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51. 发明专利

AU2013327282A1 7-azaindol-2,7-naphthyridine derivative for the treatment of tumors 未知
公开(公告)号：AU2013327282A1
公开(公告)日：2015-05-14
申请号：AU2013327282
申请日：2013-09-09
申请人： MERCK PATENT GMBH
发明人： JONCZYK ALFRED , ZENKE FRANK T , AMENDT CHRISTIANE
IPC分类号： C07D519/00 , A61K31/4375 , A61P35/00
摘要： The invention relates to the compound 4-(2-methyl-1H-pyrrolo[2,3-b]pyridino-3-yl)- [2,7]naphthyridino-1-ylamine and its pharmaceutically usable salts and/or tautomers. The invention also relates to the use of said compounds for the treatment of tumors, tumor growth, tumor metastases and/or AIDS.

53. 发明专利

CA2611892C TETRAHYDROQUINOLINE DERIVATIVES AS MOTOR PROTEIN EG5 INHIBITORS AND ANTITUMOR AGENTS 未知
公开(公告)号：CA2611892C
公开(公告)日：2013-08-13
申请号：CA2611892
申请日：2006-05-31
申请人： MERCK PATENT GMBH
发明人： STAEHLE WOLFGANG , BRUGE DAVID , SCHIEMANN KAI , FINSINGER DIRK , BUCHSTALLER HANS-PETER , ZENKE FRANK , AMENDT CHRISTIANE
IPC分类号： C07D221/16 , A61K31/473 , A61K31/4741 , A61K31/496 , A61P35/00 , C07D401/08 , C07D491/04
摘要： Compounds of formula I (see formula I) in which s, W, R, R1, R2, R3, R6, R7 and U have the meanings given in the description for use as Motor Protein EG5 inhibitors and antitumor agents.

54. 发明专利

ZA201206630B HETARYL-[1,8]NAPHTHYRIDINE DERIVATIVES 未知
公开(公告)号：ZA201206630B
公开(公告)日：2013-05-29
申请号：ZA201206630
申请日：2012-09-04
申请人： MERCK PATENT GMBH
发明人： JONCZYK ALFRED , HOELZEMANN GUENTER , ZENKE FRANK , DORSCH DIETER , AMENDT CHRISTIANE
IPC分类号： A61K20060101 , A61P20060101 , C07D20060101
摘要： Novel hetaryl-[1,8]naphthyridine derivatives of formula (I) wherein R1, R2, W1, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.

55. 发明专利

AU2011276193A8 Bipyridyl derivatives useful for the treatment of kinase - induced diseases 未知
公开(公告)号：AU2011276193A8
公开(公告)日：2013-05-02
申请号：AU2011276193
申请日：2011-06-07
申请人： MERCK PATENT GMBH
发明人： HOELZEMANN GUENTER , DORSCH DIETER , JONCZYK ALFRED , AMENDT CHRISTIANE , ZENKE FRANK
IPC分类号： C07D213/74 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61P25/00 , A61P29/00 , A61P35/00 , C07D401/14 , C07D471/04
摘要： The present invention relates to novel bipyridyl derivatives of formula (I) and to the use of such compounds in which the inhibition, regulation and/or modulation of signal transduction by ATP consuming proteins like kinases plays a role, particularly to inhibitors of TGF-beta receptor kinases, and to the use of such compounds for the treatment of kinase-induced diseases, in particular for the treatment of tumors.

56. 发明专利

ECSP13012408A DERIVADOS DE [1,8]NAFTIRIDINA 未知
公开(公告)号：ECSP13012408A
公开(公告)日：2013-03-28
申请号：ECSP13012408
申请日：2013-01-25
申请人： MERCK PATENT GMBH
发明人： DORSCH DIETER , JONCZYK ALFRED , HOELZEMANN GUENTER , AMENDT CHRISTIANE , ZENKE FRANK
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00 , C07D519/00
摘要： La presente invención se refiere a nuevos derivados de [1,8]naftiridina de la fórmula (I) y al uso de tales compuestos en donde la inhibición, regulación y/o modulación de la transducción de señales por proteínas que consumen ATP como quinasas desempeña un papel importante, en particular a inhibidores de las quinasas TGF-beta receptoras y al uso de tales compuestos para el tratamiento de enfermedades inducidas por quinasas, en particular para el tratamiento de tumores.

