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51. 发明申请

US20050192249A1 Room temperature stable agarose solutions 有权
标题翻译：室温稳定的琼脂糖溶液
公开(公告)号：US20050192249A1
公开(公告)日：2005-09-01
申请号：US11050243
申请日：2005-02-03
申请人： Wilson Moya , Neil Soice
发明人： Wilson Moya , Neil Soice
IPC分类号： A61K31/715 , A61K31/724 , C08J3/09 , C08J9/16 , C08J9/28 , C08L5/00 , C08L5/02 , C08L5/12 , C08L5/16 , C09D105/02 , C09D105/12 , C09D105/16
CPC分类号： C08J3/09 , C08J2305/00 , C08L5/02 , C08L5/12 , D06M11/13 , D06M11/155 , D06M11/38 , D06M15/03 , D06M23/10 , Y10T428/24149 , Y10T428/249953 , Y10T442/20
摘要： Room temperature stable, non-gelling polysaccharide solutions such as agaroses, dextrans and cyclodextrans are made by the present invention. It has been found that by incorporating certain gel-inhibiting additives into an aqueous polysaccharide solution, the gel point is reduced or eliminated and the solution remains liquid at room temperature indefinitely. Additives that have been found to work include salts, such as lithium chloride and zinc chloride and bases, such as sodium hydroxide and lithium hydroxide. Mixtures of said salts and said bases can also be used with the same desired results. The composition of these solutions of the present idea can be further modified to include other additives, such as organic co-solvents or non-solvents, pH modifiers, surfactants or other polymers to customize the properties of the solution to improve the processability for the desired application and to form structures such as films, beads and coated porous substrates.
摘要翻译：通过本发明制备室温稳定的非胶凝多糖溶液，如琼脂糖，葡聚糖和环糊精。已经发现，通过将某些凝胶抑制添加剂掺入多糖水溶液中，凝胶点被减少或消除，溶液在室温下保持液体无限期。已发现工作的添加剂包括盐，如氯化锂和氯化锌，以及碱，如氢氧化钠和氢氧化锂。所述盐和所述碱的混合物也可以以相同的期望结果使用。本发明的这些溶液的组成可进一步修饰，以包括其它添加剂，如有机共溶剂或非溶剂，pH调节剂，表面活性剂或其他聚合物，以定制溶液的性质，以改善所需溶剂的加工性能并且形成诸如膜，珠和涂覆的多孔基底的结构。

52. 发明授权

US5976380A Article of manufacture including a surface modified membrane and process 失效
标题翻译：制品包括表面改性膜和工艺
公开(公告)号：US5976380A
公开(公告)日：1999-11-02
申请号：US846867
申请日：1997-05-01
申请人： Wilson Moya
发明人： Wilson Moya
IPC分类号： B01D71/82 , B01D63/06 , B01D65/00 , B01D65/08 , B01D67/00 , B01D69/06 , B01D69/08 , B01D71/32 , B01D71/36 , C08J9/36 , B01D61/18
CPC分类号： B01D67/0088 , B01D63/061 , B01D63/067 , B01D65/003 , B01D65/08 , B01D2321/02 , B01D2321/04 , B01D2321/185
摘要： A filtration device is provided which includes a housing containing a porous membrane formed of a porous membrane substrate having its exposed surface completely modified with a perfluorocarbon copolymer composition. The porous membrane has substantially the same permeability as the porous membrane substrate.
摘要翻译：提供一种过滤装置，其包括壳体，该壳体由多孔膜基材形成，多孔膜具有用全氟化碳共聚物组合物完全改性的其暴露表面。多孔膜具有与多孔膜基材大致相同的渗透性。

53. 发明授权

US5928792A Process for making surface modified porous membrane with perfluorocarbon copolymer 失效
标题翻译：制备具有全氟碳共聚物的表面改性多孔膜的方法
公开(公告)号：US5928792A
公开(公告)日：1999-07-27
申请号：US847091
申请日：1997-05-10
申请人： Wilson Moya
发明人： Wilson Moya
IPC分类号： B01D71/82 , B01D67/00 , B01D71/32 , B01D71/36 , C08J5/22 , C08J9/36 , B32B27/00
CPC分类号： B01D67/0088 , C08J5/225 , C08J2327/12 , Y10T428/249978 , Y10T428/3154 , Y10T428/31544
摘要： A process is provided for producing a porous membrane product comprising a porous membrane having its surface completely modified with a perfluorocarbon copolymer composition. The porous membrane substrate is contacted with a solution containing a perfluorocarbon copolymer composition to bind the composition onto the substrate surface. The substrate is subjected to a mechanical force to remove excess perfluorocarbon copolymer composition and then is heat treated.
摘要翻译：提供了一种制备多孔膜产品的方法，该多孔膜产品包括其表面用全氟化碳共聚物组合物完全改性的多孔膜。使多孔膜基材与含有全氟化碳共聚物组合物的溶液接触以将组合物结合到基材表面上。对基材进行机械力去除过量的全氟碳共聚物组合物，然后进行热处理。

