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51. 发明授权

US07949411B1 Epicardial lead 有权
标题翻译：心外膜导联
公开(公告)号：US07949411B1
公开(公告)日：2011-05-24
申请号：US11626132
申请日：2007-01-23
申请人： Michael Yang , Sheldon Williams , Wenbo Hou , Kevin L. Morgan , Xiaoyi Min
发明人： Michael Yang , Sheldon Williams , Wenbo Hou , Kevin L. Morgan , Xiaoyi Min
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/057
摘要： Embodiments include electrical leads and methods of using electrical leads that may be used for delivering both cardioversion/defibrillation signals and pacing signals and sensing to target tissue. Some of these embodiments may also be used to sense and transmit electrical signals from target tissue. Some electrical lead embodiments are configured to be delivered into a patient's intrapericardial space by non-invasive methods.
摘要翻译：实施例包括电引线和使用电引线的方法，其可以用于将心律转复/除颤信号和起搏信号以及感测传送到目标组织。这些实施例中的一些也可以用于感测和传输来自目标组织的电信号。一些电引线实施例被配置为通过非侵入性方法递送到患者的心包内空间。

52. 发明授权

US07881810B1 Cardiac access methods and apparatus 有权
标题翻译：心脏存取方法和装置
公开(公告)号：US07881810B1
公开(公告)日：2011-02-01
申请号：US11753484
申请日：2007-05-24
申请人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
发明人： Yougandh Chitre , Gene A. Bornzin , John R. Helland , Eric Falkenberg , Kevin L. Morgan , Sheldon Williams , Michael Yang , Andrew W. McGarvey
IPC分类号： A61N1/05
CPC分类号： A61F2/2478 , A61B17/00 , A61B17/0057 , A61N1/0587
摘要： A chamber or vasculature of a heart may be accessed via the pericardial space of the heart. Initially, the pericardial space may be accessed via a transmyocardial approach or a subxiphoid approach. A lead or other implantable apparatus may thus be routed into the pericardial space, through myocardial tissue and into the chamber or vasculature. The lead or other apparatus may be used to sense activity in or provide therapy to the heart.
摘要翻译：可以通过心脏的心包空间访问心脏的腔室或脉管系统。最初，心包空间可以通过心肌的方法或亚型的方法进行。因此，引线或其它可植入装置可通过心肌组织进入心包空间并进入腔室或脉管系统。铅或其他装置可用于感测心脏的活动或提供对心脏的治疗。

53. 发明申请

US20100331940A1 IMPLANTABLE MEDICAL LEAD CONFIGURED FOR IMPROVED MRI SAFETY AND HEATING REDUCTION PERFORMANCE 有权
标题翻译：用于改善MRI安全和加热降低性能的可植入医用引线
公开(公告)号：US20100331940A1
公开(公告)日：2010-12-30
申请号：US12495612
申请日：2009-06-30
申请人： Virote Indravudh , Yong D. Zhao , Kevin L. Morgan , Dion F. Davis , Grace Jang
发明人： Virote Indravudh , Yong D. Zhao , Kevin L. Morgan , Dion F. Davis , Grace Jang
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/086
摘要： An implantable medical lead configured for improved MRI safety and heating reduction performance is disclosed herein. In one embodiment, the lead includes a tubular body having a proximal end and a distal end with a lead connector near the proximal end. In this embodiment the lead further includes a conductor extending longitudinally within the tubular body and having a proximal end that is electrically coupled to the connector and a distal end electrically coupled to a contact pin. The lead in this embodiment further includes a filter element electrically coupled to a distal end of the contact pin and a flange electrically coupled between a proximal end of the filter element and a proximal portion of an electrode. In this embodiment the flange and the proximal portion of the electrode form at least a first part of a hermetic chamber enclosing the filter element.
摘要翻译：本文公开了一种被配置用于改善MRI安全性和加热降低性能的可植入医疗引线。在一个实施例中，引线包括具有近端和远端的管状体，其具有靠近近端的引线连接器。在该实施例中，引线还包括在管状体内纵向延伸的导体，并且具有电连接到连接器的近端和电耦合到接触销的远端。该实施例中的引线还包括电耦合到接触针的远端的过滤元件和电耦合在过滤元件的近端和电极的近端部分之间的凸缘。在该实施例中，电极的凸缘和近端部分形成封闭过滤元件的密封室的至少第一部分。