57. 发明专利

MX2012014549A [1, 8]-NAFTIRIDINAS SUSTITUIDAS CON 2, 4-DIARILO COMO INHIBIDORES DE CINASA QUE SE USAN CONTRA EL CANCER. 未知
公开(公告)号：MX2012014549A
公开(公告)日：2013-02-07
申请号：MX2012014549
申请日：2011-05-31
申请人： MERCK PATENT GMBH
发明人： DORSCH DIETER , JONCZYK ALFRED , AMENDT CHRISTIANE , ZENKE FRANK , HOELZEMANN GUENTER
IPC分类号： C07D471/04 , A61K31/4375 , A61P35/00 , C07D519/00
摘要： La presente invención se refiere a nuevos derivados de [1, 8] naftiridina de la fórmula (I) y al uso de tales compuestos en donde la inhibición, regulación y/o modulación de la transducción de señales por proteínas que consumen ATP como cinasas desempeña un papel importante, en particular a inhibidores de las cinasas TGF-beta receptoras y al uso de tales compuestos para el tratamiento de enfermedades inducidas por cinasas, en particular para el tratamiento de tumores.

58. 发明专利

CA2838573A1 TREATMENT OF CANCERS AND METASTASES WITH SUSPENSIONS OF CILENGITIDE IN CARRIER 未知
公开(公告)号：CA2838573A1
公开(公告)日：2012-12-13
申请号：CA2838573
申请日：2012-05-16
申请人： MERCK PATENT GMBH
发明人： GOODMAN SIMON , AMENDT CHRISTIANE , EBER MARCUS
IPC分类号： A61K9/10 , A61K9/00 , A61K9/16 , A61K38/12 , A61K47/44
摘要： The present invention relates to a pharmaceutical composition of oligopeptides, preferably cyclic oligopeptides, said composition further comprising one or more lipophilic and/or amphiphilic compounds, in the presence or absence of water as the main ingredients, the use of the lipophilic and/or amphiphilic compounds for making pharmaceutical compositions of said oligopeptides, and methods of making said pharmaceutical composition.

59. 发明专利

SG183233A1 HETARYLAMINONAPHTHYRIDINES 未知
公开(公告)号：SG183233A1
公开(公告)日：2012-09-27
申请号：SG2012058871
申请日：2011-01-10
申请人： MERCK PATENT GMBH
发明人： JONCZYK ALFRED , DORSCH DIETER , ZENKE FRANK , AMENDT CHRISTIANE
摘要： Novel hetarylaminonaphthyridine derivatives of formula (I) wherein X, R1, R2, R3, R4, W1, W2, W3, W5 and W6 have the meaning according to claim 1, are inhibitors of ATP consuming proteins, and can be employed, inter alia, for the treatment of tumors.

60. 发明专利

ES2385329T3 Derivados de pirrol adecuados para el tratamiento de enfermedades proliferativas 未知
公开(公告)号：ES2385329T3
公开(公告)日：2012-07-23
申请号：ES04790859
申请日：2004-10-26
申请人： MERCK PATENT GMBH
发明人： FINSINGER DIRK , BUCHSTALLER HANS-PETER , BURGDORF LARS , WIESNER MATTHIAS , AMENDT CHRISTIANE , GRELL MATTHIAS , SIRRENBERG CHRISTIAN , ZENKE FRANK
IPC分类号： C07D401/12 , C07D207/32 , C07D207/337
摘要： Compuestos seleccionados del grupoN-Metilamida de ácido 4-{4-[5-(4-cloro-3-trifluormetil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(4-cloro-3-trifluormetil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{4-[5-(3-cloro-4-metil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{4-[5-(2-metoxi-5-trifluormetil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(3-cloro-4-metil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{4-[5-(3-cloro-6-metoxi-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(3-cloro-6-metoxi-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(2-metoxi-5-trifluormetil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(2,5-dimetoxi-4-cloro-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(4-brom-3-trifluormetil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(3-trifluormetil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(4-ter.-butil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(3,4-dicloro-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4- {3-[5-(4-cloro- 3- metil- 6- metoxi- fenilcarbamoil)- 1H- pirrol- 3- il]-fenoxi}-piridin- 2-carboxílico,N-Metilamida de ácido 4-{3-[5-(2,4-dimetoxi-5-trifluormetoxi-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(2-dimetilamino-5-trifluormetil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(2-(2-metilamino-etoxi)-5-metil-fenilcarbamoil)-1 H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(2-(2-dimetilamino-etoxi)-5-metil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,N-Metilamida de ácido 4-{3-[5-(2-[(2-dimetilamino-etil)-metil-amino]-5-metil-fenilcarbamoil)-1H-pirrol-3-il]-fenoxi}-piridin-2-carboxílico,así como sus solvatos, sales y estereoisómeros de utilidad farmacéutica, incluidas sus mezclas en todas lasproporciones.

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