（II）的基团：可用于治疗，例如，的呼吸系统疾病。

54. 发明申请

WO2013083206A1 DERIVATIVES OF 4-HYDROXY-1,2,3,4-TETRAHYDRONAPHTALEN-1-YL UREA AND THEIR USE IN THE TREATMENT OF, INTER ALIA, DISEASES OF THE RESPIRATORY TRACT 审中-公开
标题翻译： 4-羟基-1,2,3,4-四氢萘-1-炔酸的衍生物及其在治疗，相关性，呼吸道感染疾病中的应用
公开(公告)号：WO2013083206A1
公开(公告)日：2013-06-13
申请号：PCT/EP2011/072375
申请日：2011-12-09
申请人： CHIESI FARMACEUTICI S.p.A. , FINCH, Harry , VAN NIEL, Monique Bodil , WOO, Chi-Kit
发明人： FINCH, Harry , VAN NIEL, Monique Bodil , WOO, Chi-Kit
IPC分类号： C07D403/12 , C07D471/04 , A61K31/455 , A61K31/4196 , A61P11/06
CPC分类号： C07D471/04 , A61K9/007 , C07D401/12 , C07D403/12
摘要： Disclosed are compounds having [1,2,4]triazolo[4,3-a] pyridine groups and pharmaceutically acceptable salts thereof. The compounds are p38 MAPK inhibitors, useful as anti-inflammatory agents in the treatment of, inter alia, diseases of the respiratory tract.
摘要翻译：公开了具有[1,2,4]三唑并[4,3-a]吡啶基团的化合物及其药学上可接受的盐。这些化合物是p38MAPK抑制剂，可用作治疗尤其是呼吸道疾病的抗炎药。

55. 发明申请

WO2011110858A1 PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD 审中-公开
标题翻译：吡嗪衍生物及其在治疗呼吸道疾病如COPD中的应用
公开(公告)号：WO2011110858A1
公开(公告)日：2011-09-15
申请号：PCT/GB2011/050477
申请日：2011-03-10
申请人： PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED , EDWARDS, Christine , KULAGOWSKI, Janusz , FINCH, Harry
发明人： EDWARDS, Christine , KULAGOWSKI, Janusz , FINCH, Harry
IPC分类号： C07D487/04 , A61K31/519 , A61P1/00 , A61P11/00
CPC分类号： C07D487/04
摘要： Compounds of formula (I) are inhibitors of neutrophil elastase, wherein A is C-R 1 or N; -X 1 -X 2 - is CR 15 =N- or -NR 19 -CO-; and R 1 -R 6 , R 15 , R 15 and R 19 are as defined in the claims.
摘要翻译：式（I）化合物是中性粒细胞弹性蛋白酶抑制剂，其中A是C-R1或N; -X1-X2-是CR15 = N-或-NR19-CO-; 并且R 1 -R 6，R 15，R 15和R 19如权利要求中所定义。

56. 发明申请

WO2011098799A2 RESPIRATORY DISEASE TREATMENT 审中-公开
标题翻译：呼吸道疾病治疗
公开(公告)号：WO2011098799A2
公开(公告)日：2011-08-18
申请号：PCT/GB2011/050224
申请日：2011-02-09
申请人： PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED , FINCH, Harry , FOX, Craig
发明人： FINCH, Harry , FOX, Craig
IPC分类号： A61K9/00 , A61K31/427 , A61K31/4439 , C07D413/12
CPC分类号： C07D417/12 , A61K9/0075 , A61K9/008 , A61K31/427 , A61K31/4439
摘要： A pharmaceutical composition containing the compound 5-{4-[2-(5-ethyl-pyridin-2-yl)-2-hydroxy-ethoxy]-benzyl}-thiazolidine-2,4-dιone, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers and/or excipients, characterised in that at least 95% by weight of the 5-{4-[2-(5-ethyl-pyridin-2-yl)-2- hydroxy-ethoxy]-benzyl}-thiazolidine-2,4-dione content of the composition is the diastereomeric form 5(R)-{4-[2-(5-ethyl-pyridin-2-yI)=2(S)-hydroxy-ethoxy]=benzyl}- thiazolidιne-2,4-dione and less than 5% by weight is one or more of the other three diastereomeric forms.
摘要翻译：含有化合物5- {4- [2-（5-乙基 - 吡啶-2-基）-2-羟基 - 乙氧基] - 苄基} - 噻唑烷-2,4-d 1的药物组合物或药学上可接受的其盐和一种或多种药学上可接受的载体和/或赋形剂，其特征在于至少95重量％的5- {4- [2-（5-乙基 - 吡啶-2-基）-2-羟基 - 乙氧基] - 苄基} - 噻唑烷-2,4-二酮含量为非对映体形式5（R） - {4- [2-（5-乙基 - 吡啶-2-基）] = 2（S） - 羟基 - 乙氧基] =苄基} - 噻唑烷-2,4-二酮，并且小于5重量％是其它三种非对映体形式中的一种或多种。