54. 发明授权

US07397166B1 Electroactive polymer-actuated peristaltic pump and medical lead incorporating such a pump 失效
标题翻译：电动聚合物致动的蠕动泵和包含这种泵的医用引线
公开(公告)号：US07397166B1
公开(公告)日：2008-07-08
申请号：US11404268
申请日：2006-04-12
申请人： Kevin L. Morgan , Anne M. Shelchuk , Jeffery D. Snell , Nils Holmström , John R. Helland
发明人： Kevin L. Morgan , Anne M. Shelchuk , Jeffery D. Snell , Nils Holmström , John R. Helland
IPC分类号： H01L41/08
CPC分类号： F04B43/1223 , A61M5/14228 , A61M2205/0283 , F04B43/095 , F04B43/12 , Y10S310/80
摘要： A peristaltic pump for conveying a fluid comprises a flexible tube having an outer surface and a lumen for carrying the fluid such as a therapeutic agent. The tube has a length defined by opposed ends of the tube, the outer surface of the body carrying a plurality of longitudinally spaced-apart electroactive polymer actuators. The plurality of actuators are adapted to be responsive to electrical signals for energizing the actuators sequentially along the length of the tube to move a lumen pinch-off along the length of the tube to thereby convey the fluid from one end of the tube to the other end by means of a peristaltic pumping action. The peristaltic pump may be incorporated into a medical lead, such as an endocardial pacing lead, carrying at least one electrode.
摘要翻译：用于输送流体的蠕动泵包括具有用于承载诸如治疗剂的流体的外表面和内腔的柔性管。管具有由管的相对端限定的长度，本体的外表面承载多个纵向间隔开的电活性聚合物致动器。多个致动器适于响应于电信号，以沿着管的长度依次致动致动器，以沿着管的长度移动管腔夹紧，从而将流体从管的一端传送到另一端通过蠕动泵送动作结束。蠕动泵可以并入到携带至少一个电极的医疗引线（例如心内膜起搏引线）中。

55. 发明授权

US07272448B1 Medical lead for placement in the pericardial sac 失效
标题翻译：医疗用铅放置在心包囊内
公开(公告)号：US07272448B1
公开(公告)日：2007-09-18
申请号：US11136786
申请日：2005-05-24
申请人： Kevin L. Morgan , Annapurna Karicherla
发明人： Kevin L. Morgan , Annapurna Karicherla
IPC分类号： A61N1/05
CPC分类号： A61N1/0587
摘要： The lead body of a medical lead comprises a distal end portion carrying at least one electrode for placement in the pericardial sac of a human heart. The distal end portion of the lead body includes a multi-turn section having opposed ends, opposing forces applied to the ends tending to flatten the multi-turn section, the multi-turn section being thereby adapted to be retained within the pericardial sac. The turns of the multi-turn section may become progressively smaller from one end of the section to the other end of the section. The multi-turn section may have, in a relaxed state thereof, a generally conical, helical configuration. The at least one electrode may be carried adjacent to the end of the multi-turn section having the larger turns. Alternatively, the at least one electrode may be carried adjacent to the end of the multi-turn section having the smaller turns.
摘要翻译：医用引线的引线体包括承载至少一个用于放置在人心脏心包囊中的电极的远端部分。引线本体的远端部分包括具有相对端部的多匝部分，施加到端部的相对的力倾向于使多匝部分变平，所述多匝部分因此适于保持在心包囊内。多匝部分的匝可以从该部分的一端到该部分的另一端逐渐变小。多匝部分在其松弛状态下可具有大致圆锥形的螺旋形构造。至少一个电极可以靠近具有较大匝数的多匝部分的端部承载。或者，至少一个电极可以承载在具有较小匝数的多匝部分的端部附近。