54. 发明授权

US5498335A Process for forming porous polmyeric product from a nonporous polymeric composition and product 失效
标题翻译：从无孔聚合物组合物和产品形成多孔聚偏二烯产品的方法
公开(公告)号：US5498335A
公开(公告)日：1996-03-12
申请号：US95138
申请日：1993-07-21
申请人： Wilson Moya
发明人： Wilson Moya
IPC分类号： C08J9/28 , B01D67/00 , B01D69/02 , B32B5/18 , C08J7/02
CPC分类号： C08J7/02 , B01D67/0023 , B01D69/02 , B01D69/06 , B01D69/08 , B01D2323/16 , B01D2323/22 , B01D2325/022
摘要： A product having a porous polymeric structure is formed from a non-porous polymeric sheet by sequential contact of the non-porous sheet with a solvent for the sheet and then a non-solvent for the sheet. The porous product can be porous through all or a portion of its thickness.
摘要翻译：具有多孔聚合物结构的产品由无孔聚合物片材通过无孔片材与片材的溶剂的顺序接触，然后用于片材的非溶剂形成。多孔产品可以通过其厚度的全部或一部分是多孔的。

55. 发明授权

US5277811A Process for forming porous polymeric product from a nonporous polymeric composition and product 失效
标题翻译：从无孔聚合物组合物和产品形成多孔聚合物产品的方法
公开(公告)号：US5277811A
公开(公告)日：1994-01-11
申请号：US868619
申请日：1992-04-14
申请人： Wilson Moya
发明人： Wilson Moya
IPC分类号： C08J9/28 , B01D67/00 , B01D69/02 , B32B5/18 , C08J7/02 , B01D69/00
CPC分类号： C08J7/02 , B01D67/0023 , B01D69/02 , B01D69/06 , B01D69/08 , B01D2323/16 , B01D2323/22 , B01D2325/022
摘要： A product having a porous polymeric structure is formed from a non-porous polymeric sheet by sequential contact of the non-porous sheet with a solvent for the sheet and then a non-solvent for the sheet. The porous product can be porous through all or a portion of its thickness.
摘要翻译：具有多孔聚合物结构的产品由无孔聚合物片材通过无孔片材与片材的溶剂的顺序接触，然后用于片材的非溶剂形成。多孔产品可以通过其厚度的全部或一部分是多孔的。

56. 发明授权

US09803165B2 Stirred tank reactor and method 有权
公开(公告)号：US09803165B2
公开(公告)日：2017-10-31
申请号：US13610954
申请日：2012-09-12
申请人： Wilson Moya , Alison Dupont
发明人： Wilson Moya , Alison Dupont
IPC分类号： A23J1/00 , C12M1/02 , C12M1/00
CPC分类号： C12M27/00 , C12M23/20 , C12M23/28 , C12M47/12
摘要： Container for sample preparation or processing, such as biomass culturing or processing, and optionally sample purification. In certain embodiments, the reactor is a bioreactor that includes a stirred cell device that simulates a tangential flow filter to reduce or eliminate clogging that can be caused by the solids generated. In certain embodiments, the solids comprise a precipitate or floc or beads, such as one that includes a polymer that binds the biomolecule(s) of interest, and impurities. In its method aspects, embodiments disclosed herein include purification and isolation of biomolecules of interest derived from cell culture fluids. The methods include carrying out sample preparation or processing in a container, culturing a biomass; generating solids by precipitating or flocculating a biomolecule of interest from the cultured broth; preventing the solids from settling in the container by agitation; and purification, such as by eluting the biomolecule of interest and filtering the same.

57. 发明授权

US08691918B2 Stimulus responsive polymers for the purification of biomolecules 有权
标题翻译：用于生物分子纯化的刺激响应聚合物
公开(公告)号：US08691918B2
公开(公告)日：2014-04-08
申请号：US13108576
申请日：2011-05-16
申请人： Jad Jaber , Wilson Moya , James Hamzik , Arezki Boudif , Yu Zhang , Neil Soice , John Charkoudian , Nripen Singh
发明人： Jad Jaber , Wilson Moya , James Hamzik , Arezki Boudif , Yu Zhang , Neil Soice , John Charkoudian , Nripen Singh
IPC分类号： C08F16/00
CPC分类号： B01J41/14 , B01J41/13 , C07K1/30 , C07K1/32 , C07K16/00 , C07K2317/10 , C08F8/00 , C08F8/02 , C08F126/02 , C08F26/02
摘要： The present invention provides novel and improved stimulus responsive polymers and methods of using the same for the purification of biomolecules.
摘要翻译：本发明提供了新的和改进的刺激响应聚合物以及使用其进行生物分子纯化的方法。