57. 发明申请

WO2010076553A1 SULFONAMIDE COMPOUNDS FOR THE TREATMENT OF RESPIRATORY DISORDERS 审中-公开
标题翻译：用于治疗呼吸道疾病的磺酰胺化合物
公开(公告)号：WO2010076553A1
公开(公告)日：2010-07-08
申请号：PCT/GB2009/002951
申请日：2009-12-23
申请人： DR. REDDY'S LABORATORIES LTD , PULMAGEN THERAPEUTICS (INFLAMMATION) LIMITED , RAMDOS, Vidya , FINCH, Harry , FOX, Craig
发明人： RAMDOS, Vidya , FINCH, Harry , FOX, Craig
IPC分类号： C07D231/18 , A61K31/415 , A61P11/00
CPC分类号： C07D231/18
摘要： Compounds of formula (I) are agonists of PPARγ, useful for the treatment of respiratory disease; formula (I): wherein R 1 , R 2 or R 3 each independently represents halo, cyano, nitro, amino, alkyl, haloalkyl, alkoxy, haloalkoxy, carboxylic acid or an ester or amide thereof; R 4 represents hydrogen or alkyl; m, n or p independently represents 0, 1, 2 or 3.
摘要翻译：式（I）化合物是PPARγ的激动剂，可用于治疗呼吸系统疾病; 式（I）：其中R 1，R 2或R 3各自独立地表示卤素，氰基，硝基，氨基，烷基，卤代烷基，烷氧基，卤代烷氧基，羧酸或其酯或酰胺; R4表示氢或烷基; m，n或p独立地表示0,1,2或3。

58. 发明申请

WO2009037413A1 DIMERS OF 5- [ (4-CYANOPHENYL) SULFINYL] -6-METHYL-2-OXO-1- [3- (TRIFLUOROMETHYL)PHENYL] -1,2-DIHYDROPYRIDINE-3-CARBOXAMIDE AS INHIBITORS OF HUMAN NEUTROPHIL ELASTASE FOR TREATING RESPIRATORY DISEASES 审中-公开
标题翻译： 5- [（4-氰基苯基）磺酰基] -6-甲基-2-氧代-1- [3-（三氟甲基）苯基] -1,2-二氢吡啶-3-羧酰胺作为人类中性粒细胞酶抑制剂治疗呼吸道疾病
公开(公告)号：WO2009037413A1
公开(公告)日：2009-03-26
申请号：PCT/GB2007/003537
申请日：2007-09-19
申请人： ARGENTA DISCOVERY LIMITED , FINCH, Harry , RAY, Nicholas, Charles , EDWARDS, Christine
发明人： FINCH, Harry , RAY, Nicholas, Charles , EDWARDS, Christine
IPC分类号： C07D213/82 , A61K31/444 , A61P11/00
CPC分类号： C07D213/82
摘要： Six specific compounds having human neutrophil elastase inhibitory activity are disclosed, one of which has the structural formula wherein A - is a pharmaceutically acceptable anion. The compounds are useful inter alia for the treatment of inflammatory respiratory disease, and may be administered by inhalation.
摘要翻译：公开了具有人嗜中性粒细胞弹性蛋白酶抑制活性的六种具体化合物，其中一种具有结构式，其中A-是药学上可接受的阴离子。所述化合物特别用于治疗炎性呼吸系统疾病，并且可以通过吸入给药。

59. 发明申请

WO2008096094A1 BICYCLOR[2.2.1]HEPT-7-YLAMINE DERIVATIVES AS MUSCARINIC M3 RECEPTOR MODULATORS 审中-公开
标题翻译： BICYCLOR [2.2.1] HEPT-7-YLAMINE衍生物作为MUSCARINIC M3受体调节剂
公开(公告)号：WO2008096094A1
公开(公告)日：2008-08-14
申请号：PCT/GB2007/000410
申请日：2007-02-06
申请人： ARGENTA DISCOVERY LTD. , RAY, Nicholas, Charles , BULL, Richard, James , FINCH, Harry , VAN NIEL, Monique, Bodil , JENNINGS, Andrew, Stephen, Robert
发明人： RAY, Nicholas, Charles , BULL, Richard, James , FINCH, Harry , VAN NIEL, Monique, Bodil , JENNINGS, Andrew, Stephen, Robert
IPC分类号： C07D311/86 , C07D333/24 , C07D405/12 , C07D413/14 , A61K31/35 , A61K31/38 , A61K31/41 , A61K31/495 , A61P11/00 , C07C271/38
CPC分类号： C07D333/24 , C07C219/32 , C07C2603/18 , C07D311/86 , C07D405/12 , C07D413/14
摘要： Representatives of compounds of formula (I) having M3 receptor antagonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound.
摘要翻译：具有M3受体拮抗剂活性的式（I）化合物的代表; 包含这种化合物的组合物; 在治疗（如哮喘或COPD）中使用这种化合物; 以及用这种化合物治疗患者的方法。

60. 发明申请

WO2007129060A1 TETRAHYDROPYRROLOPYRIMIDINEDIONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS 审中-公开
标题翻译：四氢吡咯并嘧啶及其作为人类中性粒细胞抑制剂的用途
公开(公告)号：WO2007129060A1
公开(公告)日：2007-11-15
申请号：PCT/GB2007/001638
申请日：2007-05-03
申请人： ARGENTA DISCOVERY LIMITED , RAY, Nicholas, Charles , FINCH, Harry , EDWARDS, Christine , O'CONNOR, Elizabeth
发明人： RAY, Nicholas, Charles , FINCH, Harry , EDWARDS, Christine , O'CONNOR, Elizabeth
IPC分类号： C07D487/04 , A61K31/519 , A61P11/00
CPC分类号： C07D487/04 , A61K47/55 , C07D519/00
摘要： Compounds of formula (I) and multimers thereof are inhibitors of human neutrophil elastase activity, and utility in the treatment of, e.g., COPD: wherein all the substituents are as defined in claim 1.
摘要翻译：式（I）化合物及其多聚体是人中性粒细胞弹性蛋白酶活性的抑制剂，并且在治疗例如COPD中有用：其中所有取代基如权利要求1所定义。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式