56. 发明授权

US07056314B1 Steerable obturator 有权
标题翻译：导向闭孔器
公开(公告)号：US07056314B1
公开(公告)日：2006-06-06
申请号：US10452244
申请日：2003-05-30
申请人： Joseph J. Florio , Gene A. Bornzin , Kevin L. Morgan , Sheldon Williams , Janice Barstad
发明人： Joseph J. Florio , Gene A. Bornzin , Kevin L. Morgan , Sheldon Williams , Janice Barstad
IPC分类号： A61M25/01
CPC分类号： A61M25/0152 , A61B17/3478 , A61B2017/003 , A61M25/0136 , A61M25/0141 , A61M25/0147 , A61M2025/015 , A61M2025/0161
摘要： An omnidirectionally steerable obturator facilitates the delivery of the distal tip of an introducer sheath into the coronary sinus of a heart. The steerable obturator comprises an obturator body extending longitudinally along a central axis, the obturator body being configured to be received by the introducer sheath. The obturator body further has a flexible, deflectable distal end section terminating in a rounded distal tip. An actuator, controllable from a proximal end of the obturator body, is operatively associated with the flexible distal end section of the obturator body to cause deflection of the flexible distal end section of the obturator body in at least one selected direction to facilitate passage of the distal end section of the obturator body and the distal tip of the introducer sheath into the coronary sinus of the heart.The obturator body is preferably configured to be received in a close fit within at least the tip of the introducer sheath. More preferably, the distal end of the obturator body has an outer surface and the fit between the outer surface of the obturator and at least the tip of the introducer sheath comprises substantially a line-to-line fit.
摘要翻译：全向可操纵的闭孔器有利于将导引鞘的远侧末端递送到心脏的冠状窦。可操纵的闭孔器包括沿着中心轴线纵向延伸的闭孔器，所述封闭器主体构造成由引导器护套容纳。闭孔体还具有终止于圆形远端尖端的柔性的，可偏转的远端部分。从闭塞体的近端可控制的致动器与闭塞体的柔性远端部分可操作地相关联，以使闭塞体的柔性远端部分沿至少一个选定的方向偏转，以便于通过闭塞体的远端部分和导引鞘的远侧末端插入心脏的冠状窦。闭孔体优选构造成在至少引导器护套的尖端内紧密配合。更优选地，闭孔体的远端具有外表面，并且填塞物的外表面与引导器护套的至少末端之间的配合基本上包括线对齐配合。

57. 发明授权

US06687549B1 Lead conductor lumen with cross-sectional shape to minimize effects of compressive forces 失效
标题翻译：导体管腔具有横截面形状，以最小化压缩力的影响
公开(公告)号：US06687549B1
公开(公告)日：2004-02-03
申请号：US09911978
申请日：2001-07-25
申请人： John R. Helland , Kevin L. Morgan , Phong D. Doan
发明人： John R. Helland , Kevin L. Morgan , Phong D. Doan
IPC分类号： A61N106
CPC分类号： A61N1/056
摘要： An implantable endocardial lead intended for use with a cardiac stimulation device includes an elongated lead body of flexible resilient material, for example, silicone rubber or polyurethane, having a longitudinally extending lumen defined by a plurality of longitudinally extending side wall surfaces, adjacent pairs of the side wall surfaces lying in angularly disposed planes and intersecting at an energy absorbing corner ridge. An electrical conductor is located loosely within and extends longitudinally along the lumen between proximal and distal ends. With this construction, forces imposed laterally on the lead body by the conductor engaging the side wall surfaces of the lumen upon bending of the lead body are absorbed without damaging the lead body by reason of engagement of the conductor with a corner ridge causing the corner ridge thereby engaged to recede toward a condition of being coplanar with its subtended pair of side wall surfaces.
摘要翻译：旨在用于心脏刺激装置的可植入心内膜包括柔性弹性材料的细长引线体，例如硅橡胶或聚氨酯，具有由多个纵向延伸的侧壁表面限定的纵向延伸的内腔，相邻的一对侧壁表面位于角度设置的平面中并且在能量吸收拐角脊处相交。电导体松散地位于内端之间并且在近端和远端之间沿内腔纵向延伸。利用这种结构，通过在引线体弯曲时与内腔的侧壁表面接合的导体横向地施加的力被吸收，而不会因导体与导致角隅角的拐角接合而损坏引线体从而接合到与其对置的一对侧壁表面共面的状态。