58. 发明授权

US08362217B2 Purification of proteins 有权
标题翻译：蛋白质的纯化
公开(公告)号：US08362217B2
公开(公告)日：2013-01-29
申请号：US12004319
申请日：2007-12-20
申请人： Wilson Moya , Jad Jaber
发明人： Wilson Moya , Jad Jaber
IPC分类号： A61K39/395 , C07K1/32
CPC分类号： C07K1/32 , C07K1/30
摘要： The present invention relates to a selectively soluble polymer capable of binding to a desired biomolecules in a mixture containing various biological materials and the methods of using such a polymer to purify a biomolecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired biomolecule (protein, polypeptide, etc) and remains capable of binding to that biomolecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.
摘要翻译：本发明涉及能够在含有各种生物材料的混合物中结合所需生物分子的选择性可溶性聚合物以及使用这种聚合物从这种混合物中纯化生物分子的方法。聚合物在一定的工艺条件例如pH或温度和/或盐浓度下可溶于混合物中，并且在工艺条件改变时变得不溶解并沉淀出溶液。聚合物能够结合所需的生物分子（蛋白质，多肽等），并且即使在聚合物从溶液中沉淀出来之后仍然能够结合该生物分子。然后可以从流的其余部分过滤出沉淀物，并回收所需的生物分子，例如通过洗脱和进一步处理。

59. 发明授权

US08163886B2 Purification of proteins 有权
标题翻译：蛋白质的纯化
公开(公告)号：US08163886B2
公开(公告)日：2012-04-24
申请号：US12004314
申请日：2007-12-20
申请人： Wilson Moya
发明人： Wilson Moya
IPC分类号： A61K39/395 , C07K16/00 , C07K1/32 , C12P21/08
CPC分类号： C07K1/32 , C07K1/30 , C07K16/00
摘要： The present invention relates to a selectively soluble polymer capable of binding to one or more constituents in a mixture containing various biological materials and the methods of using such a polymer to purify a biomolecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and is rendered insoluble and precipitates out of solution upon a change in the process conditions. While in its solubilized state, the polymer is capable of binding to a selected entity within the stream such as impurities (DNA, RNA, host cell protein, endotoxins, etc) in a cell broth and remains capable of binding to that entity even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered and further processed.
摘要翻译：本发明涉及能够结合含有各种生物材料的混合物中的一种或多种成分的选择性可溶性聚合物以及使用这种聚合物从这种混合物中纯化生物分子的方法。聚合物在一定的工艺条件如pH或温度下可溶于混合物，并且在工艺条件改变时使聚合物变得不溶解并沉淀出溶液。虽然在其溶解状态下，聚合物能够与流中的所选择的实体结合，例如在细胞肉汤中的杂质（DNA，RNA，宿主细胞蛋白，内毒素等），并且仍然能够结合该实体，即使在聚合物从溶液中沉淀出来。然后可以从剩余的物流中过滤出沉淀物，并回收所需的生物分子并进一步处理。

60. 发明授权

US08158196B2 Method of forming coated structures 有权
标题翻译：形成涂层结构的方法
公开(公告)号：US08158196B2
公开(公告)日：2012-04-17
申请号：US13160237
申请日：2011-06-14
申请人： Wilson Moya
发明人： Wilson Moya
IPC分类号： B05D5/00
CPC分类号： B01D69/125 , B01D67/0011 , B01D67/0093 , B01D69/10 , B01D71/08 , B01D2323/08 , B01D2323/30 , B01J20/261 , B01J20/28033 , B01J20/28042 , B01J20/28045 , B01J20/286 , B01J20/3064 , B01J20/3208 , B01J20/321 , B01J20/3272 , B01J20/328 , B01J20/3282 , B01J2220/54
摘要： A process for forming room temperature water soluble polymer coatings on porous substrates by a solution of a room temperature water soluble polymer, one or more crosslinkers, a solvent for the room temperature water soluble polymer such as water and optionally one or more porogens, or functional agents, stirring the mixture until all the components are dissolved, adding the solution to a porous structure such as a non-woven fabric or a porous membrane and drying the solution on to the substrate as a coating before subjecting the coating to crosslinking. Alternatively, the coating may be partially crosslinked before drying the solution. Porous structures having a room temperature water soluble polymer coating and being capable of convective flow through the pores of the structure and diffusive flow through the coating can be formed.
摘要翻译：通过室温水溶性聚合物，一种或多种交联剂，室温水溶性聚合物如水和任选的一种或多种致孔剂的溶剂或功能性的水溶性聚合物溶液形成多孔基材上的室温水溶性聚合物涂层的方法试剂，搅拌混合物直到所有组分溶解，将溶液加入到诸如无纺织物或多孔膜的多孔结构中，并将该溶液作为涂层干燥，作为涂层，然后使涂层交联。或者，涂层在干燥溶液之前可以部分交联。可以形成具有室温水溶性聚合物涂层并且能够对流流过结构的孔和通过涂层的扩散流的多孔结构。

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