58. 发明授权

US06501993B2 Electrode assembly with a detachable distal tip 失效
标题翻译：具有可拆卸远端的电极组件
公开(公告)号：US06501993B2
公开(公告)日：2002-12-31
申请号：US09818418
申请日：2001-03-27
申请人： Kevin L. Morgan , Russell Klehn , Benedict L. Gomperz , Buehl E. Truex
发明人： Kevin L. Morgan , Russell Klehn , Benedict L. Gomperz , Buehl E. Truex
IPC分类号： A61N105
CPC分类号： A61N1/0565 , A61N2001/0578
摘要： An electrode assembly including a tip electrode and a longitudinally extending axially aligned weld electrode egageably receiving a distal end of a coiled wire strand conductor at a proximal end. A connector member includes a fastener having an enlarged head and a threaded shank, the weld electrode includes an integral weld sleeve with an annular locking tab engageable with the enlarged head to prevent longitudinal movement while permitting rotational movement. The weld electrode has an internal bore for receiving an elongated stylet selectively engageable therewith for implanting and explanting the electrode assembly. The tip electrode includes an integral attachment sleeve having an outer peripheral surface extending in a direction away from the tip and having a longitudinally extending tapped bore for engagement with the threaded shank of the connector member. The weld sleeve and attachment sleeve are mutually stepped to prevent their relative rotation when in the locked position.
摘要翻译：一种电极组件，包括尖端电极和纵向延伸的轴向对齐的焊接电极，其在近端可靠地接收线圈绞线导线的远端。连接器构件包括具有扩大的头部和螺纹柄的紧固件，焊接电极包括具有可与扩大的头部接合的环形锁定突起的整体焊接套管，以防止纵向运动，同时允许旋转运动。焊接电极具有用于接收可选择性地与其接合的细长探针的内孔，用于植入和移出电极组件。尖端电极包括整体连接套筒，其具有沿远离尖端的方向延伸的外周表面，并且具有纵向延伸的螺纹孔，用于与连接器构件的螺纹杆接合。焊接套筒和连接套筒相互台阶以防止其在锁定位置时的相对转动。

59. 发明授权

US06456890B2 Lead with polymeric tubular liner for guidewire and stylet insertion 有权
标题翻译：带有用于导丝和通孔插入的聚合物管状衬垫
公开(公告)号：US06456890B2
公开(公告)日：2002-09-24
申请号：US09797531
申请日：2001-02-28
申请人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
发明人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
IPC分类号： A61N100
CPC分类号： A61N1/056
摘要： An implantable lead for electrical stimulation of the body includes an elongated multi-lumen tube with a distal tip electrode having a longitudinally extending central bore. A cable conductor is received in one lumen of the multi-lumen tube for electrical connection to the tip electrode and an elongated polymeric tubular liner having a coefficient of friction in the range of 0.01 to 0.20 is received in another lumen of the multi-lumen tube generally aligned with the bore of the distal tip electrode for freely receiving a guidewire through the tubular liner and through the bore of the distal tip electrode. An electrically conductive proximal pin is attached to the multi-lumen tubing distant from the tip electrode and, in one embodiment, the cable conductor and the proximal end of the polymeric tubular liner are attached to the proximal pin. Initially, the guidewire is implanted into the body along a desired trajectory. With the polymeric tubular liner inserted, first the distal tip electrode, then the remainder of the multi-lumen tube, are slid onto the guidewire such that the guidewire slidably advances within the polymeric tubular liner. Thereupon, the multi-lumen tube is advanced along the guidewire until a desired site is achieved and the guidewire is removed from the body and the multi-lumen tube. In another embodiment, the distal tip electrode has no central bore but the elongated polymeric tubular liner is axially aligned with the distal tip electrode for freely receiving a stylet which is attached with the distal tip electrode.
摘要翻译：用于电刺激身体的可植入引线包括细长的多腔管，其具有具有纵向延伸的中心孔的远端尖端电极。电缆导体容纳在多腔管的一个内腔中，用于电连接到尖端电极，并且具有在0.01至0.20范围内的摩擦系数的细长聚合物管状衬垫被容纳在多腔管的另一内腔中通常与远侧末端电极的孔对准，用于自由地接收穿过管状衬垫的导丝并且穿过远端尖端电极的孔。导电近端针连接到远离尖端电极的多腔管，并且在一个实施例中，电缆导体和聚合物管状衬垫的近端附接到近端针。最初，导线沿着期望的轨迹植入体内。在插入聚合物管状衬垫的情况下，首先将远侧末端电极，然后多腔管的其余部分滑动到导丝上，使得导丝可在聚合物管状衬垫内滑动地前进。于是，多腔管沿着导丝线前进，直到达到所需的位置，导线从主体和多管腔管中取出。在另一个实施例中，远端尖端电极没有中心孔，但是细长的聚合物管状衬套与远端尖端电极轴向对齐，用于自由接收与远侧末端电极连接的探针。

60. 发明授权

US06456889B2 Lead with polymeric tubular liner for guidewire and stylet insertion 有权
标题翻译：带有用于导丝和通孔插入的聚合物管状衬垫
公开(公告)号：US06456889B2
公开(公告)日：2002-09-24
申请号：US09797281
申请日：2001-02-28
申请人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
发明人： Anne M. Pianca , Gene A. Bornzin , Christopher R. Jenney , Kevin L. Morgan , Sheldon Williams
IPC分类号： A61N1100
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An implantable lead for electrical stimulation of the body includes an elongated multi-lumen tube with a distal tip electrode having a longitudinally extending central bore. A cable conductor is received in one lumen of the multi-lumen tube for electrical connection to the tip electrode and an elongated polymeric tubular liner having a coefficient of friction in the range of 0.01 to 0.20 is received in another lumen of the multi-lumen tube generally aligned with the bore of the distal tip electrode for freely receiving a guidewire through the tubular liner and through the bore of the distal tip electrode. An electrically conductive proximal pin is attached to the multi-lumen tubing distant from the tip electrode and, in one embodiment, the cable conductor and the proximal end of the polymeric tubular liner are attached to the proximal pin. Initially, the guidewire is implanted into the body along a desired trajectory. With the polymeric tubular liner inserted, first the distal tip electrode, then the remainder of the multi-lumen tube, are slid onto the guidewire such that the guidewire slidably advances within the polymeric tubular liner. Thereupon, the multilumen tube is advanced along the guidewire until a desired site is achieved and the guidewire is removed from the body and the multi-lumen tube. In another embodiment, the distal tip electrode has no central bore but the elongated polymeric tubular liner is axially aligned with the distal tip electrode for freely receiving a stylet which is attached with the distal tip electrode.
摘要翻译：用于电刺激身体的可植入引线包括细长的多腔管，其具有具有纵向延伸的中心孔的远端尖端电极。电缆导体容纳在多腔管的一个内腔中，用于电连接到尖端电极，并且具有在0.01至0.20范围内的摩擦系数的细长聚合物管状衬垫被容纳在多腔管的另一内腔中通常与远侧末端电极的孔对准，用于自由地接收穿过管状衬垫的导丝并且穿过远端尖端电极的孔。导电近端针连接到远离尖端电极的多腔管，并且在一个实施例中，电缆导体和聚合物管状衬垫的近端附接到近端针。最初，导线沿着期望的轨迹植入体内。在插入聚合物管状衬垫的情况下，首先将远侧末端电极，然后多腔管的其余部分滑动到导丝上，使得导丝可在聚合物管状衬垫内滑动地前进。于是，多根管沿引导线前进，直到达到所需的位置，导线从主体和多管腔中取出。在另一个实施例中，远端尖端电极没有中心孔，但是细长的聚合物管状衬套与远端尖端电极轴向对齐，用于自由接收与远侧末端电极连接的探针。

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